KR102489036B1 - 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법 - Google Patents

폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법 Download PDF

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KR102489036B1
KR102489036B1 KR1020227032656A KR20227032656A KR102489036B1 KR 102489036 B1 KR102489036 B1 KR 102489036B1 KR 1020227032656 A KR1020227032656 A KR 1020227032656A KR 20227032656 A KR20227032656 A KR 20227032656A KR 102489036 B1 KR102489036 B1 KR 102489036B1
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KR20220136448A (ko
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지나 이글
레누 굽타
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인스메드 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
KR1020227032656A 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법 Active KR102489036B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237001082A KR102657132B1 (ko) 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201461993439P 2014-05-15 2014-05-15
US61/993,439 2014-05-15
US201462042126P 2014-08-26 2014-08-26
US62/042,126 2014-08-26
US201462048068P 2014-09-09 2014-09-09
US62/048,068 2014-09-09
US201462056296P 2014-09-26 2014-09-26
US62/056,296 2014-09-26
KR1020167035068A KR102447412B1 (ko) 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법
PCT/US2015/031079 WO2015175939A1 (en) 2014-05-15 2015-05-15 Methods for treating pulmonary non-tuberculous mycobacterial infections

Related Parent Applications (1)

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KR1020167035068A Division KR102447412B1 (ko) 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법

Related Child Applications (1)

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KR1020237001082A Division KR102657132B1 (ko) 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법

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KR20220136448A KR20220136448A (ko) 2022-10-07
KR102489036B1 true KR102489036B1 (ko) 2023-01-13

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KR1020247003025A Ceased KR20240018675A (ko) 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법
KR1020167035068A Active KR102447412B1 (ko) 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법
KR1020237001082A Active KR102657132B1 (ko) 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법
KR1020227032656A Active KR102489036B1 (ko) 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법

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KR1020247003025A Ceased KR20240018675A (ko) 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법
KR1020167035068A Active KR102447412B1 (ko) 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법
KR1020237001082A Active KR102657132B1 (ko) 2014-05-15 2015-05-15 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법

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US (16) US10238675B2 (enExample)
EP (5) EP4122470B1 (enExample)
JP (5) JP6646653B2 (enExample)
KR (4) KR20240018675A (enExample)
CN (1) CN106535877A (enExample)
AU (2) AU2015258947B2 (enExample)
BR (1) BR112016026699B1 (enExample)
CA (1) CA2949078C (enExample)
CY (2) CY1122129T1 (enExample)
DK (2) DK3142643T3 (enExample)
ES (4) ES2755941T3 (enExample)
HR (1) HRP20191805T1 (enExample)
HU (1) HUE051440T2 (enExample)
LT (2) LT3466432T (enExample)
ME (1) ME03536B (enExample)
MX (2) MX384843B (enExample)
NZ (1) NZ726256A (enExample)
PL (2) PL3466432T3 (enExample)
PT (2) PT3466432T (enExample)
RS (1) RS60827B1 (enExample)
SI (2) SI3142643T1 (enExample)
SM (1) SMT202000516T1 (enExample)
WO (1) WO2015175939A1 (enExample)

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US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
MX2015006681A (es) 2012-11-29 2016-04-06 Insmed Inc Formulaciones de vancomicina estabilizadas.
NO2699580T3 (enExample) 2014-01-24 2018-02-24
ES2755941T3 (es) 2014-05-15 2020-04-24 Insmed Inc Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas
KR20240091302A (ko) * 2016-07-29 2024-06-21 인스메드 인코포레이티드 기관지확장증을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카르복스아미드
US20210007985A1 (en) * 2017-04-05 2021-01-14 Aradigm Corporation Liposomal anti-infective formulations to inhibit non-tuberculous mycobacteria (ntm) microaggregate formation and establishment of ntm biofilm
MX2020004110A (es) 2017-10-16 2020-11-06 Drugrecure Aps Factor estimulante de colonias de granulocito-macrofago (gm-csf) para tratar infecciones refractarias por micobacterias no tuberculosas.
CN108310393A (zh) * 2018-02-12 2018-07-24 丹诺医药(苏州）有限公司 一种利福霉素-喹嗪酮偶联分子的应用
AU2019228717C1 (en) 2018-03-01 2025-01-09 Astrazeneca Ab Pharmaceutical compositions comprising (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2- oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
US10736847B2 (en) * 2018-07-03 2020-08-11 Becton, Dickinson And Company Inverting device for liposome preparation by centrifugation
CA3106269A1 (en) 2018-07-17 2020-01-23 Insmed Incorporated Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating lupus nephritis
WO2020141478A1 (en) * 2019-01-05 2020-07-09 Foundation For Neglected Disease Research Thiazolyl peptides for the treatment nontuberculous mycobacterial infections
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