EA027925B1 - Ендиины, их конъюгаты и способы их получения и применения - Google Patents

Ендиины, их конъюгаты и способы их получения и применения Download PDF

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Publication number
EA027925B1
EA027925B1 EA201491447A EA201491447A EA027925B1 EA 027925 B1 EA027925 B1 EA 027925B1 EA 201491447 A EA201491447 A EA 201491447A EA 201491447 A EA201491447 A EA 201491447A EA 027925 B1 EA027925 B1 EA 027925B1
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EA
Eurasian Patent Office
Prior art keywords
compound
antibody
cancer
group
alkyl
Prior art date
Application number
EA201491447A
Other languages
English (en)
Russian (ru)
Other versions
EA201491447A1 (ru
Inventor
Найду С. Чоудари
Санжив Гангвар
Билал Суфи
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47722570&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA027925(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201491447A1 publication Critical patent/EA201491447A1/ru
Publication of EA027925B1 publication Critical patent/EA027925B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EA201491447A 2012-02-13 2013-02-08 Ендиины, их конъюгаты и способы их получения и применения EA027925B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261598143P 2012-02-13 2012-02-13
US201261653785P 2012-05-31 2012-05-31
PCT/US2013/025247 WO2013122823A1 (en) 2012-02-13 2013-02-08 Enediyne compounds, conjugates thereof, and uses and methods therefor

Publications (2)

Publication Number Publication Date
EA201491447A1 EA201491447A1 (ru) 2014-11-28
EA027925B1 true EA027925B1 (ru) 2017-09-29

Family

ID=47722570

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491447A EA027925B1 (ru) 2012-02-13 2013-02-08 Ендиины, их конъюгаты и способы их получения и применения

Country Status (31)

Country Link
US (2) US8709431B2 (enExample)
EP (1) EP2814829B1 (enExample)
JP (1) JP6113194B2 (enExample)
KR (1) KR101660146B1 (enExample)
CN (1) CN104220441B (enExample)
AR (1) AR089972A1 (enExample)
AU (1) AU2013221873B2 (enExample)
BR (1) BR112014019990A8 (enExample)
CA (1) CA2864420C (enExample)
CL (1) CL2014002096A1 (enExample)
CO (1) CO7061078A2 (enExample)
CY (1) CY1118899T1 (enExample)
DK (1) DK2814829T3 (enExample)
EA (1) EA027925B1 (enExample)
ES (1) ES2615268T3 (enExample)
HK (1) HK1204326A1 (enExample)
HR (1) HRP20170334T1 (enExample)
HU (1) HUE033704T2 (enExample)
IL (1) IL233965B (enExample)
LT (1) LT2814829T (enExample)
MX (1) MX350539B (enExample)
PE (1) PE20141791A1 (enExample)
PL (1) PL2814829T3 (enExample)
PT (1) PT2814829T (enExample)
RS (1) RS55763B1 (enExample)
SG (1) SG11201404667XA (enExample)
SI (1) SI2814829T1 (enExample)
SM (1) SMT201700137T1 (enExample)
TW (1) TW201336851A (enExample)
WO (1) WO2013122823A1 (enExample)
ZA (1) ZA201406723B (enExample)

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JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
JP6474404B2 (ja) 2013-08-14 2019-02-27 ウィリアム マーシュ ライス ユニバーシティＷｉｌｌｉａｍ Ｍａｒｓｈ Ｒｉｃｅ Ｕｎｉｖｅｒｓｉｔｙ ウンシアラマイシン誘導体、合成方法、および抗腫瘍薬としてのそれらの使用
SG11201607818WA (en) 2014-03-20 2016-10-28 Bristol Myers Squibb Co Stabilized fibronectin based scaffold molecules
JP6805142B2 (ja) 2014-11-21 2020-12-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃｄ７３に対する抗体およびその使用
ES2826566T3 (es) 2014-11-21 2021-05-18 Bristol Myers Squibb Co Anticuerpos que comprenden regiones constantes pesadas modificadas
JP6622814B2 (ja) 2014-11-25 2019-12-18 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ イメージングのための新規ｐｄ−ｌ１結合ポリペプチド
CN107531720A (zh) * 2015-01-08 2018-01-02 斯克利普斯研究院 抗癌症候选药物
ES2736106T3 (es) 2015-03-10 2019-12-26 Bristol Myers Squibb Co Anticuerpos que se pueden conjugar mediante la transglutaminasa y conjugados producidos a partir de ellos
AU2016271111B2 (en) 2015-05-29 2022-04-28 Bristol-Myers Squibb Company Antibodies against OX40 and uses thereof
EP3353198B1 (en) 2015-09-23 2020-06-17 Bristol-Myers Squibb Company Glypican-3binding fibronectin based scafflold molecules
TWI660741B (zh) 2015-11-03 2019-06-01 財團法人工業技術研究院 抗體藥物複合物及其製造方法
EP3394096A1 (en) 2015-12-21 2018-10-31 Bristol-Myers Squibb Company Variant antibodies for site-specific conjugation
AU2017228470A1 (en) 2016-03-04 2018-08-30 Bristol-Myers Squibb Company Combination therapy with anti-CD73 antibodies
CN106267188B (zh) * 2016-08-15 2025-06-17 深圳大学 小分子免疫激动剂偶联pd-1抗体的新型抗体及其在抗肿瘤中的应用
US20190218294A1 (en) 2016-09-09 2019-07-18 Bristol-Myers Squibb Company Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
MX2019013132A (es) 2017-05-25 2020-01-27 Bristol Myers Squibb Co Anticuerpos que comprenden regiones constantes pesadas modificadas.
EP3720504A1 (en) * 2017-12-06 2020-10-14 Synaffix B.V. Enediyne conjugates
CN110183659B (zh) * 2018-02-21 2022-04-26 香港科技大学 含有杂环的聚合物、其制备方法及其应用
JP2022513653A (ja) 2018-11-28 2022-02-09 ブリストル－マイヤーズ スクイブ カンパニー 修飾された重鎖定常領域を含む抗体
DK3886914T3 (da) 2018-11-30 2023-07-03 Bristol Myers Squibb Co Antistof omfattende en glutaminholdig letkæde-c-terminal forlængelse, konjugater deraf og fremgangsmåder samt anvendelser
WO2020123425A2 (en) 2018-12-12 2020-06-18 Bristol-Myers Squibb Company Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses
WO2020237225A1 (en) 2019-05-22 2020-11-26 Board Of Regents, The University Of Texas System Functionalized gold carbene naphthoquinone complexes for use in the treatment of cancer
US20240377413A1 (en) 2019-09-16 2024-11-14 Bristol-Myers Squibb Company Dual capture method for analysis of antibody-drug conjugates
MX2023014899A (es) 2021-06-28 2024-04-29 Byondis Bv Nuevos conjugados que comprenden fosfoantígenos y su uso en terapia.

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Also Published As

Publication number Publication date
RS55763B1 (sr) 2017-07-31
US8709431B2 (en) 2014-04-29
AU2013221873B2 (en) 2016-11-17
CL2014002096A1 (es) 2014-11-28
EA201491447A1 (ru) 2014-11-28
PL2814829T3 (pl) 2017-06-30
CN104220441B (zh) 2017-03-29
HUE033704T2 (en) 2017-12-28
CA2864420C (en) 2016-11-15
SI2814829T1 (sl) 2017-02-28
WO2013122823A1 (en) 2013-08-22
CO7061078A2 (es) 2014-09-19
TW201336851A (zh) 2013-09-16
KR101660146B1 (ko) 2016-09-26
ZA201406723B (en) 2016-05-25
SMT201700137T1 (it) 2017-05-08
ES2615268T3 (es) 2017-06-06
US20140193438A1 (en) 2014-07-10
HK1204326A1 (en) 2015-11-13
AU2013221873A1 (en) 2014-10-02
BR112014019990A8 (pt) 2017-07-11
EP2814829B1 (en) 2016-12-07
JP6113194B2 (ja) 2017-04-12
EP2814829A1 (en) 2014-12-24
PT2814829T (pt) 2017-02-15
US20130209494A1 (en) 2013-08-15
AR089972A1 (es) 2014-10-01
MX2014009234A (es) 2014-11-10
PE20141791A1 (es) 2014-11-19
SG11201404667XA (en) 2014-09-26
LT2814829T (lt) 2017-02-27
JP2015508074A (ja) 2015-03-16
MX350539B (es) 2017-09-08
KR20140120374A (ko) 2014-10-13
BR112014019990A2 (enExample) 2017-06-20
US9156850B2 (en) 2015-10-13
DK2814829T3 (en) 2017-03-20
CN104220441A (zh) 2014-12-17
IL233965B (en) 2018-01-31
CA2864420A1 (en) 2013-08-22
HRP20170334T1 (hr) 2017-04-21
CY1118899T1 (el) 2018-01-10

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