KR20130032897A - 알코올 발효 시의 알코올 에스테르의 생성 및 원위치에서의 생성물 제거 - Google Patents
알코올 발효 시의 알코올 에스테르의 생성 및 원위치에서의 생성물 제거 Download PDFInfo
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- KR20130032897A KR20130032897A KR1020137001251A KR20137001251A KR20130032897A KR 20130032897 A KR20130032897 A KR 20130032897A KR 1020137001251 A KR1020137001251 A KR 1020137001251A KR 20137001251 A KR20137001251 A KR 20137001251A KR 20130032897 A KR20130032897 A KR 20130032897A
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- South Korea
- Prior art keywords
- butanol
- carboxylic acid
- oil
- alcohol
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/86—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by liquid-liquid treatment
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35629010P | 2010-06-18 | 2010-06-18 | |
| US61/356,290 | 2010-06-18 | ||
| US36844410P | 2010-07-28 | 2010-07-28 | |
| US36842910P | 2010-07-28 | 2010-07-28 | |
| US36843610P | 2010-07-28 | 2010-07-28 | |
| US36845110P | 2010-07-28 | 2010-07-28 | |
| US61/368,436 | 2010-07-28 | ||
| US61/368,444 | 2010-07-28 | ||
| US61/368,429 | 2010-07-28 | ||
| US61/368,451 | 2010-07-28 | ||
| US37954610P | 2010-09-02 | 2010-09-02 | |
| US61/379,546 | 2010-09-02 | ||
| US201161440034P | 2011-02-07 | 2011-02-07 | |
| US61/440,034 | 2011-02-07 | ||
| US13/160,766 | 2011-06-15 | ||
| US13/160,766 US9012190B2 (en) | 2011-06-15 | 2011-06-15 | Use of thiamine and nicotine adenine dinucleotide for butanol production |
| PCT/US2011/040856 WO2011159998A2 (en) | 2010-06-18 | 2011-06-17 | Production of alcohol esters and in situ product removal during alcohol fermentation |
Publications (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103119172B (zh) * | 2010-06-18 | 2016-05-11 | 布特马斯先进生物燃料有限责任公司 | 在提取发酵中用于醇移除的来源于油的提取溶剂 |
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| WO2024238681A1 (en) * | 2023-05-16 | 2024-11-21 | Icm, Inc. | Feed product and method of making |
| WO2025242894A1 (en) * | 2024-05-24 | 2025-11-27 | Firmenich Sa | Modified biomass extracts |
| CN119639266B (zh) * | 2025-02-13 | 2025-07-25 | 江苏冠军科技集团股份有限公司 | 一种生物基环保溶剂稀释剂及其制备方法和应用 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57152890A (en) * | 1981-03-16 | 1982-09-21 | Nippon Kagaku Kikai Seizo Kk | Alcoholic fermentation of syrup made from starch |
| JPS5992094A (ja) * | 1982-11-18 | 1984-05-28 | Agency Of Ind Science & Technol | 有機廃棄物の嫌気性消化方法 |
| JPS59216591A (ja) * | 1983-05-23 | 1984-12-06 | Chiyoda Chem Eng & Constr Co Ltd | ブタノ−ルの製造法 |
| JPS60172290A (ja) * | 1984-02-17 | 1985-09-05 | Kao Corp | ブタノ−ルの製造方法 |
| JPS61173786A (ja) * | 1985-01-28 | 1986-08-05 | Mitsui Eng & Shipbuild Co Ltd | アルコ−ル発酵法 |
| JPS62502443A (ja) * | 1985-04-09 | 1987-09-24 | フオエスト−アルピネ アクチエンゲゼルシヤフト | アルコ−ルおよびたん白質に富む飼料を同時に製造する方法 |
| US4865973A (en) * | 1985-09-13 | 1989-09-12 | Queen's University At Kingston | Process for extractive fermentation |
| DE4230645C2 (de) | 1992-09-12 | 1996-03-07 | Bernd Hansen | Ampulle |
| AU2388295A (en) | 1994-04-15 | 1995-11-10 | Midwest Research Institute | Recombinant zymomonas for pentose fermentation |
