IN2014DN10551A - - Google Patents

Info

Publication number
IN2014DN10551A
IN2014DN10551A IN10551DEN2014A IN2014DN10551A IN 2014DN10551 A IN2014DN10551 A IN 2014DN10551A IN 10551DEN2014 A IN10551DEN2014 A IN 10551DEN2014A IN 2014DN10551 A IN2014DN10551 A IN 2014DN10551A
Authority
IN
India
Prior art keywords
derivatives
antifungal
semisynthetic
complexes
plant
Prior art date
Application number
Inventor
Edward Borowski
Natalia Salewska
Majewska Joanna Boros
Maria Milewska
Malgorzata Wysocka
Slawomir Milewski
Izabela Lacka
Michal Sabisz
Original Assignee
Blirt S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blirt S A filed Critical Blirt S A
Publication of IN2014DN10551A publication Critical patent/IN2014DN10551A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

The invention provides semisynthetic N substituted derivatives of the antifungal antibiotic Amphotericin B and water soluble salts and complexes pharmaceutical compositions and plant and building treatment products comprising the derivatives and their use as antifungal antibiotics.
IN10551DEN2014 2012-06-15 2013-06-14 IN2014DN10551A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL39954512 2012-06-15
PCT/EP2013/062436 WO2013186384A1 (en) 2012-06-15 2013-06-14 N-substituted second generation derivatives of antifungal antibiotic amphotericin b and methods of their preparation and application

Publications (1)

Publication Number Publication Date
IN2014DN10551A true IN2014DN10551A (en) 2015-08-21

Family

ID=48626066

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10551DEN2014 IN2014DN10551A (en) 2012-06-15 2013-06-14

Country Status (12)

