KR20090068289A - Ｇｌｋ를 통해 매개되는 질환의 치료에 유용한 벤조일 아미노 헤테로시클릴 화합물 - Google Patents
Ｇｌｋ를 통해 매개되는 질환의 치료에 유용한 벤조일 아미노 헤테로시클릴 화합물 Download PDFInfo
- Publication number
- KR20090068289A KR20090068289A KR1020097010059A KR20097010059A KR20090068289A KR 20090068289 A KR20090068289 A KR 20090068289A KR 1020097010059 A KR1020097010059 A KR 1020097010059A KR 20097010059 A KR20097010059 A KR 20097010059A KR 20090068289 A KR20090068289 A KR 20090068289A
- Authority
- KR
- South Korea
- Prior art keywords
- oxy
- alkyl
- methyl
- ring
- oxo
- Prior art date
Links
- 0 Cc1n[s]c(NC(c2cc(O)cc(OC(CCN3*)C3=O)c2)=O)n1 Chemical compound Cc1n[s]c(NC(c2cc(O)cc(OC(CCN3*)C3=O)c2)=O)n1 0.000 description 4
- GUBLPYZHXNFDCH-UHFFFAOYSA-P CC(CC(OC(CCN1C)C1=O)=C1)(C=C1Oc(cc1OCN2C)ccc1C2=O)C([NH2+]C(C=CN)=[NH2+])=O Chemical compound CC(CC(OC(CCN1C)C1=O)=C1)(C=C1Oc(cc1OCN2C)ccc1C2=O)C([NH2+]C(C=CN)=[NH2+])=O GUBLPYZHXNFDCH-UHFFFAOYSA-P 0.000 description 1
- OFNJRYQYELWRRZ-UHFFFAOYSA-N CCOC(C(CCO)Oc1cc(C(Nc2cnc(C)cn2)=O)cc(Oc(cc2)cnc2C(N2CCC2)=O)c1)=O Chemical compound CCOC(C(CCO)Oc1cc(C(Nc2cnc(C)cn2)=O)cc(Oc(cc2)cnc2C(N2CCC2)=O)c1)=O OFNJRYQYELWRRZ-UHFFFAOYSA-N 0.000 description 1
- BOFIDECCEVUIHX-UHFFFAOYSA-N CN(CCN1Oc2cc(C(OC)=O)cc(OCc3ccccc3)c2)C1=O Chemical compound CN(CCN1Oc2cc(C(OC)=O)cc(OCc3ccccc3)c2)C1=O BOFIDECCEVUIHX-UHFFFAOYSA-N 0.000 description 1
- LCTNBHMNJQZKHN-UHFFFAOYSA-N CN(CCOc1c2ccc(F)c1)C2=O Chemical compound CN(CCOc1c2ccc(F)c1)C2=O LCTNBHMNJQZKHN-UHFFFAOYSA-N 0.000 description 1
- SMFBVLBQZIDZIA-FQEVSTJZSA-N CN(CC[C@@H]1Oc2cc(C(OC)=O)cc(Oc(c(Cl)c3)ccc3C(N3CCC3)=O)c2)C1=O Chemical compound CN(CC[C@@H]1Oc2cc(C(OC)=O)cc(Oc(c(Cl)c3)ccc3C(N3CCC3)=O)c2)C1=O SMFBVLBQZIDZIA-FQEVSTJZSA-N 0.000 description 1
- VMTDDJMMXZADRV-NRFANRHFSA-N Cc1ncc(NC(c2cc(O[C@@H](CCN3C)C3=O)cc(OCc3ccccc3)c2)=O)nc1 Chemical compound Cc1ncc(NC(c2cc(O[C@@H](CCN3C)C3=O)cc(OCc3ccccc3)c2)=O)nc1 VMTDDJMMXZADRV-NRFANRHFSA-N 0.000 description 1
- WJELXFTXLUJSPG-UHFFFAOYSA-N OC(c1cc(OCc2ccccc2)cc(Oc2ccc(C(N3CCC3)=O)nc2)c1)=O Chemical compound OC(c1cc(OCc2ccccc2)cc(Oc2ccc(C(N3CCC3)=O)nc2)c1)=O WJELXFTXLUJSPG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86249306P | 2006-10-23 | 2006-10-23 | |
| US60/862,493 | 2006-10-23 | ||
| US89199307P | 2007-02-28 | 2007-02-28 | |
| US60/891,993 | 2007-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20090068289A true KR20090068289A (ko) | 2009-06-25 |
Family
ID=39324963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020097010059A KR20090068289A (ko) | 2006-10-23 | 2007-10-22 | Ｇｌｋ를 통해 매개되는 질환의 치료에 유용한 벤조일 아미노 헤테로시클릴 화합물 |
Country Status (18)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2322709T3 (es) * | 2004-02-18 | 2009-06-25 | Astrazeneca Ab | Derivados de benzamida y su uso como agentes activadores de la glucocinasa. |
| TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
| US7642259B2 (en) * | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| TW200825060A (en) * | 2006-10-26 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| KR20110052676A (ko) * | 2008-08-04 | 2011-05-18 | 아스트라제네카 아베 | 피라졸로[3,4]피리미딘-4-일 유도체 및 당뇨병 및 비만을 치료하기 위한 이의 용도 |
| GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
| GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
