KR101903931B1 - 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체 - Google Patents

조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체 Download PDF

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KR101903931B1
KR101903931B1 KR1020177034610A KR20177034610A KR101903931B1 KR 101903931 B1 KR101903931 B1 KR 101903931B1 KR 1020177034610 A KR1020177034610 A KR 1020177034610A KR 20177034610 A KR20177034610 A KR 20177034610A KR 101903931 B1 KR101903931 B1 KR 101903931B1
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gln
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KR20170137218A (ko
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주오지 왕
준리앙 판
요안나 그루드진스카
크리스티안 보츠마이어
얀 테베
외르그 비르켄펠드
니나 보브스트
시모네 브뤼크너
수사네 스타이니그
페터 숄츠
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바이엘 헬스케어 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Filtering Materials (AREA)
KR1020177034610A 2010-03-01 2011-03-01 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체 Expired - Fee Related KR101903931B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30929010P 2010-03-01 2010-03-01
US61/309,290 2010-03-01
PCT/US2011/026766 WO2011109452A1 (en) 2010-03-01 2011-03-01 Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020127025683A Division KR101807894B1 (ko) 2010-03-01 2011-03-01 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020187022511A Division KR101974980B1 (ko) 2010-03-01 2011-03-01 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체

Publications (2)

Publication Number Publication Date
KR20170137218A KR20170137218A (ko) 2017-12-12
KR101903931B1 true KR101903931B1 (ko) 2018-10-02

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Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020177034610A Expired - Fee Related KR101903931B1 (ko) 2010-03-01 2011-03-01 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체
KR1020187022511A Expired - Fee Related KR101974980B1 (ko) 2010-03-01 2011-03-01 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체
KR1020197012160A Ceased KR20190047135A (ko) 2010-03-01 2011-03-01 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체
KR1020127025683A Expired - Fee Related KR101807894B1 (ko) 2010-03-01 2011-03-01 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020187022511A Expired - Fee Related KR101974980B1 (ko) 2010-03-01 2011-03-01 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체
KR1020197012160A Ceased KR20190047135A (ko) 2010-03-01 2011-03-01 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체
KR1020127025683A Expired - Fee Related KR101807894B1 (ko) 2010-03-01 2011-03-01 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체

Country Status (37)

Country Link
US (3) US9309324B2 (https=)
EP (2) EP3345615B1 (https=)
JP (4) JP6025570B2 (https=)
KR (4) KR101903931B1 (https=)
CN (5) CN102939098B (https=)
AU (1) AU2011223710B2 (https=)
BR (1) BR112012022258A2 (https=)
CA (3) CA2791685C (https=)
CL (2) CL2012002415A1 (https=)
CO (1) CO6620068A2 (https=)
CR (1) CR20120453A (https=)
CU (1) CU23982B1 (https=)
CY (2) CY1119410T1 (https=)
DK (2) DK2542257T3 (https=)
DO (1) DOP2012000239A (https=)
EA (2) EA032189B9 (https=)
EC (2) ECSP12012134A (https=)
ES (2) ES2642512T3 (https=)
GT (1) GT201200252A (https=)
HK (2) HK1232232A1 (https=)
HR (2) HRP20171472T1 (https=)
HU (2) HUE047173T2 (https=)
IL (3) IL221551B (https=)
LT (2) LT2542257T (https=)
ME (2) ME03578B (https=)
MX (2) MX2012010198A (https=)
MY (1) MY174760A (https=)
NZ (2) NZ602115A (https=)
PE (1) PE20160538A1 (https=)
PH (4) PH12012501742A1 (https=)
PL (2) PL2542257T3 (https=)
PT (2) PT3345615T (https=)
RS (2) RS59830B1 (https=)
SG (3) SG10201903166PA (https=)
SI (2) SI2542257T1 (https=)
SM (1) SMT201700454T1 (https=)
WO (1) WO2011109452A1 (https=)

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UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
WO2010072691A1 (en) 2008-12-22 2010-07-01 Novo Nordisk A/S Antibodies against tissue factor pathway inhibitor
PT3345615T (pt) * 2010-03-01 2020-01-17 Bayer Healthcare Llc Anticorpos monoclonais otimizados contra inibidor da via do fator tecidual (tfpi)
JP2013533871A (ja) * 2010-06-30 2013-08-29 ノヴォ ノルディスク アー／エス 組織因子経路インヒビターに特異的に結合することが可能な抗体
PL2694544T3 (pl) * 2011-04-01 2019-07-31 Bayer Healthcare Llc Przeciwciała monoklonalne przeciwko inhibitorowi szlaku czynnika tkankowego (TFPI)
US9975962B2 (en) * 2012-03-30 2018-05-22 Bayer Healthcare Llc Thrombin/plasmin-regulated antibodies that bind TFPI
US9592297B2 (en) * 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
US20160009817A1 (en) * 2013-03-15 2016-01-14 Bayer Healthcare Llc Pro-drug antibodies against tissue factor pathway inhibitor
EP2970497B1 (en) 2013-03-15 2017-10-25 Bayer HealthCare LLC Anti-tfpi antibody variants with differential binding across ph range for improved pharmacokinetics
MY178445A (en) * 2015-02-25 2020-10-13 Mogam Inst Biomedical Res Novel antibody binding to tfpi and composition comprising the same
KR102438650B1 (ko) 2015-08-19 2022-08-31 화이자 인코포레이티드 조직 인자 경로 억제제 항체 및 그의 용도
KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
CA3115607A1 (en) * 2018-10-11 2020-04-16 Pfizer Inc. Dosage regimen for tfpi antagonists
KR102692277B1 (ko) * 2019-03-11 2024-08-05 현대자동차주식회사 상용 전기차용 모터 마운트
CN112442127A (zh) * 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体
AU2021378707A1 (en) * 2020-11-13 2023-06-01 Hanmi Pharm. Co., Ltd. Use of therapeutic enzyme fusion protein in prevention and treatment of renal diseases caused by or accompanied by Fabry disease
CN117285632A (zh) * 2022-06-17 2023-12-26 安源医药科技（上海）有限公司 针对tfpi的单克隆抗体及其用途

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