| US5712133A (en) | 1994-04-15 | 1998-01-27 | Midwest Research Institute | Pentose fermentation by recombinant zymomonas |
| US5514583A (en) | 1994-04-15 | 1996-05-07 | Midwest Research Institute | Recombinant zymomonas for pentose fermentation |
| US7223575B2 (en) | 2000-05-01 | 2007-05-29 | Midwest Research Institute | Zymomonas pentose-sugar fermenting strains and uses thereof |
| JP2004208667A (ja) * | 2003-01-06 | 2004-07-29 | Minoru Morita | バイオマス資源を利用したエタノール製造方法 |
| CN1183238C (zh) * | 2003-03-28 | 2005-01-05 | 刘阳 | 生物酶法制造植物油脂肪酸甲酯的新方法 |
| US20070014905A1 (en) * | 2003-06-30 | 2007-01-18 | Purdue Research Foundation | Starchy material processed to produce one or more products comprising starch, ethanol, sugar syrup, oil, protein, fiber, gluten meal, and mixtures thereof |
| DK1735454T3 (en) * | 2004-03-25 | 2017-08-28 | Novozymes Inc | PROCEDURES FOR DEVELOPMENT OR CONVERSION OF PLANT CELL CELL POLICY ACCHARIDES |
| TWI240384B (en) * | 2004-04-16 | 2005-09-21 | Powerchip Semiconductor Corp | Method of manufacturing non-volatile memory cell |
| JP5804666B2 (ja) | 2005-04-12 | 2015-11-04 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | バイオマスの処理および利用における別の供給流れの集中 |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| BRPI0619325B8 (pt) | 2005-10-26 | 2020-11-17 | Butamax Advanced Biofuels Llc | célula hospedeira microbiana recombinante e método para produção de isobutanol |
| US7666282B2 (en) | 2005-12-28 | 2010-02-23 | E.I. Du Pont De Nemours And Company | Process for providing ethanol |
| JP2007245096A (ja) * | 2006-03-17 | 2007-09-27 | Tokyo Electric Power Co Inc:The | バイオマスから有用物質を製造する方法 |
| ZA200807719B (en) * | 2006-05-02 | 2009-12-30 | Du Pont | Fermentive production of four carbon alcohols |
| US8962298B2 (en) | 2006-05-02 | 2015-02-24 | Butamax Advanced Biofuels Llc | Recombinant host cell comprising a diol dehydratase |
| DE102006040567A1 (de) * | 2006-08-30 | 2008-03-06 | Bayer Technology Services Gmbh | Verfahren zur Herstellung von Bioethanol |
| US8227015B2 (en) | 2006-09-26 | 2012-07-24 | Keith Bruinsma | Solvent extraction of oil from distillers dried grains and methods of using extraction products |
| US7741119B2 (en) | 2006-09-28 | 2010-06-22 | E. I. Du Pont De Nemours And Company | Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production |
| EP2097528A2 (en) * | 2006-10-31 | 2009-09-09 | DSMIP Assets B.V. | Butanol production in a eukaryotic cell |
| CN101595218A (zh) * | 2006-10-31 | 2009-12-02 | 帝斯曼知识产权资产管理有限公司 | 在真核细胞中生产丁醇 |
| WO2008115564A2 (en) | 2007-03-19 | 2008-09-25 | Jump2Go | Interactive radio system and method |
| BRPI0808600A2 (pt) | 2007-04-18 | 2018-12-26 | Du Pont | "método para a conversão de acetolactato em dihidroxi-isovalerato, método para a produção de isobutanol, célula hospedeira recombinante e método para a identificação e isolameno de uma construção genética" |
| JP2008278825A (ja) * | 2007-05-11 | 2008-11-20 | Chuo Kakoki Kk | バイオエタノールの製造方法 |
| BRPI0816477A2 (pt) * | 2007-08-27 | 2014-10-14 | Iogen Energy Corp | Método para a produção de um produto de fermentação a partir de uma matéria-prima lignocelulósica pré-tratada |
