KR20030079979A - 치환된 아자인돌옥소아세틱 피페라진 유도체의 조성물 및항바이러스 활성 - Google Patents

치환된 아자인돌옥소아세틱 피페라진 유도체의 조성물 및항바이러스 활성 Download PDF

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Publication number
KR20030079979A
KR20030079979A KR10-2003-7010208A KR20037010208A KR20030079979A KR 20030079979 A KR20030079979 A KR 20030079979A KR 20037010208 A KR20037010208 A KR 20037010208A KR 20030079979 A KR20030079979 A KR 20030079979A
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KR
South Korea
Prior art keywords
alkyl
heteroaryl
group
same
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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KR10-2003-7010208A
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English (en)
Korean (ko)
Inventor
타오 왕
종싱 장
니콜라스 에이. 민웰
존 에프. 카도우
지웨이 인
Original Assignee
브리스톨-마이어스스퀴브컴파니
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Application filed by 브리스톨-마이어스스퀴브컴파니 filed Critical 브리스톨-마이어스스퀴브컴파니
Publication of KR20030079979A publication Critical patent/KR20030079979A/ko
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR10-2003-7010208A 2001-02-02 2002-01-02 치환된 아자인돌옥소아세틱 피페라진 유도체의 조성물 및항바이러스 활성 Withdrawn KR20030079979A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26618301P 2001-02-02 2001-02-02
US60/266,183 2001-02-02
US31440601P 2001-08-23 2001-08-23
US60/314,406 2001-08-23
PCT/US2002/000455 WO2002062423A1 (en) 2001-02-02 2002-01-02 Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

Publications (1)

Publication Number Publication Date
KR20030079979A true KR20030079979A (ko) 2003-10-10

Family

ID=26951680

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7010208A Withdrawn KR20030079979A (ko) 2001-02-02 2002-01-02 치환된 아자인돌옥소아세틱 피페라진 유도체의 조성물 및항바이러스 활성

Country Status (31)

Country Link
US (1) US20030069266A1 (enExample)
EP (1) EP1363705B9 (enExample)
JP (1) JP4328527B2 (enExample)
KR (1) KR20030079979A (enExample)
CN (1) CN100384423C (enExample)
AR (1) AR034292A1 (enExample)
BG (1) BG66359B1 (enExample)
BR (1) BRPI0206636B8 (enExample)
CA (1) CA2437524C (enExample)
CY (1) CY1113194T1 (enExample)
CZ (1) CZ303750B6 (enExample)
DK (1) DK1363705T3 (enExample)
EE (1) EE05424B1 (enExample)
ES (1) ES2387981T3 (enExample)
HR (1) HRP20030694A2 (enExample)
HU (1) HU229305B1 (enExample)
IL (2) IL157029A0 (enExample)
IS (1) IS2912B (enExample)
MX (1) MXPA03006939A (enExample)
MY (1) MY137480A (enExample)
NO (1) NO326510B1 (enExample)
NZ (1) NZ527193A (enExample)
PE (1) PE20020855A1 (enExample)
PL (1) PL364279A1 (enExample)
PT (1) PT1363705E (enExample)
RS (1) RS52489B (enExample)
RU (1) RU2303038C2 (enExample)
SK (1) SK287900B6 (enExample)
TW (1) TWI318978B (enExample)
WO (1) WO2002062423A1 (enExample)
ZA (1) ZA200305885B (enExample)

