MX2016015455A - Derivado de macrolido de polieno. - Google Patents

Derivado de macrolido de polieno.

Info

Publication number
MX2016015455A
MX2016015455A MX2016015455A MX2016015455A MX2016015455A MX 2016015455 A MX2016015455 A MX 2016015455A MX 2016015455 A MX2016015455 A MX 2016015455A MX 2016015455 A MX2016015455 A MX 2016015455A MX 2016015455 A MX2016015455 A MX 2016015455A
Authority
MX
Mexico
Prior art keywords
polyene macrolide
macrolide derivative
formula
derivative
polyene
Prior art date
Application number
MX2016015455A
Other languages
English (en)
Inventor
Miyazaki Keisuke
Ohara Takafumi
Sugimoto Hideki
Fujitani Manabu
OGATA Yuki
Suzuki Naoyuki
Takaya Kenji
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of MX2016015455A publication Critical patent/MX2016015455A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención es el siguiente derivado de Anfotericina B: (ver Fórmula) en donde cada símbolo se define en la descripción. El compuesto de la presente invención se caracteriza por tener una estructura de urea, estructura cíclica, hidroxialquilo o monoalquilcarbamoilo sustituido en la posición 16 (X). El compuesto de la presente invención tiene actividad antifúngica.
MX2016015455A 2014-06-12 2015-06-12 Derivado de macrolido de polieno. MX2016015455A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014121341 2014-06-12
PCT/JP2015/066976 WO2015190587A1 (ja) 2014-06-12 2015-06-12 ポリエンマクロライド誘導体

Publications (1)

Publication Number Publication Date
MX2016015455A true MX2016015455A (es) 2017-03-23

Family

ID=54833670

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016015455A MX2016015455A (es) 2014-06-12 2015-06-12 Derivado de macrolido de polieno.

Country Status (16)

Country Link
US (2) US10246478B2 (es)
EP (1) EP3156410A4 (es)
JP (1) JP6601818B2 (es)
KR (1) KR102106765B1 (es)
CN (1) CN106414473B (es)
AU (1) AU2015272398B2 (es)
BR (1) BR112016028890A8 (es)
CA (1) CA2951516C (es)
EA (1) EA037093B1 (es)
IL (1) IL249430B (es)
MA (1) MA39568A1 (es)
MX (1) MX2016015455A (es)
PH (1) PH12016502357A1 (es)
SG (1) SG11201610162XA (es)
TW (1) TWI702223B (es)
WO (1) WO2015190587A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10087206B2 (en) * 2014-10-17 2018-10-02 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B
AU2016205187B2 (en) * 2015-01-08 2020-02-27 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin B
US9957290B2 (en) * 2015-04-15 2018-05-01 Sfunga Therapeutics, Inc. Derivatives of amphotericin B
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
WO2018106571A1 (en) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
AU2019335409A1 (en) 2018-09-07 2021-05-06 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin B derivatives with reduced toxicity
KR20230061405A (ko) * 2020-08-10 2023-05-08 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 암포테리신 b의 하이브리드 아미드 유도체
CN111909226A (zh) * 2020-08-11 2020-11-10 深圳市儿童医院 一种葡萄糖酸修饰的两性霉素b衍生物及其用途
CN115536716A (zh) * 2021-06-29 2022-12-30 中国科学院上海药物研究所 两性霉素b半合成衍生物及其制备方法和用途
CN113773355B (zh) * 2021-08-23 2023-03-10 湖南省微生物研究院 一种多烯大环内酯类化合物及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122086B1 (en) 1979-04-09 1982-06-30 Politechnika Gdanska Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh
ZA807892B (en) 1979-12-24 1981-12-30 Dumex Ltd As Water soluble guanidine derivatives of polyene marcrolides and the esters thereof
JPS56123794A (en) * 1980-02-29 1981-09-29 Nippon Denso Co Ltd Load driving unit for vehicle
JPH024295A (ja) * 1988-06-22 1990-01-09 Toshiba Corp 医用画像診断装置
GB8829593D0 (en) * 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds
FR2654339B1 (fr) 1989-11-14 1994-10-28 Mayoly Spindler Laboratoires Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.
FR2683723B1 (fr) * 1991-11-14 1995-05-19 Mayoly Spindler Laboratoires Nouveaux medicaments antiviraux actifs sur le virus vih.
WO1993016090A1 (en) 1992-02-12 1993-08-19 Smithkline Beecham Plc Amphotericin b derivative
GB9203476D0 (en) * 1992-02-19 1992-04-08 Smithkline Beecham Plc Novel compounds
US5606038A (en) 1995-04-10 1997-02-25 Competitive Technologies, Inc. Amphiphilic polyene macrolide antibiotic compounds
PL180253B1 (pl) 1995-05-13 2001-01-31 Politechnika Gdanska Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL
FR2776927B1 (fr) 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
WO2001009758A2 (en) 1999-08-02 2001-02-08 Glaxo Group Limited Computer-implemented methods and systems for estimating costs and benefits associated with disease management interventions
CA2394833A1 (en) 2000-01-14 2001-07-19 Binh T. Dang Derivatives of polyene macrolides and preparation and use thereof
EP1987049A1 (en) * 2006-02-23 2008-11-05 ETH Zürich Amphotericin derivatives
EP2174944A4 (en) 2007-07-30 2010-09-22 Shanghai Inst Pharm Industry POLYENDIESTERANTIBIOTIKA
MX365184B (es) 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
CA2876074A1 (en) * 2012-06-15 2013-12-19 Blirt S.A. N-substituted second generation derivatives of antifungal antibiotic amphotericin b and methods of their preparation and application
CA2925904C (en) * 2013-10-07 2021-11-23 The Board Of Trustees Of The University Of Illinois Amphotericin b derivatives with improved therapeutic index
WO2016112243A1 (en) 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Urea derivatives of amphotericin b derived from secondary amines
US9957290B2 (en) * 2015-04-15 2018-05-01 Sfunga Therapeutics, Inc. Derivatives of amphotericin B

Also Published As

Publication number Publication date
US20190135847A1 (en) 2019-05-09
IL249430A0 (en) 2017-02-28
AU2015272398B2 (en) 2018-04-26
EA201692508A1 (ru) 2017-04-28
US20170190729A1 (en) 2017-07-06
IL249430B (en) 2020-05-31
EP3156410A4 (en) 2018-01-03
CA2951516A1 (en) 2015-12-17
SG11201610162XA (en) 2017-01-27
PH12016502357A1 (en) 2017-02-13
AU2015272398A1 (en) 2016-12-08
TWI702223B (zh) 2020-08-21
US10246478B2 (en) 2019-04-02
US10696707B2 (en) 2020-06-30
MA39568A1 (fr) 2017-09-29
TW201625655A (zh) 2016-07-16
KR20170016957A (ko) 2017-02-14
JPWO2015190587A1 (ja) 2017-04-20
BR112016028890A8 (pt) 2021-03-23
CN106414473B (zh) 2020-03-13
KR102106765B1 (ko) 2020-05-06
EA037093B1 (ru) 2021-02-04
CA2951516C (en) 2019-04-02
EP3156410A1 (en) 2017-04-19
JP6601818B2 (ja) 2019-11-06
CN106414473A (zh) 2017-02-15
WO2015190587A1 (ja) 2015-12-17
BR112016028890A2 (pt) 2017-08-22

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