KR101098749B1 - 결정질의 순수한 모다피닐 및 이의 제조 방법 - Google Patents

결정질의 순수한 모다피닐 및 이의 제조 방법 Download PDF

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Publication number
KR101098749B1
KR101098749B1 KR1020077020660A KR20077020660A KR101098749B1 KR 101098749 B1 KR101098749 B1 KR 101098749B1 KR 1020077020660 A KR1020077020660 A KR 1020077020660A KR 20077020660 A KR20077020660 A KR 20077020660A KR 101098749 B1 KR101098749 B1 KR 101098749B1
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South Korea
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modafinil
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mixture
water
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KR20070097131A (ko
Inventor
클라우드 싱어
네오미 게르숀
아리나 시우스
아니타 리베르만
쥬디쓰 아론히메
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테바 파마슈티컬 인더스트리즈 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Laminated Bodies (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Glass Compositions (AREA)
KR1020077020660A 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법 Expired - Fee Related KR101098749B1 (ko)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US22111000P 2000-07-27 2000-07-27
US60/221,110 2000-07-27
US22649100P 2000-08-18 2000-08-18
US60/226,491 2000-08-18
US22916000P 2000-08-30 2000-08-30
US60/229,160 2000-08-30
US23008800P 2000-09-05 2000-09-05
US60/230,088 2000-09-05
US25933201P 2001-01-02 2001-01-02
US60/259,332 2001-01-02

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020067003797A Division KR20060024028A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020097018672A Division KR101019448B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법

Publications (2)

Publication Number Publication Date
KR20070097131A KR20070097131A (ko) 2007-10-02
KR101098749B1 true KR101098749B1 (ko) 2011-12-23

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Family Applications (8)

Application Number Title Priority Date Filing Date
KR1020077020660A Expired - Fee Related KR101098749B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067026810A Expired - Fee Related KR100729298B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020037001061A Expired - Fee Related KR100729292B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020107017690A Expired - Fee Related KR101081212B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020097018672A Expired - Fee Related KR101019448B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067003797A Ceased KR20060024028A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067017034A Ceased KR20060097771A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020097019167A Ceased KR20090106661A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법

Family Applications After (7)

Application Number Title Priority Date Filing Date
KR1020067026810A Expired - Fee Related KR100729298B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020037001061A Expired - Fee Related KR100729292B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020107017690A Expired - Fee Related KR101081212B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020097018672A Expired - Fee Related KR101019448B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067003797A Ceased KR20060024028A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067017034A Ceased KR20060097771A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020097019167A Ceased KR20090106661A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법

Country Status (24)

