KR102298281B1 - 유사 이동층 크로마토그래피를 이용한 중성 모유 올리고당의 정제 방법 - Google Patents

유사 이동층 크로마토그래피를 이용한 중성 모유 올리고당의 정제 방법 Download PDF

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KR102298281B1
KR102298281B1 KR1020167008862A KR20167008862A KR102298281B1 KR 102298281 B1 KR102298281 B1 KR 102298281B1 KR 1020167008862 A KR1020167008862 A KR 1020167008862A KR 20167008862 A KR20167008862 A KR 20167008862A KR 102298281 B1 KR102298281 B1 KR 102298281B1
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KR20160090791A (ko
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스테판 젠와인
마르쿠스 헬프리치
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젠와인 바이오테크놀로지 게엠바하
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterised by the components to be separated
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
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    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
    • B01D61/422—Electrodialysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/18—Iodine; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • C—CHEMISTRY; METALLURGY
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor

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  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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KR1020167008862A 2013-10-04 2014-10-02 유사 이동층 크로마토그래피를 이용한 중성 모유 올리고당의 정제 방법 Active KR102298281B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13187369.7A EP2857410A1 (en) 2013-10-04 2013-10-04 Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
EP13187369.7 2013-10-04
PCT/EP2014/071145 WO2015049331A1 (en) 2013-10-04 2014-10-02 Process for purification of a neutral human milk oligosaccharide using simulated moving bed chromatography

Publications (2)

Publication Number Publication Date
KR20160090791A KR20160090791A (ko) 2016-08-01
KR102298281B1 true KR102298281B1 (ko) 2021-09-07