Country Link
US (1) US9745335B2 (en)
EP (1) EP2861610A1 (en)
JP (1) JP2015519389A (en)
KR (1) KR20150027217A (en)
CN (1) CN104520309B (en)
AU (1) AU2013276480B2 (en)
BR (1) BR112014031060A2 (en)
CA (1) CA2876074A1 (en)
IN (1) IN2014DN10551A (en)
MX (1) MX2014015249A (en)
RU (1) RU2014152459A (en)
WO (1) WO2013186384A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015272398B2 (en) * 2014-06-12 2018-04-26 Shionogi And Co., Ltd. Polyene macrolide derivative
CA3021061C (en) 2015-04-15 2023-10-24 Martin D. Burke Derivatives of amphotericin b
CN111491639A (en) * 2017-09-20 2020-08-04 异位性医疗有限责任公司 Compositions and methods for treating and ameliorating respiratory conditions and mucosal inflammation
RU2688658C1 (en) * 2018-04-10 2019-05-22 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Antifungal semi-synthetic polyene antibiotic, water-soluble salts thereof and pharmaceutical compositions based thereon
CN110669087B (en) * 2018-07-02 2023-03-31 上海医药工业研究院 Amphotericin B peptide derivative and preparation method thereof
CN113166188B (en) * 2018-12-13 2023-06-20 正大天晴药业集团股份有限公司 Amphotericin B peptide derivatives
CA3149916A1 (en) * 2019-08-08 2021-02-11 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin b
WO2022003181A1 (en) * 2020-07-03 2022-01-06 Nanotracks Diagnostics Urea derivatives of amphotericin amb, compositions containing same, and uses thereof, isocyanate derivatives of omega-amino alkyl, and use thereof for obtaining said urea derivatives
FR3112145A1 (en) * 2020-07-03 2022-01-07 Nanotracks Diagnostics UREA DERIVATIVES OF POLYENIC MACROLIDES, SPECIAL CHEMICAL COMPOUNDS LIKELY TO BE USED TO OBTAIN THESE UREA DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USES
CN111875653A (en) * 2020-08-11 2020-11-03 深圳市儿童医院 Disulfide bond-containing amphotericin B derivative and application thereof
RU2751333C1 (en) * 2020-12-16 2021-07-13 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Method for obtaining antifungal semisynthetic polyene antibiotic
CN115536716A (en) * 2021-06-29 2022-12-30 中国科学院上海药物研究所 Amphotericin B semisynthetic derivative, preparation method and application thereof
CN113603738B (en) * 2021-07-23 2023-05-23 西南大学 PH responsive amphotericin B derivative and preparation method and application thereof
CN114133428B (en) * 2021-12-09 2023-10-27 华东理工大学 Amphotericin B hydrophilic polypeptide derivative and application thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244590A (en) * 1960-12-23 1966-04-05 Rutgers Res And Educational Fo Polyenic compounds and procedures related thereto
GB1359473A (en) 1970-11-03 1974-07-10 Prodotti Antibiotici Spa Polyenic antibiotic
PL82224B1 (en) 1971-08-13 1975-10-31
FI60877C (en) 1971-08-13 1982-04-13 Politechnika Gdanska PROTECTION OF THERAPEUTIC ACTIVITIES OF THERAPEUTIC ACTIVITIES WITH A DISPENSABLE POLYENMACROLIDANTIBIOTICS-N-GLYCOSYL DERIVATIVES
US4195172A (en) * 1976-04-22 1980-03-25 Politechnika Gdanska Salts of N-glycosyl derivatives of polyene macrolides, especially N-methylglucamine salts as well as the method of their preparation
PL100966B1 (en) * 1976-04-22 1978-11-30 METHOD OF OBTAINING N-GLYCOSYL DERIVATIVES OF POLYENUM MACROLIDES AND THEIR SALT, ESPECIALLY N-METHYL GLUCAMINE SALT
DE2706156C3 (en) 1977-02-14 1981-08-20 Vsesojuznyj naučno-issledovatel'skij technologičeskij institut antibiotikov i fermentov medicinskogo naznačenija, Leningrad N, N, N-trimethyl derivatives of amphoteric, antifungal polyene antibiotics and processes for their preparation
US4144328A (en) 1977-02-28 1979-03-13 Vainshtein Viktor A N,N,N-Trimethyl derivatives of polyene amphoteric antibiotics, process of producing same and pharmaceutical composition
PL122884B1 (en) 1978-07-19 1982-08-31 Politechnika Gdanska Method of manufacture of quaternary trimethylammonium salts of inorganic derivatives of polyene macrolides
US4272525A (en) * 1978-10-23 1981-06-09 Schering Corporation Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them
PL120111B1 (en) 1978-11-10 1982-02-27 Politechnika Gdanska Process for preparing novel n-substituted derivatives of antibiotics from the group of polyenic macrolydestibiotikov iz gruppy polienovykh makrolidov
PL120035B1 (en) 1978-12-20 1982-02-27 Politechnika Gdanska Process for preparing novel methyl esters of n-substituted derivatives of antibiotics from the group of polyenic macrolydesykh proizvodnykh antibiotikov iz gruppy polienovykh makrolidov
ZA807892B (en) 1979-12-24 1981-12-30 Dumex Ltd As Water soluble guanidine derivatives of polyene marcrolides and the esters thereof
PL138831B1 (en) 1983-11-16 1986-11-29 Politechnika Gdanska Process for preparing l-aspartates of 3-/n,n-dimethylamino/-propylamides of antibiotics from polyene macrolids group
PL142848B1 (en) * 1984-10-29 1987-12-31 Politechnika Gdanska Method of obtaining derivatives of n-/n,n-dimethylaminoacyl methyl esters and 3-/n,n-dimethylamino/-propylamides of polyenic acrolydes
GB8829592D0 (en) 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds
GB8829593D0 (en) 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds
FR2654339B1 (en) * 1989-11-14 1994-10-28 Mayoly Spindler Laboratoires NOVEL SOLUBLE AND NON-TOXIC DERIVATIVES OF BASIC POLYENIC MACROLIDES, THEIR PREPARATION AND THEIR APPLICATIONS.
GB9203476D0 (en) 1992-02-19 1992-04-08 Smithkline Beecham Plc Novel compounds
PL180253B1 (en) * 1995-05-13 2001-01-31 Politechnika Gdanska N-methyl n-glycoside derivatives of methyl esters of antibiotic from the group of polyene macrolydes and their salts, method of obtaining them and using them in medical care
US5942495A (en) * 1996-05-10 1999-08-24 Btg International Limited Antibiotics
US5981721A (en) 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
FR2776927B1 (en) 1998-04-07 2002-07-05 Univ Paris Curie COMPOSITIONS FOR VECTORIZING MOLECULES
EP1278527A4 (en) 2000-01-14 2003-04-09 Intrabiotics Pharmaceuticals Derivatives of polyene macrolides and preparation and use thereof
US6413537B1 (en) 2000-03-10 2002-07-02 Wisconsin Alumni Research Foundation Nystatin formulation having reduced toxicity
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
JP2002096091A (en) * 2000-09-21 2002-04-02 Hitachi Ltd Oil and fat component decomposition composition and oil and fat decomposition method
EP1987049A1 (en) * 2006-02-23 2008-11-05 ETH Zürich Amphotericin derivatives
PL210774B1 (en) 2006-06-19 2012-02-29 Politechnika Gdanska Spatially hospheric N-amineacyl derivatives of amphotercin B, the manner of obtaining them and application for fighting of fungicidal microorganisms
US8217013B2 (en) 2007-07-30 2012-07-10 Shanghai Institute Of Pharmaceutical Industry Polyene diester antibiotics

