HUE036870T2 - Compositions and methods for suppressing endometrial proliferation - Google Patents

Compositions and methods for suppressing endometrial proliferation

Info

Publication number
HUE036870T2
HUE036870T2 HUE07871232A HUE07871232A HUE036870T2 HU E036870 T2 HUE036870 T2 HU E036870T2 HU E07871232 A HUE07871232 A HU E07871232A HU E07871232 A HUE07871232 A HU E07871232A HU E036870 T2 HUE036870 T2 HU E036870T2
Authority
HU
Hungary
Prior art keywords
compositions
methods
endometrial proliferation
suppressing endometrial
suppressing
Prior art date
Application number
HUE07871232A
Other languages
Hungarian (hu)
Inventor
Joseph Podolski
Original Assignee
Repros Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Repros Therapeutics Inc filed Critical Repros Therapeutics Inc
Publication of HUE036870T2 publication Critical patent/HUE036870T2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
HUE07871232A 2006-10-24 2007-10-24 Compositions and methods for suppressing endometrial proliferation HUE036870T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86263206P 2006-10-24 2006-10-24
US88534807P 2007-01-17 2007-01-17

Publications (1)

Publication Number Publication Date
HUE036870T2 true HUE036870T2 (en) 2018-08-28

Family

ID=39468586

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE07871232A HUE036870T2 (en) 2006-10-24 2007-10-24 Compositions and methods for suppressing endometrial proliferation
HUE17184128A HUE051484T2 (en) 2006-10-24 2007-10-24 Compositions and methods for suppressing endometrial proliferations

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE17184128A HUE051484T2 (en) 2006-10-24 2007-10-24 Compositions and methods for suppressing endometrial proliferations

Country Status (25)

Country Link
US (3) US9283234B2 (en)
EP (3) EP3263112B1 (en)
JP (5) JP2010507685A (en)
KR (1) KR20090067198A (en)
AU (1) AU2007327707B2 (en)
BR (1) BRPI0717747A2 (en)
CA (1) CA2673128C (en)
CR (1) CR10826A (en)
CY (2) CY1119521T1 (en)
DK (2) DK3263112T3 (en)
EA (1) EA017227B1 (en)
EC (1) ECSP099349A (en)
ES (2) ES2814343T3 (en)
HK (1) HK1216849A1 (en)
HU (2) HUE036870T2 (en)
IL (2) IL197893A (en)
LT (2) LT3263112T (en)
MX (2) MX2009003953A (en)
MY (1) MY150763A (en)
NO (1) NO342085B1 (en)
NZ (1) NZ576274A (en)
PL (2) PL3263112T3 (en)
PT (2) PT2078032T (en)
SI (2) SI2078032T1 (en)
WO (1) WO2008067086A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2654152A1 (en) 2006-06-02 2007-12-13 Pear Tree Women's Health Care Method of treating atrophic vaginitis
TWI477276B (en) * 2008-04-28 2015-03-21 Repros Therapeutics Inc Antiprogestin dosing regimens
TW201002736A (en) * 2008-04-28 2010-01-16 Repros Therapeutics Inc Compositions and methods for treating progesterone-dependent conditions
US8512745B2 (en) 2008-12-08 2013-08-20 Laboratoire Hra Pharma Ulipristal acetate tablets
UA113283C2 (en) * 2010-12-23 2017-01-10 19-NORSTEROIDS AND THEIR APPLICATIONS FOR THE TREATMENT OF PROGESTERON-STAINLESS STATES
EP2471537A1 (en) * 2010-12-30 2012-07-04 PregLem S.A. Treatment of pain associated with dislocation of basal endometrium
IN2014DN10548A (en) 2012-05-31 2015-08-21 Repros Therapeutics Inc
WO2014070517A1 (en) 2012-11-02 2014-05-08 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions
FR2997628B1 (en) * 2012-11-08 2015-01-16 Hra Pharma Lab CO-MICRONIZATION PRODUCT COMPRISING A SELECTIVE MODULATOR OF PROGESTERONE RECEPTORS
CN105120874A (en) 2013-04-10 2015-12-02 普雷格莱姆股份有限公司 Progesteron receptor modulators for use in the therapy of uterine fibroids
EP3402471A4 (en) * 2016-01-12 2019-08-28 Repros Therapeutics Inc. Trans-clomiphene and progesterone receptor antagonist combination therapy for treating hormone-dependent conditions

