EA201692508A1 - Производное полиенового макролида - Google Patents

Производное полиенового макролида

Info

Publication number
EA201692508A1
EA201692508A1 EA201692508A EA201692508A EA201692508A1 EA 201692508 A1 EA201692508 A1 EA 201692508A1 EA 201692508 A EA201692508 A EA 201692508A EA 201692508 A EA201692508 A EA 201692508A EA 201692508 A1 EA201692508 A1 EA 201692508A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polyene macrolide
macrolide derivative
present
compound
derivative
Prior art date
Application number
EA201692508A
Other languages
English (en)
Other versions
EA037093B1 (ru
Inventor
Кейсуке Миядзаки
Кендзи Такая
Такафуми Охара
Хидеки Сугимото
Манабу Фудзитани
Юки Огата
Наоюки Судзуки
Original Assignee
Сионоги Энд Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сионоги Энд Ко., Лтд. filed Critical Сионоги Энд Ко., Лтд.
Publication of EA201692508A1 publication Critical patent/EA201692508A1/ru
Publication of EA037093B1 publication Critical patent/EA037093B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Настоящее изобретение представляет собой следующее производное амфотерицина Вгде каждый символ определен в описании. Соединение по настоящему изобретению имеет в 16 положении (X), который представляет собой структуру мочевины, циклическую структуру, гидроксиалкил или замещенный моноалкилкарбамоил. Соединение по настоящему изобретению имеет противогрибковую активность.
EA201692508A 2014-06-12 2015-06-12 Производное полиенового макролида EA037093B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014121341 2014-06-12
PCT/JP2015/066976 WO2015190587A1 (ja) 2014-06-12 2015-06-12 ポリエンマクロライド誘導体

Publications (2)

Publication Number Publication Date
EA201692508A1 true EA201692508A1 (ru) 2017-04-28
EA037093B1 EA037093B1 (ru) 2021-02-04

Family

ID=54833670

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692508A EA037093B1 (ru) 2014-06-12 2015-06-12 Производное полиенового макролида

Country Status (16)