Country Link
US (3) US6849120B2 (enExample)
EP (3) EP1309547B1 (enExample)
JP (2) JP4302977B2 (enExample)
KR (8) KR101098749B1 (enExample)
CN (2) CN100500651C (enExample)
AT (1) ATE453618T1 (enExample)
AU (1) AU2001283008A1 (enExample)
CA (3) CA2634702C (enExample)
CY (1) CY1110234T1 (enExample)
CZ (1) CZ2003529A3 (enExample)
DE (3) DE20122504U1 (enExample)
DK (2) DK1309547T3 (enExample)
ES (2) ES2337838T3 (enExample)
HR (2) HRP20030131B1 (enExample)
HU (1) HUP0400927A3 (enExample)
IL (2) IL154122A0 (enExample)
IS (1) IS6699A (enExample)
MX (1) MXPA03000747A (enExample)
NZ (1) NZ524359A (enExample)
PL (1) PL206371B1 (enExample)
PT (2) PT1787980E (enExample)
SK (1) SK2242003A3 (enExample)
WO (1) WO2002010125A1 (enExample)
ZA (1) ZA200300672B (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101098749B1 (ko) * 2000-07-27 2011-12-23 테바 파마슈티컬 인더스트리즈 리미티드 결정질의 순수한 모다피닐 및 이의 제조 방법
DE60137069D1 (de) * 2000-10-11 2009-01-29 Cephalon Inc Arzneizusammensetzungen enthaltend modafinilverbindungen
CA2425338C (en) 2000-10-11 2010-04-20 Cephalon, Inc. Compositions comprising modafinil compounds
WO2004000284A1 (en) 2002-06-21 2003-12-31 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
JP4906233B2 (ja) 2002-03-01 2012-03-28 ユニバーシティー オブ サウス フロリダ 少なくとも１種の有効薬剤成分を含有する多構成要素固相
ITMI20020991A1 (it) 2002-05-10 2003-11-10 Dinamite Dipharma S P A In For Procedimento per la sintesi del modafinil
US6875893B2 (en) 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
TW200413296A (en) * 2002-08-09 2004-08-01 Cephalon France Modafinil polymorphic forms
US6992219B2 (en) * 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
CN1753867A (zh) * 2003-02-24 2006-03-29 马林克罗特公司 制备二苯甲基硫代乙酰胺的方法
US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
DE60329167D1 (de) * 2003-05-16 2009-10-22 Cephalon France Verfahren zur Herstellung von Modafinil
ITMI20031298A1 (it) * 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).
EP1670753A4 (en) * 2003-09-04 2008-01-02 Cephalon Inc MODAFINIL COMPOSITIONS
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1516869A1 (en) 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
CN1980888B (zh) * 2004-02-06 2011-04-13 赛福伦公司 莫达芬尼组合物
EP1718607A4 (en) * 2004-02-06 2008-05-28 Cephalon Inc COMPOSITIONS BASED ON MODAFINIL
US20090018202A1 (en) * 2004-02-06 2009-01-15 Cephalon, Inc. Modafinil compositions
EP2292213A1 (en) 2004-02-06 2011-03-09 Cephalon, Inc. Compositions comprising a polymorphic form of armodafinil
US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
EP1586560A1 (en) 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituted arylmethanesulfinyl derivatives
US7314875B2 (en) 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
US7297817B2 (en) 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US20060086667A1 (en) * 2004-09-13 2006-04-27 Cephalon, Inc., U.S. Corporation Methods for the separation of enantiomeric sulfinylacetamides
BRPI0500520A (pt) * 2005-02-16 2006-09-26 Henry Jun Suzuki uso de agentes flavorizantes aromáticos de alto ponto de fusão como agentes solubilizantes ou inibidores de cristalização em composições farmacêuticas
BRPI0501120A (pt) * 2005-02-18 2006-10-03 Henry Jun Suzuki composições farmacêuticas orais e parenterais contendo altas concentrações de agentes solubilizantes aromáticos
CN100393699C (zh) * 2005-03-10 2008-06-11 浙江工业大学 2-（二苯基甲基亚硫酰基）乙酰胺的合成方法
JP2009518398A (ja) * 2005-12-09 2009-05-07 マリンクロッド・インコーポレイテッド モダフィニルおよびその類似体の製造方法
US20070293702A1 (en) * 2006-02-21 2007-12-20 Viviana Braude Novel crystalline forms of armodafinil and preparation thereof
BRPI0714173A2 (pt) * 2006-07-12 2012-12-25 Elan Pharma Int Ltd composiÇço nanoparticulada estÁvel,mÉtodos para preparar a composiÇço, para prevenir e/ou tratar estados de doenÇas, sintomas, sÍndromes e condiÇÕes do sistema nervoso central, para melhorar ou manter a biodisponibilidade de modafinil, e para tratar distérbio com base neurolàgica, composiÇço farmacÊutica, e forma de dosagem
US20080181966A1 (en) * 2006-10-18 2008-07-31 Cephalon, Inc. Modafinil pharmaceutical compositions
CA2688430A1 (en) * 2007-06-04 2008-12-11 Generics [Uk] Limited Novel process
US7960586B2 (en) * 2007-08-16 2011-06-14 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
FR2923482B1 (fr) * 2007-11-09 2010-01-29 Servier Lab Nouvelle forme cristalline vi de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
US20090105346A1 (en) * 2007-10-02 2009-04-23 Alexandr Jegorov Novel crystalline forms of armodafinil and preparation thereof
US20100036164A1 (en) * 2008-08-06 2010-02-11 Srinivas Areveli Preparation of armodafinil form i
US8551887B2 (en) 2009-12-22 2013-10-08 Air Products And Chemicals, Inc. Method for chemical mechanical planarization of a copper-containing substrate
CN102070498A (zh) * 2011-01-12 2011-05-25 华东师范大学 一种亚砜的制备方法
CN102746202B (zh) * 2012-07-04 2013-12-18 广州市博兴化工科技有限公司 一种含有甲基亚砜结构的丙烯酸酯化合物及其制备方法和应用
SG10202012791TA (en) 2013-11-15 2021-01-28 Akebia Therapeutics Inc Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
KR102369295B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 벤딩 타입 힌지 스프링
KR102369302B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 압축 타입 힌지 스프링
KR102393940B1 (ko) 2020-11-12 2022-05-09 주식회사 에스코넥 토션 타입 힌지 스프링

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098824A (en) 1975-10-02 1978-07-04 Laboratoire L. Lafon Benzhydrylsulphinyl derivatives
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2593809B1 (fr) 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
FR2606015B1 (fr) 1986-08-13 1989-05-19 Lafon Labor Derives du benzhydrylthiomethane, leurs procedes de preparation et leurs applications en therapeutique
FR2611709B1 (fr) 1987-02-26 1989-06-09 Lafon Labor 2-(benzhydrylsulfonyl)acetamide, son procede de preparation et son application en therapeutique
US5843347A (en) * 1993-03-23 1998-12-01 Laboratoire L. Lafon Extrusion and freeze-drying method for preparing particles containing an active ingredient
FR2707637B1 (fr) 1993-06-30 1995-10-06 Lafon Labor Nouveaux dérivés d'acétamide, leur procédé de préparation et leur utilisation en thérapeutique.
US5618845A (en) * 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
FR2771004B1 (fr) * 1997-11-19 2000-02-18 Inst Curie Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse
US6346548B1 (en) * 1999-08-16 2002-02-12 Cephalon, Inc. Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
US6455588B1 (en) * 1999-08-20 2002-09-24 Cephalon, Inc. Compositions including modafinil for treatment of eating disorders and for appetite stimulation
CN1249932A (zh) * 1999-09-29 2000-04-12 付俊昌 一种莫达芬尼及其光学对映体l及d异构体的新用途
FR2804322B1 (fr) * 2000-01-31 2002-04-19 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament destine a corriger les troubles de la vigilance associes aux myopathies
KR101098749B1 (ko) * 2000-07-27 2011-12-23 테바 파마슈티컬 인더스트리즈 리미티드 결정질의 순수한 모다피닐 및 이의 제조 방법
US6919378B2 (en) 2000-10-11 2005-07-19 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
IL143106A (en) * 2001-05-13 2005-11-20 Chemagis Ltd Process for the preparation of diphenylmethylthioacetamide
KR100911779B1 (ko) 2001-05-25 2009-08-12 세파론, 인코포레이티드 모다피닐을 포함하는 고형 제약 제제
ITMI20020991A1 (it) 2002-05-10 2003-11-10 Dinamite Dipharma S P A In For Procedimento per la sintesi del modafinil
US7229644B2 (en) 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
US6875893B2 (en) * 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
AU2003249105A1 (en) 2002-07-08 2004-01-23 Ranbaxy Laboratories Limited Processes for the preparation of oral dosage formulations of modafinil
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
US6992219B2 (en) 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
US20040116532A1 (en) 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
CA2409429A1 (en) * 2002-10-17 2004-04-17 Bayer Inc. Hydrogenated nitrile rubber composites with improved proccesability
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
WO2004075827A2 (en) 2003-01-31 2004-09-10 Alembic Limited Process for the preparation of 2-[(diphenylmethyl) thio] acetamide
CN1753867A (zh) 2003-02-24 2006-03-29 马林克罗特公司 制备二苯甲基硫代乙酰胺的方法
CA2420180A1 (en) * 2003-02-28 2004-08-28 Bernard Charles Sherman Tablets comprising modafinil
AR045423A1 (es) * 2003-05-13 2005-10-26 Cephalon Inc Combinaciones de analiticos y antidepresivos
US20040229941A1 (en) * 2003-05-13 2004-11-18 Cephalon, Inc. Analeptic and antidepressant combinations
AR045314A1 (es) * 2003-05-13 2005-10-26 Cephalon Inc Composiciones farmaceuticas de analepticos y antidepresivos
US20040229943A1 (en) * 2003-05-16 2004-11-18 Cephalon Inc Analeptic and drug combinations
ITMI20031298A1 (it) 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).