| JP4707007B2 (ja) * | 2007-10-05 | 2011-06-22 | 智浩 青戸 | ヤーコンからエタノールを製造する方法及び装置 |
| JP2009106258A (ja) * | 2007-10-12 | 2009-05-21 | Nippon Steel Engineering Co Ltd | エタノール製造方法 |
| DE602008006446D1 (de) | 2007-10-30 | 2011-06-01 | Du Pont | Verfahren zur herstellung von etahnol in einem xylose enthaltenden medium unter verwendung eines rekombinanten zymomonas stammes mit reduzierter hima expression |
| EP2225373A4 (en) * | 2007-12-13 | 2014-04-30 | Glycos Biotechnologies Inc | MICROBIAL CONVERSION OF OILS AND FATTY ACIDS IN HIGH-VALUE CHEMICALS |
| EP2677028B1 (en) | 2007-12-20 | 2016-03-09 | Butamax (TM) Advanced Biofuels LLC | Ketol-acid reductoisomerase using NADH |
| CA2990939A1 (en) * | 2007-12-23 | 2009-07-09 | Gevo, Inc. | Yeast organism producing isobutanol at a high yield |
| JP2011514140A (ja) | 2007-12-27 | 2011-05-06 | ジーヴォ，インコーポレイテッド | 低濃度水溶液からの高級アルコールの回収 |
| US8580329B2 (en) * | 2008-01-08 | 2013-11-12 | Daniel W. Sonnek | Dry-mill ethanol plant extraction enhancement |
| JP2009213449A (ja) * | 2008-03-12 | 2009-09-24 | Tokyo Electric Power Co Inc:The | 油系植物バイオマス残渣を原料とする単糖類、エタノールの製造方法 |
| US7998722B2 (en) | 2008-03-27 | 2011-08-16 | E. I. Du Pont De Nemours And Company | Zymomonas with improved xylose utilization |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| EP2283141B1 (en) | 2008-06-04 | 2014-04-23 | Butamax (TM) Advanced Biofuels LLC | A method for producing butanol using extraction and gas stripping |
| BRPI0909989A2 (pt) | 2008-06-05 | 2021-06-22 | Butamax Advanced Biofuels Llc | célula de levedura recombinante e método para a produção de um produto |
| EP2337851B1 (en) | 2008-09-29 | 2014-08-13 | Butamax Advanced Biofuels Llc | IDENTIFICATION AND USE OF BACTERIAL Ý2Fe-2S¨DIHYDROXY-ACID DEHYDRATASES |
| CN101418320B (zh) * | 2008-12-10 | 2011-05-18 | 中国科学院微生物研究所 | 一种生产丁醇的方法 |
| US8247208B2 (en) | 2008-12-22 | 2012-08-21 | Alliance For Sustainable Energy Llc | Zymomonas with improved xylose utilization in stress conditions |
| EP2419517A2 (en) * | 2009-04-13 | 2012-02-22 | Butamax(TM) Advanced Biofuels LLC | Method for producing butanol using extractive fermentation |
| US9260708B2 (en) | 2009-09-29 | 2016-02-16 | Butamax Advanced Biofuels Llc | Yeast production host cells |
| EP2504447A2 (en) * | 2009-11-23 | 2012-10-03 | ButamaxTM Advanced Biofuels LLC | Method for producing butanol using extractive fermentation with osmolyte addition |
| CN103119172B (zh) * | 2010-06-18 | 2016-05-11 | 布特马斯先进生物燃料有限责任公司 | 在提取发酵中用于醇移除的来源于油的提取溶剂 |
| US10079208B2 (en) | 2016-07-28 | 2018-09-18 | Globalfoundries Inc. | IC structure with interface liner and methods of forming same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018175481A1 (en) * | 2017-03-20 | 2018-09-27 | Lanzatech, Inc. | A process and system for product recovery and cell recycle |
| EA037782B1 (ru) * | 2017-03-20 | 2021-05-20 | Ланцатек, Инк. | Способ и система для выделения продукта и повторного использования клеток |
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