| AR076220A1 (es) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivados de pirazol [4,5 - e] pirimidina |
| AR076221A1 (es) * | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
| EP2445908A1 (en) * | 2009-06-22 | 2012-05-02 | Cadila Healthcare Limited | Disubstituted benzamide derivatives as glucokinase (gk) activators |
| EP2459554B1 (en) | 2009-07-31 | 2013-09-18 | Cadila Healthcare Limited | Substituted benzamide derivatives as glucokinase (gk) activators |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| UY36629A (es) | 2015-04-17 | 2016-11-30 | Abbvie Inc | Indazolonas como moduladores de la señalización de tnf |
| GB201714777D0 (en) | 2017-09-14 | 2017-11-01 | Univ London Queen Mary | Agent |
Family Cites Families (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2750393A (en) | 1954-12-01 | 1956-06-12 | Sterling Drug Inc | Iodinated 5-henzamidotetrazoles and preparation thereof |
| US2967194A (en) | 1958-05-15 | 1961-01-03 | Pennsalt Chemicals Corp | 4-trifluoromethylsalicylamides |
| FR1526074A (fr) | 1967-03-22 | 1968-05-24 | Rech S Ind S O R I Soc D | Méthoxy-phényl-amino-2-thiazoles, leurs amides et leurs procédés de préparation |
| GB1352415A (en) | 1970-05-03 | 1974-05-08 | Boots Co Ltd | Esters of substituted nicotine acids |
| FR2088019A1 (en) | 1970-05-08 | 1972-01-07 | Rabot Ets David | Esters of 2 and 6-substituted nicotinic acids - with vasomotor active |
| CS173097B1 (US07902200-20110308-C00018.png) | 1972-12-01 | 1977-02-28 | ||
| GB1400540A (en) | 1972-12-06 | 1975-07-16 | Smith Kline French Lab | Salicylamides and compositions thereof |
| US4009174A (en) | 1972-12-08 | 1977-02-22 | The Boots Company Limited | Esters of substituted nicotinic acids |
| GB1437800A (en) | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
| JPS5734314B2 (US07902200-20110308-C00018.png) | 1973-12-22 | 1982-07-22 | ||
| GB1561350A (en) | 1976-11-05 | 1980-02-20 | May & Baker Ltd | Benzamide derivatives |
| FR2344284A1 (fr) | 1976-03-17 | 1977-10-14 | Cerm Cent Europ Rech Mauvernay | Nouveaux composes tricycliques a cycle furannique et leur application comme antidepresseurs |
| GB1588242A (en) | 1977-10-28 | 1981-04-23 | May & Baker Ltd | N-(tetrazol-5-yl)-salicylamide derivatives |
| US4474792A (en) | 1979-06-18 | 1984-10-02 | Riker Laboratories, Inc. | N-Tetrazolyl benzamides and anti-allergic use thereof |
| JPS5721320A (en) | 1980-07-11 | 1982-02-04 | Chugai Pharmaceut Co Ltd | Blood sugar level depressing agent |
| JPS5775962A (en) | 1980-10-29 | 1982-05-12 | Shionogi & Co Ltd | 2-alkoxybenzamide derivative |
| FR2493848B2 (fr) | 1980-11-07 | 1986-05-16 | Delalande Sa | Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique |
| JPS5869812A (ja) | 1981-10-22 | 1983-04-26 | Chugai Pharmaceut Co Ltd | 血糖降下剤 |
| JPS59139357A (ja) | 1983-01-28 | 1984-08-10 | Torii Yakuhin Kk | アミジン誘導体 |
| JPS61205937A (ja) | 1985-03-09 | 1986-09-12 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀カラ−写真感光材料 |
| JPS62142168A (ja) | 1985-10-16 | 1987-06-25 | Mitsubishi Chem Ind Ltd | チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤 |
| JPS62158252A (ja) | 1985-12-28 | 1987-07-14 | Kirin Brewery Co Ltd | ４−アミノピリジンベンズアミド誘導体 |
| CA1327358C (en) | 1987-11-17 | 1994-03-01 | Morio Fujiu | Fluoro cytidine derivatives |
