KR20130087014A - 알코올 생산성 향상을 위한 지방산의 보충 - Google Patents
알코올 생산성 향상을 위한 지방산의 보충 Download PDFInfo
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- KR20130087014A KR20130087014A KR1020137001249A KR20137001249A KR20130087014A KR 20130087014 A KR20130087014 A KR 20130087014A KR 1020137001249 A KR1020137001249 A KR 1020137001249A KR 20137001249 A KR20137001249 A KR 20137001249A KR 20130087014 A KR20130087014 A KR 20130087014A
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/86—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by liquid-liquid treatment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
- B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Liquid Carbonaceous Fuels (AREA)
- Fats And Perfumes (AREA)
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- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
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| US36844410P | 2010-07-28 | 2010-07-28 | |
| US36843610P | 2010-07-28 | 2010-07-28 | |
| US36845110P | 2010-07-28 | 2010-07-28 | |
| US36842910P | 2010-07-28 | 2010-07-28 | |
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| US37954610P | 2010-09-02 | 2010-09-02 | |
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| US201161440034P | 2011-02-07 | 2011-02-07 | |
| US61/440,034 | 2011-02-07 | ||
| US13/160,766 US9012190B2 (en) | 2011-06-15 | 2011-06-15 | Use of thiamine and nicotine adenine dinucleotide for butanol production |
| US13/160,766 | 2011-06-15 | ||
| PCT/US2011/040796 WO2011159962A1 (en) | 2010-06-18 | 2011-06-17 | Supplementation of fatty acids for improving alcohol productivity |
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| CA2831130C (en) | 2011-03-24 | 2021-10-26 | Butamax (Tm) Advanced Biofuels Llc | Host cells and methods for production of isobutanol |
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| CA2861613A1 (en) | 2011-12-30 | 2013-07-04 | Butamax Advanced Biofuels Llc | Fermentative production of alcohols |
| BR112014026199B1 (pt) | 2012-04-25 | 2021-06-29 | Purac Biochem B.V. | Processo de fermentação |
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| WO2014159309A1 (en) * | 2013-03-12 | 2014-10-02 | Butamax Advanced Biofuels Llc | Processes and systems for the production of alcohols |
| CA2901374A1 (en) * | 2013-03-15 | 2014-09-18 | Butamax Advanced Biofuels Llc | Method for production of butanol using extractive fermentation |
| JP2015037389A (ja) * | 2013-08-19 | 2015-02-26 | 独立行政法人産業技術総合研究所 | 脂質分解酵素及び非イオン性界面活性剤添加によるリグノセルロース系バイオマスからの酵素糖化反応および同時糖化発酵の改善方法 |
| RU2555537C2 (ru) * | 2013-10-14 | 2015-07-10 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский государственный университет" | Способ очистки гидролизатов лигноцеллюлозного сырья от ингибиторов ацетонобутилового брожения |
| US20160326551A1 (en) * | 2013-12-31 | 2016-11-10 | Butamax Advanced Biofuels Llc | Isobutanol tolerance in yeast with an altered lipid profile |
| KR101485905B1 (ko) * | 2014-10-06 | 2015-01-26 | 김준호 | 이산화탄소 감소효과를 갖는 지방산효소에너지 조성물 및 이의 제조방법 |
| JP2019520819A (ja) | 2016-07-22 | 2019-07-25 | フェート・エンフェー (フラームス・インステリング・フーア・テクノロジシュ・オンダーゾエク・エンフェー) | 発酵によって溶媒を製造するための方法及び装置 |
| CN108265088A (zh) * | 2017-01-03 | 2018-07-10 | 北京化工大学 | 一种利用脂肪酶催化醇类发酵产物制备酯类化合物的方法 |
| WO2018175481A1 (en) * | 2017-03-20 | 2018-09-27 | Lanzatech, Inc. | A process and system for product recovery and cell recycle |
| US11484842B2 (en) | 2017-09-05 | 2022-11-01 | Vito Nv | Method and apparatus for in situ product recovery |
| EP3450564A1 (en) | 2017-09-05 | 2019-03-06 | Vito NV | Method of producing organic solvents in a bioreactor |