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KR20070097131A (ko) 2007-10-02
KR20030029636A (ko) 2003-04-14
KR101019448B1 (ko) 2011-03-07
CA2416792C (en) 2010-02-09
EP1309547A4 (en) 2005-03-02
US20050034652A1 (en) 2005-02-17
HUP0400927A3 (en) 2007-11-28
PT1787980E (pt) 2010-03-18
KR20090106661A (ko) 2009-10-09
PL365613A1 (en) 2005-01-10
KR20090103962A (ko) 2009-10-01
DE20122504U1 (de) 2005-12-29
DK1309547T3 (da) 2007-05-21
US8048222B2 (en) 2011-11-01
DE60140973D1 (de) 2010-02-11
CN100500651C (zh) 2009-06-17
JP2009024006A (ja) 2009-02-05
ES2277937T3 (es) 2007-08-01
CA2634702C (en) 2011-07-19
EP1787980A3 (en) 2007-08-08
US20050038124A1 (en) 2005-02-17
US7235691B2 (en) 2007-06-26
EP1309547B1 (en) 2007-01-17
US6849120B2 (en) 2005-02-01
WO2002010125A1 (en) 2002-02-07
KR20060024028A (ko) 2006-03-15
HRP20030131A2 (en) 2005-04-30
ES2337838T3 (es) 2010-04-29
CZ2003529A3 (cs) 2003-09-17
DK1787980T3 (da) 2010-04-26
KR20060097771A (ko) 2006-09-15
CN1466570A (zh) 2004-01-07
CA2685310C (en) 2012-10-16
CY1110234T1 (el) 2015-01-14
JP4980309B2 (ja) 2012-07-18
CA2685310A1 (en) 2002-02-07
MXPA03000747A (es) 2003-06-04
KR100729292B1 (ko) 2007-06-18
ZA200300672B (en) 2004-02-18
NZ524359A (en) 2005-06-24
IL154122A (en) 2009-07-20
KR101081212B1 (ko) 2011-11-07
IS6699A (is) 2003-01-24
KR20100098462A (ko) 2010-09-06
KR20070007970A (ko) 2007-01-16
EP1309547A1 (en) 2003-05-14
AU2001283008A1 (en) 2002-02-13
DE60126099D1 (de) 2007-03-08
US20020043207A1 (en) 2002-04-18
KR100729298B1 (ko) 2007-06-18
PT1309547E (pt) 2007-03-30
CA2416792A1 (en) 2002-02-07
IL154122A0 (en) 2003-07-31
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JP4302977B2 (ja) 2009-07-29
HRP20030131B1 (en) 2011-03-31
EP2168946A1 (en) 2010-03-31
ATE453618T1 (de) 2010-01-15
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CN101186590A (zh) 2008-05-28
HUP0400927A2 (hu) 2004-07-28
HRP20080373A2 (hr) 2008-12-31
PL206371B1 (pl) 2010-07-30
DE60126099T2 (de) 2007-11-15
EP1787980A2 (en) 2007-05-23
JP2004509080A (ja) 2004-03-25

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