BR112017006163A2 - edulcorantes não calóricos e métodos para a sua sintetização - Google Patents

edulcorantes não calóricos e métodos para a sua sintetização

Info

Publication number
BR112017006163A2
BR112017006163A2 BR112017006163-5A BR112017006163A BR112017006163A2 BR 112017006163 A2 BR112017006163 A2 BR 112017006163A2 BR 112017006163 A BR112017006163 A BR 112017006163A BR 112017006163 A2 BR112017006163 A2 BR 112017006163A2
Authority
BR
Brazil
Prior art keywords
methods
rebaudioside
synthesis
caloric sweeteners
reb
Prior art date
Application number
BR112017006163-5A
Other languages
English (en)
Other versions
BR112017006163B1 (pt
Inventor
Guohong Mao
Yu Xiaodan
Original Assignee
Conagen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conagen Inc. filed Critical Conagen Inc.
Publication of BR112017006163A2 publication Critical patent/BR112017006163A2/pt
Publication of BR112017006163B1 publication Critical patent/BR112017006163B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01013—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Seasonings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
  • Tea And Coffee (AREA)
  • Medicinal Preparation (AREA)

Abstract

são divulgados glicosídeos de esteviol mencionados como rebaudiosídeo v e rebaudiosídeo w. são divulgados também métodos para a produção de rebaudiosídeo m (reb m), rebaudiosídeo g (reb g), rebaudiosídeo ka (reb ka), rebaudiosídeo v (reb v) e rebaudiosídeo (reb w).
BR112017006163-5A 2014-10-03 2015-10-02 Produto de consumo oral e método para adoçar o mesmo BR112017006163B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462059498P 2014-10-03 2014-10-03
US62/059,498 2014-10-03
US201462098929P 2014-12-31 2014-12-31
US62/098,929 2014-12-31
PCT/US2015/053782 WO2016054544A1 (en) 2014-10-03 2015-10-02 Non-caloric sweeteners and methods for synthesizing

Publications (2)

Publication Number Publication Date
BR112017006163A2 true BR112017006163A2 (pt) 2018-07-31
BR112017006163B1 BR112017006163B1 (pt) 2022-04-05

Family

ID=55631622

Family Applications (3)

Application Number Title Priority Date Filing Date
BR112017006163-5A BR112017006163B1 (pt) 2014-10-03 2015-10-02 Produto de consumo oral e método para adoçar o mesmo
BR112017006139-2A BR112017006139B1 (pt) 2014-10-03 2015-10-02 Método para a sintetização de rebaudiosídeo m ou rebaudiosídeo d e rebaudiosídeo m
BR112017006155-4A BR112017006155A2 (pt) 2014-10-03 2015-10-02 edulcorantes não calóricos e métodos para a sua sintetização

Family Applications After (2)

Application Number Title Priority Date Filing Date
BR112017006139-2A BR112017006139B1 (pt) 2014-10-03 2015-10-02 Método para a sintetização de rebaudiosídeo m ou rebaudiosídeo d e rebaudiosídeo m
BR112017006155-4A BR112017006155A2 (pt) 2014-10-03 2015-10-02 edulcorantes não calóricos e métodos para a sua sintetização

Country Status (14)

Country Link
US (22) US9850270B2 (pt)
EP (4) EP3201211B1 (pt)
JP (4) JP6774945B2 (pt)
KR (4) KR102557670B1 (pt)
CN (7) CN106795195B (pt)
AU (4) AU2015327858B2 (pt)
BR (3) BR112017006163B1 (pt)
CA (4) CA2958437C (pt)
DK (3) DK3200615T3 (pt)
ES (3) ES2693371T3 (pt)
HU (2) HUE045992T2 (pt)
MX (4) MX368414B (pt)
MY (4) MY190567A (pt)
WO (4) WO2016054534A1 (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014214004B2 (en) 2013-02-06 2018-05-24 Evolva Sa Methods for improved production of Rebaudioside D and Rebaudioside M
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
US10264811B2 (en) 2014-05-19 2019-04-23 Epc Natural Products Co., Ltd. Stevia sweetener with improved solubility
WO2016054534A1 (en) * 2014-10-03 2016-04-07 Conagen Inc. Non-caloric sweeteners and methods for synthesizing
WO2016100689A1 (en) 2014-12-17 2016-06-23 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
US10364450B2 (en) 2015-01-30 2019-07-30 Evolva Sa Production of steviol glycoside in recombinant hosts
CA2980090A1 (en) 2015-04-03 2016-10-06 Dsm Ip Assets B.V. Steviol glycosides
CA2977541A1 (en) * 2015-04-14 2016-10-20 Conagen Inc. Production of non-caloric sweeteners using engineered whole-cell catalysts
US20190203244A1 (en) * 2015-08-20 2019-07-04 Pepsico, Inc. Preparation of rebaudioside m in a single reaction vessel
MY198001A (en) 2016-04-13 2023-07-25 Evolva Sa Production of steviol glycoside in recombinant hosts
BR112018075932A2 (pt) 2016-06-15 2019-10-01 Codexis Inc variante de beta-glicosidase de ocorrência não natural, polinucleotídeo recombinante, vetor, célula hospedeira, métodos para produção de pelo menos uma variante de beta-glicosidade de ocorrência não natural, para conversão de um substrato aceptor de grupo glicosila em um produto beta-glicosilado e para transglicosilação de um substrato, e, composição.
MY190181A (en) * 2016-06-17 2022-03-31 Cargill Inc Steviol glycoside compositions for oral ingestion or use
US11091743B2 (en) 2016-08-12 2021-08-17 Amyris, Inc. UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides
CA3039105C (en) * 2016-10-14 2024-03-05 Conagen Inc. Biosynthetic production of steviol glycosides and processes therefore
JP6842800B2 (ja) * 2016-10-21 2021-03-17 ペプシコ・インク 酵素的方法を使用してレバウディオサイドｊを調製するための方法
EP3530745A4 (en) 2016-10-21 2020-07-22 Pepsico, Inc. PROCESS FOR PREPARING REBAUDIOSIDE N USING AN ENZYMATIC PROCESS
WO2018093196A1 (ko) * 2016-11-17 2018-05-24 서울대학교산학협력단 변형 류코노스톡속 균주를 이용한 스테비오사이드 배당체의 합성 방법 및 이에 의하여 제조된 신규한 스테비오사이드 배당체
CA3175100A1 (en) * 2017-02-03 2018-08-09 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
CN117752032A (zh) * 2017-04-25 2024-03-26 可口可乐公司 二氢查耳酮对甜菊醇糖苷和罗汉果苷甜味剂的甜度和味道改善
CN107164435B (zh) * 2017-05-27 2020-03-31 中国药科大学 一种莱鲍迪苷ka的制备方法
CN110730616A (zh) * 2017-06-08 2020-01-24 三得利控股株式会社 甜味增强的饮食品
CN110809408A (zh) 2017-06-30 2020-02-18 科纳根公司 通过β-葡糖苷酶水解甜菊醇糖苷
EP3765627A4 (en) * 2018-03-12 2021-10-13 Conagen Inc. BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDES REBAUDIOSIDE J AND REBAUDIOSIDE N
EP3813545A4 (en) * 2018-05-08 2023-03-22 EPC Natural Products Co., Ltd. STEVIOL GLYCOSIDE COMPOSITIONS WITH ENHANCED FLAVOR
CN109021038B (zh) * 2018-06-11 2021-07-27 江西师范大学 一种甜菊糖苷的制备方法
WO2020028039A1 (en) * 2018-07-30 2020-02-06 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
JP6887025B2 (ja) * 2018-08-17 2021-06-16 邦泰生物工程（深▲セン▼）有限公司 安定型ニコチンアミドリボシド組成物及びその調製方法
CN111073923A (zh) * 2018-10-22 2020-04-28 山东三元生物科技股份有限公司 一种莱鲍迪苷m的酶法制备方法
AU2019391944A1 (en) * 2018-12-07 2021-07-29 Suntory Holdings Limited Composition
EP3892107A4 (en) * 2018-12-07 2022-09-14 Suntory Holdings Limited COFFEE DRINK WITH IMPROVED TASTE QUALITY THANKS TO SUGAR AND SWEETENER
EP3892106A4 (en) * 2018-12-07 2022-08-17 Suntory Holdings Limited COFFEE BEVERAGE WITH IMPROVED TASTE QUALITY PROVIDED BY SUGAR AND SWEETENER
CN113194739A (zh) * 2018-12-07 2021-07-30 三得利控股株式会社 组合物
BR112021011419A2 (pt) * 2018-12-12 2021-09-08 Conagen Inc. Método de produção de rebaudiosídeo r6-2a e/ou r6-2b, r7-2, r6-1 e r6-4a e/ou r6-4b, rebaudiosídeo sintético e produto de consumo oral
CN109750072B (zh) * 2019-01-31 2022-04-19 南京工业大学 一种酶法制备莱鲍迪苷e的方法
US20240148037A1 (en) * 2019-10-16 2024-05-09 Sweegen, Inc. Steviol glycoside formulations for food and beverages
CN110872586B (zh) * 2019-11-11 2024-01-30 天津大学 固定化葡萄糖基转移酶及制备方法及催化生产莱鲍迪苷d的方法
CN110734944B (zh) * 2019-11-11 2023-02-21 中化健康产业发展有限公司 一步法合成莱鲍迪苷m的方法
CN110846363B (zh) * 2019-11-11 2023-02-17 天津大学 一锅法生产莱鲍迪苷d的方法
CN110846305B (zh) * 2019-11-11 2023-11-28 中化健康产业发展有限公司 一种固定化糖基转移酶催化莱鲍迪苷a生成莱鲍迪苷m的方法
BR112022018080A2 (pt) * 2020-03-13 2022-10-25 Amyris Inc Composições de adoçante de rebaudiosídeo m
IL297384A (en) * 2020-04-20 2022-12-01 Coca Cola Co Beverages containing siamanoside i with improved taste
JP7210626B2 (ja) * 2021-02-18 2023-01-23 ペプシコ・インク 酵素的方法を使用してレバウディオサイドｊを調製するための方法
US20230345984A1 (en) 2022-03-23 2023-11-02 Sweegen,Inc Sweeteners
CN114921434B (zh) * 2022-05-27 2024-02-20 中化健康产业发展有限公司 催化Reb A生产Reb M的重组糖基转移酶
DE202022103252U1 (de) 2022-06-09 2022-07-01 Wal Ankita Eine natürliche Süßstoffzusammensetzung als Süßungsmittel für Diabetes
CN116076694A (zh) * 2022-10-12 2023-05-09 四川盈嘉合生科技有限公司 一种甜菊糖苷甜味剂及其制备方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US17804A (en) * 1857-07-14 Improvement in locks
US4612942A (en) 1984-03-08 1986-09-23 Stevia Company, Inc. Flavor enhancing and modifying materials
JPH04149191A (ja) * 1990-10-09 1992-05-22 Nakano Vinegar Co Ltd ステビオサイド糖転移化合物及びその製造方法
US20090183270A1 (en) 2002-10-02 2009-07-16 Adams Thomas R Transgenic plants with enhanced agronomic traits
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US20100092638A1 (en) 2006-10-24 2010-04-15 Chad Allen Hansen Consumables
US20130071521A1 (en) 2007-03-14 2013-03-21 Pepsico, Inc. Rebaudioside d sweeteners and food products sweetened with rebaudioside d
US8277862B2 (en) * 2007-03-14 2012-10-02 Concentrate Manufacturing Company Of Ireland Beverage products having steviol glycosides and at least one acid
MY158626A (en) 2008-10-03 2016-10-31 Morita Kagaku Kogyo New steviol glycoside
MY180803A (en) * 2010-06-02 2020-12-09 Evolva Inc Recombinant production of steviol glycosides
WO2012075030A1 (en) * 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
WO2013022989A2 (en) * 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
CN104684414A (zh) * 2011-12-19 2015-06-03 可口可乐公司 纯化甜叶菊醇糖苷的方法和其用途
JP6251669B2 (ja) 2012-03-16 2017-12-20 サントリーホールディングス株式会社 ステビオール配糖体化酵素およびそれをコードする遺伝子
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
EP2852296B1 (en) * 2012-05-22 2021-12-15 PureCircle SDN BHD Process for producing a high-purity steviol glycoside
CN103710318B (zh) * 2012-09-29 2017-01-18 中国科学院上海生命科学研究院 利用微生物生产甜菊糖苷类化合物的方法
AU2014214004B2 (en) * 2013-02-06 2018-05-24 Evolva Sa Methods for improved production of Rebaudioside D and Rebaudioside M
MY184253A (en) 2013-02-11 2021-03-29 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
US9717267B2 (en) 2013-03-14 2017-08-01 The Coca-Cola Company Beverages containing rare sugars
CA2900849A1 (en) * 2013-03-14 2014-09-25 Chromocell Corporation Compounds, compositions, and methods for modulating sweet taste
US10570164B2 (en) 2013-03-15 2020-02-25 The Coca-Cola Company Steviol glycosides, their compositions and their purification
US20140342043A1 (en) 2013-05-14 2014-11-20 Pepsico, Inc. Rebaudioside Sweetener Compositions and Food Products Sweetened with Same
RU2658361C2 (ru) 2013-06-19 2018-06-21 Конаджен Инк. Ребаудиозид е и пищевые продукты, подслащенные ребаудиозидом е
CN108064135A (zh) 2013-07-15 2018-05-22 帝斯曼知识产权资产管理有限公司 二萜的生产
CN103397064B (zh) * 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
AU2014342939B2 (en) * 2013-11-01 2018-03-22 Conagen Inc. Recombinant production of steviol glycosides
WO2015113231A1 (zh) 2014-01-28 2015-08-06 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
US9522929B2 (en) * 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
US9907326B2 (en) 2014-09-30 2018-03-06 Suntory Beverage & Food Limited Carbonated beverage, syrup used for preparing carbonated beverage, method for manufacturing carbonated beverage, and method for suppressing foaming in carbonated beverage
WO2016054534A1 (en) * 2014-10-03 2016-04-07 Conagen Inc. Non-caloric sweeteners and methods for synthesizing
MY190181A (en) * 2016-06-17 2022-03-31 Cargill Inc Steviol glycoside compositions for oral ingestion or use
CA3039105C (en) * 2016-10-14 2024-03-05 Conagen Inc. Biosynthetic production of steviol glycosides and processes therefore
BR112021011419A2 (pt) * 2018-12-12 2021-09-08 Conagen Inc. Método de produção de rebaudiosídeo r6-2a e/ou r6-2b, r7-2, r6-1 e r6-4a e/ou r6-4b, rebaudiosídeo sintético e produto de consumo oral
US20240148037A1 (en) * 2019-10-16 2024-05-09 Sweegen, Inc. Steviol glycoside formulations for food and beverages

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