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US20050124623A1 (en) * 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
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UA88297C2 (ru) * 2004-03-15 2009-10-12 Бристол-Майэрс Сквибб Компани Пиперазиновые пролекарства и замещенные пиперидиновые антивирусные средства
US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
DK1753764T3 (da) 2004-06-09 2009-02-16 Glaxo Group Ltd Pyrrolopyridin-derivater
KR100958828B1 (ko) 2004-09-03 2010-05-24 주식회사유한양행 피롤로[3,2-ｂ]피리딘 유도체 및 그의 제조방법
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7183284B2 (en) * 2004-12-29 2007-02-27 Bristol-Myers Squibb Company Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents
US7601715B2 (en) 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
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US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US7504399B2 (en) * 2006-06-08 2009-03-17 Bristol-Meyers Squibb Company Piperazine enamines as antiviral agents
US8318941B2 (en) * 2006-07-06 2012-11-27 Bristol-Myers Squibb Company Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
JP5351025B2 (ja) * 2006-09-22 2013-11-27 ノバルティス アーゲー ヘテロ環式有機化合物
WO2009158394A1 (en) 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Diketo azolopiperidines and azolopiperazines as anti-hiv agents
ES2389478T3 (es) 2008-06-25 2012-10-26 Bristol-Myers Squibb Company Derivados de dicetopiperidina como inhibidores de la fijación del VIH
WO2012019003A1 (en) 2010-08-06 2012-02-09 Bristol-Myers Squibb Company Substituted indole and azaindole oxoacetyl piperazinamide derivatives
EP2646439B1 (en) 2010-12-02 2016-05-25 Bristol-Myers Squibb Company Alkyl amides as hiv attachment inhibitors
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US8835454B2 (en) 2011-08-29 2014-09-16 Bristol-Myers Squibb Company Fused bicyclic diamine derivatives as HIV attachment inhibitors
PT2812332T (pt) 2012-02-08 2017-11-15 Viiv Healthcare Uk (No 4) Ltd Métodos para a preparação do composto profármaco piperazina inibidor da conjugação ao vih
WO2013138436A1 (en) 2012-03-14 2013-09-19 Bristol-Myers Squibb Company Cyclolic hydrazine derivatives as hiv attachment inhibitors
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Also Published As

Publication number Publication date
SK9592003A3 (en) 2004-08-03
RU2303038C2 (ru) 2007-07-20
TWI318978B (en) 2010-01-01
CZ303750B6 (cs) 2013-04-17
AR034292A1 (es) 2004-02-18
EP1363705B9 (en) 2012-11-07
CN1612763A (zh) 2005-05-04
HRP20030694A2 (en) 2005-04-30
ZA200305885B (en) 2005-01-26
CN100384423C (zh) 2008-04-30
NZ527193A (en) 2004-05-28
EP1363705A1 (en) 2003-11-26
NO20033436D0 (no) 2003-08-01
SK287900B6 (sk) 2012-03-02
CA2437524C (en) 2010-04-27
EP1363705A4 (en) 2009-08-12
CA2437524A1 (en) 2002-08-15
IL157029A (en) 2015-11-30
HUP0304062A3 (en) 2010-06-28
CZ20032316A3 (cs) 2004-01-14
PT1363705E (pt) 2012-08-17
IS6899A (is) 2003-07-30
JP4328527B2 (ja) 2009-09-09
EP1363705B1 (en) 2012-06-13
RU2003127077A (ru) 2005-03-20
WO2002062423A1 (en) 2002-08-15
BG108021A (bg) 2004-04-30
DK1363705T3 (da) 2012-09-24
EE200300359A (et) 2003-12-15
US20030069266A1 (en) 2003-04-10
HK1056698A1 (en) 2004-02-27
YU60903A (sh) 2006-05-25
BG66359B1 (bg) 2013-09-30
RS52489B (sr) 2013-02-28
BR0206636A (pt) 2004-02-25
BRPI0206636B8 (pt) 2021-05-25
PE20020855A1 (es) 2002-09-27
NO326510B1 (no) 2008-12-22
NO20033436L (no) 2003-10-01
IL157029A0 (en) 2004-02-08
EE05424B1 (et) 2011-06-15
ES2387981T3 (es) 2012-10-05
CY1113194T1 (el) 2016-04-13
BRPI0206636B1 (pt) 2018-05-02
MXPA03006939A (es) 2003-11-18
HUP0304062A2 (hu) 2004-04-28
IS2912B (is) 2014-11-15
HU229305B1 (en) 2013-10-28
PL364279A1 (en) 2004-12-13
JP2004522755A (ja) 2004-07-29
MY137480A (en) 2009-01-30

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