JP6113194B2 - エンジイン化合物、その抱合体、ならびにその使用および方法 - Google Patents
エンジイン化合物、その抱合体、ならびにその使用および方法 Download PDFInfo
- Publication number
- JP6113194B2 JP6113194B2 JP2014556700A JP2014556700A JP6113194B2 JP 6113194 B2 JP6113194 B2 JP 6113194B2 JP 2014556700 A JP2014556700 A JP 2014556700A JP 2014556700 A JP2014556700 A JP 2014556700A JP 6113194 B2 JP6113194 B2 JP 6113194B2
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- Prior art keywords
- substituted
- unsubstituted
- alkyl
- compound
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 CC(C)C1C2(C*CC2)C1C Chemical compound CC(C)C1C2(C*CC2)C1C 0.000 description 6
- UNYDWXGETNKFSJ-UHFFFAOYSA-N CC(C)C(CN)=O Chemical compound CC(C)C(CN)=O UNYDWXGETNKFSJ-UHFFFAOYSA-N 0.000 description 1
- PFQRENKUNQSQPF-YFKPBYRVSA-N CC(C)C([C@H](CO)N)=O Chemical compound CC(C)C([C@H](CO)N)=O PFQRENKUNQSQPF-YFKPBYRVSA-N 0.000 description 1
- ODVQBCMVPSTNQJ-UHFFFAOYSA-N CCC(C1)=CC=C(C(C2)[Zn])C1C2=O Chemical compound CCC(C1)=CC=C(C(C2)[Zn])C1C2=O ODVQBCMVPSTNQJ-UHFFFAOYSA-N 0.000 description 1
- QHCCDDQKNUYGNC-UHFFFAOYSA-N CCCCNCC Chemical compound CCCCNCC QHCCDDQKNUYGNC-UHFFFAOYSA-N 0.000 description 1
- YUGJDXIRBHJTNM-CGUJYUCGSA-N C[C@H]([C@@]1([C@H](C#C/C=C\C#CC2O)Nc3c4C(c(c5c6)ccc6NC([C@H](CO)N)=O)=O)O[C@]12c3cc(O)c4C5=O)O Chemical compound C[C@H]([C@@]1([C@H](C#C/C=C\C#CC2O)Nc3c4C(c(c5c6)ccc6NC([C@H](CO)N)=O)=O)O[C@]12c3cc(O)c4C5=O)O YUGJDXIRBHJTNM-CGUJYUCGSA-N 0.000 description 1
- IOIRXKAKUFMWSS-DBFXAIQTSA-N C[C@H]([C@@]1([C@H](C#C/C=C\C#C[C@H]2O)Nc3c4C(c(c5c6)ccc6N)=O)O[C@]12c3cc(O)c4C5=O)O Chemical compound C[C@H]([C@@]1([C@H](C#C/C=C\C#C[C@H]2O)Nc3c4C(c(c5c6)ccc6N)=O)O[C@]12c3cc(O)c4C5=O)O IOIRXKAKUFMWSS-DBFXAIQTSA-N 0.000 description 1
- IMEDYQARUYWOTG-UNKUOTRSSA-N C[C@H]([C@@]1([C@H](C#C/C=C\C#C[C@H]2O)Nc3c4C(c(c5c6)ccc6NCCN)=O)O[C@]12c3cc(O)c4C5=O)O Chemical compound C[C@H]([C@@]1([C@H](C#C/C=C\C#C[C@H]2O)Nc3c4C(c(c5c6)ccc6NCCN)=O)O[C@]12c3cc(O)c4C5=O)O IMEDYQARUYWOTG-UNKUOTRSSA-N 0.000 description 1
- IKOQWBMRWLHEDL-OGVDLQMXSA-N C[C@H]([C@@]1([C@H](C#C/C=C\C#C[C@H]2O)Nc3c4C(c(cc5)c6cc5NC(CN)=O)=O)O[C@]12c3cc(O)c4C6=O)O Chemical compound C[C@H]([C@@]1([C@H](C#C/C=C\C#C[C@H]2O)Nc3c4C(c(cc5)c6cc5NC(CN)=O)=O)O[C@]12c3cc(O)c4C6=O)O IKOQWBMRWLHEDL-OGVDLQMXSA-N 0.000 description 1
- QYQALUQFCKTYOA-IPGLSALDSA-N C[C@H]([C@@]1([C@H](C#C/C=C\C#C[C@H]2O)Nc3c4C(c(cc5)c6cc5NC([C@H](CCCNC(N)=O)N)=O)=O)O[C@]12c3cc(O)c4C6=O)O Chemical compound C[C@H]([C@@]1([C@H](C#C/C=C\C#C[C@H]2O)Nc3c4C(c(cc5)c6cc5NC([C@H](CCCNC(N)=O)N)=O)=O)O[C@]12c3cc(O)c4C6=O)O QYQALUQFCKTYOA-IPGLSALDSA-N 0.000 description 1
- BDUIQYQKSAQZDY-NOYXVJMLSA-N C[C@H]([C@@]12O[C@]11c(cc(c(C(c3c4ccc(NC(c(cc5)ccc5N)=O)c3)=O)c3C4=O)O)c3N[C@H]2C#C/C=C\C#C[C@H]1O)O Chemical compound C[C@H]([C@@]12O[C@]11c(cc(c(C(c3c4ccc(NC(c(cc5)ccc5N)=O)c3)=O)c3C4=O)O)c3N[C@H]2C#C/C=C\C#C[C@H]1O)O BDUIQYQKSAQZDY-NOYXVJMLSA-N 0.000 description 1
- IDZYALPNQUHLJJ-RPMQURADSA-N C[C@H]([C@](C1C[C@@H](C#C/C=C\C#C2)O)([C@H]2Nc(c2cc(O)c3C(c4c5ccc(NC([C@H](CCCCN)N)=O)c4)=O)c3C5=O)[C@]12O)O Chemical compound C[C@H]([C@](C1C[C@@H](C#C/C=C\C#C2)O)([C@H]2Nc(c2cc(O)c3C(c4c5ccc(NC([C@H](CCCCN)N)=O)c4)=O)c3C5=O)[C@]12O)O IDZYALPNQUHLJJ-RPMQURADSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261598143P | 2012-02-13 | 2012-02-13 | |
| US61/598,143 | 2012-02-13 | ||
| US201261653785P | 2012-05-31 | 2012-05-31 | |
| US61/653,785 | 2012-05-31 | ||
| PCT/US2013/025247 WO2013122823A1 (en) | 2012-02-13 | 2013-02-08 | Enediyne compounds, conjugates thereof, and uses and methods therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508074A JP2015508074A (ja) | 2015-03-16 |
| JP2015508074A5 JP2015508074A5 (enExample) | 2016-02-18 |
| JP6113194B2 true JP6113194B2 (ja) | 2017-04-12 |
Family
ID=47722570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014556700A Expired - Fee Related JP6113194B2 (ja) | 2012-02-13 | 2013-02-08 | エンジイン化合物、その抱合体、ならびにその使用および方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8709431B2 (enExample) |
| EP (1) | EP2814829B1 (enExample) |
| JP (1) | JP6113194B2 (enExample) |
| KR (1) | KR101660146B1 (enExample) |
| CN (1) | CN104220441B (enExample) |
| AR (1) | AR089972A1 (enExample) |
| AU (1) | AU2013221873B2 (enExample) |
| BR (1) | BR112014019990A8 (enExample) |
| CA (1) | CA2864420C (enExample) |
| CL (1) | CL2014002096A1 (enExample) |
| CO (1) | CO7061078A2 (enExample) |
| CY (1) | CY1118899T1 (enExample) |
| DK (1) | DK2814829T3 (enExample) |
| EA (1) | EA027925B1 (enExample) |
| ES (1) | ES2615268T3 (enExample) |
| HK (1) | HK1204326A1 (enExample) |
| HR (1) | HRP20170334T1 (enExample) |
| HU (1) | HUE033704T2 (enExample) |
| IL (1) | IL233965B (enExample) |
| LT (1) | LT2814829T (enExample) |
| MX (1) | MX350539B (enExample) |
| PE (1) | PE20141791A1 (enExample) |
| PL (1) | PL2814829T3 (enExample) |
| PT (1) | PT2814829T (enExample) |
| RS (1) | RS55763B1 (enExample) |
| SG (1) | SG11201404667XA (enExample) |
| SI (1) | SI2814829T1 (enExample) |
| SM (1) | SMT201700137T1 (enExample) |
| TW (1) | TW201336851A (enExample) |
| WO (1) | WO2013122823A1 (enExample) |
| ZA (1) | ZA201406723B (enExample) |
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|---|---|---|---|---|
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| KR20160068738A (ko) * | 2013-08-14 | 2016-06-15 | 윌리엄 마쉬 라이스 유니버시티 | 운시알라마이신의 유도체, 합성 방법 및 항종양 제제로서 이들의 용도 |
| SG11201607818WA (en) | 2014-03-20 | 2016-10-28 | Bristol Myers Squibb Co | Stabilized fibronectin based scaffold molecules |
| PL3221346T3 (pl) | 2014-11-21 | 2021-03-08 | Bristol-Myers Squibb Company | Przeciwciała ze zmodyfikowanym regionem stałym łańcucha ciężkiego |
| TWI711630B (zh) | 2014-11-21 | 2020-12-01 | 美商必治妥美雅史谷比公司 | 抗ｃｄ７３抗體及其用途 |
| WO2016086021A1 (en) | 2014-11-25 | 2016-06-02 | Bristol-Myers Squibb Company | Novel pd-l1 binding polypeptides for imaging |
| WO2016112282A1 (en) * | 2015-01-08 | 2016-07-14 | The Scripps Research Institute | Anticancer drug candidates |
| ES2736106T3 (es) | 2015-03-10 | 2019-12-26 | Bristol Myers Squibb Co | Anticuerpos que se pueden conjugar mediante la transglutaminasa y conjugados producidos a partir de ellos |
| EA035412B1 (ru) | 2015-05-29 | 2020-06-10 | Бристол-Майерс Сквибб Компани | Антитела к ox40 и их применение |
| EP3353198B1 (en) | 2015-09-23 | 2020-06-17 | Bristol-Myers Squibb Company | Glypican-3binding fibronectin based scafflold molecules |
| CN107029242A (zh) | 2015-11-03 | 2017-08-11 | 财团法人工业技术研究院 | 抗体药物复合物及其制造方法 |
| US20180362619A1 (en) | 2015-12-21 | 2018-12-20 | Bristol-Myers Squibb Company | Variant antibodies for site-specific conjugation |
| CA3016187A1 (en) | 2016-03-04 | 2017-09-08 | Bristol-Myers Squibb Company | Combination therapy with anti-cd73 antibodies |
| CN106267188B (zh) * | 2016-08-15 | 2025-06-17 | 深圳大学 | 小分子免疫激动剂偶联pd-1抗体的新型抗体及其在抗肿瘤中的应用 |
| US20190218294A1 (en) | 2016-09-09 | 2019-07-18 | Bristol-Myers Squibb Company | Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| US20200299400A1 (en) | 2017-05-25 | 2020-09-24 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
| EP3720504A1 (en) * | 2017-12-06 | 2020-10-14 | Synaffix B.V. | Enediyne conjugates |
| CN110183659B (zh) * | 2018-02-21 | 2022-04-26 | 香港科技大学 | 含有杂环的聚合物、其制备方法及其应用 |
| JP2022513653A (ja) | 2018-11-28 | 2022-02-09 | ブリストル－マイヤーズ スクイブ カンパニー | 修飾された重鎖定常領域を含む抗体 |
| KR102861586B1 (ko) | 2018-11-30 | 2025-09-17 | 브리스톨-마이어스 스큅 컴퍼니 | 글루타민-함유 경쇄 c-말단 연장부를 포함하는 항체, 그의 접합체, 및 방법 및 용도 |
| JP7514836B2 (ja) | 2018-12-12 | 2024-07-11 | ブリストル－マイヤーズ スクイブ カンパニー | トランスグルタミナーゼによるコンジュゲーションのための改変抗体、ならびにそのコンジュゲート、方法および用途 |
| AU2020279478A1 (en) * | 2019-05-22 | 2021-12-09 | Board Of Regents, The University Of Texas System | Functionalized gold carbene naphthoquinone complexes for use in the treatment of cancer |
| US20240377413A1 (en) | 2019-09-16 | 2024-11-14 | Bristol-Myers Squibb Company | Dual capture method for analysis of antibody-drug conjugates |
| JP2024524363A (ja) | 2021-06-28 | 2024-07-05 | ビョンディス・ビー．ブイ． | ホスホ抗原を含む複合体及び治療における使用 |
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