BRPI0206636B8 - composição e atividade antiviral de derivados de piperazina azaindoloxoacéticos substituídos, composições farmacêuticas que os contêm e usos - Google Patents

composição e atividade antiviral de derivados de piperazina azaindoloxoacéticos substituídos, composições farmacêuticas que os contêm e usos

Info

Publication number
BRPI0206636B8
BRPI0206636B8 BRPI0206636A BRPI0206636B8 BR PI0206636 B8 BRPI0206636 B8 BR PI0206636B8 BR PI0206636 A BRPI0206636 A BR PI0206636A BR PI0206636 B8 BRPI0206636 B8 BR PI0206636B8
Authority
BR
Brazil
Prior art keywords
activity
piperazine derivatives
azaindoloxoacetic
pharmaceutical compositions
substituted
Prior art date
Application number
Other languages
English (en)
Portuguese (pt)
Inventor
F Kadow John
A Meanwell Nicholas
Wang Tao
Yin Zhiwei
Zhang Zhongxing
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0206636A publication Critical patent/BR0206636A/pt
Publication of BRPI0206636B1 publication Critical patent/BRPI0206636B1/pt
Publication of BRPI0206636B8 publication Critical patent/BRPI0206636B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
BR0206636-0 2001-02-02 2002-01-02 composição e atividade antiviral de derivados de piperazina azaindoloxoacéticos substituídos, composições farmacêuticas que os contêm e usos BRPI0206636B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26618301P 2001-02-02 2001-02-02
US60/266.183 2001-02-02
US31440601P 2001-08-23 2001-08-23
US60/314.406 2001-08-23
PCT/US2002/000455 WO2002062423A1 (en) 2001-02-02 2002-01-02 Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

Publications (3)

Publication Number Publication Date
BR0206636A BR0206636A (pt) 2004-02-25
BRPI0206636B1 BRPI0206636B1 (pt) 2018-05-02
BRPI0206636B8 true BRPI0206636B8 (pt) 2021-05-25

Family

ID=26951680

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0206636-0 BRPI0206636B8 (pt) 2001-02-02 2002-01-02 composição e atividade antiviral de derivados de piperazina azaindoloxoacéticos substituídos, composições farmacêuticas que os contêm e usos

Country Status (31)

Country Link
US (1) US20030069266A1 (enExample)
EP (1) EP1363705B9 (enExample)
JP (1) JP4328527B2 (enExample)
KR (1) KR20030079979A (enExample)
CN (1) CN100384423C (enExample)
AR (1) AR034292A1 (enExample)
BG (1) BG66359B1 (enExample)
BR (1) BRPI0206636B8 (enExample)
CA (1) CA2437524C (enExample)
CY (1) CY1113194T1 (enExample)
CZ (1) CZ303750B6 (enExample)
DK (1) DK1363705T3 (enExample)
EE (1) EE05424B1 (enExample)
ES (1) ES2387981T3 (enExample)
HR (1) HRP20030694A2 (enExample)
HU (1) HU229305B1 (enExample)
IL (2) IL157029A0 (enExample)
IS (1) IS2912B (enExample)
MX (1) MXPA03006939A (enExample)
MY (1) MY137480A (enExample)
NO (1) NO326510B1 (enExample)
NZ (1) NZ527193A (enExample)
PE (1) PE20020855A1 (enExample)
PL (1) PL364279A1 (enExample)
PT (1) PT1363705E (enExample)
RS (1) RS52489B (enExample)
RU (1) RU2303038C2 (enExample)
SK (1) SK287900B6 (enExample)
TW (1) TWI318978B (enExample)
WO (1) WO2002062423A1 (enExample)
ZA (1) ZA200305885B (enExample)

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US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
EP1476163A4 (en) * 2002-02-23 2009-05-27 Bristol Myers Squibb Co METHOD FOR TREATING HIV INFECTION BY PREVENTING INTERACTION OF CD4 AND GP120
US7348337B2 (en) 2002-05-28 2008-03-25 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
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CA2509413C (en) 2002-12-20 2012-05-01 Glaxo Group Limited Benzazepine derivatives for the treatment of neurological disorders
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
US20050124623A1 (en) * 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
US7745625B2 (en) * 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
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US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
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US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7183284B2 (en) * 2004-12-29 2007-02-27 Bristol-Myers Squibb Company Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents
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US7396830B2 (en) * 2005-10-04 2008-07-08 Bristol-Myers Squibb Company Piperazine amidines as antiviral agents
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US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US7504399B2 (en) * 2006-06-08 2009-03-17 Bristol-Meyers Squibb Company Piperazine enamines as antiviral agents
US8318941B2 (en) * 2006-07-06 2012-11-27 Bristol-Myers Squibb Company Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
CA2662574A1 (en) * 2006-09-22 2008-03-27 Novartis Ag Heterocyclic organic compounds
JP5433691B2 (ja) 2008-06-25 2014-03-05 ブリストル−マイヤーズ スクイブ カンパニー Ｈｉｖ結合阻害剤としてのジケトピペリジン誘導体
WO2009158394A1 (en) 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Diketo azolopiperidines and azolopiperazines as anti-hiv agents
US8450361B2 (en) 2010-08-06 2013-05-28 Bristol-Myers Squibb Company Substituted indole and azaindole oxoacetyl piperazinamide derivatives
EP2646439B1 (en) 2010-12-02 2016-05-25 Bristol-Myers Squibb Company Alkyl amides as hiv attachment inhibitors
US8685982B2 (en) 2011-04-12 2014-04-01 Bristol-Myers Squibb Company Thioamide, amidoxime and amidrazone derivatives as HIV attachment inhibitors
WO2013033061A1 (en) 2011-08-29 2013-03-07 Bristol-Myers Squibb Company Fused bicyclic diamine derivatives as hiv attachment inhibitors
US8664213B2 (en) 2011-08-29 2014-03-04 Bristol-Myers Squibb Company Spiro bicyclic diamine derivatives as HIV attachment inhibitors
EA024872B1 (ru) 2012-02-08 2016-10-31 Бристол-Майерс Сквибб Компани Способы получения пиперазинового пролекарства - ингибитора присоединения вич
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WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
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Also Published As

Publication number Publication date
EP1363705A1 (en) 2003-11-26
PT1363705E (pt) 2012-08-17
SK287900B6 (sk) 2012-03-02
CA2437524A1 (en) 2002-08-15
NO20033436L (no) 2003-10-01
BRPI0206636B1 (pt) 2018-05-02
RU2303038C2 (ru) 2007-07-20
IS2912B (is) 2014-11-15
HU229305B1 (en) 2013-10-28
PE20020855A1 (es) 2002-09-27
IL157029A (en) 2015-11-30
ES2387981T3 (es) 2012-10-05
SK9592003A3 (en) 2004-08-03
HK1056698A1 (en) 2004-02-27
NZ527193A (en) 2004-05-28
YU60903A (sh) 2006-05-25
DK1363705T3 (da) 2012-09-24
EE05424B1 (et) 2011-06-15
CA2437524C (en) 2010-04-27
HUP0304062A3 (en) 2010-06-28
CN1612763A (zh) 2005-05-04
TWI318978B (en) 2010-01-01
CZ20032316A3 (cs) 2004-01-14
HRP20030694A2 (en) 2005-04-30
NO20033436D0 (no) 2003-08-01
WO2002062423A1 (en) 2002-08-15
US20030069266A1 (en) 2003-04-10
ZA200305885B (en) 2005-01-26
RU2003127077A (ru) 2005-03-20
JP2004522755A (ja) 2004-07-29
CN100384423C (zh) 2008-04-30
EP1363705B1 (en) 2012-06-13
EE200300359A (et) 2003-12-15
IL157029A0 (en) 2004-02-08
RS52489B (sr) 2013-02-28
EP1363705B9 (en) 2012-11-07
AR034292A1 (es) 2004-02-18
JP4328527B2 (ja) 2009-09-09
MY137480A (en) 2009-01-30
BR0206636A (pt) 2004-02-25
IS6899A (is) 2003-07-30
NO326510B1 (no) 2008-12-22
KR20030079979A (ko) 2003-10-10
BG66359B1 (bg) 2013-09-30
MXPA03006939A (es) 2003-11-18
PL364279A1 (en) 2004-12-13
CY1113194T1 (el) 2016-04-13
BG108021A (bg) 2004-04-30
HUP0304062A2 (hu) 2004-04-28
CZ303750B6 (cs) 2013-04-17
EP1363705A4 (en) 2009-08-12

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