Also Published As

Publication number Publication date
JP2015519389A (en) 2015-07-09
CN104520309A (en) 2015-04-15
RU2014152459A (en) 2016-08-10
EP2861610A1 (en) 2015-04-22
CA2876074A1 (en) 2013-12-19
US20150291648A1 (en) 2015-10-15
AU2013276480A1 (en) 2015-01-15
BR112014031060A2 (en) 2017-06-27
MX2014015249A (en) 2015-08-20
AU2013276480B2 (en) 2018-01-04
KR20150027217A (en) 2015-03-11
WO2013186384A1 (en) 2013-12-19
US9745335B2 (en) 2017-08-29
CN104520309B (en) 2018-05-04

Similar Documents

Publication Publication Date Title
IN2014DN10551A (en)
MX2016016666A (en) Boronic acid derivatives and therapeutic uses thereof.
MX2016015093A (en) Boronic acid derivatives and therapeutic uses thereof.
EP3263135A4 (en) Pharmaceutical composition for treating cancer comprising microrna as active ingredient
PH12015502261A1 (en) Macrocyclic deaza-purinones for the treatment of viral infections
MX2015008627A (en) Boronic acid derivatives and therapeutic uses thereof.
PH12015500983A1 (en) Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
ZA201906451B (en) 4-pyridone compound or salt thereof, and pharmaceutical composition and formulation including same
MX2020005181A (en) Aminopyridine derivatives as tam family kinase inhibitors.
PH12014501738A1 (en) Piperidino-pyrimidine derivatives for the treatment of viral infections
CL2013000016A1 (en) Compounds derived from imidazopyridine; preparation procedure; Pharmaceutical composition and its use in the treatment of cancer.
MX2014011825A (en) Isoxazole î²-lactamase inhibitors.
EP3159338A4 (en) Pyrimidine-2,4-diamine derivative and anticancer pharmaceutical composition comprising same as effective ingredient
IN2014DN10670A (en)
PL2861573T3 (en) Oxathiazine derivatives as antibacterial and anticancer agents.
EP3034082A4 (en) Pharmaceutical composition for treating or preventing neuropsychitric disease, containing flavone-6-c-glucose derivatives as active ingredients
EP3093023A4 (en) Pharmaceutical composition for cancer treatment and pharmaceutical preparation for cancer treatment containing same composition as active ingredient
EP3371162A4 (en) Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use
PL3811967T3 (en) Preparation of biologically active complexes
IN2013MU03216A (en)
EP2910246A4 (en) Pharmaceutical composition for preventing or treating cancer, containing enoblock as active ingredient
IN2014DN07481A (en)
CL2015000659A1 (en) Compounds derived from macrolides; Preparation process; pharmaceutical composition; and its use in the treatment and / or prevention of bacterial infections.
PH12016500809B1 (en) Glucopyranosyl - substituted indole-urea derivatives and their use as sglt inhibitors
IL244102A0 (en) Cyclopentylamine derivatives, their preparation and pharmaceutical compositions containing them