| JP2852659B2 (ja) | 1988-03-03 | 1999-02-03 | 富山化学工業株式会社 | ピペラジン誘導体およびその塩 |
| DE3822449A1 (de) | 1988-07-02 | 1990-01-04 | Henkel Kgaa | Oxidationshaarfaerbemittel mit neuen kupplern |
| JPH04300874A (ja) | 1991-03-29 | 1992-10-23 | Tsumura & Co | 新規２，４−ジアミノ−１，３，５−トリアジン誘導体 |
| JPH04300832A (ja) | 1991-03-29 | 1992-10-23 | Tsumura & Co | ２，４−ジアミノ−１，３，５−トリアジン誘導体を有 効成分とするロイコトリエン拮抗剤 |
| US5466715A (en) | 1991-12-31 | 1995-11-14 | Sterling Winthrop Inc. | 3,4-disubstituted phenols-immunomodulating agents |
| US5258407A (en) | 1991-12-31 | 1993-11-02 | Sterling Winthrop Inc. | 3,4-disubstituted phenols-immunomodulating agents |
| US5273986A (en) | 1992-07-02 | 1993-12-28 | Hoffmann-La Roche Inc. | Cycloalkylthiazoles |
| JPH0627025A (ja) | 1992-07-06 | 1994-02-04 | Toto Ltd | 分子認識機能膜及びこれを用いたセンサー |
| EP0619116A3 (en) | 1993-04-05 | 1994-11-23 | Hoechst Japan | Use of synthetic retinoids for osteopathy. |
| GB9307527D0 (en) | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
| US5661153A (en) | 1994-07-19 | 1997-08-26 | Japan Energy Corporation | 1-arylpyrimidine derivatives and pharmaceutical use thereof |
| US5792109A (en) | 1994-09-01 | 1998-08-11 | Leland L. Ladd | Irrigation pump and system |
| JPH08143565A (ja) | 1994-11-16 | 1996-06-04 | Fujisawa Pharmaceut Co Ltd | ベンズアミド化合物 |
| US5510478A (en) | 1994-11-30 | 1996-04-23 | American Home Products Corporation | 2-arylamidothiazole derivatives with CNS activity |
| US5672750A (en) | 1994-12-16 | 1997-09-30 | Eastman Chemical Company | Preparation of aromatic amides from carbon monoxide, an amine and an aromatic chloride |
| US5849735A (en) | 1995-01-17 | 1998-12-15 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| JPH08301760A (ja) | 1995-05-10 | 1996-11-19 | Shiseido Co Ltd | 皮膚外用剤 |
| JP3168915B2 (ja) | 1995-05-25 | 2001-05-21 | 田辺製薬株式会社 | 医薬組成物 |
| US5712270A (en) | 1995-11-06 | 1998-01-27 | American Home Products Corporation | 2-arylamidothiazole derivatives with CNS activity |
| JP3735741B2 (ja) | 1995-11-24 | 2006-01-18 | 株式会社大塚製薬工場 | 縮環ピリミジン誘導体 |
| JPH10101672A (ja) | 1996-08-06 | 1998-04-21 | Otsuka Pharmaceut Factory Inc | アデノシン増強剤 |
| JPH10101671A (ja) | 1996-08-08 | 1998-04-21 | Otsuka Pharmaceut Factory Inc | 一酸化窒素合成酵素阻害剤 |
| AUPO395396A0 (en) | 1996-12-02 | 1997-01-02 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
| FR2757852B1 (fr) | 1996-12-31 | 1999-02-19 | Cird Galderma | Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations |
| JPH10212271A (ja) | 1997-01-31 | 1998-08-11 | Zeria Pharmaceut Co Ltd | Ｎ−置換ベンゾイルアミン誘導体、それを含有する医薬及び該化合物の製造中間体 |
| JPH1129480A (ja) | 1997-05-12 | 1999-02-02 | Otsuka Pharmaceut Factory Inc | 縮環ピリミジン誘導体を含有する医薬組成物 |
| RU2199532C2 (ru) | 1997-06-27 | 2003-02-27 | Фудзисава Фармасьютикал Ко., Лтд. | Сульфонамидное соединение |
| US6242474B1 (en) | 1997-06-27 | 2001-06-05 | Fujisawa Pharmaceutical Co., Ltd. | Aromatic ring derivatives |
| US6613942B1 (en) | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| US6114483A (en) | 1997-08-27 | 2000-09-05 | E. I. Du Pont De Nemours And Company | Polymerization of olefins |
| WO1999024415A1 (fr) | 1997-11-12 | 1999-05-20 | Institute Of Medicinal Molecular Design, Inc. | Agonistes du recepteur du retinoide |