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US (2) US10435427B2 (enExample)
EP (2) EP2857410A1 (enExample)
JP (1) JP6666243B2 (enExample)
KR (1) KR102298281B1 (enExample)
CN (2) CN109705175B (enExample)
BR (1) BR112016007342B1 (enExample)
DK (1) DK3063159T3 (enExample)
ES (1) ES2868249T3 (enExample)
MX (2) MX373919B (enExample)
PH (1) PH12016500594B1 (enExample)
PL (1) PL3063159T3 (enExample)
RU (1) RU2685537C2 (enExample)
WO (1) WO2015049331A1 (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2857410A1 (en) 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
DK2896628T3 (en) 2014-01-20 2019-01-14 Jennewein Biotechnologie Gmbh Process for Effective Purification of Neutral Milk Oligosaccharides (HMOs) from Microbial Fermentation
US10314852B2 (en) 2014-10-24 2019-06-11 Glycom A/S Mixtures of HMOs
EP3390652B1 (en) 2015-12-18 2024-12-04 Glycom A/S Fermentative production of oligosaccharides
US11312741B2 (en) 2016-04-19 2022-04-26 Glycom A/S Separation of oligosaccharides from fermentation broth
WO2017221208A1 (en) 2016-06-24 2017-12-28 Glycom A/S Compositions comprising hmos, their production and use for the prevention and/or treatment of viral and/or bacterial infections
KR101979608B1 (ko) * 2017-04-17 2019-08-28 재단법인 탄소순환형 차세대 바이오매스 생산전환 기술연구단 푸코오스 분리방법 및 이를 위한 장치
AU2018295414A1 (en) * 2017-07-07 2020-01-16 Societe Des Produits Nestle S.A. Human milk fortifier
WO2019012461A1 (en) 2017-07-12 2019-01-17 Glycom A/S AMORPHOUS MIXTURE COMPRISING A NEUTRAL MONO- OR OLIGOSACCHARIDE AND A NON-GLUCIDIC ACID COMPONENT
EP3450443A1 (en) * 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
WO2019050321A1 (ko) * 2017-09-07 2019-03-14 (주)프로테옴텍 다수의 검사선을 구비한 크로마토그래피용 스트립, 이를 포함하는 진단 키트 및 다수의 경쟁적 반응 측정 단계를 포함하는 정성, 반정량, 정량 분석방법
CN111164090A (zh) * 2017-09-29 2020-05-15 菲仕兰坎皮纳荷兰公司 用于从微生物发酵纯化中性母乳寡糖（hmo）的方法
EP3494805B1 (en) 2017-12-08 2025-08-13 Chr. Hansen HMO GmbH Spray-dried tetrasaccharides
PL3494804T3 (pl) 2017-12-08 2025-10-06 Chr. Hansen HMO GmbH Suszona rozpyłowo 3-fukozylolaktoza
EP3494807A1 (en) 2017-12-11 2019-06-12 Jennewein Biotechnologie GmbH Spray-dried sialyllactose
ES3040419T3 (en) 2017-12-08 2025-10-30 Chr Hansen Hmo Gmbh Spray-dried lacto-n-fucopentaose
CN111447845B (zh) * 2017-12-08 2022-10-28 科汉森母乳低聚糖股份有限公司 喷雾干燥的唾液酸乳糖
PL3524067T3 (pl) 2018-02-08 2025-06-09 Chr. Hansen HMO GmbH Suszona rozpyłowo mieszanina oligosacharydów mleka ludzkiego
EP3546060A1 (en) * 2018-03-27 2019-10-02 DuPont Nutrition Biosciences ApS Process for spray drying fucosyllactose solutions and related product compositions
WO2019160922A1 (en) * 2018-02-19 2019-08-22 Dupont Nutrition Biosciences Aps Process for spray drying fucosyllactose solutions and related product compositions
KR20210006916A (ko) 2018-05-07 2021-01-19 젠와인 바이오테크놀로지 게엠바하 미생물 발효에 의해 수득된 탄수화물로부터 락토-Ｎ-네오테트라오스 (LNnT)를 정제하기 위한 간단한 방법
WO2019226431A1 (en) * 2018-05-23 2019-11-28 Dsm Ip Assets B.V. Production of oligosaccharides
US20210298328A1 (en) * 2018-08-08 2021-09-30 Mars, Incoroprated Pet food products comprising oligosaccharides and methods of use
AU2019362595B2 (en) 2018-10-18 2024-12-19 Basf Se Crystalline form II of 2'-O-fucosyllactose, process for its preparation, nutritional, cosmetic or pharmaceutical formulation containing the same
EP3741770A1 (en) * 2019-05-21 2020-11-25 Jennewein Biotechnologie GmbH Purification of oligosaccharides from a fermentation broth by using filtration
EP3750902A1 (en) * 2019-06-14 2020-12-16 Jennewein Biotechnologie GmbH Process for the purification of lacto-n-neotetraose
WO2021011905A1 (en) * 2019-07-18 2021-01-21 The Regents Of The University Of California Human milk oligosaccharides for control of dietary response and metabolic phenotype
MX2022002949A (es) 2019-09-24 2022-04-06 Prolacta Bioscience Inc Composiciones y metodos para el tratamiento de enfermedades inflamatorias e inmunes.
CN110672756B (zh) * 2019-11-07 2020-12-29 江南大学 一种奶粉中2’-岩藻糖基乳糖含量的检测方法
CN115003681B (zh) * 2020-01-29 2024-07-05 帝斯曼知识产权资产管理有限公司 用于回收和纯化人乳寡糖的方法
KR20220155595A (ko) * 2020-03-20 2022-11-23 글리콤 에이/에스 고체 hmo 생성물을 제공하는 방법, 및 이에 의해 수득된 고체 hmo 생성물
WO2021250191A1 (en) * 2020-06-12 2021-12-16 Basf Se Improved demineralization of fermentation broths and purification of fine chemicals such as oligosaccharides
IL300573A (en) 2020-08-14 2023-04-01 Prolacta Bioscience Inc Breast milk oligosaccharide compositions for use with bacteriotherapy
CN112526022A (zh) * 2020-11-27 2021-03-19 内蒙古伊利实业集团股份有限公司 一种乳中母乳低聚糖的检测方法
JP2024502629A (ja) 2021-01-12 2024-01-22 プロラクタ バイオサイエンス，インコーポレイテッド シンバイオティック治療レジメン
