KR20140082796A - 항-HtrA1 항체 및 사용 방법 - Google Patents

항-HtrA1 항체 및 사용 방법 Download PDF

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Publication number
KR20140082796A
KR20140082796A KR1020147012525A KR20147012525A KR20140082796A KR 20140082796 A KR20140082796 A KR 20140082796A KR 1020147012525 A KR1020147012525 A KR 1020147012525A KR 20147012525 A KR20147012525 A KR 20147012525A KR 20140082796 A KR20140082796 A KR 20140082796A
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South Korea
Prior art keywords
seq
amino acid
hvr
acid sequence
antibody
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Ceased
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KR1020147012525A
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English (en)
Korean (ko)
Inventor
얀 우
메노 반 루케렌-캄파그네
다니엘 키르츠호퍼
마이클 테리 리파리
제이알. 케네쓰 제이. 카트스츠케
폴 엠. 모란
스콧 스타위키
웨이-칭 리앙
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제넨테크, 인크.
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Publication of KR20140082796A publication Critical patent/KR20140082796A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
KR1020147012525A 2011-10-14 2012-10-12 항-HtrA1 항체 및 사용 방법 Ceased KR20140082796A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161547649P 2011-10-14 2011-10-14
US61/547,649 2011-10-14
PCT/US2012/059878 WO2013055998A1 (en) 2011-10-14 2012-10-12 ANTI-HtrA1 ANTIBODIES AND METHODS OF USE

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020207001304A Division KR102102862B1 (ko) 2011-10-14 2012-10-12 항-HtrA1 항체 및 사용 방법

Publications (1)

Publication Number Publication Date
KR20140082796A true KR20140082796A (ko) 2014-07-02

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KR1020147012525A Ceased KR20140082796A (ko) 2011-10-14 2012-10-12 항-HtrA1 항체 및 사용 방법
KR1020207001304A Expired - Fee Related KR102102862B1 (ko) 2011-10-14 2012-10-12 항-HtrA1 항체 및 사용 방법

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Country Link
US (3) US9738727B2 (enExample)
EP (2) EP2766393B1 (enExample)
JP (2) JP6532678B2 (enExample)
KR (2) KR20140082796A (enExample)
CN (2) CN103917556B (enExample)
AR (1) AR088322A1 (enExample)
AU (2) AU2012322618A1 (enExample)
BR (1) BR112014008862A2 (enExample)
CA (1) CA2850032C (enExample)
CL (1) CL2014000888A1 (enExample)
CO (1) CO7020870A2 (enExample)
CR (1) CR20140212A (enExample)
DK (1) DK2766393T3 (enExample)
EA (1) EA201490778A1 (enExample)
ES (1) ES2687951T3 (enExample)
HK (1) HK1255608A1 (enExample)
HR (1) HRP20181457T1 (enExample)
HU (1) HUE039133T2 (enExample)
IL (1) IL232055B (enExample)
LT (1) LT2766393T (enExample)
MA (1) MA35712B1 (enExample)
MX (2) MX372661B (enExample)
PE (1) PE20141562A1 (enExample)
PH (1) PH12014500841B1 (enExample)
PL (1) PL2766393T3 (enExample)
PT (1) PT2766393T (enExample)
RS (1) RS57645B1 (enExample)
SG (1) SG11201401477XA (enExample)
SI (1) SI2766393T1 (enExample)
TR (1) TR201811270T4 (enExample)
TW (1) TW201321414A (enExample)
WO (1) WO2013055998A1 (enExample)
ZA (1) ZA201402172B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190095925A (ko) * 2016-12-22 2019-08-16 다이이찌 산쿄 가부시키가이샤 가령 황반 변성증 치료용 펩티드

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SG11201608868PA (en) 2014-05-01 2016-11-29 Genentech Inc Anti-factor d antibody variants and uses thereof
CA2960297A1 (en) 2014-11-10 2016-05-19 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
EP3368090A1 (en) 2015-10-30 2018-09-05 H. Hoffnabb-La Roche Ag Anti-factor d antibody variant conjugates and uses thereof
EP3368074A2 (en) 2015-10-30 2018-09-05 Hoffmann-La Roche AG Anti-factor d antibodies and conjugates
HK1257426A1 (zh) 2015-10-30 2019-10-18 豪夫迈‧罗氏有限公司 抗-因子d抗体制剂
SI3368578T1 (sl) * 2015-10-30 2021-08-31 F. Hoffmann-La Roche Ag Protitelesa proti HtrA1 in postopki uporabe
JP7164521B2 (ja) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体
MX392422B (es) 2016-06-21 2025-03-24 Orion Ophthalmology LLC Derivados de prolinamida heterociclica
JP2018096930A (ja) * 2016-12-16 2018-06-21 公益財団法人ヒューマンサイエンス振興財団 加齢黄斑変性の診断マーカー、診断キット、診断補助方法、及び、発症リスク判定方法
WO2018183213A1 (en) 2017-03-27 2018-10-04 The Schepens Eye Research Institute, Inc. Blood biomarkers and diagnostic methods for small vessel diseases
US11453718B2 (en) 2017-03-27 2022-09-27 The Schepens Eye Research Institute, Inc. NOTCH3 agonist compositions and methods for treating small vessel diseases
CN111512160B (zh) * 2017-12-21 2024-04-09 豪夫迈·罗氏有限公司 Htra1 rna拮抗剂的伴随诊断
US11866472B2 (en) 2018-06-21 2024-01-09 Daiichi Sankyo Company, Limited Peptide for treating retinitis pigmentosa
WO2020102680A1 (en) * 2018-11-16 2020-05-22 Gemini Therapeutics Inc. Antibody-based therapeutics for targeting htra1 and methods of use
WO2020109343A1 (en) 2018-11-29 2020-06-04 F. Hoffmann-La Roche Ag Combination therapy for treatment of macular degeneration
TW202041533A (zh) * 2018-12-24 2020-11-16 美商威特拉公司 用於鑑別表位(epitopes)及互補位(paratopes)之方法
CN113966401A (zh) * 2019-04-10 2022-01-21 犹他大学研究基金会 用于治疗amd的htra1调节
TW202144410A (zh) 2020-03-13 2021-12-01 美商建南德克公司 抗介白素－３３抗體及其用途
EP4192501A1 (en) * 2020-08-04 2023-06-14 Exelixis, Inc. Cd47 binding agents and uses thereof
TW202246351A (zh) * 2021-02-08 2022-12-01 美商恩格姆生物製藥公司 Htra1結合劑及其使用方法

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