KR102354784B1 - 니코틴아미드 모노뉴클레오티드 유도체 및 그 용도 - Google Patents

니코틴아미드 모노뉴클레오티드 유도체 및 그 용도 Download PDF

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KR102354784B1
KR102354784B1 KR1020187006160A KR20187006160A KR102354784B1 KR 102354784 B1 KR102354784 B1 KR 102354784B1 KR 1020187006160 A KR1020187006160 A KR 1020187006160A KR 20187006160 A KR20187006160 A KR 20187006160A KR 102354784 B1 KR102354784 B1 KR 102354784B1
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alkyl
delete delete
aryl
hydrogen
heterocyclyl
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KR20180039658A (ko
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칼 디. 노밍턴
데이비드 에이. 싱클레어
데이비드 리빙스톤
제임스 엠. 맥커린
브루스 스츠크체판키에위크츠
조나단 엔. 크렘스키
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메트로 인터내셔널 바이오테크 엘엘씨
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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KR1020187006160A 2015-08-05 2016-08-05 니코틴아미드 모노뉴클레오티드 유도체 및 그 용도 Active KR102354784B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562201447P 2015-08-05 2015-08-05
US62/201,447 2015-08-05
PCT/US2016/045855 WO2017024255A1 (en) 2015-08-05 2016-08-05 Nicotinamide mononucleotide derivatives and their uses

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KR20180039658A KR20180039658A (ko) 2018-04-18
KR102354784B1 true KR102354784B1 (ko) 2022-01-25

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US (6) US9855289B2 (enExample)
EP (1) EP3331894B1 (enExample)
JP (1) JP6949002B6 (enExample)
KR (1) KR102354784B1 (enExample)
CN (1) CN108137639B (enExample)
AU (1) AU2016302005B2 (enExample)
BR (1) BR112018002168B1 (enExample)
CA (1) CA2994553C (enExample)
DK (1) DK3331894T3 (enExample)
EA (1) EA035664B1 (enExample)
ES (1) ES2862170T3 (enExample)
IL (1) IL257327B (enExample)
MX (1) MX2018001363A (enExample)
PL (1) PL3331894T3 (enExample)
PT (1) PT3331894T (enExample)
WO (1) WO2017024255A1 (enExample)
ZA (1) ZA201801196B (enExample)

Families Citing this family (49)

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US9855289B2 (en) 2015-08-05 2018-01-02 Metro International Biotech, Llc Nicotinamide mononucleotide derivatives and their uses
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
US10611790B2 (en) 2015-11-02 2020-04-07 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
ES2948968T3 (es) 2016-04-20 2023-09-22 Chromadex Inc Uso del ribósido de ácido nicotínico o derivados del ribósido de nicotinamida, y derivados reducidos de los mismos, como precursores que aumentan el NAD++
US20200009170A1 (en) * 2016-09-13 2020-01-09 Megumi Tanaka Sleep display agent property and method for improving sleep disorders
US20190328761A1 (en) 2016-12-21 2019-10-31 Newsouth Innovations Pty Limited Methods for enhancing vascular density
US11286274B2 (en) 2017-06-19 2022-03-29 Mitopower Llc Nicotinamide riboside derivatives and their uses
WO2019152416A1 (en) 2018-01-30 2019-08-08 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
US11814652B2 (en) * 2018-03-22 2023-11-14 Oriental Yeast Co., Ltd. Pluripotent stem cell differentiation-promoting agent
EP3794005B1 (en) 2018-05-15 2025-10-22 Jumpstart Fertility Pty Ltd Inorganic salts of nicotinic acid mononucleotide as anti-aging agents
WO2020131578A2 (en) * 2018-12-17 2020-06-25 Mitopower Llc Nicotinyl riboside compounds and their uses
WO2020174492A1 (en) 2019-02-25 2020-09-03 Celagenex Research (India) Pvt. Ltd. Synergistic bioactive compositions for enhancing cellular energy
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
AU2020288608B2 (en) * 2019-06-05 2025-04-10 Société des Produits Nestlé S.A. Reduced nicotinamideribosides for the treatment/prevention of liver disease
JP7675061B2 (ja) 2019-07-19 2025-05-12 バイオシント アクチェンゲゼルシャフト ニコチンアミドリボフラノシド塩の製造方法、ニコチンアミドリボフラノシド塩自体、およびその使用
CN114423439B (zh) 2019-09-09 2024-12-31 努瓦米德股份有限公司 Nmn用于预防和/或治疗疼痛的用途及相应组合物
FR3100449B1 (fr) 2019-09-09 2022-08-26 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement de la douleur et compositions correspondantes
FR3102058A1 (fr) 2019-10-18 2021-04-23 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement de la polyarthrite rhumatoïde et compositions correspondantes
CN112823778B (zh) * 2019-11-21 2024-06-14 百瑞全球有限公司 毛发护理组合物及其制备方法
FR3103702B1 (fr) 2019-11-28 2022-02-11 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement de la spondylarthrite ankylosante et compositions correspondantes
FR3106056B1 (fr) 2020-01-13 2021-12-17 Nuvamid Utilisation de NMN pour la prévention et/ou le traitement d’une douleur articulaire induite par l’activité physique et compositions correspondantes
FR3107897B1 (fr) * 2020-03-06 2023-05-26 Nuvamid Sa Dérivés de nicotinamide mononucléotides
FR3108031B1 (fr) 2020-03-12 2024-02-16 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement d’une douleur dorsale et compositions correspondantes
FR3108032B1 (fr) * 2020-03-12 2024-02-16 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement d’une douleur musculaire, ligamentaire ou tendineuse induite par l’activité physique et compositions correspondantes
KR20220160611A (ko) * 2020-03-30 2022-12-06 오리엔탈고우보고오교가부시끼가이샤 줄기세포의 염색체 안정화제
AU2021260118A1 (en) * 2020-04-24 2022-11-17 Nuvamid Sa Nicotinamide mononucleotide and nicotinamide riboside derivatives and use thereof in the treatment of viral infections and respiratory complications, in particular caused by influenzavirus or coronavirus
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