KR102376451B1 - 성장 분화 인자 15(ｇｄｆ-15) 작제물 - Google Patents

성장 분화 인자 15(ｇｄｆ-15) 작제물 Download PDF

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KR102376451B1
KR102376451B1 KR1020167005421A KR20167005421A KR102376451B1 KR 102376451 B1 KR102376451 B1 KR 102376451B1 KR 1020167005421 A KR1020167005421 A KR 1020167005421A KR 20167005421 A KR20167005421 A KR 20167005421A KR 102376451 B1 KR102376451 B1 KR 102376451B1
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gdf15
dhcpmfc
sequence
polypeptide
seq
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KR20160038896A (ko
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유메이 슝
이 장
재키 지. 쉥
아그네스 에바 햄버거
뮈리엘 베니언트-엘리슨
그랜트 시마모토
샤오산 민
줄런 왕
지에 탕
구나세카란 카난
마리사 목
케네스 워커
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암젠 인크
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020167005421A 2013-07-31 2014-07-31 성장 분화 인자 15(ｇｄｆ-15) 작제물 Active KR102376451B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227008673A KR102616674B1 (ko) 2013-07-31 2014-07-31 성장 분화 인자 15(ｇｄｆ-15) 작제물

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361860723P 2013-07-31 2013-07-31
US61/860,723 2013-07-31
PCT/US2014/049254 WO2015017710A1 (en) 2013-07-31 2014-07-31 Growth differentiation factor 15 (gdf-15) constructs

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KR1020227008673A Division KR102616674B1 (ko) 2013-07-31 2014-07-31 성장 분화 인자 15(ｇｄｆ-15) 작제물

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KR20160038896A KR20160038896A (ko) 2016-04-07
KR102376451B1 true KR102376451B1 (ko) 2022-03-23

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KR1020227008673A Active KR102616674B1 (ko) 2013-07-31 2014-07-31 성장 분화 인자 15(ｇｄｆ-15) 작제물
KR1020237043685A Pending KR20240000642A (ko) 2013-07-31 2014-07-31 성장 분화 인자 15(ｇｄｆ-15) 작제물
KR1020167005421A Active KR102376451B1 (ko) 2013-07-31 2014-07-31 성장 분화 인자 15(ｇｄｆ-15) 작제물

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KR1020227008673A Active KR102616674B1 (ko) 2013-07-31 2014-07-31 성장 분화 인자 15(ｇｄｆ-15) 작제물
KR1020237043685A Pending KR20240000642A (ko) 2013-07-31 2014-07-31 성장 분화 인자 15(ｇｄｆ-15) 작제물

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US (4) US9862752B2 (enExample)
EP (2) EP3763734A1 (enExample)
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KR (3) KR102616674B1 (enExample)
CN (2) CN105980400B (enExample)
AP (1) AP2016009011A0 (enExample)
AR (1) AR097181A1 (enExample)
AU (1) AU2014296107B2 (enExample)
BR (1) BR112016002213A2 (enExample)
CA (1) CA2918624C (enExample)
CL (1) CL2016000249A1 (enExample)
CR (1) CR20160097A (enExample)
CY (1) CY1123836T1 (enExample)
DK (1) DK3027642T3 (enExample)
EA (2) EA037355B1 (enExample)
ES (1) ES2828670T3 (enExample)
HU (1) HUE050630T2 (enExample)
IL (1) IL243749B (enExample)
JO (1) JO3566B1 (enExample)
LT (1) LT3027642T (enExample)
MA (1) MA38873B1 (enExample)
MX (2) MX387211B (enExample)
NZ (2) NZ754961A (enExample)
PE (1) PE20160189A1 (enExample)
PH (1) PH12016500208B1 (enExample)
PL (1) PL3027642T3 (enExample)
PT (1) PT3027642T (enExample)
SG (1) SG11201600713RA (enExample)
SI (1) SI3027642T1 (enExample)
TN (1) TN2016000035A1 (enExample)
TW (1) TWI648401B (enExample)
UA (1) UA116665C2 (enExample)
UY (1) UY35686A (enExample)
WO (1) WO2015017710A1 (enExample)
ZA (1) ZA201600523B (enExample)

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