KR101482159B1 - 아자비시클로 옥탄 유도체, 이의 제조 방법 및 디펩티딜 펩티다아제 ⅳ의 저해제로서의 이의 용도 - Google Patents

아자비시클로 옥탄 유도체, 이의 제조 방법 및 디펩티딜 펩티다아제 ⅳ의 저해제로서의 이의 용도 Download PDF

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KR101482159B1
KR101482159B1 KR1020097017567A KR20097017567A KR101482159B1 KR 101482159 B1 KR101482159 B1 KR 101482159B1 KR 1020097017567 A KR1020097017567 A KR 1020097017567A KR 20097017567 A KR20097017567 A KR 20097017567A KR 101482159 B1 KR101482159 B1 KR 101482159B1
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group
compound
acid
alkyl
cyclopenta
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KR20090108093A (ko
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펭초 탕
지강 린
헤준 뤼
후키앙 자오
리 리
Original Assignee
샹하이 헨그루이 파마수티컬 컴퍼니 리미티드
장쑤 한서 파마슈티칼 캄파니 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
KR1020097017567A 2007-01-23 2007-10-30 아자비시클로 옥탄 유도체, 이의 제조 방법 및 디펩티딜 펩티다아제 ⅳ의 저해제로서의 이의 용도 Expired - Fee Related KR101482159B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNA2007100043308A CN101230058A (zh) 2007-01-23 2007-01-23 双环氮杂烷类衍生物、其制备方法及其在医药上的用途
CN200710004330.8 2007-01-23
PCT/CN2007/070990 WO2008089636A1 (en) 2007-01-23 2007-10-30 Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase iv

Publications (2)

Publication Number Publication Date
KR20090108093A KR20090108093A (ko) 2009-10-14
KR101482159B1 true KR101482159B1 (ko) 2015-01-13

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KR1020097017567A Expired - Fee Related KR101482159B1 (ko) 2007-01-23 2007-10-30 아자비시클로 옥탄 유도체, 이의 제조 방법 및 디펩티딜 펩티다아제 ⅳ의 저해제로서의 이의 용도

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Country Link
US (1) US8178575B2 (enExample)
EP (1) EP2133077B1 (enExample)
JP (1) JP5424256B2 (enExample)
KR (1) KR101482159B1 (enExample)
CN (2) CN101230058A (enExample)
AU (1) AU2007345133B8 (enExample)
BR (1) BRPI0719650A2 (enExample)
CA (1) CA2673164C (enExample)
MX (1) MX2009007765A (enExample)
RU (1) RU2447063C2 (enExample)
WO (1) WO2008089636A1 (enExample)

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CA2712352C (en) * 2008-01-23 2016-05-10 Jiangsu Hansoh Pharmaceutical Co., Ltd. Dicycloazaalkane derivates, preparation processes and medical uses thereof
CN101919851B (zh) * 2009-06-09 2012-02-08 江苏恒瑞医药股份有限公司 治疗哺乳动物包括人2型糖尿病的药物组合物
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013091539A1 (zh) * 2011-12-21 2013-06-27 江苏恒瑞医药股份有限公司 吡咯并六元杂芳环类衍生物、其制备方法及其在医药上的应用
CN102827064B (zh) * 2012-08-14 2014-01-29 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
CN102827063B (zh) * 2012-08-14 2014-06-25 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
CN103709150B (zh) * 2012-10-09 2017-06-30 江苏豪森药业集团有限公司 托西酸贝格列汀晶型及其制备方法和用途
IN2015DN03795A (enExample) 2012-10-24 2015-10-02 Inserm Inst Nat De La Santé Et De La Rech Médicale
US9540324B2 (en) 2013-09-26 2017-01-10 Luc Therapeutics, Inc. Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B
US10426818B2 (en) 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
JP6937828B2 (ja) 2016-11-23 2021-09-22 江蘇恒瑞医薬股▲ふん▼有限公司 ピロロ６員複素芳香環誘導体の製造方法、および中間体
CN111491920B (zh) * 2017-10-20 2024-01-30 范德比尔特大学 毒蕈碱性乙酰胆碱受体m4的拮抗剂
US11352344B2 (en) 2017-10-31 2022-06-07 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
SG11202005563YA (en) 2017-12-15 2020-07-29 Praxis Biotech LLC Inhibitors of fibroblast activation protein
CA3090130A1 (en) 2018-02-02 2019-08-08 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
JP2022514352A (ja) 2018-12-21 2022-02-10 プラクシス バイオテック エルエルシー 線維芽細胞活性化タンパク質の阻害剤
CN111620816B (zh) * 2020-05-27 2023-06-02 上海赛默罗生物科技有限公司 螺桨烷类衍生物、其制备方法、药物组合物和用途

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WO2006028961A2 (en) * 2004-09-03 2006-03-16 Athersys, Inc. Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators

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US20050227960A1 (en) * 2004-02-19 2005-10-13 Batt Douglas G Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
WO2006028961A2 (en) * 2004-09-03 2006-03-16 Athersys, Inc. Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators

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Also Published As

Publication number Publication date
CN101914092B (zh) 2012-12-26
JP2010516635A (ja) 2010-05-20
WO2008089636A1 (en) 2008-07-31
CN101230058A (zh) 2008-07-30
AU2007345133A1 (en) 2008-07-31
KR20090108093A (ko) 2009-10-14
AU2007345133B8 (en) 2013-05-02
EP2133077B1 (en) 2014-08-13
MX2009007765A (es) 2009-07-30
RU2447063C2 (ru) 2012-04-10
CA2673164A1 (en) 2008-07-31
RU2009124304A (ru) 2011-02-27
US8178575B2 (en) 2012-05-15
AU2007345133B2 (en) 2013-02-21
US20100016314A1 (en) 2010-01-21
HK1117164A1 (en) 2009-01-09
CN101914092A (zh) 2010-12-15
BRPI0719650A2 (pt) 2013-12-10
EP2133077A4 (en) 2010-12-22
JP5424256B2 (ja) 2014-02-26
CA2673164C (en) 2016-05-10
EP2133077A1 (en) 2009-12-16

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