CN104027818A - 调节肌细胞增殖和分化的microrna - Google Patents

调节肌细胞增殖和分化的microrna Download PDF

Info

Publication number
CN104027818A
CN104027818A CN201410112733.4A CN201410112733A CN104027818A CN 104027818 A CN104027818 A CN 104027818A CN 201410112733 A CN201410112733 A CN 201410112733A CN 104027818 A CN104027818 A CN 104027818A
Authority
CN
China
Prior art keywords
mir
sequence
expression
mirna
muscle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410112733.4A
Other languages
English (en)
Chinese (zh)
Inventor
王大之
陈健夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Publication of CN104027818A publication Critical patent/CN104027818A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/113Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141MicroRNAs, miRNAs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • C12N2310/3517Marker; Tag
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00Production
    • C12N2330/10Production naturally occurring

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201410112733.4A 2005-12-12 2006-12-12 调节肌细胞增殖和分化的microrna Pending CN104027818A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74954405P 2005-12-12 2005-12-12
US60/749,544 2005-12-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200680052681.XA Division CN101448942B (zh) 2005-12-12 2006-12-12 调节肌细胞增殖和分化的microrna

Publications (1)

Publication Number Publication Date
CN104027818A true CN104027818A (zh) 2014-09-10

Family

ID=38163464

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200680052681.XA Expired - Fee Related CN101448942B (zh) 2005-12-12 2006-12-12 调节肌细胞增殖和分化的microrna
CN201410112733.4A Pending CN104027818A (zh) 2005-12-12 2006-12-12 调节肌细胞增殖和分化的microrna

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN200680052681.XA Expired - Fee Related CN101448942B (zh) 2005-12-12 2006-12-12 调节肌细胞增殖和分化的microrna

Country Status (14)

Country Link
US (3) US8431542B2 (enExample)
EP (3) EP1969125B1 (enExample)
JP (3) JP2009519339A (enExample)
KR (2) KR101485071B1 (enExample)
CN (2) CN101448942B (enExample)
AU (1) AU2006326517B2 (enExample)
BR (1) BRPI0619755A2 (enExample)
CA (2) CA2903764A1 (enExample)
DK (1) DK1969125T3 (enExample)
ES (1) ES2387250T3 (enExample)
NZ (3) NZ602571A (enExample)
PL (1) PL1969125T3 (enExample)
PT (1) PT1969125E (enExample)
WO (1) WO2007070483A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104498497A (zh) * 2014-12-10 2015-04-08 山东农业大学 一种与奶山羊乳腺上皮细胞凋亡相关的miRNA及其在奶山羊育种中的应用
CN104877960A (zh) * 2015-06-01 2015-09-02 东北农业大学 miR-2400显著促进牛骨骼肌卫星细胞增殖的生物功能
CN105713972A (zh) * 2016-03-16 2016-06-29 上海中医药大学 miRNA在制备药物性心脏病生物标志物中的用途
CN108324946A (zh) * 2017-01-20 2018-07-27 上海市东方医院 miRNA708、和/或301簇的微小RNA在改善心脏功能方面的应用
CN108823209A (zh) * 2018-07-18 2018-11-16 华中农业大学 骨骼肌特异性启动子及应用
CN112119159A (zh) * 2018-03-14 2020-12-22 贝斯以色列女执事医疗中心 micro-RNA和肥胖

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006107826A2 (en) 2005-04-04 2006-10-12 The Board Of Regents Of The University Of Texas System Micro-rna's that regulate muscle cells
AU2006326517B2 (en) 2005-12-12 2013-02-21 The University Of North Carolina At Chapel Hill MicroRNAs that regulate muscle cell proliferation and differentiation
KR101485495B1 (ko) 2006-08-01 2015-01-22 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 베타-마이오신 중사슬의 발현을 활성화하는 마이크로-rna의 동정
GB2440782A (en) * 2006-08-04 2008-02-13 Cesare Peschle Uses and compositions comprising miRNAs
HUE037173T2 (hu) 2006-08-08 2018-08-28 Univ Bonn Rheinische Friedrich Wilhelms 5'-Foszfát-oligonukleotidok szerkezete és alkalmazása
CN107129957A (zh) 2007-06-29 2017-09-05 北京强新生物科技有限公司 促使长dsRNA可用于哺乳动物和其他所选动物细胞中的基因寻靶
WO2009018493A1 (en) * 2007-07-31 2009-02-05 The Board Of Regents Of The University Of Texas System A micro-rna family that modulates fibrosis and uses thereof
CN101808649B (zh) * 2007-07-31 2014-05-21 得克萨斯系统大学董事会 控制肌球蛋白表达和肌纤维身份的微小rna
US7994150B2 (en) * 2008-02-21 2011-08-09 Board Of Regents, The University Of Texas System Micro-RNAs that modulate smooth muscle proliferation and differentiation and uses thereof
US8202848B2 (en) 2008-03-17 2012-06-19 Board Of Regents, The University Of Texas System Identification of micro-RNAS involved in neuromuscular synapse maintenance and regeneration
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
EP2303292A4 (en) 2008-06-09 2013-01-02 New York Medical College COMPOSITIONS WITH CARDIAL STEM CELLS WITH OVEREXPRESSION OF SPECIFIC MICRORNAS AND METHOD FOR THEIR USE IN THE REPAIR OF THE CARED MYOCARDIC
GB0811715D0 (en) * 2008-06-26 2008-07-30 Angeletti P Ist Richerche Bio Therapeutic agents
CA2751489A1 (en) 2009-02-04 2010-08-12 Board Of Regents, The University Of Texas System Dual targeting of mir-208 and mir-499 in the treatment of cardiac disorders
EP2427472B1 (en) 2009-05-05 2016-06-22 Miragen Therapeutics Lipophilic polynucleotide conjugates
CA2762303A1 (en) * 2009-05-25 2010-12-02 Carola Ponzetto Differentiation therapy for sarcomas
EP2540829B1 (en) * 2010-02-26 2015-11-25 Lsip, Llc Marker for detection of myogenic diseases, and method for detection of the diseases using same
WO2011126089A1 (ja) * 2010-04-08 2011-10-13 京都府公立大学法人 体液由来検体を用いた横紋筋肉腫の検出方法
US9987309B2 (en) 2010-07-08 2018-06-05 Duke University Direct reprogramming of cells to cardiac myocyte fate
KR101235256B1 (ko) * 2010-09-13 2013-02-21 서울대학교산학협력단 miRNA를 타겟으로 한 신경퇴행성 질환 치료
JP5995855B2 (ja) * 2010-11-05 2016-09-21 ミラゲン セラピューティクス,インコーポレイテッド 塩基修飾オリゴヌクレオチド
WO2012065024A1 (en) * 2010-11-11 2012-05-18 University Of Miami Compositions, cells, kits and methods for autologous stem cell therapy
CA2817371A1 (en) 2010-12-15 2012-06-21 Miragen Therapeutics Microrna inhibitors comprising locked nucleotides
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
KR20140037868A (ko) * 2011-05-09 2014-03-27 더 유니버시티 코트 오브 더 유니버시티 오브 글래스고우 폐동맥 고혈압의 치료에서 마이크로rna를 조절하는 방법
CA2840222A1 (en) * 2011-07-01 2013-01-10 Board Of Regents, The University Of Texas System Compositions and methods for treating skeletal myopathy
US20140259192A1 (en) * 2011-07-12 2014-09-11 Sanofi Transgenic animal comprising a deletion or functional deletion of the 3'utr of an endogenous gene
WO2013037065A1 (en) * 2011-09-13 2013-03-21 Ottawa Hospital Research Institute Microrna inhibitors
US9428749B2 (en) * 2011-10-06 2016-08-30 The Board Of Regents, The University Of Texas System Control of whole body energy homeostasis by microRNA regulation
CN104685056A (zh) 2012-06-21 2015-06-03 米拉根医疗股份有限公司 包含锁核酸基序的基于寡核苷酸的抑制剂
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
WO2014145356A1 (en) 2013-03-15 2014-09-18 MiRagen Therapeutics, Inc. Bridged bicyclic nucleosides
JP6410791B2 (ja) 2013-03-15 2018-10-24 ミラゲン セラピューティクス, インコーポレイテッド Mir−145のロックト核酸阻害剤およびその使用
WO2014201254A1 (en) * 2013-06-12 2014-12-18 University Of Washington Through Its Center For Commercialization Methods for maturing cardiomyocytes and uses thereof
CN103710387B (zh) * 2013-12-25 2015-10-14 天津农学院 一种促进牛骨骼肌卫星细胞体外增殖的方法
JP6566536B2 (ja) * 2014-06-16 2019-08-28 国立大学法人山口大学 フォワードプライマー
US10620109B2 (en) 2015-01-14 2020-04-14 Kyoto University Method for selecting skeletal muscle progenitor cell
HK1249108A1 (zh) 2015-01-20 2018-10-26 米拉根医疗股份有限公司 Mir-92抑制剂及其用途
EP3426781B1 (en) 2016-03-07 2024-06-26 The United States of America, as represented by The Secretary, Department of Health and Human Services Micrornas and methods of their use
CN106399473B (zh) * 2016-08-23 2019-12-06 南京大学 检测和评价力量训练效果的miRNA标志物或其组合及其应用
WO2018070510A1 (ja) * 2016-10-13 2018-04-19 国立研究開発法人国立精神・神経医療研究センター 筋分化誘導剤
WO2018080658A1 (en) * 2016-10-27 2018-05-03 Aalborg University Therapeutic targeting of a microrna to treat duchenne muscular dystrophy
CN107096030A (zh) * 2017-03-20 2017-08-29 天津农学院 一种利用miR‑143抑制剂延缓小鼠失神经后肌肉萎缩的方法
US11365412B2 (en) 2017-04-05 2022-06-21 University Of Cincinnati Promotion of cardiomyocyte proliferation and regenerative treatment of the heart by inhibition of microRNA-128
WO2019035690A1 (ko) * 2017-08-18 2019-02-21 서울대학교병원 근육 질환 및 신경근육 질환 예방, 치료 또는 진단을 위한 miR-18b의 용도
KR102177130B1 (ko) 2017-08-18 2020-11-10 (주)큐라미스 근육 질환 및 신경근육 질환 예방, 치료 또는 진단을 위한 miR-18b의 용도
EP3720455A4 (en) * 2017-12-08 2021-09-22 The University of Washington METHODS AND COMPOSITIONS FOR DETECTING AND PROMOTING CARDIOLIPID REMODELING AND CARDIOMYOCYTE MATURATION AND RELATED METHODS FOR TREATING MITOCHONDRIAL DYSFUNCTION
CN108690846A (zh) * 2018-04-17 2018-10-23 上海大学 抑制MiR-29b基因表达的应用
SG11202102058UA (en) 2018-08-30 2021-03-30 Tenaya Therapeutics Inc Cardiac cell reprogramming with myocardin and ascl1
CN111041052B (zh) * 2019-12-30 2021-05-28 嘉兴学院 mir-206在抑制猪脂肪细胞内的甘油三酯生成以及瘦肉猪育种中的应用
EP4114421A1 (en) * 2020-03-02 2023-01-11 Tenaya Therapeutics, Inc. Gene vector control by cardiomyocyte-expressed micrornas
KR20230023612A (ko) 2020-04-02 2023-02-17 마이레큘, 인크. 조작된 올리고뉴클레오티드를 사용한 표적화된 억제
CN112266912A (zh) * 2020-10-22 2021-01-26 上海大学 靶向miR-29b的gRNA、AAV8-CRISPR/Cas9系统及其应用
WO2023034966A1 (en) * 2021-09-03 2023-03-09 The University Of North Carolina At Chapel Hill Compositions and methods of using the same for treating disorders associated with thymosin βeta 4
CN114480672B (zh) * 2022-02-22 2023-08-15 青岛农业大学 一种通过miR-145筛选高产肉率碱地黑牛的方法
CN114748497B (zh) * 2022-04-27 2024-10-18 广州市妇女儿童医疗中心 一种调控子宫肌收缩的miRNA分子miR-206及其应用
CN115181722B (zh) * 2022-08-30 2024-06-11 江苏农牧科技职业学院 一种鹅骨骼肌卫星细胞的体外分离和培养方法
CN117511884B (zh) * 2023-12-06 2024-06-11 中国农业科学院兰州畜牧与兽药研究所 Rtl1在抑制牦牛成肌细胞分化中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004076622A2 (en) * 2003-02-10 2004-09-10 National Institute Of Advanced Industrial Science And Technology Regulation of gene expression by dna interference
US20040242528A1 (en) * 2003-05-28 2004-12-02 Hagstrom James E. Intravenous delivery of polynucleotides to cells in mammalian limb
US20050059005A1 (en) * 2001-09-28 2005-03-17 Thomas Tuschl Microrna molecules
US20050124566A1 (en) * 2001-05-18 2005-06-09 Sirna Therapeutics, Inc. RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7781415B2 (en) * 2003-02-07 2010-08-24 Roche Madison Inc. Process for delivering sirna to cardiac muscle tissue
SE521643C2 (sv) * 2003-02-26 2003-11-18 Scania Cv Publ Kraftöverföring med från en huvudväxel skild rangeväxel
CA2857881A1 (en) * 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
WO2006107826A2 (en) 2005-04-04 2006-10-12 The Board Of Regents Of The University Of Texas System Micro-rna's that regulate muscle cells
US7338670B2 (en) 2005-04-14 2008-03-04 Duke University Use of an agent that restores tissue perfusion and oxygenation
AU2006326517B2 (en) 2005-12-12 2013-02-21 The University Of North Carolina At Chapel Hill MicroRNAs that regulate muscle cell proliferation and differentiation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050124566A1 (en) * 2001-05-18 2005-06-09 Sirna Therapeutics, Inc. RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)
US20050059005A1 (en) * 2001-09-28 2005-03-17 Thomas Tuschl Microrna molecules
WO2004076622A2 (en) * 2003-02-10 2004-09-10 National Institute Of Advanced Industrial Science And Technology Regulation of gene expression by dna interference
US20040242528A1 (en) * 2003-05-28 2004-12-02 Hagstrom James E. Intravenous delivery of polynucleotides to cells in mammalian limb

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAK KYUN KIM,ET AL: "Muscle-specifi c microRNA miR-206 promotes muscle differentiation", 《THE JOURNAL OF CELL BIOLOGY》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104498497A (zh) * 2014-12-10 2015-04-08 山东农业大学 一种与奶山羊乳腺上皮细胞凋亡相关的miRNA及其在奶山羊育种中的应用
CN104877960A (zh) * 2015-06-01 2015-09-02 东北农业大学 miR-2400显著促进牛骨骼肌卫星细胞增殖的生物功能
CN104877960B (zh) * 2015-06-01 2017-09-19 东北农业大学 miR‑2400显著促进牛骨骼肌卫星细胞增殖的生物功能
CN105713972A (zh) * 2016-03-16 2016-06-29 上海中医药大学 miRNA在制备药物性心脏病生物标志物中的用途
CN108324946A (zh) * 2017-01-20 2018-07-27 上海市东方医院 miRNA708、和/或301簇的微小RNA在改善心脏功能方面的应用
CN108324946B (zh) * 2017-01-20 2022-02-18 上海市东方医院 miRNA708、和/或301簇的微小RNA在改善心脏功能方面的应用
CN112119159A (zh) * 2018-03-14 2020-12-22 贝斯以色列女执事医疗中心 micro-RNA和肥胖
CN108823209A (zh) * 2018-07-18 2018-11-16 华中农业大学 骨骼肌特异性启动子及应用
CN108823209B (zh) * 2018-07-18 2021-04-09 华中农业大学 骨骼肌特异性启动子及应用

Also Published As

Publication number Publication date
EP1969125A2 (en) 2008-09-17
NZ569738A (en) 2012-03-30
PL1969125T3 (pl) 2012-11-30
AU2006326517A1 (en) 2007-06-21
US20130225665A1 (en) 2013-08-29
CN101448942B (zh) 2014-04-23
JP2014094943A (ja) 2014-05-22
US20100292297A1 (en) 2010-11-18
EP2671949A1 (en) 2013-12-11
AU2006326517B2 (en) 2013-02-21
EP1969125A4 (en) 2010-10-20
WO2007070483A9 (en) 2011-06-16
CN101448942A (zh) 2009-06-03
NZ593688A (en) 2013-01-25
ES2387250T3 (es) 2012-09-19
DK1969125T3 (da) 2012-07-23
KR20080080177A (ko) 2008-09-02
WO2007070483A2 (en) 2007-06-21
KR101485071B1 (ko) 2015-01-26
NZ602571A (en) 2014-03-28
KR20140130562A (ko) 2014-11-10
CA2903764A1 (en) 2007-06-21
WO2007070483A3 (en) 2008-07-24
BRPI0619755A2 (pt) 2011-10-18
US9072764B2 (en) 2015-07-07
EP2497827A1 (en) 2012-09-12
US8431542B2 (en) 2013-04-30
US20130225658A1 (en) 2013-08-29
JP5796027B2 (ja) 2015-10-21
JP5740460B2 (ja) 2015-06-24
JP2013126996A (ja) 2013-06-27
JP2009519339A (ja) 2009-05-14
CA2634046A1 (en) 2007-06-21
EP1969125B1 (en) 2012-06-13
PT1969125E (pt) 2012-08-16

Similar Documents

Publication Publication Date Title
US9072764B2 (en) MicroRNAs that regulate muscle cell proliferation and differentiation
Williams Functional aspects of animal microRNAs
EP2208499A1 (en) Nucleic acid capable of regulating the proliferation of cell
US9023821B2 (en) Use of MicroRNA for treating diseases associated with a dysfunction of the cilia in multiciliated epithelial cells
US20110020816A1 (en) Precursor miRNA loop-modulated target regulation
CA3134991A1 (en) Pharmaceutical composition for treating cancer comprising microrna as active ingredient
Nadeem et al. MicroRNAs: A new paradigm towards mechanistic insight of diseases.
WO2011111715A1 (ja) 細胞周期を制御する核酸
AU2013202293B2 (en) MicroRNAs that regulate muscle cell proliferation and differentiation
US20100305195A1 (en) microrna mediator of cardiomyopathy and heart failure
HK1192280A (en) Micro-rna mir-145 that regulate muscle cell proliferation and differentiation
MX2008007552A (es) Microacidos ribonucleicos que regulan la proliferacion y diferenciacion de celulas musculares
Tripathi et al. Noncoding RNAs in human health and diseases
Callis et al. miRNAs and Their Emerging Role in Cardiac Hypertrophy
Bhat Study of the role of miR-204 in photoreceptor development
Ge Regulation of skeletal myogenesis by the mTOR signaling network

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20140910