EP4418878A1 (en) * 2021-10-18 2024-08-28 DSM IP Assets B.V. A method for providing an amorphous hmo product by drying
CN117003803A (zh) 2022-05-07 2023-11-07 山东恒鲁生物科技有限公司 一种三糖的新晶型
CN115873051B (zh) 2022-05-17 2024-06-25 山东恒鲁生物科技有限公司 三糖的新晶型
CN115073539B (zh) * 2022-07-21 2023-06-16 南京工业大学 一种2’-岩藻糖基乳糖分离纯化的方法
CN115260255B (zh) * 2022-08-30 2024-06-28 南京工业大学 一种利用模拟移动床分离纯化2’-岩藻糖基乳糖的方法
WO2024130119A2 (en) 2022-12-16 2024-06-20 Prolacta Bioscience, Inc. Synbiotic compositions for short chain fatty acid production
CN115856151B (zh) * 2022-12-27 2025-08-12 深圳市中科朗健生物技术有限公司 一种同时测定多种人乳低聚糖的高效液相色谱检测方法
CN115838390A (zh) * 2022-12-30 2023-03-24 保龄宝生物股份有限公司 一种利用三组分色谱分离技术制备高含量2′-岩藻糖基乳糖的方法
WO2024165630A1 (en) * 2023-02-07 2024-08-15 N.V. Nutricia Nutritional composition with improved segregation resistance
CN118805902A (zh) * 2023-04-19 2024-10-22 科·汉森有限公司 母乳低聚糖
WO2025056571A1 (en) 2023-09-12 2025-03-20 Frieslandcampina Nederland B.V. Milk extracellular vesicle enrichment process
CN117089503B (zh) 2023-10-17 2024-01-02 保龄宝生物股份有限公司 一种大肠杆菌k-12 mg1655 blbyzt6及其应用
WO2025149372A1 (en) 2024-01-09 2025-07-17 Frieslandcampina Nederland B.V. Milk extracellular vesicle enrichment process using peg
CN119192253B (zh) * 2024-09-06 2025-10-21 虹摹生物科技(上海)有限公司 一种岩藻糖基乳糖及其纯化方法
CN120847064B (zh) * 2025-09-23 2025-12-05 吉林省科技创新研究院有限公司 一种液体中微量可见异物分析鉴定方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012156898A1 (en) * 2011-05-13 2012-11-22 Glycom A/S DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0779800B2 (ja) 1986-01-23 1995-08-30 オムロン株式会社 電子血圧計
JPH0639206B2 (ja) 1988-04-18 1994-05-25 田村プラスチック製品株式会社 ルーフバイザーの取り付け方法
JPH02286695A (ja) 1989-04-28 1990-11-26 Sumitomo Heavy Ind Ltd オリゴ糖の分離方法
NZ240002A (en) * 1991-09-30 1993-11-25 Lactose Co Of Nz Ltd Method of producing a dry powder containing lactose and "oligosaccharides"
JPH0779927B2 (ja) 1992-05-22 1995-08-30 川崎重工業株式会社 擬似移動床式液体クロマトオリゴ糖分離装置
JPH06253879A (ja) * 1993-03-01 1994-09-13 Snow Brand Milk Prod Co Ltd グルクロン酸結合オリゴ糖の分離方法
DE4326665C2 (de) * 1993-08-09 1995-07-13 Biotest Pharma Gmbh Verfahren zur Sterilfiltration von Milch
JP3368389B2 (ja) 1993-09-14 2003-01-20 雪印乳業株式会社 シアル酸含有オリゴ糖の分離方法
FI962204A0 (fi) * 1996-05-24 1996-05-24 Cultor Oy Foerfarande foer fraktionering av en loesning
CN1242776A (zh) * 1996-10-10 2000-01-26 尼澳斯技术股份有限公司 用超滤、反渗透和纳滤纯化糖类
DK0931097T3 (da) 1996-10-10 2006-01-16 Neose Technologies Inc Kulhydratoprensning ved anvendelse af omvendt osmose og nanofiltrering
EP1531832B1 (en) * 2002-06-28 2009-04-15 Glykos Finland Oy Therapeutic compositions for use in prophylaxis or treatment of diarrheas
EP1634599A1 (en) * 2004-08-20 2006-03-15 N.V. Nutricia Iimmune stimulatory infant nutrition
JP5184768B2 (ja) 2006-09-05 2013-04-17 株式会社林原 トレハロース高含有糖液の回収方法並びに結晶トレハロースの製造方法
EP2293677B1 (en) 2008-06-13 2017-11-15 N.V. Nutricia Nutritional composition for infants delivered via caesarean section
CN101367844A (zh) * 2008-09-17 2009-02-18 无锡绿色分离应用技术研究所有限公司 一种从阿拉伯胶水解液中提取阿拉伯糖的方法
CN102459295A (zh) 2009-04-07 2012-05-16 格礼卡姆股份公司 2’-o-岩藻糖基乳糖的合成
ES2660698T3 (es) * 2009-06-08 2018-03-23 Jennewein Biotechnologie Gmbh Síntesis de HMO
CN101831475A (zh) * 2010-03-24 2010-09-15 方煜宇 一种生产高纯度低聚半乳糖的方法
CN103025749B (zh) * 2010-06-01 2016-06-01 格礼卡姆股份公司 2’-o-岩藻糖基乳糖的多晶型物及其制备
EP2465507A1 (en) 2010-11-23 2012-06-20 Nestec S.A. Oligosaccharide composition for treating skin diseases
DE12746649T1 (de) 2011-02-16 2016-09-29 Glycosyn LLC Biosynthese menschlicher milcholigosaccaride in manipulierten Bakterien
CN102676604A (zh) * 2011-03-08 2012-09-19 保龄宝生物股份有限公司 一种连续模拟移动床色谱分离制备高纯度低聚半乳糖的方法
AU2012257395A1 (en) * 2011-05-13 2013-12-12 Glycom A/S Method for generating human milk oligosaccharides (HMOs) or precursors thereof
JP6129821B2 (ja) * 2011-05-13 2017-05-17 グリコシン リミテッド ライアビリティー カンパニー プレバイオティクスとしての、精製された２’−フコシルラクトース、３−フコシルラクトース、およびラクトジフコテトラオースの使用
EP2526784A1 (en) * 2011-05-24 2012-11-28 Nestec S.A. Milk oligosaccharide-galactooligosaccharide composition for infant formula containing the soluble oligosaccharide fraction present in milk, and having a low level of monosaccharides, and a process to produce the composition
DE202013012827U1 (de) * 2012-06-14 2020-02-13 Glycom A/S Verbesserung der Stabilität und Reinheit sowie Erhöhung der Bioverfügbarkeit von menschlichen Milch-Oligosacchariden oder Vorläufern oder Mischungen davon
CN103113422B (zh) * 2013-02-06 2015-06-10 广西轻工业科学技术研究院 一种用模拟流动床分离精制高纯度l-阿拉伯糖、d-木糖的方法
EP2857410A1 (en) 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012156898A1 (en) * 2011-05-13 2012-11-22 Glycom A/S DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF

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