Country Link
US (2) US10246478B2 (ru)
EP (1) EP3156410A4 (ru)
JP (1) JP6601818B2 (ru)
KR (1) KR102106765B1 (ru)
CN (1) CN106414473B (ru)
AU (1) AU2015272398B2 (ru)
BR (1) BR112016028890A8 (ru)
CA (1) CA2951516C (ru)
EA (1) EA037093B1 (ru)
IL (1) IL249430B (ru)
MA (1) MA39568A1 (ru)
MX (1) MX2016015455A (ru)
PH (1) PH12016502357A1 (ru)
SG (1) SG11201610162XA (ru)
TW (1) TWI702223B (ru)
WO (1) WO2015190587A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015331904B2 (en) * 2014-10-17 2021-02-11 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B
EP3242554A4 (en) * 2015-01-08 2018-06-06 The Board of Trustees of the University of Illionis Concise synthesis of urea derivatives of amphotericin b
JP7240811B2 (ja) * 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
WO2018106571A1 (en) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
JP7477177B2 (ja) 2018-09-07 2024-05-01 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 毒性が低減されたハイブリッドアムホテリシンｂ誘導体
JP2023537921A (ja) * 2020-08-10 2023-09-06 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ アムホテリシンｂのハイブリッドアミド誘導体
CN111909226A (zh) * 2020-08-11 2020-11-10 深圳市儿童医院 一种葡萄糖酸修饰的两性霉素b衍生物及其用途
CN115536716A (zh) * 2021-06-29 2022-12-30 中国科学院上海药物研究所 两性霉素b半合成衍生物及其制备方法和用途
CN113773355B (zh) * 2021-08-23 2023-03-10 湖南省微生物研究院 一种多烯大环内酯类化合物及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122086B1 (en) 1979-04-09 1982-06-30 Politechnika Gdanska Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh
ZA807892B (en) 1979-12-24 1981-12-30 Dumex Ltd As Water soluble guanidine derivatives of polyene marcrolides and the esters thereof
JPS56123794A (en) * 1980-02-29 1981-09-29 Nippon Denso Co Ltd Load driving unit for vehicle
JPH024295A (ja) * 1988-06-22 1990-01-09 Toshiba Corp 医用画像診断装置
GB8829593D0 (en) * 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds
FR2654339B1 (fr) 1989-11-14 1994-10-28 Mayoly Spindler Laboratoires Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.
FR2683723B1 (fr) * 1991-11-14 1995-05-19 Mayoly Spindler Laboratoires Nouveaux medicaments antiviraux actifs sur le virus vih.
WO1993016090A1 (en) 1992-02-12 1993-08-19 Smithkline Beecham Plc Amphotericin b derivative
GB9203476D0 (en) * 1992-02-19 1992-04-08 Smithkline Beecham Plc Novel compounds
US5606038A (en) 1995-04-10 1997-02-25 Competitive Technologies, Inc. Amphiphilic polyene macrolide antibiotic compounds
PL180253B1 (pl) 1995-05-13 2001-01-31 Politechnika Gdanska Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL
FR2776927B1 (fr) 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
EP1198755A2 (en) 1999-08-02 2002-04-24 Glaxo Group Limited Computer-implemented methods and systems for estimating costs and benefits associated with disease management interventions
JP2003519662A (ja) 2000-01-14 2003-06-24 イントラバイオティクス ファーマシューティカルズ，インコーポレイテッド ポリエン・マクロライド誘導体並びにその製法及び使用
WO2007096137A1 (en) * 2006-02-23 2007-08-30 Eth Zurich Amphotericin derivatives
EP2174944A4 (en) 2007-07-30 2010-09-22 Shanghai Inst Pharm Industry POLYENDIESTERANTIBIOTIKA
MX365184B (es) 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
BR112014031060A2 (pt) 2012-06-15 2017-06-27 Blirt S A composto de fórmula 1a; composição farmacêutica; uso do composto; método para tratamento de infecção fúngica em um paciente; produto de proteção de planta; método para tratamento de infecção fúngica em uma planta; produto de tratamento de edifício antifúngico; método para tratamento de um edifício; e composto para uso
KR102548341B1 (ko) * 2013-10-07 2023-06-26 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 개선된 치료 지수를 갖는 암포테리신 b 유도체
WO2016112243A1 (en) 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Urea derivatives of amphotericin b derived from secondary amines
JP7240811B2 (ja) 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体

Also Published As

Publication number Publication date
AU2015272398B2 (en) 2018-04-26
US20170190729A1 (en) 2017-07-06
MA39568A1 (fr) 2017-09-29
CN106414473B (zh) 2020-03-13
US10696707B2 (en) 2020-06-30
KR102106765B1 (ko) 2020-05-06
US10246478B2 (en) 2019-04-02
IL249430A0 (en) 2017-02-28
CN106414473A (zh) 2017-02-15
JPWO2015190587A1 (ja) 2017-04-20
CA2951516A1 (en) 2015-12-17
KR20170016957A (ko) 2017-02-14
PH12016502357A1 (en) 2017-02-13
WO2015190587A1 (ja) 2015-12-17
MX2016015455A (es) 2017-03-23
US20190135847A1 (en) 2019-05-09
IL249430B (en) 2020-05-31
EP3156410A1 (en) 2017-04-19
BR112016028890A8 (pt) 2021-03-23
JP6601818B2 (ja) 2019-11-06
CA2951516C (en) 2019-04-02
BR112016028890A2 (pt) 2017-08-22
TWI702223B (zh) 2020-08-21
AU2015272398A1 (en) 2016-12-08
SG11201610162XA (en) 2017-01-27
TW201625655A (zh) 2016-07-16
EA037093B1 (ru) 2021-02-04
EP3156410A4 (en) 2018-01-03

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU