KR102557670B1 - 비칼로리 감미료 및 합성 방법 - Google Patents

비칼로리 감미료 및 합성 방법 Download PDF

Info

Publication number
KR102557670B1
KR102557670B1 KR1020177008543A KR20177008543A KR102557670B1 KR 102557670 B1 KR102557670 B1 KR 102557670B1 KR 1020177008543 A KR1020177008543 A KR 1020177008543A KR 20177008543 A KR20177008543 A KR 20177008543A KR 102557670 B1 KR102557670 B1 KR 102557670B1
Authority
KR
South Korea
Prior art keywords
rebaudioside
leu
udp
glucose
glycosyltransferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020177008543A
Other languages
English (en)
Korean (ko)
Other versions
KR20170062461A (ko
Inventor
구오홍 마오
시아오단 유
Original Assignee
코나겐 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 코나겐 인크. filed Critical 코나겐 인크.
Publication of KR20170062461A publication Critical patent/KR20170062461A/ko
Application granted granted Critical
Publication of KR102557670B1 publication Critical patent/KR102557670B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/56Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52Adding ingredients
    • A23L2/60Sweeteners
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30Artificial sweetening agents
    • A23L27/33Artificial sweetening agents containing sugars or derivatives
    • A23L27/36Terpene glycosides
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/256Polyterpene radicals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • C12N9/1062Sucrose synthase (2.4.1.13)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/18Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • C12Y204/01013Sucrose synthase (2.4.1.13)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • C12Y204/01017Glucuronosyltransferase (2.4.1.17)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Seasonings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Tea And Coffee (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
KR1020177008543A 2014-10-03 2015-10-02 비칼로리 감미료 및 합성 방법 Active KR102557670B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462059498P 2014-10-03 2014-10-03
US62/059,498 2014-10-03
US201462098929P 2014-12-31 2014-12-31
US62/098,929 2014-12-31
PCT/US2015/053767 WO2016054534A1 (en) 2014-10-03 2015-10-02 Non-caloric sweeteners and methods for synthesizing

Publications (2)

Publication Number Publication Date
KR20170062461A KR20170062461A (ko) 2017-06-07
KR102557670B1 true KR102557670B1 (ko) 2023-07-20

Family

ID=55631622

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020177008543A Active KR102557670B1 (ko) 2014-10-03 2015-10-02 비칼로리 감미료 및 합성 방법
KR1020177008544A Active KR102521967B1 (ko) 2014-10-03 2015-10-02 비칼로리 감미료 및 합성 방법
KR1020177008546A Active KR102536036B1 (ko) 2014-10-03 2015-10-02 비칼로리 감미료 및 합성 방법
KR1020177008545A Active KR102526446B1 (ko) 2014-10-03 2015-10-02 비칼로리 감미료 및 합성 방법

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020177008544A Active KR102521967B1 (ko) 2014-10-03 2015-10-02 비칼로리 감미료 및 합성 방법
KR1020177008546A Active KR102536036B1 (ko) 2014-10-03 2015-10-02 비칼로리 감미료 및 합성 방법
KR1020177008545A Active KR102526446B1 (ko) 2014-10-03 2015-10-02 비칼로리 감미료 및 합성 방법

Country Status (14)

Country Link
US (22) US10023604B2 (https=)
EP (4) EP3200615B1 (https=)
JP (4) JP6774945B2 (https=)
KR (4) KR102557670B1 (https=)
CN (7) CN106715451B (https=)
AU (4) AU2015327858B2 (https=)
BR (3) BR112017006139B1 (https=)
CA (4) CA2958105C (https=)
DK (3) DK3200615T3 (https=)
ES (3) ES2693371T3 (https=)
HU (2) HUE045992T2 (https=)
MX (4) MX378831B (https=)
MY (4) MY179680A (https=)
WO (4) WO2016054534A1 (https=)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201505597SA (en) 2013-02-06 2015-08-28 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
US10264811B2 (en) 2014-05-19 2019-04-23 Epc Natural Products Co., Ltd. Stevia sweetener with improved solubility
DK3200615T3 (da) 2014-10-03 2019-08-19 Conagen Inc Kaloriefrie sødestoffer og fremgangsmåder til syntetisering
EP3232817A4 (en) 2014-12-17 2018-10-10 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
SG11201705606PA (en) 2015-01-30 2017-08-30 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3718417B1 (en) 2015-04-03 2025-09-03 DSM IP Assets B.V. Steviol glycosides
JP6793957B2 (ja) 2015-04-14 2020-12-02 コナゲン インコーポレイテッド 改変された全細胞触媒を用いたノンカロリー甘味料の生成
US20190203244A1 (en) * 2015-08-20 2019-07-04 Pepsico, Inc. Preparation of rebaudioside m in a single reaction vessel
US10982249B2 (en) 2016-04-13 2021-04-20 Evolva Sa Production of steviol glycosides in recombinant hosts
MX2018015534A (es) 2016-06-15 2019-03-14 Codexis Inc Beta-glucosidasas dise?adas y metodos de glucosilacion.
JP2019517812A (ja) * 2016-06-17 2019-06-27 カーギル インコーポレイテッド 経口摂取または経口使用のためのステビオールグリコシド組成物
AU2017308143B2 (en) 2016-08-12 2022-04-07 Amyris, Inc. UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides
CN110191643B (zh) * 2016-10-14 2023-06-06 科纳根公司 甜菊醇糖苷的生物合成生产及其工艺
BR112019008048A2 (pt) 2016-10-21 2019-07-02 Pepsico Inc método para preparar rebaudiosídeo n com o uso de método enzimático
US11359222B2 (en) 2016-10-21 2022-06-14 Pepsico, Inc. Enzymatic method for preparing Rebaudioside j
WO2018093196A1 (ko) * 2016-11-17 2018-05-24 서울대학교산학협력단 변형 류코노스톡속 균주를 이용한 스테비오사이드 배당체의 합성 방법 및 이에 의하여 제조된 신규한 스테비오사이드 배당체
BR112019011200B1 (pt) 2016-12-01 2021-12-28 Arvinas Operations, Inc Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio
CA3175070A1 (en) 2017-02-03 2018-08-09 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
ES3042101T3 (en) * 2017-04-25 2025-11-18 Coca Cola Co Sweetness and taste improvement of steviol glycoside and mogroside sweeteners with dihydrochalcones
CN107164435B (zh) * 2017-05-27 2020-03-31 中国药科大学 一种莱鲍迪苷ka的制备方法
WO2018225817A1 (ja) 2017-06-08 2018-12-13 サントリーホールディングス株式会社 甘味の増大した飲食品
MX2019015404A (es) 2017-06-30 2020-07-20 Conagen Inc Hidrólisis de glucósidos de esteviol por beta-glucosidasa.
CN111868252B (zh) 2018-03-12 2025-06-03 科纳根公司 甜菊糖苷莱苞迪苷j和莱苞迪苷n的生物合成生产
CN112135527B (zh) * 2018-05-08 2023-08-15 伊比西(北京)植物药物技术有限公司 具有改善风味的甜菊醇糖甙组合物
CN109021038B (zh) * 2018-06-11 2021-07-27 江西师范大学 一种甜菊糖苷的制备方法