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038389A (en) * 1975-05-07 1977-07-26 The Upjohn Company Medroxyprogesterone acetate compositions
US4409208A (en) 1980-04-15 1983-10-11 The Salk Institute For Biological Studies GnRH antagonists
ZA8231B (en) 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
US4619914A (en) 1983-03-10 1986-10-28 The Salk Institute For Biological Studies GNRH antagonists IIIB
US4780461A (en) 1983-06-15 1988-10-25 Schering Aktiengesellschaft 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same
US4547370A (en) 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
DE3347126A1 (en) 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11SS-ARYL-ESTRADIENE, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM
US4569927A (en) 1984-02-23 1986-02-11 The Salk Institute For Biological Studies GnRH Antagonists IV
US4565804A (en) 1984-09-07 1986-01-21 The Salk Institute For Biological Studies GnRH Antagonists VI
DE3506785A1 (en) 1985-02-22 1986-08-28 Schering AG, Berlin und Bergkamen, 1000 Berlin 11SS-N, N-DIMETHYLAMINOPHENYL ESTRADIENE, THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3625315A1 (en) 1986-07-25 1988-01-28 Schering Ag 11SS- (4-ISOPROPENYLPHENYL) -ESTRA-4,9-DIENES, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM
US5446178A (en) 1987-03-18 1995-08-29 Schering Aktiengesellschaft Process for preparing 19,11β-bridged steroids
DE3708942A1 (en) 1987-03-18 1988-09-29 Schering Ag 19.11SS-BRIDGED STEROIDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3866410D1 (en) 1987-04-24 1992-01-09 Akzo Nv 11-ARYLESTRANDERIVATIVES AND 11-ARYLPREGNANDERIVATIVES.
EP0321010B1 (en) 1987-12-12 1993-02-03 Akzo N.V. New 11-arylsteroid compounds
DE3820948A1 (en) 1988-06-16 1989-12-21 Schering Ag 10SS, 11SS BRIDGED STEROIDS
DE3822770A1 (en) 1988-07-01 1990-01-04 Schering Ag 13-ALKYL-11SS-PHENYLGONANE
DE3832303A1 (en) 1988-09-20 1990-04-12 Schering Ag 11SS-PHENYL-14SSH STEROIDS
DE3917274A1 (en) 1989-05-24 1990-11-29 Schering Ag 9 (ALPHA) -HYDROXY-19, 11 (BETA) -BRIDGED STEROIDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3921059A1 (en) 1989-06-23 1991-01-10 Schering Ag 11 (BETA) -ARYL-4-ESTRENE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
DE4042007A1 (en) 1990-12-22 1992-06-25 Schering Ag 6,7-MODIFIED-11 (BETA) -ARYL-4-ESTRENE
US5407928A (en) 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
DE4038128A1 (en) 1990-11-27 1992-06-04 Schering Ag 8-EN-19, 11 (BETA) BRIDGED STEROIDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL PREPARATIONS CONTAINING THEM
ZA929315B (en) 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
DE4216003A1 (en) 1992-05-12 1993-11-18 Schering Ag New 11,19-, phenylene-17-hydroxy-4-androsten-3-one derivs. - are implantation inhibitors which have little or no effect on ovulation
DE4216004B4 (en) 1992-05-12 2008-03-27 Bayer Schering Pharma Akiengesellschaft Use of competitive progesterone antagonists
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
PT650480E (en) 1992-07-01 2002-03-28 Ortho Pharma Corp 1-ARYLSULPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES
US5468736A (en) * 1993-02-25 1995-11-21 The Medical College Of Hampton Road Hormone replacement therapy
DE4332284C2 (en) 1993-09-20 1997-05-28 Jenapharm Gmbh 11-Benzaldoxime-17beta-methoxy-17alpha-methoxymethyl-estradiene derivatives, process for their preparation and medicaments containing these compounds
DE4332283A1 (en) 1993-09-20 1995-04-13 Jenapharm Gmbh Novel 11-benzaldoximestradiene derivatives, processes for their preparation and medicaments containing these compounds
US5681817A (en) * 1994-02-04 1997-10-28 The Medical College Of Hampton Roads Treatment of ovarian estrogen dependent conditions
DE4434488A1 (en) 1994-09-14 1996-03-21 Schering Ag Steroid esters and amides, processes for their preparation and their pharmaceutical use
US5576310A (en) 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
US5521166A (en) * 1994-12-19 1996-05-28 Ortho Pharmaceitical Corporation Antiprogestin cyclophasic hormonal regimen
US5693646A (en) 1994-12-22 1997-12-02 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
US5780050A (en) * 1995-07-20 1998-07-14 Theratech, Inc. Drug delivery compositions for improved stability of steroids
WO1997041145A1 (en) * 1996-05-01 1997-11-06 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
US5753655A (en) 1996-10-10 1998-05-19 Ortho Pharmaceutical Corporation 1-arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and methods of preparation
DE19652408C2 (en) 1996-12-06 2002-04-18 Schering Ag Steroid esters, processes for their preparation and their use in the manufacture of medicinal products
DE19706061A1 (en) 1997-02-07 1998-08-13 Schering Ag Anti-gestagen effective steroids with fluorinated 17alpha alkyl chain
DE19809845A1 (en) 1998-03-03 1999-09-09 Jenapharm Gmbh S-substituted 11beta-benzaldoxime-estra-4,9-diene-carbonic acid thiol esters, processes for their preparation and pharmaceutical preparations containing these compounds
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6689768B2 (en) * 1998-04-15 2004-02-10 Jenapharm Gmbh & Co. Kg Pharmaceutical preparations for treating side effects during and/or after GnRHa therapy
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
US6417214B1 (en) 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6306851B1 (en) 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
SE514556C2 (en) 1999-07-09 2001-03-12 Jema Jori Ab Method for managing a database
DE60021422T2 (en) 1999-12-29 2006-05-24 The Government of the United States of America, as represented by the Secretary National Institute of Health, Office of Technology Transfer A process for the preparation of 17α-acetoxy-11β- [4-n, n- (dimethylamino) phenyl] -21-methoxy-19-norpregna-4,9-diene-3,20-dione, intermediates and processes useful in the process for the preparation of such intermediates
US7109171B2 (en) * 2000-02-28 2006-09-19 Praecis Pharmaceuticals Inc. Methods for treating FSH related conditions with GnRH antagonists
ES2546336T3 (en) * 2000-03-17 2015-09-22 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 19-norpregnadienodione 17-alpha-substituted, 11-beta-substituted-4-aryl and 21-substituted as antiprogestational agents
BRPI0513141A (en) * 2004-07-09 2008-04-29 Population Council Inc vaginal ring composition, and long-term contraceptive process

