BR112014019990A2 - - Google Patents

Info

Publication number
BR112014019990A2
BR112014019990A2 BR112014019990A BR112014019990A BR112014019990A2 BR 112014019990 A2 BR112014019990 A2 BR 112014019990A2 BR 112014019990 A BR112014019990 A BR 112014019990A BR 112014019990 A BR112014019990 A BR 112014019990A BR 112014019990 A2 BR112014019990 A2 BR 112014019990A2
Authority
BR
Brazil
Application number
BR112014019990A
Other languages
Portuguese (pt)
Other versions
BR112014019990A8 (pt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47722570&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014019990(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of BR112014019990A2 publication Critical patent/BR112014019990A2/pt
Publication of BR112014019990A8 publication Critical patent/BR112014019990A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR112014019990A 2012-02-13 2013-02-08 Compostos enediinos, seus conjugados e usos e métodos para esses compostos BR112014019990A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261598143P 2012-02-13 2012-02-13
US201261653785P 2012-05-31 2012-05-31
PCT/US2013/025247 WO2013122823A1 (en) 2012-02-13 2013-02-08 Enediyne compounds, conjugates thereof, and uses and methods therefor

Publications (2)

Publication Number Publication Date
BR112014019990A2 true BR112014019990A2 (enExample) 2017-06-20
BR112014019990A8 BR112014019990A8 (pt) 2017-07-11

Family

ID=47722570

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014019990A BR112014019990A8 (pt) 2012-02-13 2013-02-08 Compostos enediinos, seus conjugados e usos e métodos para esses compostos

Country Status (31)

Country Link
US (2) US8709431B2 (enExample)
EP (1) EP2814829B1 (enExample)
JP (1) JP6113194B2 (enExample)
KR (1) KR101660146B1 (enExample)
CN (1) CN104220441B (enExample)
AR (1) AR089972A1 (enExample)
AU (1) AU2013221873B2 (enExample)
BR (1) BR112014019990A8 (enExample)
CA (1) CA2864420C (enExample)
CL (1) CL2014002096A1 (enExample)
CO (1) CO7061078A2 (enExample)
CY (1) CY1118899T1 (enExample)
DK (1) DK2814829T3 (enExample)
EA (1) EA027925B1 (enExample)
ES (1) ES2615268T3 (enExample)
HK (1) HK1204326A1 (enExample)
HR (1) HRP20170334T1 (enExample)
HU (1) HUE033704T2 (enExample)
IL (1) IL233965B (enExample)
LT (1) LT2814829T (enExample)
MX (1) MX350539B (enExample)
PE (1) PE20141791A1 (enExample)
PL (1) PL2814829T3 (enExample)
PT (1) PT2814829T (enExample)
RS (1) RS55763B1 (enExample)
SG (1) SG11201404667XA (enExample)
SI (1) SI2814829T1 (enExample)
SM (1) SMT201700137T1 (enExample)
TW (1) TW201336851A (enExample)
WO (1) WO2013122823A1 (enExample)
ZA (1) ZA201406723B (enExample)

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JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
MX368016B (es) * 2013-08-14 2019-09-13 Univ Rice William M Derivados de uncialamicina, métodos de sintesis y su uso como agentes antitumor.
WO2015143156A1 (en) 2014-03-20 2015-09-24 Bristol-Myers Squibb Company Stabilized fibronectin based scaffold molecules
KR20230125855A (ko) 2014-11-21 2023-08-29 브리스톨-마이어스 스큅 컴퍼니 Cd73에 대항한 항체 및 그의 용도
LT3221346T (lt) 2014-11-21 2020-11-10 Bristol-Myers Squibb Company Antikūnai, apimantys modifikuotas sunkiosios grandinės pastoviąsias sritis
KR102632418B1 (ko) 2014-11-25 2024-01-31 브리스톨-마이어스 스큅 컴퍼니 영상화를 위한 신규 pd-l1 결합 폴리펩티드
CN107531720A (zh) * 2015-01-08 2018-01-02 斯克利普斯研究院 抗癌症候选药物
JP2018510864A (ja) 2015-03-10 2018-04-19 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ トランスグルタミナーゼによって結合可能な抗体およびそれによって製造される結合体
UY36687A (es) 2015-05-29 2016-11-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Anticuerpos contra ox40 y sus usos
EP3353198B1 (en) 2015-09-23 2020-06-17 Bristol-Myers Squibb Company Glypican-3binding fibronectin based scafflold molecules
EP3165237B1 (en) 2015-11-03 2018-12-19 Industrial Technology Research Institute Antibody-drug conjugate (adc) and method for forming the same
KR20180089433A (ko) 2015-12-21 2018-08-08 브리스톨-마이어스 스큅 컴퍼니 부위-특이적 접합을 위한 변이체 항체
KR20220033522A (ko) 2016-03-04 2022-03-16 브리스톨-마이어스 스큅 컴퍼니 항-cd73 항체와의 조합 요법
CN106267188B (zh) * 2016-08-15 2025-06-17 深圳大学 小分子免疫激动剂偶联pd-1抗体的新型抗体及其在抗肿瘤中的应用
US20190218294A1 (en) 2016-09-09 2019-07-18 Bristol-Myers Squibb Company Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
CN110719915A (zh) 2017-05-25 2020-01-21 百时美施贵宝公司 包含经修饰的重链恒定区的抗体
WO2019110725A1 (en) * 2017-12-06 2019-06-13 Synaffix B.V. Enediyne conjugates
CN110183659B (zh) * 2018-02-21 2022-04-26 香港科技大学 含有杂环的聚合物、其制备方法及其应用
EP3887397A1 (en) 2018-11-28 2021-10-06 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
RS64205B1 (sr) 2018-11-30 2023-06-30 Bristol Myers Squibb Co Antitelo koje sadrži c-terminalnu ekstenziju lakog lanca koja sadrži glutamin, njegovi konjugati, i postupci i primene
JP7514836B2 (ja) 2018-12-12 2024-07-11 ブリストル－マイヤーズ スクイブ カンパニー トランスグルタミナーゼによるコンジュゲーションのための改変抗体、ならびにそのコンジュゲート、方法および用途
CA3140716A1 (en) * 2019-05-22 2020-11-26 Board Of Regents, The University Of Texas System Functionalized gold carbene naphthoquinone complexes for use in the treatment of cancer
US20240377413A1 (en) 2019-09-16 2024-11-14 Bristol-Myers Squibb Company Dual capture method for analysis of antibody-drug conjugates
MX2023014899A (es) 2021-06-28 2024-04-29 Byondis Bv Nuevos conjugados que comprenden fosfoantígenos y su uso en terapia.

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Also Published As

Publication number Publication date
HRP20170334T1 (hr) 2017-04-21
JP2015508074A (ja) 2015-03-16
CO7061078A2 (es) 2014-09-19
MX2014009234A (es) 2014-11-10
AU2013221873A1 (en) 2014-10-02
CN104220441A (zh) 2014-12-17
IL233965B (en) 2018-01-31
PL2814829T3 (pl) 2017-06-30
EP2814829B1 (en) 2016-12-07
HUE033704T2 (en) 2017-12-28
PE20141791A1 (es) 2014-11-19
CY1118899T1 (el) 2018-01-10
HK1204326A1 (en) 2015-11-13
US8709431B2 (en) 2014-04-29
MX350539B (es) 2017-09-08
TW201336851A (zh) 2013-09-16
EA201491447A1 (ru) 2014-11-28
CN104220441B (zh) 2017-03-29
AU2013221873B2 (en) 2016-11-17
WO2013122823A1 (en) 2013-08-22
KR20140120374A (ko) 2014-10-13
SMT201700137T1 (it) 2017-05-08
ZA201406723B (en) 2016-05-25
US9156850B2 (en) 2015-10-13
KR101660146B1 (ko) 2016-09-26
EA027925B1 (ru) 2017-09-29
SI2814829T1 (sl) 2017-02-28
RS55763B1 (sr) 2017-07-31
AR089972A1 (es) 2014-10-01
CA2864420A1 (en) 2013-08-22
BR112014019990A8 (pt) 2017-07-11
JP6113194B2 (ja) 2017-04-12
CL2014002096A1 (es) 2014-11-28
US20130209494A1 (en) 2013-08-15
ES2615268T3 (es) 2017-06-06
SG11201404667XA (en) 2014-09-26
PT2814829T (pt) 2017-02-15
US20140193438A1 (en) 2014-07-10
LT2814829T (lt) 2017-02-27
DK2814829T3 (en) 2017-03-20
CA2864420C (en) 2016-11-15
EP2814829A1 (en) 2014-12-24

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements