KR101485071B1 - 마이크로 rna를 이용한 근육 세포 증식 및 분화 조절방법과 근육 세포 치료방법 및 유전자 발현 억제방법그리고 마이크로 rna 분자의 발현용 벡터와 이를 이용한키트 및 미오사이트 - Google Patents
마이크로 rna를 이용한 근육 세포 증식 및 분화 조절방법과 근육 세포 치료방법 및 유전자 발현 억제방법그리고 마이크로 rna 분자의 발현용 벡터와 이를 이용한키트 및 미오사이트 Download PDFInfo
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- KR101485071B1 KR101485071B1 KR1020087017004A KR20087017004A KR101485071B1 KR 101485071 B1 KR101485071 B1 KR 101485071B1 KR 1020087017004 A KR1020087017004 A KR 1020087017004A KR 20087017004 A KR20087017004 A KR 20087017004A KR 101485071 B1 KR101485071 B1 KR 101485071B1
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- A61P5/00—Drugs for disorders of the endocrine system
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
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- C12N2310/3517—Marker; Tag
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- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
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- Biotechnology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Plant Pathology (AREA)
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- Neurology (AREA)
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- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74954405P | 2005-12-12 | 2005-12-12 | |
| US60/749,544 | 2005-12-12 | ||
| PCT/US2006/047255 WO2007070483A2 (en) | 2005-12-12 | 2006-12-12 | Micrornas that regulate muscle cell proliferation and differentiation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147028814A Division KR20140130562A (ko) | 2005-12-12 | 2006-12-12 | 마이크로 rna를 이용한 근육 세포 증식 및 분화 조절 방법과 근육 세포 치료방법 및 유전자 발현 억제방법 그리고 마이크로 rna 분자의 발현용 벡터와 이를 이용한 키트 및 미오사이트 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20080080177A KR20080080177A (ko) | 2008-09-02 |
| KR101485071B1 true KR101485071B1 (ko) | 2015-01-26 |
Family
ID=38163464
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087017004A Expired - Fee Related KR101485071B1 (ko) | 2005-12-12 | 2006-12-12 | 마이크로 rna를 이용한 근육 세포 증식 및 분화 조절방법과 근육 세포 치료방법 및 유전자 발현 억제방법그리고 마이크로 rna 분자의 발현용 벡터와 이를 이용한키트 및 미오사이트 |
| KR1020147028814A Ceased KR20140130562A (ko) | 2005-12-12 | 2006-12-12 | 마이크로 rna를 이용한 근육 세포 증식 및 분화 조절 방법과 근육 세포 치료방법 및 유전자 발현 억제방법 그리고 마이크로 rna 분자의 발현용 벡터와 이를 이용한 키트 및 미오사이트 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147028814A Ceased KR20140130562A (ko) | 2005-12-12 | 2006-12-12 | 마이크로 rna를 이용한 근육 세포 증식 및 분화 조절 방법과 근육 세포 치료방법 및 유전자 발현 억제방법 그리고 마이크로 rna 분자의 발현용 벡터와 이를 이용한 키트 및 미오사이트 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8431542B2 (enExample) |
| EP (3) | EP2671949A1 (enExample) |
| JP (3) | JP2009519339A (enExample) |
| KR (2) | KR101485071B1 (enExample) |
| CN (2) | CN101448942B (enExample) |
| AU (1) | AU2006326517B2 (enExample) |
| BR (1) | BRPI0619755A2 (enExample) |
| CA (2) | CA2634046A1 (enExample) |
| DK (1) | DK1969125T3 (enExample) |
| ES (1) | ES2387250T3 (enExample) |
| NZ (3) | NZ569738A (enExample) |
| PL (1) | PL1969125T3 (enExample) |
| PT (1) | PT1969125E (enExample) |
| WO (1) | WO2007070483A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9072764B2 (en) | 2005-12-12 | 2015-07-07 | The University Of North Carolina At Chapel Hill | MicroRNAs that regulate muscle cell proliferation and differentiation |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006107826A2 (en) | 2005-04-04 | 2006-10-12 | The Board Of Regents Of The University Of Texas System | Micro-rna's that regulate muscle cells |
| EP2434017A3 (en) | 2006-08-01 | 2012-09-05 | Board of Regents of the University of Texas System | Identification of a micro-RNA that activates expression of beta-myosin heavy chain |
| GB2440782A (en) * | 2006-08-04 | 2008-02-13 | Cesare Peschle | Uses and compositions comprising miRNAs |
| HUE037173T2 (hu) | 2006-08-08 | 2018-08-28 | Univ Bonn Rheinische Friedrich Wilhelms | 5'-Foszfát-oligonukleotidok szerkezete és alkalmazása |
| CA2728575A1 (en) | 2007-06-29 | 2009-01-08 | Boston Biomedical, Inc. | Enabling the use of long dsrna for gene targeting in mammalian and other selected animal cells |
| WO2009018492A2 (en) * | 2007-07-31 | 2009-02-05 | The Board Of Regents Of The University Of Texas System | Micro-rnas that control myosin expression and myofiber identity |
| ES2621161T3 (es) * | 2007-07-31 | 2017-07-03 | The Board Of Regents Of The University Of Texas System | Familia de micro-ARN que modula la fibrosis y usos de la misma |
| CA2716343A1 (en) * | 2008-02-21 | 2009-08-27 | The Board Of Regents Of The University Of Texas System | Micro-rnas that modulate smooth muscle proliferation and differentiation and uses thereof |
| CA2718520C (en) * | 2008-03-17 | 2020-01-07 | The Board Of Regents Of The University Of Texas System | Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration |
| EP2297323A1 (en) | 2008-05-21 | 2011-03-23 | Hartmann, Gunther | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| AU2009257663B2 (en) * | 2008-06-09 | 2014-06-26 | New York Medical College | Compositions comprising cardiac stem cells overexpressing specific microRNA and methods of their use in repairing damaged myocardium |
| GB0811715D0 (en) * | 2008-06-26 | 2008-07-30 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| MX2011008190A (es) | 2009-02-04 | 2011-10-06 | Univ Texas | Direccionamiento dual de mir-208 y mir-499 en el tratamiento de trastornos cardiacos. |
| DK2427472T3 (en) | 2009-05-05 | 2016-09-12 | Miragen Therapeutics | Lipophilic polynukleotidkonjugater |
| EP2435570A1 (en) * | 2009-05-25 | 2012-04-04 | Carola Ponzetto | Differentiation therapy for sarcomas |
| US20130034850A1 (en) * | 2010-02-26 | 2013-02-07 | Natinal Center of Neurology and Psychiatry | Marker for detecting myogenic disease and detection method using the same |
| KR20130069587A (ko) * | 2010-04-08 | 2013-06-26 | 교토후고리츠다이가쿠호진 | 체액 유래 검체를 사용한 횡문근육종의 검출 방법 |
| US9987309B2 (en) * | 2010-07-08 | 2018-06-05 | Duke University | Direct reprogramming of cells to cardiac myocyte fate |
| KR101235256B1 (ko) * | 2010-09-13 | 2013-02-21 | 서울대학교산학협력단 | miRNA를 타겟으로 한 신경퇴행성 질환 치료 |
| AU2011323085B2 (en) | 2010-11-05 | 2014-10-30 | Miragen Therapeutics | Base modified oligonucleotides |
| EP2638158A4 (en) * | 2010-11-11 | 2015-07-15 | Univ Miami | COMPOSITIONS, CELLS, KITS AND METHODS FOR AUTOLOGOUS STEM CELL THERAPY |
| US8642751B2 (en) | 2010-12-15 | 2014-02-04 | Miragen Therapeutics | MicroRNA inhibitors comprising locked nucleotides |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| CN103814131A (zh) * | 2011-05-09 | 2014-05-21 | 格拉斯哥大学理事会 | 在肺动脉高血压的治疗中调控microrna的方法 |
| US20140221464A1 (en) * | 2011-07-01 | 2014-08-07 | Board Of Regents, The University Of Texas System | Compositions and Methods for Treating Skeletal Myopathy |