| GB9725298D0 (en) | 1997-11-28 | 1998-01-28 | Zeneca Ltd | Insecticidal thiazole derivatives |
| JP4253126B2 (ja) | 1998-01-29 | 2009-04-08 | アムジェン インコーポレイテッド | Ｐｐａｒ−ガンマ調節剤 |
| DE19816780A1 (de) | 1998-04-16 | 1999-10-21 | Bayer Ag | Substituierte 2-Oxo-alkansäure-[2-(indol-3-yl)-ethyl]amide |
| GB9811969D0 (en) | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
| US6197798B1 (en) | 1998-07-21 | 2001-03-06 | Novartis Ag | Amino-benzocycloalkane derivatives |
| JP4191825B2 (ja) | 1998-09-10 | 2008-12-03 | あすか製薬株式会社 | ５−アミノイソキサゾール誘導体 |
| RU2242469C2 (ru) | 1999-03-29 | 2004-12-20 | Ф.Хоффманн-Ля Рош Аг | Активаторы глюкокиназы |
| US6610846B1 (en) | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
| US6320050B1 (en) | 1999-03-29 | 2001-11-20 | Hoffmann-La Roche Inc. | Heteroaromatic glucokinase activators |
| WO2001035950A2 (en) | 1999-11-18 | 2001-05-25 | Centaur Pharmaceuticals, Inc. | Benzamide therapeutics and methods for treating inflammatory bowel disease |
| WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| EP1132381A1 (en) | 2000-03-08 | 2001-09-12 | Cermol S.A. | Ester derivatives of dimethylpropionic acid and pharmaceutical compositions containing them |
| US6534651B2 (en) | 2000-04-06 | 2003-03-18 | Inotek Pharmaceuticals Corp. | 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof |
| CA2407416C (en) | 2000-05-03 | 2006-07-18 | Paige Erin Mahaney | Alkynyl phenyl heteroaromatic glucokinase activators |
| MXPA03003572A (es) | 2000-11-22 | 2003-07-14 | Yamanouchi Pharma Co Ltd | Derivados de benceno sustituidos o sales de los mismos. |
| PT1341774E (pt) | 2000-12-06 | 2006-05-31 | Hoffmann La Roche | Activadores heteroaromaticos, fundidos de glicocinase |
| EP1344525A4 (en) | 2000-12-22 | 2005-05-25 | Ishihara Sangyo Kaisha | ANILINE DERIVATIVES OR ITS SALTS AND CYTOKINE PRODUCTION INHIBITORS CONTAINING THEM |
| JPWO2002062775A1 (ja) | 2001-02-02 | 2004-06-10 | 山之内製薬株式会社 | ２−アシルアミノチアゾール誘導体又はその塩 |
| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| US7491748B2 (en) | 2001-08-09 | 2009-02-17 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| EP1336607A1 (en) | 2002-02-19 | 2003-08-20 | Novo Nordisk A/S | Amide derivatives as glucokinase activators |
| US6911545B2 (en) | 2001-12-19 | 2005-06-28 | Hoffman-La Roche Inc. | Crystals of glucokinase and methods of growing them |
| DE60328671D1 (de) | 2002-03-26 | 2009-09-17 | Banyu Pharma Co Ltd | Neue aminobenzamidderivate |
| US20060004010A1 (en) | 2002-07-10 | 2006-01-05 | Hiromu Habashita | Ccr4 antagonist and medical use thereof |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| AU2004215514B2 (en) | 2003-02-26 | 2010-03-04 | Msd K.K. | Heteroarylcarbamoylbenzene derivative |
| GB0325402D0 (en) | 2003-10-31 | 2003-12-03 | Astrazeneca Ab | Compounds |
| US20050171172A1 (en) | 2003-11-13 | 2005-08-04 | Ambit Biosciences Corporation | Amide derivatives as PDGFR modulators |
| EP1702919B1 (en) | 2003-12-29 | 2012-05-30 | Msd K.K. | Novel 2-heteroaryl-substituted benzimidazole derivative |
| TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| WO2006114180A1 (de) | 2005-04-25 | 2006-11-02 | Merck Patent Gmbh | Neuartige aza-heterozyklen als kinase-inhibitoren |
| JP2008542247A (ja) * | 2005-05-24 | 2008-11-27 | アストラゼネカ アクチボラグ | グルコキナーゼモジュレーターとしての２−フェニル置換イミダゾール［４，５ｂ］ピリジン／ピラジンおよびプリン誘導体 |
| US7642259B2 (en) * | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| WO2007017649A1 (en) * | 2005-08-09 | 2007-02-15 | Astrazeneca Ab | Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes |
| WO2007053657A1 (en) * | 2005-11-01 | 2007-05-10 | Janssen Pharmaceutica N.V. | Substituted pyrrolones as allosteric modulators of glucokinase |
-
2007
- 2007-10-19 TW TW096139393A patent/TW200825063A/zh unknown
- 2007-10-22 BR BRPI0718504-9A patent/BRPI0718504A2/pt not_active Application Discontinuation
- 2007-10-22 RU RU2009114982/04A patent/RU2009114982A/ru not_active Application Discontinuation
- 2007-10-22 JP JP2009533935A patent/JP2010507640A/ja not_active Withdrawn
- 2007-10-22 PE PE2007001425A patent/PE20081467A1/es not_active Application Discontinuation
- 2007-10-22 KR KR1020097010059A patent/KR20090068289A/ko not_active Application Discontinuation
- 2007-10-22 AU AU2007310608A patent/AU2007310608A1/en not_active Abandoned
- 2007-10-22 EP EP07824267A patent/EP2086964A2/en not_active Withdrawn
- 2007-10-22 CL CL200703033A patent/CL2007003033A1/es unknown
- 2007-10-22 WO PCT/GB2007/004018 patent/WO2008050101A2/en active Application Filing
- 2007-10-22 CA CA002667435A patent/CA2667435A1/en not_active Abandoned
- 2007-10-22 MX MX2009004362A patent/MX2009004362A/es not_active Application Discontinuation
- 2007-10-22 AR ARP070104658A patent/AR063499A1/es unknown
- 2007-10-22 US US11/876,370 patent/US7902200B2/en not_active Expired - Fee Related
- 2007-10-29 UY UY30660A patent/UY30660A1/es unknown
-
2009
- 2009-04-16 IL IL198142A patent/IL198142A0/en unknown
- 2009-04-20 CO CO09039732A patent/CO6160318A2/es unknown
- 2009-04-22 NO NO20091599A patent/NO20091599L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UY30660A1 (es) | 2008-05-31 |
| CA2667435A1 (en) | 2008-05-02 |
| AU2007310608A1 (en) | 2008-05-02 |
| TW200825063A (en) | 2008-06-16 |
| IL198142A0 (en) | 2009-12-24 |
| WO2008050101A2 (en) | 2008-05-02 |
| RU2009114982A (ru) | 2010-11-27 |
| EP2086964A2 (en) | 2009-08-12 |
| US20080171734A1 (en) | 2008-07-17 |
| PE20081467A1 (es) | 2008-12-07 |
| JP2010507640A (ja) | 2010-03-11 |
| MX2009004362A (es) | 2009-05-05 |
| BRPI0718504A2 (pt) | 2013-12-03 |
| NO20091599L (no) | 2009-07-21 |
| CO6160318A2 (es) | 2010-05-20 |
| AR063499A1 (es) | 2009-01-28 |
| CL2007003033A1 (es) | 2008-05-16 |
| WO2008050101A3 (en) | 2008-07-17 |
| US7902200B2 (en) | 2011-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20090068289A (ko) | Ｇｌｋ를 통해 매개되는 질환의 치료에 유용한 벤조일 아미노 헤테로시클릴 화합물 | |
| KR101346902B1 (ko) | 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체 | |
| US7943607B2 (en) | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes | |
| JP4673429B2 (ja) | グルコキナーゼ（ｇｌｋ）活性化剤としてのベンゾイルアミノヘテロシクリル化合物 | |
| JP2009500442A (ja) | ２型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての２−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物 | |
| JP2007523905A (ja) | 化合物 | |
| JP2008516937A (ja) | グルコキナーゼ酵素に作用するベンズアミド誘導体 | |
| KR20070024650A (ko) | 당뇨병 치료에 있어서 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체 | |
| JP2009500444A (ja) | 糖尿病の治療においてｇｌｋアクチベータとして使用するためのヘテロアリールベンズアミド誘導体 | |
| EP1915367A1 (en) | Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |