KR101660146B1 - 에네디인 화합물, 그의 접합체, 및 그에 대한 용도 및 방법 - Google Patents

에네디인 화합물, 그의 접합체, 및 그에 대한 용도 및 방법 Download PDF

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Publication number
KR101660146B1
KR101660146B1 KR1020147025070A KR20147025070A KR101660146B1 KR 101660146 B1 KR101660146 B1 KR 101660146B1 KR 1020147025070 A KR1020147025070 A KR 1020147025070A KR 20147025070 A KR20147025070 A KR 20147025070A KR 101660146 B1 KR101660146 B1 KR 101660146B1
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formula
antibody
rti
group
compound
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Expired - Fee Related
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Korean (ko)
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KR20140120374A (ko
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나이두 에스. 쇼우다리
산지브 갱워
빌랄 수피
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020147025070A 2012-02-13 2013-02-08 에네디인 화합물, 그의 접합체, 및 그에 대한 용도 및 방법 Expired - Fee Related KR101660146B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261598143P 2012-02-13 2012-02-13
US61/598,143 2012-02-13
US201261653785P 2012-05-31 2012-05-31
US61/653,785 2012-05-31
PCT/US2013/025247 WO2013122823A1 (en) 2012-02-13 2013-02-08 Enediyne compounds, conjugates thereof, and uses and methods therefor

Publications (2)

Publication Number Publication Date
KR20140120374A KR20140120374A (ko) 2014-10-13
KR101660146B1 true KR101660146B1 (ko) 2016-09-26

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KR1020147025070A Expired - Fee Related KR101660146B1 (ko) 2012-02-13 2013-02-08 에네디인 화합물, 그의 접합체, 및 그에 대한 용도 및 방법

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US (2) US8709431B2 (enExample)
EP (1) EP2814829B1 (enExample)
JP (1) JP6113194B2 (enExample)
KR (1) KR101660146B1 (enExample)
CN (1) CN104220441B (enExample)
AR (1) AR089972A1 (enExample)
AU (1) AU2013221873B2 (enExample)
BR (1) BR112014019990A8 (enExample)
CA (1) CA2864420C (enExample)
CL (1) CL2014002096A1 (enExample)
CO (1) CO7061078A2 (enExample)
CY (1) CY1118899T1 (enExample)
DK (1) DK2814829T3 (enExample)
EA (1) EA027925B1 (enExample)
ES (1) ES2615268T3 (enExample)
HK (1) HK1204326A1 (enExample)
HR (1) HRP20170334T1 (enExample)
HU (1) HUE033704T2 (enExample)
IL (1) IL233965B (enExample)
LT (1) LT2814829T (enExample)
MX (1) MX350539B (enExample)
PE (1) PE20141791A1 (enExample)
PL (1) PL2814829T3 (enExample)
PT (1) PT2814829T (enExample)
RS (1) RS55763B1 (enExample)
SG (1) SG11201404667XA (enExample)
SI (1) SI2814829T1 (enExample)
SM (1) SMT201700137T1 (enExample)
TW (1) TW201336851A (enExample)
WO (1) WO2013122823A1 (enExample)
ZA (1) ZA201406723B (enExample)

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HRP20201756T8 (hr) 2014-11-21 2021-08-20 Bristol-Myers Squibb Company Antitijela koja sadrže modificirane regije teškog lanca
TWI711630B (zh) 2014-11-21 2020-12-01 美商必治妥美雅史谷比公司 抗ｃｄ７３抗體及其用途
CN114591420A (zh) 2014-11-25 2022-06-07 百时美施贵宝公司 用于成像的新型pd-l1结合多肽
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ES2736106T3 (es) 2015-03-10 2019-12-26 Bristol Myers Squibb Co Anticuerpos que se pueden conjugar mediante la transglutaminasa y conjugados producidos a partir de ellos
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KR20180089433A (ko) 2015-12-21 2018-08-08 브리스톨-마이어스 스큅 컴퍼니 부위-특이적 접합을 위한 변이체 항체
CA3016187A1 (en) 2016-03-04 2017-09-08 Bristol-Myers Squibb Company Combination therapy with anti-cd73 antibodies
CN106267188B (zh) * 2016-08-15 2025-06-17 深圳大学 小分子免疫激动剂偶联pd-1抗体的新型抗体及其在抗肿瘤中的应用
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CN111683686A (zh) * 2017-12-06 2020-09-18 西纳福克斯股份有限公司 烯二炔缀合物
CN110183659B (zh) * 2018-02-21 2022-04-26 香港科技大学 含有杂环的聚合物、其制备方法及其应用
KR20210096167A (ko) 2018-11-28 2021-08-04 브리스톨-마이어스 스큅 컴퍼니 변형된 중쇄 불변 영역을 포함하는 항체
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CN114174305A (zh) * 2019-05-22 2022-03-11 德克萨斯大学系统董事会 用于治疗癌症的官能化的金卡宾萘醌络合物
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EP2814829A1 (en) 2014-12-24
EP2814829B1 (en) 2016-12-07
ES2615268T3 (es) 2017-06-06
MX2014009234A (es) 2014-11-10
AU2013221873A1 (en) 2014-10-02
CN104220441B (zh) 2017-03-29
DK2814829T3 (en) 2017-03-20
MX350539B (es) 2017-09-08
HRP20170334T1 (hr) 2017-04-21
JP6113194B2 (ja) 2017-04-12
AR089972A1 (es) 2014-10-01
LT2814829T (lt) 2017-02-27
US8709431B2 (en) 2014-04-29
CA2864420A1 (en) 2013-08-22
US20140193438A1 (en) 2014-07-10
US20130209494A1 (en) 2013-08-15
CN104220441A (zh) 2014-12-17
IL233965B (en) 2018-01-31
CA2864420C (en) 2016-11-15
RS55763B1 (sr) 2017-07-31
SI2814829T1 (sl) 2017-02-28
HK1204326A1 (en) 2015-11-13
HUE033704T2 (en) 2017-12-28
EA201491447A1 (ru) 2014-11-28
WO2013122823A1 (en) 2013-08-22
KR20140120374A (ko) 2014-10-13
PT2814829T (pt) 2017-02-15
PL2814829T3 (pl) 2017-06-30
EA027925B1 (ru) 2017-09-29
US9156850B2 (en) 2015-10-13
CL2014002096A1 (es) 2014-11-28
ZA201406723B (en) 2016-05-25
AU2013221873B2 (en) 2016-11-17
BR112014019990A8 (pt) 2017-07-11
TW201336851A (zh) 2013-09-16
CY1118899T1 (el) 2018-01-10
CO7061078A2 (es) 2014-09-19
SG11201404667XA (en) 2014-09-26
SMT201700137T1 (it) 2017-05-08
JP2015508074A (ja) 2015-03-16
PE20141791A1 (es) 2014-11-19
BR112014019990A2 (enExample) 2017-06-20

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