| EP2731422B1 (en) * | 2011-07-12 | 2017-08-09 | Mart Saarma | miRNA antagonists for use in treating neurodegenerative disorders by increasing expression of GDNF |
| US9018188B2 (en) | 2011-09-13 | 2015-04-28 | Ottawa Hospital Research Institute | MicroRNA inhibitors |
| US9428749B2 (en) * | 2011-10-06 | 2016-08-30 | The Board Of Regents, The University Of Texas System | Control of whole body energy homeostasis by microRNA regulation |
| JP6208228B2 (ja) | 2012-06-21 | 2017-10-04 | ミラゲン セラピューティクス, インコーポレイテッド | ロックド核酸モチーフを含むオリゴヌクレオチドベースの阻害剤 |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| US9752143B2 (en) | 2013-03-15 | 2017-09-05 | MiRagen Therapeutics, Inc. | Locked nucleic acid inhibitor of miR-145 and uses thereof |
| EP2970968B1 (en) | 2013-03-15 | 2018-01-10 | Miragen Therapeutics, Inc. | Bridged bicyclic nucleosides |
| WO2014201254A1 (en) * | 2013-06-12 | 2014-12-18 | University Of Washington Through Its Center For Commercialization | Methods for maturing cardiomyocytes and uses thereof |
| CN103710387B (zh) * | 2013-12-25 | 2015-10-14 | 天津农学院 | 一种促进牛骨骼肌卫星细胞体外增殖的方法 |
| JP6566536B2 (ja) * | 2014-06-16 | 2019-08-28 | 国立大学法人山口大学 | フォワードプライマー |
| CN104498497A (zh) * | 2014-12-10 | 2015-04-08 | 山东农业大学 | 一种与奶山羊乳腺上皮细胞凋亡相关的miRNA及其在奶山羊育种中的应用 |
| US10620109B2 (en) | 2015-01-14 | 2020-04-14 | Kyoto University | Method for selecting skeletal muscle progenitor cell |
| EP3247716A4 (en) | 2015-01-20 | 2018-10-17 | Miragen Therapeutics, Inc. | Mir-92 inhibitors and uses thereof |
| CN104877960B (zh) * | 2015-06-01 | 2017-09-19 | 东北农业大学 | miR‑2400显著促进牛骨骼肌卫星细胞增殖的生物功能 |
| CN117757794A (zh) | 2016-03-07 | 2024-03-26 | 美国政府(由卫生和人类服务部的部长所代表) | 微小rna及其使用方法 |
| CN105713972A (zh) * | 2016-03-16 | 2016-06-29 | 上海中医药大学 | miRNA在制备药物性心脏病生物标志物中的用途 |
| CN106399473B (zh) * | 2016-08-23 | 2019-12-06 | 南京大学 | 检测和评价力量训练效果的miRNA标志物或其组合及其应用 |
| EP3527212A4 (en) * | 2016-10-13 | 2020-05-06 | National Center of Neurology and Psychiatry | Myogenesis inducing agent |
| WO2018080658A1 (en) * | 2016-10-27 | 2018-05-03 | Aalborg University | Therapeutic targeting of a microrna to treat duchenne muscular dystrophy |
| CN108324946B (zh) * | 2017-01-20 | 2022-02-18 | 上海市东方医院 | miRNA708、和/或301簇的微小RNA在改善心脏功能方面的应用 |
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| JP7318166B2 (ja) * | 2018-03-14 | 2023-08-01 | ベス イスラエル デアコネス メディカル センター | マイクロrna22の阻害剤 |
| CN108690846A (zh) * | 2018-04-17 | 2018-10-23 | 上海大学 | 抑制MiR-29b基因表达的应用 |
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| CA3173567A1 (en) * | 2020-03-02 | 2021-09-10 | Tenaya Therapeutics, Inc. | Gene vector control by cardiomyocyte-expressed micrornas |
| EP4127175A4 (en) | 2020-04-02 | 2025-01-22 | Mirecule, Inc. | Targeted inhibition using engineered oligonucleotides |
| CN112266912A (zh) * | 2020-10-22 | 2021-01-26 | 上海大学 | 靶向miR-29b的gRNA、AAV8-CRISPR/Cas9系统及其应用 |
| WO2023034966A1 (en) * | 2021-09-03 | 2023-03-09 | The University Of North Carolina At Chapel Hill | Compositions and methods of using the same for treating disorders associated with thymosin βeta 4 |
| CN114480672B (zh) * | 2022-02-22 | 2023-08-15 | 青岛农业大学 | 一种通过miR-145筛选高产肉率碱地黑牛的方法 |
| CN114748497B (zh) * | 2022-04-27 | 2024-10-18 | 广州市妇女儿童医疗中心 | 一种调控子宫肌收缩的miRNA分子miR-206及其应用 |
| CN115181722B (zh) * | 2022-08-30 | 2024-06-11 | 江苏农牧科技职业学院 | 一种鹅骨骼肌卫星细胞的体外分离和培养方法 |
| CN117511884B (zh) * | 2023-12-06 | 2024-06-11 | 中国农业科学院兰州畜牧与兽药研究所 | Rtl1在抑制牦牛成肌细胞分化中的应用 |
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