| CN108315359B (zh) * | 2018-03-23 | 2021-07-27 | 安玉民 | 利用马铃薯秸秆制取酒精和调配饲料的方法 |
| CN110645725A (zh) * | 2019-09-29 | 2020-01-03 | 广东利人酒业有限公司 | 一种低温冷冻过滤系统 |
| CN116508784B (zh) * | 2023-05-11 | 2024-01-19 | 南京工业大学 | 棕榈酸在提高施氏假单胞菌在促进植物生长和减少农田土壤氧化亚氮排放中的应用 |
| WO2024238681A1 (en) * | 2023-05-16 | 2024-11-21 | Icm, Inc. | Feed product and method of making |
| WO2025242894A1 (en) * | 2024-05-24 | 2025-11-27 | Firmenich Sa | Modified biomass extracts |
| CN119639266B (zh) * | 2025-02-13 | 2025-07-25 | 江苏冠军科技集团股份有限公司 | 一种生物基环保溶剂稀释剂及其制备方法和应用 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57152890A (en) * | 1981-03-16 | 1982-09-21 | Nippon Kagaku Kikai Seizo Kk | Alcoholic fermentation of syrup made from starch |
| JPS5992094A (ja) * | 1982-11-18 | 1984-05-28 | Agency Of Ind Science & Technol | 有機廃棄物の嫌気性消化方法 |
| JPS59216591A (ja) * | 1983-05-23 | 1984-12-06 | Chiyoda Chem Eng & Constr Co Ltd | ブタノ−ルの製造法 |
| JPS60172290A (ja) * | 1984-02-17 | 1985-09-05 | Kao Corp | ブタノ−ルの製造方法 |
| JPS61173786A (ja) * | 1985-01-28 | 1986-08-05 | Mitsui Eng & Shipbuild Co Ltd | アルコ−ル発酵法 |
| JPS62502443A (ja) * | 1985-04-09 | 1987-09-24 | フオエスト−アルピネ アクチエンゲゼルシヤフト | アルコ−ルおよびたん白質に富む飼料を同時に製造する方法 |
| US4865973A (en) * | 1985-09-13 | 1989-09-12 | Queen's University At Kingston | Process for extractive fermentation |
| DE4230645C2 (de) | 1992-09-12 | 1996-03-07 | Bernd Hansen | Ampulle |
| WO1995028476A1 (en) | 1994-04-15 | 1995-10-26 | Midwest Research Institute | Recombinant zymomonas for pentose fermentation |
| US5514583A (en) | 1994-04-15 | 1996-05-07 | Midwest Research Institute | Recombinant zymomonas for pentose fermentation |
| US5712133A (en) | 1994-04-15 | 1998-01-27 | Midwest Research Institute | Pentose fermentation by recombinant zymomonas |
| US7223575B2 (en) | 2000-05-01 | 2007-05-29 | Midwest Research Institute | Zymomonas pentose-sugar fermenting strains and uses thereof |
| JP2004208667A (ja) * | 2003-01-06 | 2004-07-29 | Minoru Morita | バイオマス資源を利用したエタノール製造方法 |
| CN1183238C (zh) * | 2003-03-28 | 2005-01-05 | 刘阳 | 生物酶法制造植物油脂肪酸甲酯的新方法 |
| US20070014905A1 (en) * | 2003-06-30 | 2007-01-18 | Purdue Research Foundation | Starchy material processed to produce one or more products comprising starch, ethanol, sugar syrup, oil, protein, fiber, gluten meal, and mixtures thereof |
| PL3219806T3 (pl) * | 2004-03-25 | 2020-11-02 | Novozymes, Inc. | Sposoby rozkładania lub przekształcania polisacharydów ściany komórkowej roślin |
| TWI240384B (en) * | 2004-04-16 | 2005-09-21 | Powerchip Semiconductor Corp | Method of manufacturing non-volatile memory cell |
| JP5149785B2 (ja) | 2005-04-12 | 2013-02-20 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | エタノールを得るためのバイオマスの処理 |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| NZ566406A (en) | 2005-10-26 | 2012-04-27 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| US7666282B2 (en) | 2005-12-28 | 2010-02-23 | E.I. Du Pont De Nemours And Company | Process for providing ethanol |
| JP2007245096A (ja) * | 2006-03-17 | 2007-09-27 | Tokyo Electric Power Co Inc:The | バイオマスから有用物質を製造する方法 |
| CN101437948A (zh) * | 2006-05-02 | 2009-05-20 | 纳幕尔杜邦公司 | 四碳醇的发酵生产 |
| US8206970B2 (en) | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
| DE102006040567A1 (de) * | 2006-08-30 | 2008-03-06 | Bayer Technology Services Gmbh | Verfahren zur Herstellung von Bioethanol |
| US8227015B2 (en) | 2006-09-26 | 2012-07-24 | Keith Bruinsma | Solvent extraction of oil from distillers dried grains and methods of using extraction products |
| US7741119B2 (en) | 2006-09-28 | 2010-06-22 | E. I. Du Pont De Nemours And Company | Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production |
| EP2097528A2 (en) * | 2006-10-31 | 2009-09-09 | DSMIP Assets B.V. | Butanol production in a eukaryotic cell |
| CN101595218A (zh) * | 2006-10-31 | 2009-12-02 | 帝斯曼知识产权资产管理有限公司 | 在真核细胞中生产丁醇 |
| US20090030537A1 (en) | 2007-03-19 | 2009-01-29 | Allen Hartle | Interactive radio system and method |
| KR101573775B1 (ko) | 2007-04-18 | 2015-12-04 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 고도 활성 케톨-산 리덕토아이소머라아제 효소를 이용한 아이소부탄올의 발효 생산 |
| JP2008278825A (ja) * | 2007-05-11 | 2008-11-20 | Chuo Kakoki Kk | バイオエタノールの製造方法 |
| CA2697073A1 (en) * | 2007-08-27 | 2009-03-05 | Iogen Energy Corporation | Method for the production of a fermentation product from a pretreated lignocellulosic feedstock |
| JP4707007B2 (ja) * | 2007-10-05 | 2011-06-22 | 智浩 青戸 | ヤーコンからエタノールを製造する方法及び装置 |
| JP2009106258A (ja) * | 2007-10-12 | 2009-05-21 | Nippon Steel Engineering Co Ltd | エタノール製造方法 |
| ATE506447T1 (de) | 2007-10-30 | 2011-05-15 | Du Pont | Verfahren zur herstellung von etahnol in einem xylose enthaltenden medium unter verwendung eines rekombinanten zymomonas stammes mit reduzierter hima expression |
| SG186646A1 (en) * | 2007-12-13 | 2013-01-30 | Glycos Biotechnologies Inc | Microbial conversion of oils and fatty acids to high-value chemicals |
| EP2677028B1 (en) | 2007-12-20 | 2016-03-09 | Butamax (TM) Advanced Biofuels LLC | Ketol-acid reductoisomerase using NADH |
| JP2011507532A (ja) * | 2007-12-23 | 2011-03-10 | ジーヴォ,インコーポレイテッド | 高収率でイソブタノールを産生する酵母生物 |
| JP2011514140A (ja) | 2007-12-27 | 2011-05-06 | ジーヴォ,インコーポレイテッド | 低濃度水溶液からの高級アルコールの回収 |
| US8580329B2 (en) * | 2008-01-08 | 2013-11-12 | Daniel W. Sonnek | Dry-mill ethanol plant extraction enhancement |
| JP2009213449A (ja) * | 2008-03-12 | 2009-09-24 | Tokyo Electric Power Co Inc:The | 油系植物バイオマス残渣を原料とする単糖類、エタノールの製造方法 |
| CA2716585C (en) | 2008-03-27 | 2017-05-09 | E.I. Du Pont De Nemours And Company | Zymomonas recombinant for substituted glyceraldehyde-3-phosphate dehydrogenase promoter and xylose isomerase gene for improved xylose utilization |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| NZ588988A (en) * | 2008-06-04 | 2012-08-31 | Butamax Tm Advanced Biofuels | A method for producing butanol using two-phase extractive fermentation |
| BRPI0909989A2 (pt) | 2008-06-05 | 2021-06-22 | Butamax Advanced Biofuels Llc | célula de levedura recombinante e método para a produção de um produto |
| MX2011003238A (es) | 2008-09-29 | 2011-04-28 | Butamax Tm Advanced Biofuels | Identificacion y uso de dihidroxiacido deshidratasas [2fe-2s] bacterianas. |
| CN101418320B (zh) * | 2008-12-10 | 2011-05-18 | 中国科学院微生物研究所 | 一种生产丁醇的方法 |
| US8247208B2 (en) | 2008-12-22 | 2012-08-21 | Alliance For Sustainable Energy Llc | Zymomonas with improved xylose utilization in stress conditions |
| US20110097773A1 (en) * | 2009-04-13 | 2011-04-28 | Butamax(Tm) Advanced Biofuels Llc | Method for producing butanol using extractive fermentation |
| WO2011041426A1 (en) | 2009-09-29 | 2011-04-07 | Butamax(Tm) Advanced Biofuels Llc | Improved yeast production host cells |
| CA2779460A1 (en) * | 2009-11-23 | 2011-05-26 | Butamax(Tm) Advanced Biofuels Llc | Method for producing butanol using extractive fermentation with osmolyte addition |
| AU2011268220B2 (en) * | 2010-06-18 | 2015-01-29 | Butamax(Tm) Advanced Biofuels Llc | Extraction solvents derived from oil for alcohol removal in extractive fermentation |
| US10079208B2 (en) | 2016-07-28 | 2018-09-18 | Globalfoundries Inc. | IC structure with interface liner and methods of forming same |
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