WO2020028039A1 (en) * 2018-07-30 2020-02-06 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
JP6887025B2 (ja) * 2018-08-17 2021-06-16 邦泰生物工程(深▲セン▼)有限公司 安定型ニコチンアミドリボシド組成物及びその調製方法
CN111073923A (zh) * 2018-10-22 2020-04-28 山东三元生物科技股份有限公司 一种莱鲍迪苷m的酶法制备方法
CN113302298B (zh) 2018-11-09 2025-02-25 银杏生物制品公司 罗汉果甙的生物合成
EP3892107A4 (en) * 2018-12-07 2022-09-14 Suntory Holdings Limited COFFEE BEVERAGE WITH IMPROVED TASTE QUALITY PROVIDED BY SUGAR AND SWEETENER
WO2020116664A1 (en) * 2018-12-07 2020-06-11 Suntory Holdings Limited Composition
CN113163789A (zh) * 2018-12-07 2021-07-23 三得利控股株式会社 糖及甜味剂所呈现的味质得到改善的咖啡饮料
SG11202105335UA (en) * 2018-12-07 2021-06-29 Suntory Holdings Ltd Composition
MX2021006986A (es) * 2018-12-12 2021-08-16 Conagen Inc Produccion biosintetica de variantes de glucosidos de esteviol.
CN109750072B (zh) * 2019-01-31 2022-04-19 南京工业大学 一种酶法制备莱鲍迪苷e的方法
EP3799057A1 (en) 2019-09-25 2021-03-31 Koninklijke Philips N.V. Prediction tool for patient immune response to a therapy
EP4044823A4 (en) * 2019-10-16 2024-04-24 Sweegen, Inc. STEVIOL GLYCOSIDE FORMULATIONS FOR FOOD AND BEVERAGES
CN110846363B (zh) * 2019-11-11 2023-02-17 天津大学 一锅法生产莱鲍迪苷d的方法
CN110872586B (zh) * 2019-11-11 2024-01-30 天津大学 固定化葡萄糖基转移酶及制备方法及催化生产莱鲍迪苷d的方法
CN110734944B (zh) * 2019-11-11 2023-02-21 中化健康产业发展有限公司 一步法合成莱鲍迪苷m的方法
CN110846305B (zh) * 2019-11-11 2023-11-28 中化健康产业发展有限公司 一种固定化糖基转移酶催化莱鲍迪苷a生成莱鲍迪苷m的方法
CA3171399A1 (en) * 2020-03-13 2021-09-16 Stanley W. HERRMANN Rebaudioside m sweetener compositions
KR20230005877A (ko) * 2020-04-20 2023-01-10 더 코카콜라 컴파니 향미가 증강된 시아메노사이드 i를 포함하는 음료
US20250320470A1 (en) * 2020-12-23 2025-10-16 Samyang Corporation Glycosyltransferase and steviol glucoside preparation method using same
JP7210626B2 (ja) * 2021-02-18 2023-01-23 ペプシコ・インク 酵素的方法を使用してレバウディオサイドjを調製するための方法
WO2023121426A1 (ko) * 2021-12-24 2023-06-29 주식회사 삼양사 레바우디오사이드의 생산
WO2023183832A1 (en) 2022-03-23 2023-09-28 Sweegen, Inc. Sweetener comprising rebaudiose m and brazzein
CN114921434B (zh) * 2022-05-27 2024-02-20 中化健康产业发展有限公司 催化Reb A生产Reb M的重组糖基转移酶
DE202022103252U1 (de) 2022-06-09 2022-07-01 Wal Ankita Eine natürliche Süßstoffzusammensetzung als Süßungsmittel für Diabetes
CN116076694B (zh) * 2022-10-12 2024-06-28 四川盈嘉合生科技有限公司 一种甜菊糖苷甜味剂及其制备方法
CN121465226A (zh) * 2023-09-15 2026-02-06 郑州大学 呈味肽及其筛选
WO2025143773A1 (ko) * 2023-12-26 2025-07-03 주식회사 삼양사 수크로우스 합성효소 변이체, udp-글루코실트랜스퍼라제 변이체 및 이들의 스테비올 배당체 생산 용도
KR102777875B1 (ko) * 2024-10-22 2025-03-13 대한민국 신규 페디오코커스 속 균주 및 그의 용도
CN119842657B (zh) * 2025-03-18 2025-05-27 青岛奔月生物技术有限公司 蔗糖合酶突变体及其应用
CN120813686A (zh) * 2025-05-07 2025-10-17 邦泰生物工程(深圳)有限公司 一种udp-葡萄糖基转移酶突变体及其制备莱鲍迪苷d的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013022989A2 (en) 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
WO2014122328A1 (en) 2013-02-11 2014-08-14 Evolva Sa Efficient production of steviol glycosides in recombinant hosts

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US17804A (en) * 1857-07-14 Improvement in locks
US4612942A (en) 1984-03-08 1986-09-23 Stevia Company, Inc. Flavor enhancing and modifying materials
JPH04149191A (ja) * 1990-10-09 1992-05-22 Nakano Vinegar Co Ltd ステビオサイド糖転移化合物及びその製造方法
US20090183270A1 (en) 2002-10-02 2009-07-16 Adams Thomas R Transgenic plants with enhanced agronomic traits
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US20100092638A1 (en) 2006-10-24 2010-04-15 Chad Allen Hansen Consumables
US20130071521A1 (en) 2007-03-14 2013-03-21 Pepsico, Inc. Rebaudioside d sweeteners and food products sweetened with rebaudioside d
US8277862B2 (en) 2007-03-14 2012-10-02 Concentrate Manufacturing Company Of Ireland Beverage products having steviol glycosides and at least one acid
CN107033200A (zh) * 2008-10-03 2017-08-11 守田化学工业株式会社 新的甜菊醇糖苷
US8501261B2 (en) * 2010-05-21 2013-08-06 Purecircle Sdn Bhd High-purity Rebaudioside C and process for purification of the same
CN105671108A (zh) * 2010-06-02 2016-06-15 沃维公司 甜菊糖苷的重组生产
CA2819253A1 (en) * 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
EP3009010B1 (en) * 2011-12-19 2020-02-05 PureCircle SDN BHD Methods for purifying steviol glycosides
US10000783B2 (en) 2012-03-16 2018-06-19 Suntory Holdings Limited Steviol glucosyltransferases and genes encoding the same
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
BR112014028819A2 (pt) * 2012-05-22 2017-07-25 Purecircle Sdn Bhd glicosídeos de esteviol de pureza elevada
CN103710318B (zh) * 2012-09-29 2017-01-18 中国科学院上海生命科学研究院 利用微生物生产甜菊糖苷类化合物的方法
SG11201505597SA (en) 2013-02-06 2015-08-28 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
US9717267B2 (en) 2013-03-14 2017-08-01 The Coca-Cola Company Beverages containing rare sugars
US20160015064A1 (en) * 2013-03-14 2016-01-21 Chromocell Corporation Compounds, compositions, and methods for modulating sweet taste
EP2970354B1 (en) 2013-03-15 2018-05-30 The Coca-Cola Company Steviol glycosides and their compositions
US20140342043A1 (en) 2013-05-14 2014-11-20 Pepsico, Inc. Rebaudioside Sweetener Compositions and Food Products Sweetened with Same
TWI657746B (zh) 2013-06-19 2019-05-01 美商科納根股份有限公司 含有甜葉菊苷e之可食用產品及使用其製備和強化可食用產品之甜味的方法
EP3021689B1 (en) 2013-07-15 2021-03-24 DSM IP Assets B.V. Diterpene production
CN103397064B (zh) * 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
ES2709439T3 (es) 2013-11-01 2019-04-16 Conagen Inc Producción recombinante de glucósidos de esteviol
EP3508584A1 (en) 2014-01-28 2019-07-10 PepsiCo, Inc. Method for preparing rebaudioside m by using enzyme method
US9522929B2 (en) * 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
EP3202269B1 (en) * 2014-09-30 2020-04-08 Suntory Holdings Limited Carbonated beverage, syrup to be used for preparing carbonated beverage, method for manufacturing carbonated beverage, and method for suppressing generation of bubbles in carbonated beverage
DK3200615T3 (da) 2014-10-03 2019-08-19 Conagen Inc Kaloriefrie sødestoffer og fremgangsmåder til syntetisering
JP6793957B2 (ja) * 2015-04-14 2020-12-02 コナゲン インコーポレイテッド 改変された全細胞触媒を用いたノンカロリー甘味料の生成
JP2019517812A (ja) * 2016-06-17 2019-06-27 カーギル インコーポレイテッド 経口摂取または経口使用のためのステビオールグリコシド組成物
CN110191643B (zh) * 2016-10-14 2023-06-06 科纳根公司 甜菊醇糖苷的生物合成生产及其工艺
MX2021006986A (es) * 2018-12-12 2021-08-16 Conagen Inc Produccion biosintetica de variantes de glucosidos de esteviol.
EP4044823A4 (en) * 2019-10-16 2024-04-24 Sweegen, Inc. STEVIOL GLYCOSIDE FORMULATIONS FOR FOOD AND BEVERAGES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013022989A2 (en) 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
JP2014524247A (ja) 2011-08-08 2014-09-22 エヴォルヴァ エスアー. ステビオール配糖体の組換え生産
WO2014122328A1 (en) 2013-02-11 2014-08-14 Evolva Sa Efficient production of steviol glycosides in recombinant hosts

Also Published As

Publication number Publication date
MX378831B (es) 2025-03-10
US10800803B2 (en) 2020-10-13
AU2015327858B2 (en) 2020-06-18
CN106795195A (zh) 2017-05-31
EP3200615A4 (en) 2018-04-04
BR112017006330A2 (pt) 2018-01-16
ES2741741T3 (es) 2020-02-12
ES2693371T3 (es) 2018-12-11
US20200339621A1 (en) 2020-10-29
CN114908135A (zh) 2022-08-16
EP3200615B1 (en) 2019-05-29
CN106714578B (zh) 2020-07-28
US9850270B2 (en) 2017-12-26
MX367090B (es) 2019-08-05
BR112017006163A2 (pt) 2018-07-31
US20180057520A1 (en) 2018-03-01
CN106795195B (zh) 2021-11-12
US20170218421A1 (en) 2017-08-03
US10010101B2 (en) 2018-07-03
CA2958434A1 (en) 2016-04-07
KR102526446B1 (ko) 2023-04-27
US20160097072A1 (en) 2016-04-07
HUE045992T2 (hu) 2020-01-28
WO2016054534A1 (en) 2016-04-07
EP3201212A4 (en) 2017-11-22
JP6722177B2 (ja) 2020-07-15
EP3200615A1 (en) 2017-08-09
US11453692B2 (en) 2022-09-27
US20180258126A1 (en) 2018-09-13
EP3201351A1 (en) 2017-08-09
HUE053331T2 (hu) 2021-06-28
US10442831B2 (en) 2019-10-15
US20200331952A1 (en) 2020-10-22
MY179680A (en) 2020-11-11
US20160097070A1 (en) 2016-04-07
CA2958093C (en) 2021-01-26
CN114908135B (zh) 2024-10-18
US20170362267A1 (en) 2017-12-21
DK3200615T3 (da) 2019-08-19
ES2869823T3 (es) 2021-10-25
US10570163B2 (en) 2020-02-25
KR102521967B1 (ko) 2023-04-13
US20160095338A1 (en) 2016-04-07
US9908913B2 (en) 2018-03-06
WO2016054548A1 (en) 2016-04-07
JP2017537606A (ja) 2017-12-21
CN106715451A (zh) 2017-05-24
US10160781B2 (en) 2018-12-25
MY190567A (en) 2022-04-27
CN115918884A (zh) 2023-04-07
EP3201211B1 (en) 2021-09-29
CA2958437C (en) 2021-03-30
US9643990B2 (en) 2017-05-09
JP6774945B2 (ja) 2020-10-28
EP3201351B1 (en) 2021-01-06
US20180258124A1 (en) 2018-09-13
CA2958105C (en) 2021-01-26
US10450338B2 (en) 2019-10-22
MY182725A (en) 2021-02-03
CN106795547A (zh) 2017-05-31
CN106714578A (zh) 2017-05-24
US20180057519A1 (en) 2018-03-01
US20160097071A1 (en) 2016-04-07
EP3201212A1 (en) 2017-08-09
KR20170066371A (ko) 2017-06-14
CA2958093A1 (en) 2016-04-07
EP3201212B1 (en) 2018-09-19
AU2015327862A1 (en) 2017-03-09
BR112017006163B1 (pt) 2022-04-05
AU2015327940B2 (en) 2020-04-16
BR112017006139A2 (pt) 2018-07-03
AU2015327862B2 (en) 2020-05-07
US10597419B2 (en) 2020-03-24
JP6883512B2 (ja) 2021-06-09
US9567619B2 (en) 2017-02-14
CN106715451B (zh) 2022-11-08
BR112017006139B1 (pt) 2022-04-05
MX368414B (es) 2019-10-02
CA2958105A1 (en) 2016-04-07
US20180057522A1 (en) 2018-03-01
DK3201351T3 (da) 2021-02-22
EP3201351A4 (en) 2018-03-28
US10584143B2 (en) 2020-03-10
US9783566B2 (en) 2017-10-10
JP2017535251A (ja) 2017-11-30
AU2015327940A1 (en) 2017-03-16
JP6854238B2 (ja) 2021-04-14
JP2017529857A (ja) 2017-10-12
DK3201212T3 (en) 2018-11-26
US10023604B2 (en) 2018-07-17
CN115918884B (zh) 2024-04-30
JP2017531634A (ja) 2017-10-26
AU2015327854B2 (en) 2019-09-12
US20180258125A1 (en) 2018-09-13
WO2016054544A1 (en) 2016-04-07
US10774103B2 (en) 2020-09-15
US20170181452A1 (en) 2017-06-29
AU2015327854A1 (en) 2017-03-09
CN106795547B (zh) 2021-07-23
US20230002435A1 (en) 2023-01-05
US11186604B2 (en) 2021-11-30
US20160153018A1 (en) 2016-06-02
US10010099B2 (en) 2018-07-03
MX2017004246A (es) 2017-05-19
CN113603736A (zh) 2021-11-05
MX2017004245A (es) 2017-05-19
CA2958434C (en) 2021-01-19
MX2017004247A (es) 2017-05-19
US10059732B2 (en) 2018-08-28
EP3201211A4 (en) 2018-04-04
WO2016054540A1 (en) 2016-04-07
MX2017004248A (es) 2017-05-19
KR20170067738A (ko) 2017-06-16
AU2015327858A1 (en) 2017-03-09
MX389979B (es) 2025-03-20
US11884694B2 (en) 2024-01-30
KR20170062461A (ko) 2017-06-07
MY183062A (en) 2021-02-10
BR112017006155A2 (pt) 2018-07-03
US20170218420A1 (en) 2017-08-03
US20160326206A1 (en) 2016-11-10
US20220162248A1 (en) 2022-05-26
KR20170061680A (ko) 2017-06-05
US20180057521A1 (en) 2018-03-01
US20170196248A1 (en) 2017-07-13
KR102536036B1 (ko) 2023-05-23
EP3201211A1 (en) 2017-08-09
CA2958437A1 (en) 2016-04-07

Similar Documents

Publication Publication Date Title
US11884694B2 (en) Non-caloric sweeteners and methods for synthesizing
KR102378988B1 (ko) 무칼로리 감미제
HK40063380A (en) Non-caloric sweeteners and methods for synthesizing
HK1237787A1 (en) Non-caloric sweeteners and methods for synthesizing
HK1237822A1 (en) Non-caloric sweeteners and methods for synthesizing
HK1236753A1 (en) Non-caloric sweeteners and methods for synthesizing
HK1236954B (en) Non-caloric sweeteners and methods for synthesizing
HK1236954A1 (en) Non-caloric sweeteners and methods for synthesizing

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20170328

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20200907

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20220929

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20230417

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20230717

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20230718

End annual number: 3

Start annual number: 1

PG1601 Publication of registration