KR102422625B1 - 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝 - Google Patents

유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝 Download PDF

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KR102422625B1
KR102422625B1 KR1020187012992A KR20187012992A KR102422625B1 KR 102422625 B1 KR102422625 B1 KR 102422625B1 KR 1020187012992 A KR1020187012992 A KR 1020187012992A KR 20187012992 A KR20187012992 A KR 20187012992A KR 102422625 B1 KR102422625 B1 KR 102422625B1
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polynucleic acid
acid polymer
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KR20180098528A (ko
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이고르 보레코브스키
자나 크랄로비코바
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유니버시티 오브 사우스앰톤
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Priority claimed from GB1614744.9A external-priority patent/GB2559100A/en
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KR1020187012992A 2015-10-09 2016-10-07 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝 Active KR102422625B1 (ko)

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KR1020227024328A KR20220105174A (ko) 2015-10-09 2016-10-07 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝

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Application Number Priority Date Filing Date Title
GB1517937.7 2015-10-09
GB1517937.7A GB2546719B (en) 2015-10-09 2015-10-09 Modulation of gene expression and screening for deregulated protein expression
GB1614744.9 2016-08-31
GB1614744.9A GB2559100A (en) 2016-08-31 2016-08-31 Modulation of gene expression and screening for deregulated protein expression
PCT/GB2016/053136 WO2017060731A1 (en) 2015-10-09 2016-10-07 Modulation of gene expression and screening for deregulated protein expression

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KR20180098528A KR20180098528A (ko) 2018-09-04
KR102422625B1 true KR102422625B1 (ko) 2022-07-20

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KR1020187012992A Active KR102422625B1 (ko) 2015-10-09 2016-10-07 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝
KR1020227024328A Pending KR20220105174A (ko) 2015-10-09 2016-10-07 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝

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US (4) US10196639B2 (enExample)
EP (1) EP3359685A1 (enExample)
JP (3) JP6923517B2 (enExample)
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CN (1) CN108603230A (enExample)
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CA (1) CA3000971A1 (enExample)
IL (2) IL308174A (enExample)
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EP3201339A4 (en) 2014-10-03 2018-09-19 Cold Spring Harbor Laboratory Targeted augmentation of nuclear gene output
KR102422625B1 (ko) 2015-10-09 2022-07-20 유니버시티 오브 사우스앰톤 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝
KR102604132B1 (ko) 2015-12-14 2023-11-17 콜드스프링하버러보러토리 상염색체 우성 정신 지체 5 및 드라베 증후군의 치료를 위한 안티센스 올리고머
US11096956B2 (en) 2015-12-14 2021-08-24 Stoke Therapeutics, Inc. Antisense oligomers and uses thereof
CN111194215B (zh) 2017-08-04 2024-03-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
SG11202001590RA (en) 2017-08-25 2020-03-30 Stoke Therapeutics Inc Antisense oligomers for treatment of conditions and diseases
JP2021521889A (ja) * 2018-04-17 2021-08-30 アプライド ステムセル，インコーポレイテッド 脊髄性筋萎縮症を処置するための組成物および方法
EP3788169A4 (en) 2018-05-04 2022-08-10 Stoke Therapeutics, Inc. Methods and compositions for treatment of cholesteryl ester storage disease
EP3801640A4 (en) * 2018-05-30 2022-03-23 The Regents Of The University Of California GENE EDIT OF MONOGENIC DISEASES IN HUMAN HEMATOPOIETIC STEM CELLS - CORRECTION OF X-LINKED AGAMMAGLOBULINEMIA (XLA)
WO2020163405A1 (en) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
JP7603595B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
US11129829B2 (en) * 2019-06-17 2021-09-28 Skyhawk Therapeutics, Inc. Methods for modulating splicing
BR112022002905A2 (pt) * 2019-08-19 2022-07-12 Stoke Therapeutics Inc Composições e métodos para modular splicing e expressão de proteína
KR20220146501A (ko) * 2020-02-12 2022-11-01 더 칠드런스 호스피탈 오브 필라델피아 유전자 발현의 유도성 대체 스플라이싱 조절을 위한 조성물 및 방법
CN111349649B (zh) * 2020-03-16 2020-11-17 三峡大学 一种用于双孢蘑菇的基因编辑的方法及应用
MX2022014151A (es) 2020-05-11 2022-11-30 Stoke Therapeutics Inc Oligomeros antisentido de opa1 para tratamiento de afecciones y enfermedades.
CA3204779A1 (en) * 2021-01-26 2022-08-04 Brage Storstein Andresen Splice switching oligonucleotides targeting pseudoexons
CN112908470B (zh) * 2021-02-08 2023-10-03 深圳市人民医院 一种基于rna结合蛋白基因的肝细胞癌预后评分系统及其应用
US20250101419A1 (en) * 2022-01-26 2025-03-27 Syddansk Universitet Allele specific splice switching oligonucleotides targeting pseudoexons
CN119424374A (zh) * 2024-11-14 2025-02-14 中国药科大学 一种具有细菌靶向性的岩藻多糖改良复合物及其制备方法和应用

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