SG11201407397WA - Formulations and methods for vaginal delivery of antiprogestins - Google Patents
Formulations and methods for vaginal delivery of antiprogestinsInfo
- Publication number
- SG11201407397WA SG11201407397WA SG11201407397WA SG11201407397WA SG11201407397WA SG 11201407397W A SG11201407397W A SG 11201407397WA SG 11201407397W A SG11201407397W A SG 11201407397WA SG 11201407397W A SG11201407397W A SG 11201407397WA SG 11201407397W A SG11201407397W A SG 11201407397WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- antiprogestins
- woodlands
- rule
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Abstract
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 5 December 2013 (05.12.2013) WIPOIPCT (10) International Publication Number WO 2013/181449 A1 (51) International Patent Classification: A61K 9/00 (2006.01) A61K 9/48 (2006.01) (21) International Application Number: PCT/US2013/043447 (22) International Filing Date: 30 May 2013 (30.05.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 61/653,674 31 May 2012 (31.05.2012) US (71) Applicant: REPROS THERAPEUTICS INC. [US/US]; 2408 Timberloch Place, Suite B-7, The Woodlands, TX 77380 (US). (72) Inventors: PODOLSKI, Joseph, S.; 3 Pebble Hollow Court, The Woodlands, TX 77381 (US). HSU, Kuang; 71 N. Misty Morning Trace, The Woodlands, TX 77381 (US). (74) Agents: CLOUGH, David, W. et al.; Morgan, Lewis & Bockius LLP, Attention: Docketing Department, 1111 Pennsylvania Avenue, N.W., Washington, DC 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) (54) Title: FORMULATIONS AND METHODS FOR VAGINAL DELIVERY OF ANTIPROGESTINS Figure 1 Observed AUC of Combined Parent and Metabolite 3000 2500 2000 0\ T-H 00 I t Imgoral 3mgoral Bmgoral 9mgoral 12mgora! 12mgVaginal (57) Abstract: The subject matter of the present invention is pertinent to the field of vaginal delivery of pharmaceutically active © agents. Embodiments of the instant invention disclose methods for treating variety a of progesterone related disorders by vaginal ad- CJ ministration of pullulan a capsule comprising one or more antiprogestins.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261653674P | 2012-05-31 | 2012-05-31 | |
PCT/US2013/043447 WO2013181449A1 (en) | 2012-05-31 | 2013-05-30 | Formulations and methods for vaginal delivery of antiprogestins |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201407397WA true SG11201407397WA (en) | 2014-12-30 |
Family
ID=48614182
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201704858PA SG10201704858PA (en) | 2012-05-31 | 2013-05-30 | Formulations and methods for vaginal delivery of antiprogestins |
SG11201407397WA SG11201407397WA (en) | 2012-05-31 | 2013-05-30 | Formulations and methods for vaginal delivery of antiprogestins |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201704858PA SG10201704858PA (en) | 2012-05-31 | 2013-05-30 | Formulations and methods for vaginal delivery of antiprogestins |
Country Status (23)
Country | Link |
---|---|
US (1) | US10328022B2 (en) |
EP (1) | EP2854763B1 (en) |
JP (1) | JP6341910B2 (en) |
KR (1) | KR102127348B1 (en) |
CN (1) | CN104334158B (en) |
AU (1) | AU2013267359C1 (en) |
BR (1) | BR112014029131B1 (en) |
CA (1) | CA2872644A1 (en) |
CL (1) | CL2014003232A1 (en) |
CO (1) | CO7141411A2 (en) |
CR (1) | CR20140567A (en) |
EA (1) | EA030444B1 (en) |
ES (1) | ES2701400T3 (en) |
HK (1) | HK1206622A1 (en) |
IL (1) | IL235450B (en) |
IN (1) | IN2014DN10548A (en) |
MX (2) | MX363640B (en) |
NZ (1) | NZ702467A (en) |
PH (1) | PH12014502516B1 (en) |
SG (2) | SG10201704858PA (en) |
UA (1) | UA114106C2 (en) |
WO (1) | WO2013181449A1 (en) |
ZA (1) | ZA201408262B (en) |
Families Citing this family (22)
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EP3936133A1 (en) | 2011-11-23 | 2022-01-12 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10064815B2 (en) | 2014-05-05 | 2018-09-04 | Repros Therapeutics Inc. | Formulations and methods for vaginal delivery of antiprogestins |
KR20170005819A (en) | 2014-05-22 | 2017-01-16 | 쎄러퓨틱스엠디, 인코퍼레이티드 | Natural combination hormone replacement formulations and therapies |
US11623008B2 (en) * | 2014-08-20 | 2023-04-11 | Professional Compounding Centers Of America | Excipient compositions for mucoadhesive pharmaceutical compositions including a synergistic combination of amylopectin, pullulan, hyaluronic acid, and xyloglucan |
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US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
AU2017239645A1 (en) | 2016-04-01 | 2018-10-18 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
AU2018251256B2 (en) * | 2017-04-14 | 2023-10-05 | Capsugel Belgium Nv | Pullulan capsules |
AU2018253392B2 (en) | 2017-04-14 | 2023-11-02 | Capsugel Belgium Nv | Process for making pullulan |
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-
2013
- 2013-05-30 WO PCT/US2013/043447 patent/WO2013181449A1/en active Application Filing
- 2013-05-30 UA UAA201414106A patent/UA114106C2/en unknown
- 2013-05-30 ES ES13728632T patent/ES2701400T3/en active Active
- 2013-05-30 IN IN10548DEN2014 patent/IN2014DN10548A/en unknown
- 2013-05-30 CA CA2872644A patent/CA2872644A1/en not_active Abandoned
- 2013-05-30 NZ NZ702467A patent/NZ702467A/en not_active IP Right Cessation
- 2013-05-30 SG SG10201704858PA patent/SG10201704858PA/en unknown
- 2013-05-30 MX MX2014014054A patent/MX363640B/en unknown
- 2013-05-30 EP EP13728632.4A patent/EP2854763B1/en active Active
- 2013-05-30 KR KR1020147032210A patent/KR102127348B1/en active IP Right Grant
- 2013-05-30 CN CN201380028413.4A patent/CN104334158B/en not_active Expired - Fee Related
- 2013-05-30 AU AU2013267359A patent/AU2013267359C1/en not_active Ceased
- 2013-05-30 US US14/403,141 patent/US10328022B2/en not_active Expired - Fee Related
- 2013-05-30 EA EA201492290A patent/EA030444B1/en unknown
- 2013-05-30 JP JP2015515205A patent/JP6341910B2/en not_active Expired - Fee Related
- 2013-05-30 BR BR112014029131-4A patent/BR112014029131B1/en not_active IP Right Cessation
- 2013-05-30 SG SG11201407397WA patent/SG11201407397WA/en unknown
-
2014
- 2014-11-02 IL IL235450A patent/IL235450B/en active IP Right Grant
- 2014-11-11 ZA ZA2014/08262A patent/ZA201408262B/en unknown
- 2014-11-11 PH PH12014502516A patent/PH12014502516B1/en unknown
- 2014-11-19 MX MX2019003467A patent/MX2019003467A/en unknown
- 2014-11-25 CO CO14259346A patent/CO7141411A2/en unknown
- 2014-11-27 CL CL2014003232A patent/CL2014003232A1/en unknown
- 2014-12-09 CR CR20140567A patent/CR20140567A/en unknown
-
2015
- 2015-07-30 HK HK15107275.4A patent/HK1206622A1/en not_active IP Right Cessation
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