CL2014000888A1 - Anticuerpos anti-htra1; acido nucleico que codifica dicho anticuerpo; célula anfitriona; metodo para producir dicho anticuerpo; uso para tratar degeneración macular. - Google Patents

Anticuerpos anti-htra1; acido nucleico que codifica dicho anticuerpo; célula anfitriona; metodo para producir dicho anticuerpo; uso para tratar degeneración macular.

Info

Publication number
CL2014000888A1
CL2014000888A1 CL2014000888A CL2014000888A CL2014000888A1 CL 2014000888 A1 CL2014000888 A1 CL 2014000888A1 CL 2014000888 A CL2014000888 A CL 2014000888A CL 2014000888 A CL2014000888 A CL 2014000888A CL 2014000888 A1 CL2014000888 A1 CL 2014000888A1
Authority
CL
Chile
Prior art keywords
antibody
producing
nucleic acid
host cell
acid encoding
Prior art date
Application number
CL2014000888A
Other languages
English (en)
Spanish (es)
Inventor
Yan Wu
Daniel Kirchhofer
Lookeren Campagne Menno Van
Michael Terry Lipari
Jr Kennth J Katschke
Paul M Moran
Scott Stawicki
Wei Ching Liang
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CL2014000888A1 publication Critical patent/CL2014000888A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CL2014000888A 2011-10-14 2014-04-09 Anticuerpos anti-htra1; acido nucleico que codifica dicho anticuerpo; célula anfitriona; metodo para producir dicho anticuerpo; uso para tratar degeneración macular. CL2014000888A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161547649P 2011-10-14 2011-10-14

Publications (1)

Publication Number Publication Date
CL2014000888A1 true CL2014000888A1 (es) 2014-07-25

Family

ID=48082468

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014000888A CL2014000888A1 (es) 2011-10-14 2014-04-09 Anticuerpos anti-htra1; acido nucleico que codifica dicho anticuerpo; célula anfitriona; metodo para producir dicho anticuerpo; uso para tratar degeneración macular.

Country Status (33)

Country Link
US (3) US9738727B2 (enExample)
EP (2) EP2766393B1 (enExample)
JP (2) JP6532678B2 (enExample)
KR (2) KR102102862B1 (enExample)
CN (2) CN108373506A (enExample)
AR (1) AR088322A1 (enExample)
AU (2) AU2012322618A1 (enExample)
BR (1) BR112014008862A2 (enExample)
CA (1) CA2850032C (enExample)
CL (1) CL2014000888A1 (enExample)
CO (1) CO7020870A2 (enExample)
CR (1) CR20140212A (enExample)
DK (1) DK2766393T3 (enExample)
EA (1) EA201490778A1 (enExample)
ES (1) ES2687951T3 (enExample)
HK (1) HK1255608A1 (enExample)
HR (1) HRP20181457T1 (enExample)
HU (1) HUE039133T2 (enExample)
IL (1) IL232055B (enExample)
LT (1) LT2766393T (enExample)
MA (1) MA35712B1 (enExample)
MX (2) MX390891B (enExample)
PE (1) PE20141562A1 (enExample)
PH (1) PH12014500841B1 (enExample)
PL (1) PL2766393T3 (enExample)
PT (1) PT2766393T (enExample)
RS (1) RS57645B1 (enExample)
SG (1) SG11201401477XA (enExample)
SI (1) SI2766393T1 (enExample)
TR (1) TR201811270T4 (enExample)
TW (1) TW201321414A (enExample)
WO (1) WO2013055998A1 (enExample)
ZA (1) ZA201402172B (enExample)

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US10093978B2 (en) 2013-08-12 2018-10-09 Genentech, Inc. Compositions for detecting complement factor H (CFH) and complement factor I (CFI) polymorphisms
MX2016014160A (es) 2014-05-01 2017-02-16 Genentech Inc Variantes del anticuerpo anti-factor d y sus usos.
CA2960297A1 (en) 2014-11-10 2016-05-19 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
CN108472382A (zh) 2015-10-30 2018-08-31 豪夫迈·罗氏有限公司 抗-因子d抗体变体缀合物及其用途
US10407510B2 (en) 2015-10-30 2019-09-10 Genentech, Inc. Anti-factor D antibodies and conjugates
US20170137535A1 (en) 2015-10-30 2017-05-18 Genentech, Inc. Anti-factor d antibody formulations
ES2870141T3 (es) * 2015-10-30 2021-10-26 Hoffmann La Roche Anticuerpos anti-HtrA1 y procedimientos de uso de los mismos
ES2971784T3 (es) 2016-06-21 2024-06-07 Orion Ophthalmology LLC Derivados heterocíclicos de prolinamida
EP3472151A4 (en) 2016-06-21 2020-03-04 Orion Ophthalmology LLC CARBOCYCLIC PROLINAMIDE DERIVATIVES
JP2018096930A (ja) * 2016-12-16 2018-06-21 公益財団法人ヒューマンサイエンス振興財団 加齢黄斑変性の診断マーカー、診断キット、診断補助方法、及び、発症リスク判定方法
DK3561056T5 (da) * 2016-12-22 2024-09-02 Daiichi Sankyo Co Ltd Peptid til behandling af aldersrelateret makuladegeneration
US20200103419A1 (en) 2017-03-27 2020-04-02 The Schepens Eye Research Institute, Inc. Blood biomarkers and diagnostic methods for small vessel diseases
US11453718B2 (en) 2017-03-27 2022-09-27 The Schepens Eye Research Institute, Inc. NOTCH3 agonist compositions and methods for treating small vessel diseases
JP2021507253A (ja) * 2017-12-21 2021-02-22 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Htra1 rnaアンタゴニストについてのコンパニオン診断
JP7303189B2 (ja) * 2018-06-21 2023-07-04 第一三共株式会社 網膜色素変性症治療用ペプチド
TW202039585A (zh) * 2018-11-16 2020-11-01 美商雙子治療公司 靶向htra1之基於抗體之療法及使用方法
WO2020109343A1 (en) 2018-11-29 2020-06-04 F. Hoffmann-La Roche Ag Combination therapy for treatment of macular degeneration
SG11202106452YA (en) * 2018-12-24 2021-07-29 Visterra Inc Methods for identifying epitopes and paratopes
CA3136119A1 (en) 2019-04-10 2020-10-15 University Of Utah Research Foundation Htra1 modulation for treatment of amd
PH12022552371A1 (en) 2020-03-13 2023-12-18 Genentech Inc Anti-interleukin-33 antibodies and uses thereof
CN116507639A (zh) * 2020-08-04 2023-07-28 埃克塞里艾克西斯公司 Cd47结合剂及其用途
TW202246351A (zh) * 2021-02-08 2022-12-01 美商恩格姆生物製藥公司 Htra1結合劑及其使用方法

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