DE69624236T2 - Ausgewählte lösliche ester von indolcarbazolen die hydroxyl enthalten - Google Patents

Ausgewählte lösliche ester von indolcarbazolen die hydroxyl enthalten

Info

Publication number
DE69624236T2
DE69624236T2 DE69624236T DE69624236T DE69624236T2 DE 69624236 T2 DE69624236 T2 DE 69624236T2 DE 69624236 T DE69624236 T DE 69624236T DE 69624236 T DE69624236 T DE 69624236T DE 69624236 T2 DE69624236 T2 DE 69624236T2
Authority
DE
Germany
Prior art keywords
indolcarbazoles
containing hydroxyl
soluble esters
esters
selected soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69624236T
Other languages
English (en)
Other versions
DE69624236D1 (de
Inventor
P Mallamo
L Hudkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Cephalon LLC
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Cephalon LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/417,611 external-priority patent/US5650407A/en
Application filed by Kyowa Hakko Kogyo Co Ltd, Cephalon LLC filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of DE69624236D1 publication Critical patent/DE69624236D1/de
Application granted granted Critical
Publication of DE69624236T2 publication Critical patent/DE69624236T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
DE69624236T 1995-04-05 1996-04-03 Ausgewählte lösliche ester von indolcarbazolen die hydroxyl enthalten Expired - Fee Related DE69624236T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/417,611 US5650407A (en) 1995-04-05 1995-04-05 Selected soluble esters of hydroxyl-containing indolocarbazoles
US08/624,707 US5686444A (en) 1995-04-05 1996-03-26 Selected soluble esters of hydroxyl-containing indolocarbazoles
PCT/US1996/004568 WO1996031515A1 (en) 1995-04-05 1996-04-03 Selected soluble esters of hydroxyl-containing indolocarbazoles

Publications (2)

Publication Number Publication Date
DE69624236D1 DE69624236D1 (de) 2002-11-14
DE69624236T2 true DE69624236T2 (de) 2003-09-11

Family

ID=27023791

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69624236T Expired - Fee Related DE69624236T2 (de) 1995-04-05 1996-04-03 Ausgewählte lösliche ester von indolcarbazolen die hydroxyl enthalten

Country Status (16)

Country Link
US (2) US5686444A (de)
EP (1) EP0827505B1 (de)
JP (1) JPH11504623A (de)
KR (1) KR100429117B1 (de)
AT (1) ATE225793T1 (de)
AU (1) AU700658B2 (de)
BR (1) BR9608044A (de)
CA (1) CA2215111A1 (de)
DE (1) DE69624236T2 (de)
DK (1) DK0827505T3 (de)
ES (1) ES2183941T3 (de)
HK (1) HK1009370A1 (de)
NO (1) NO311575B1 (de)
NZ (1) NZ306205A (de)
PT (1) PT827505E (de)
WO (1) WO1996031515A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686444A (en) 1995-04-05 1997-11-11 Cephalon, Inc. Selected soluble esters of hydroxyl-containing indolocarbazoles
AU2012199A (en) * 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
US6200968B1 (en) * 1998-08-06 2001-03-13 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
CN1329034C (zh) * 1998-09-25 2007-08-01 赛福伦公司 预防/治疗感觉毛细胞和耳蜗神经元损伤的药物
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1500989A (fr) * 1966-08-30 1967-11-10 Produits cosmétiques pour les soins de la peau
GB1317185A (en) * 1969-06-20 1973-05-16 Glaxo Lab Ltd Acyloxy-3alpha-hydroxy-pregnones
US4534899A (en) * 1981-07-20 1985-08-13 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4894226A (en) * 1986-11-14 1990-01-16 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polyproline conjugation
JPH0826036B2 (ja) * 1987-01-22 1996-03-13 協和醗酵工業株式会社 生理活性物質ｋ−２５２の誘導体
WO1988007045A1 (en) * 1987-03-09 1988-09-22 Kyowa Hakko Kogyo Co., Ltd. Derivatives of physiologically active substance k-252
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
WO1993008809A1 (en) * 1991-11-08 1993-05-13 The University Of Southern California Compositions containing k-252 compounds for potentiation of neurotrophin activity
US5461146A (en) * 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
CA2123895A1 (en) * 1992-09-21 1994-03-31 Tatsuya Tamaoki A therapeutic agent for thrombocytopenia
EP0643966A4 (de) * 1993-03-03 1995-08-09 Kyowa Hakko Kogyo Kk Wirkstoff zur verbesserung des empfindlichkeit für antineoplastische wirkstoffe.
NZ267337A (en) * 1993-05-28 2005-01-28 Kyowa Hakko Kogyo Kk Indolocarbazole derivatives and pharmaceutical compositions thereof
US5650407A (en) 1995-04-05 1997-07-22 Cephalon, Inc. Selected soluble esters of hydroxyl-containing indolocarbazoles
US5686444A (en) 1995-04-05 1997-11-11 Cephalon, Inc. Selected soluble esters of hydroxyl-containing indolocarbazoles

Also Published As

Publication number Publication date
NO311575B1 (no) 2001-12-10
EP0827505A1 (de) 1998-03-11
MX9707632A (es) 1998-06-30
ES2183941T3 (es) 2003-04-01
KR19980703588A (ko) 1998-11-05
US5686444A (en) 1997-11-11
NO974580L (no) 1997-11-27
DE69624236D1 (de) 2002-11-14
EP0827505A4 (de) 1998-08-12
NO974580D0 (no) 1997-10-03
AU5440896A (en) 1996-10-23
KR100429117B1 (ko) 2004-07-19
ATE225793T1 (de) 2002-10-15
USRE38332E1 (en) 2003-11-25
HK1009370A1 (en) 1999-06-04
EP0827505B1 (de) 2002-10-09
DK0827505T3 (da) 2003-02-17
NZ306205A (en) 2000-01-28
AU700658B2 (en) 1999-01-14
WO1996031515A1 (en) 1996-10-10
PT827505E (pt) 2003-01-31
JPH11504623A (ja) 1999-04-27
BR9608044A (pt) 1999-01-26
CA2215111A1 (en) 1996-10-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee