SG11201802870RA - Modulation of gene expression and screening for deregulated protein expression - Google Patents

Modulation of gene expression and screening for deregulated protein expression

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Publication number
SG11201802870RA
SG11201802870RA SG11201802870RA SG11201802870RA SG11201802870RA SG 11201802870R A SG11201802870R A SG 11201802870RA SG 11201802870R A SG11201802870R A SG 11201802870RA SG 11201802870R A SG11201802870R A SG 11201802870RA SG 11201802870R A SG11201802870R A SG 11201802870RA
Authority
SG
Singapore
Prior art keywords
screening
modulation
expression
gene expression
deregulated protein
Prior art date
Application number
SG11201802870RA
Other languages
English (en)
Inventor
Igor Vorechovsky
Jana Kralovicova
Original Assignee
Univ Southampton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB1517937.7A external-priority patent/GB2546719B/en
Priority claimed from GB1614744.9A external-priority patent/GB2559100A/en
Application filed by Univ Southampton filed Critical Univ Southampton
Publication of SG11201802870RA publication Critical patent/SG11201802870RA/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A—HUMAN NECESSITIES
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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SG11201802870RA 2015-10-09 2016-10-07 Modulation of gene expression and screening for deregulated protein expression SG11201802870RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1517937.7A GB2546719B (en) 2015-10-09 2015-10-09 Modulation of gene expression and screening for deregulated protein expression
GB1614744.9A GB2559100A (en) 2016-08-31 2016-08-31 Modulation of gene expression and screening for deregulated protein expression
PCT/GB2016/053136 WO2017060731A1 (en) 2015-10-09 2016-10-07 Modulation of gene expression and screening for deregulated protein expression

Publications (1)

Publication Number Publication Date
SG11201802870RA true SG11201802870RA (en) 2018-05-30

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SG11201802870RA SG11201802870RA (en) 2015-10-09 2016-10-07 Modulation of gene expression and screening for deregulated protein expression

Country Status (10)

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US (4) US10196639B2 (enExample)
EP (1) EP3359685A1 (enExample)
JP (3) JP6923517B2 (enExample)
KR (2) KR102422625B1 (enExample)
CN (1) CN108603230A (enExample)
AU (3) AU2016334804B2 (enExample)
CA (1) CA3000971A1 (enExample)
IL (2) IL308174A (enExample)
SG (1) SG11201802870RA (enExample)
WO (1) WO2017060731A1 (enExample)

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JP2021521889A (ja) * 2018-04-17 2021-08-30 アプライド ステムセル，インコーポレイテッド 脊髄性筋萎縮症を処置するための組成物および方法
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JP7603595B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
US11129829B2 (en) * 2019-06-17 2021-09-28 Skyhawk Therapeutics, Inc. Methods for modulating splicing
BR112022002905A2 (pt) * 2019-08-19 2022-07-12 Stoke Therapeutics Inc Composições e métodos para modular splicing e expressão de proteína
KR20220146501A (ko) * 2020-02-12 2022-11-01 더 칠드런스 호스피탈 오브 필라델피아 유전자 발현의 유도성 대체 스플라이싱 조절을 위한 조성물 및 방법
CN111349649B (zh) * 2020-03-16 2020-11-17 三峡大学 一种用于双孢蘑菇的基因编辑的方法及应用
MX2022014151A (es) 2020-05-11 2022-11-30 Stoke Therapeutics Inc Oligomeros antisentido de opa1 para tratamiento de afecciones y enfermedades.
CA3204779A1 (en) * 2021-01-26 2022-08-04 Brage Storstein Andresen Splice switching oligonucleotides targeting pseudoexons
CN112908470B (zh) * 2021-02-08 2023-10-03 深圳市人民医院 一种基于rna结合蛋白基因的肝细胞癌预后评分系统及其应用
US20250101419A1 (en) * 2022-01-26 2025-03-27 Syddansk Universitet Allele specific splice switching oligonucleotides targeting pseudoexons
CN119424374A (zh) * 2024-11-14 2025-02-14 中国药科大学 一种具有细菌靶向性的岩藻多糖改良复合物及其制备方法和应用

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