Also Published As

Publication number Publication date
ES2643318T3 (en) 2017-11-22
LT3263112T (en) 2020-10-12
AU2007327707B2 (en) 2012-07-12
CA2673128A1 (en) 2008-06-05
ES2814343T3 (en) 2021-03-26
IL197893A (en) 2015-06-30
US20170189421A1 (en) 2017-07-06
WO2008067086A2 (en) 2008-06-05
CA2673128C (en) 2018-07-03
EP3263112B1 (en) 2020-05-13
KR20090067198A (en) 2009-06-24
EA200970409A1 (en) 2009-10-30
LT2078032T (en) 2017-11-10
EP3693376A1 (en) 2020-08-12
NZ576274A (en) 2011-12-22
US20140235602A1 (en) 2014-08-21
PT3263112T (en) 2020-08-25
PL2078032T3 (en) 2018-01-31
SI3263112T1 (en) 2020-10-30
NO342085B1 (en) 2018-03-19
US9283234B2 (en) 2016-03-15
JP2019131587A (en) 2019-08-08
JP6175364B2 (en) 2017-08-02
CY1119521T1 (en) 2018-03-07
EP2078032A2 (en) 2009-07-15
JP2014051530A (en) 2014-03-20
DK3263112T3 (en) 2020-08-17
ECSP099349A (en) 2009-06-30
BRPI0717747A2 (en) 2013-10-22
PL3263112T3 (en) 2021-01-11
JP2016183199A (en) 2016-10-20
NO20091966L (en) 2009-07-21
AU2007327707A1 (en) 2008-06-05
JP2017203049A (en) 2017-11-16
EP2078032B1 (en) 2017-08-02
IL238823B (en) 2018-06-28
CY1123239T1 (en) 2021-10-29
HUE051484T2 (en) 2021-03-01
EP2078032A4 (en) 2011-09-14
PT2078032T (en) 2017-11-10
SI2078032T1 (en) 2017-12-29
EA017227B1 (en) 2012-10-30
IL197893A0 (en) 2009-12-24
MY150763A (en) 2014-02-28
MX343130B (en) 2016-10-26
EP3263112A1 (en) 2018-01-03
DK2078032T3 (en) 2017-11-13
WO2008067086A3 (en) 2008-11-06
JP2010507685A (en) 2010-03-11
CR10826A (en) 2009-09-29
US9616074B2 (en) 2017-04-11
MX2009003953A (en) 2009-04-28
US20100216756A1 (en) 2010-08-26
HK1216849A1 (en) 2016-12-09
IL238823A0 (en) 2015-06-30

Similar Documents

Publication Publication Date Title
HK1216849A1 (en) Compositions and methods for suppressing endometrial proliferation
IL195619A0 (en) Compositions and methods for joininig non-conjoined iumens
HK1137670A1 (en) Compositions and methods for arthrodetic procedures
EP2035014A4 (en) Fucoidan compositions and methods
HK1145339A1 (en) Methods and compositions for targeted integration
EP2010117A4 (en) Compositions and methods for inhibiting adhesions
EP2018167A4 (en) Compositions and methods for fgf receptor kinases inhibitors
ZA201001300B (en) Antigen-asjuvant compositions and methods
PT2101766T (en) Compositions and methods of using (r)-pramipexole
IL195787A0 (en) Methods and compositions for improving cognitive function
EP2049122A4 (en) Methods and compositions for inhibiting angiogenesis
EP2101731A4 (en) Endoxifen methods and compositions
EP1991200A4 (en) Fluoroquinolone compositions
EP2152247A4 (en) Anti-insomnia compositions and methods
PL2101766T3 (en) Compositions and methods of using (r)-pramipexole
GB0721291D0 (en) Methods and compositions
EP2088865A4 (en) Guggulphospholipid methods and compositions
GB0617171D0 (en) Novel compositions and methods
IL205248A0 (en) Compositions and methods for making androstenediones
EP2084241A4 (en) Toughened binder compositions for use in advance processes
GB0719526D0 (en) Compositions and methods
EP2278984A4 (en) Compositions and methods for enhancing fertility
GB0620930D0 (en) Composition and method for use thereof
TWI319265B (en) Glitch suppressing apparatus
RS56491B1 (en) Compositions and methods for suppressing endometrial proliferation