KR20090106661A - 결정질의 순수한 모다피닐 및 이의 제조 방법 - Google Patents

결정질의 순수한 모다피닐 및 이의 제조 방법 Download PDF

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Publication number
KR20090106661A
KR20090106661A KR1020097019167A KR20097019167A KR20090106661A KR 20090106661 A KR20090106661 A KR 20090106661A KR 1020097019167 A KR1020097019167 A KR 1020097019167A KR 20097019167 A KR20097019167 A KR 20097019167A KR 20090106661 A KR20090106661 A KR 20090106661A
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South Korea
Prior art keywords
modafinil
type
preparation
mixture
water
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Ceased
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KR1020097019167A
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English (en)
Korean (ko)
Inventor
클우드 싱어
네오미 게르숀
아리나 시우스
아나타 리베르만
쥬디쓰 아론메
Original Assignee
테바 파마슈티컬 인더스트리즈 리미티드
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Publication of KR20090106661A publication Critical patent/KR20090106661A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Laminated Bodies (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Glass Compositions (AREA)
KR1020097019167A 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법 Ceased KR20090106661A (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US22111000P 2000-07-27 2000-07-27
US60/221,110 2000-07-27
US22649100P 2000-08-18 2000-08-18
US60/226,491 2000-08-18
US22916000P 2000-08-30 2000-08-30
US60/229,160 2000-08-30
US23008800P 2000-09-05 2000-09-05
US60/230,088 2000-09-05
US25933201P 2001-01-02 2001-01-02
US60/259,332 2001-01-02
PCT/US2001/023689 WO2002010125A1 (en) 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020067017034A Division KR20060097771A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법

Publications (1)

Publication Number Publication Date
KR20090106661A true KR20090106661A (ko) 2009-10-09

Family

ID=27539819

Family Applications (8)

Application Number Title Priority Date Filing Date
KR1020077020660A Expired - Fee Related KR101098749B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067026810A Expired - Fee Related KR100729298B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020037001061A Expired - Fee Related KR100729292B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020107017690A Expired - Fee Related KR101081212B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020097018672A Expired - Fee Related KR101019448B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067003797A Ceased KR20060024028A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067017034A Ceased KR20060097771A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020097019167A Ceased KR20090106661A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법

Family Applications Before (7)

Application Number Title Priority Date Filing Date
KR1020077020660A Expired - Fee Related KR101098749B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067026810A Expired - Fee Related KR100729298B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020037001061A Expired - Fee Related KR100729292B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020107017690A Expired - Fee Related KR101081212B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020097018672A Expired - Fee Related KR101019448B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067003797A Ceased KR20060024028A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067017034A Ceased KR20060097771A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법

Country Status (24)

Country Link
US (3) US6849120B2 (enExample)
EP (3) EP1309547B1 (enExample)
JP (2) JP4302977B2 (enExample)
KR (8) KR101098749B1 (enExample)
CN (2) CN100500651C (enExample)
AT (1) ATE453618T1 (enExample)
AU (1) AU2001283008A1 (enExample)
CA (3) CA2634702C (enExample)
CY (1) CY1110234T1 (enExample)
CZ (1) CZ2003529A3 (enExample)
DE (3) DE20122504U1 (enExample)
DK (2) DK1309547T3 (enExample)
ES (2) ES2337838T3 (enExample)
HR (2) HRP20030131B1 (enExample)
HU (1) HUP0400927A3 (enExample)
IL (2) IL154122A0 (enExample)
IS (1) IS6699A (enExample)
MX (1) MXPA03000747A (enExample)
NZ (1) NZ524359A (enExample)
PL (1) PL206371B1 (enExample)
PT (2) PT1787980E (enExample)
SK (1) SK2242003A3 (enExample)
WO (1) WO2002010125A1 (enExample)
ZA (1) ZA200300672B (enExample)

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KR20070097131A (ko) 2007-10-02
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KR101019448B1 (ko) 2011-03-07
CA2416792C (en) 2010-02-09
EP1309547A4 (en) 2005-03-02
US20050034652A1 (en) 2005-02-17
HUP0400927A3 (en) 2007-11-28
PT1787980E (pt) 2010-03-18
PL365613A1 (en) 2005-01-10
KR20090103962A (ko) 2009-10-01
DE20122504U1 (de) 2005-12-29
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US8048222B2 (en) 2011-11-01
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CN100500651C (zh) 2009-06-17
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US6849120B2 (en) 2005-02-01
WO2002010125A1 (en) 2002-02-07
KR20060024028A (ko) 2006-03-15
HRP20030131A2 (en) 2005-04-30
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CZ2003529A3 (cs) 2003-09-17
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CN1466570A (zh) 2004-01-07
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NZ524359A (en) 2005-06-24
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