KR102127348B1 - 항-프로게스틴의 경질 전달을 위한 제제 및 방법 - Google Patents

항-프로게스틴의 경질 전달을 위한 제제 및 방법 Download PDF

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KR102127348B1
KR102127348B1 KR1020147032210A KR20147032210A KR102127348B1 KR 102127348 B1 KR102127348 B1 KR 102127348B1 KR 1020147032210 A KR1020147032210 A KR 1020147032210A KR 20147032210 A KR20147032210 A KR 20147032210A KR 102127348 B1 KR102127348 B1 KR 102127348B1
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pharmaceutical composition
capsule
progestin
day
administered
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Korean (ko)
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KR20150014928A (ko
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조셉 에스. 포돌스키
쿠앙 슈
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앨러간 파마슈티컬스 인터내셔널 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020147032210A 2012-05-31 2013-05-30 항-프로게스틴의 경질 전달을 위한 제제 및 방법 Expired - Fee Related KR102127348B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261653674P 2012-05-31 2012-05-31
US61/653,674 2012-05-31
PCT/US2013/043447 WO2013181449A1 (en) 2012-05-31 2013-05-30 Formulations and methods for vaginal delivery of antiprogestins

Publications (2)

Publication Number Publication Date
KR20150014928A KR20150014928A (ko) 2015-02-09
KR102127348B1 true KR102127348B1 (ko) 2020-06-29

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KR1020147032210A Expired - Fee Related KR102127348B1 (ko) 2012-05-31 2013-05-30 항-프로게스틴의 경질 전달을 위한 제제 및 방법

Country Status (22)

Country Link
US (1) US10328022B2 (enExample)
EP (1) EP2854763B1 (enExample)
JP (1) JP6341910B2 (enExample)
KR (1) KR102127348B1 (enExample)
CN (1) CN104334158B (enExample)
AU (1) AU2013267359C1 (enExample)
BR (1) BR112014029131B1 (enExample)
CA (1) CA2872644A1 (enExample)
CL (1) CL2014003232A1 (enExample)
CO (1) CO7141411A2 (enExample)
CR (1) CR20140567A (enExample)
EA (1) EA030444B1 (enExample)
ES (1) ES2701400T3 (enExample)
IL (1) IL235450B (enExample)
IN (1) IN2014DN10548A (enExample)
MX (2) MX363640B (enExample)
NZ (1) NZ702467A (enExample)
PH (1) PH12014502516B1 (enExample)
SG (2) SG11201407397WA (enExample)
UA (1) UA114106C2 (enExample)
WO (1) WO2013181449A1 (enExample)
ZA (1) ZA201408262B (enExample)

Families Citing this family (22)

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EP2782584B1 (en) 2011-11-23 2021-06-09 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10064815B2 (en) * 2014-05-05 2018-09-04 Repros Therapeutics Inc. Formulations and methods for vaginal delivery of antiprogestins
AR100562A1 (es) 2014-05-22 2016-10-12 Therapeuticsmd Inc Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal
US11623008B2 (en) 2014-08-20 2023-04-11 Professional Compounding Centers Of America Excipient compositions for mucoadhesive pharmaceutical compositions including a synergistic combination of amylopectin, pullulan, hyaluronic acid, and xyloglucan
AU2015336065A1 (en) * 2014-10-20 2017-05-04 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
EP3025709B1 (en) 2014-11-27 2020-09-30 Capsugel Belgium NV Dosage form articles for external mucosal applications
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
HRP20250979T1 (hr) * 2017-04-14 2025-10-24 Capsugel Belgium Nv Pululan kapsule
US11319566B2 (en) 2017-04-14 2022-05-03 Capsugel Belgium Nv Process for making pullulan

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Also Published As

Publication number Publication date
WO2013181449A1 (en) 2013-12-05
MX2019003467A (es) 2019-06-06
UA114106C2 (xx) 2017-04-25
ES2701400T3 (es) 2019-02-22
JP2015518052A (ja) 2015-06-25
EA030444B1 (ru) 2018-08-31
CN104334158A (zh) 2015-02-04
IL235450B (en) 2020-02-27
CR20140567A (es) 2015-03-09
US10328022B2 (en) 2019-06-25
PH12014502516A1 (en) 2015-01-12
JP6341910B2 (ja) 2018-06-13
AU2013267359C1 (en) 2016-09-29
SG10201704858PA (en) 2017-07-28
CA2872644A1 (en) 2013-12-05
EP2854763A1 (en) 2015-04-08
IN2014DN10548A (enExample) 2015-08-21
CN104334158B (zh) 2018-08-10
EA201492290A1 (ru) 2015-03-31
NZ702467A (en) 2016-07-29
CL2014003232A1 (es) 2015-03-13
MX363640B (es) 2019-03-28
KR20150014928A (ko) 2015-02-09
AU2013267359A1 (en) 2014-11-20
ZA201408262B (en) 2015-12-23
BR112014029131B1 (pt) 2021-03-09
US20150111862A1 (en) 2015-04-23
MX2014014054A (es) 2015-02-12
EP2854763B1 (en) 2018-09-26
BR112014029131A2 (pt) 2018-05-29
MX382986B (es) 2025-03-13
AU2013267359B2 (en) 2016-05-26
IL235450A0 (en) 2014-12-31
CO7141411A2 (es) 2014-12-12
PH12014502516B1 (en) 2015-01-12
HK1206622A1 (en) 2016-01-15
SG11201407397WA (en) 2014-12-30

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