AU2007345133B8 - Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV - Google Patents

Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV Download PDF

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Publication number
AU2007345133B8
AU2007345133B8 AU2007345133A AU2007345133A AU2007345133B8 AU 2007345133 B8 AU2007345133 B8 AU 2007345133B8 AU 2007345133 A AU2007345133 A AU 2007345133A AU 2007345133 A AU2007345133 A AU 2007345133A AU 2007345133 B8 AU2007345133 B8 AU 2007345133B8
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AU
Australia
Prior art keywords
alkyl
group
heteroaryl
aryl
heterocyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007345133A
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English (en)
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AU2007345133A1 (en
AU2007345133B2 (en
Inventor
Li Li
Zhigang Lin
Hejun Lu
Pengcho Tang
Fuqiang Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Hengrui Pharmaceutical Co Ltd
Jiangsu Hansoh Pharmaceutical Group Co Ltd
Original Assignee
Shanghai Hengrui Pharmaceutical Co Ltd
Jiangsu Hansoh Pharmaceutical Co Ltd
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Publication of AU2007345133A1 publication Critical patent/AU2007345133A1/en
Assigned to JIANGSU HANSOH PHARMACEUTICAL CO., LTD., SHANGHAI HENGRUI PHARMACEUTICAL CO.LTD. reassignment JIANGSU HANSOH PHARMACEUTICAL CO., LTD. Request for Assignment Assignors: SHANGHAI HENGRUI PHARMACEUTICAL CO.LTD.
Publication of AU2007345133B2 publication Critical patent/AU2007345133B2/en
Application granted granted Critical
Publication of AU2007345133B8 publication Critical patent/AU2007345133B8/en
Ceased legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
AU2007345133A 2007-01-23 2007-10-30 Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV Ceased AU2007345133B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200710004330.8 2007-01-23
CNA2007100043308A CN101230058A (zh) 2007-01-23 2007-01-23 双环氮杂烷类衍生物、其制备方法及其在医药上的用途
PCT/CN2007/070990 WO2008089636A1 (en) 2007-01-23 2007-10-30 Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase iv

Publications (3)

Publication Number Publication Date
AU2007345133A1 AU2007345133A1 (en) 2008-07-31
AU2007345133B2 AU2007345133B2 (en) 2013-02-21
AU2007345133B8 true AU2007345133B8 (en) 2013-05-02

Family

ID=39644101

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007345133A Ceased AU2007345133B8 (en) 2007-01-23 2007-10-30 Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV

Country Status (11)

Country Link
US (1) US8178575B2 (enExample)
EP (1) EP2133077B1 (enExample)
JP (1) JP5424256B2 (enExample)
KR (1) KR101482159B1 (enExample)
CN (2) CN101230058A (enExample)
AU (1) AU2007345133B8 (enExample)
BR (1) BRPI0719650A2 (enExample)
CA (1) CA2673164C (enExample)
MX (1) MX2009007765A (enExample)
RU (1) RU2447063C2 (enExample)
WO (1) WO2008089636A1 (enExample)

Families Citing this family (25)

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Publication number Priority date Publication date Assignee Title
US8304411B2 (en) 2008-01-23 2012-11-06 Jiangsu Hansoh Pharmaceutical Co., Ltd. Dicycloazaalkane derivates, preparation processes and medical uses thereof
CN101919851B (zh) * 2009-06-09 2012-02-08 江苏恒瑞医药股份有限公司 治疗哺乳动物包括人2型糖尿病的药物组合物
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
PL2796460T3 (pl) * 2011-12-21 2018-12-31 Jiangsu Hengrui Medicine Co. Ltd. Sześcioczłonowa pirolowa heteroarylowa pochodna pierścieniowa, sposób jej otrzymywania i zastosowania medyczne
CN102827063B (zh) * 2012-08-14 2014-06-25 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
CN102827064B (zh) * 2012-08-14 2014-01-29 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
CN103709150B (zh) * 2012-10-09 2017-06-30 江苏豪森药业集团有限公司 托西酸贝格列汀晶型及其制备方法和用途
WO2014064215A1 (en) 2012-10-24 2014-05-01 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL
EP3461827B1 (en) 2013-09-26 2022-02-23 Cadent Therapeutics, Inc. Selective octahydro-cyclopenta[c]pyrrole negative modulators of nr2b
WO2016151018A1 (en) 2015-03-24 2016-09-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Method and pharmaceutical composition for use in the treatment of diabetes
BR112019008812A2 (pt) 2016-11-23 2019-07-16 Jiangsu Hengrui Medicine Co método de preparação para e intermediário de derivado de pirrolo anel heteroaromático de seis elementos
AU2018300980A1 (en) 2017-07-12 2020-01-02 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
ES3064093T3 (en) 2017-10-20 2026-04-22 Univ Vanderbilt Antagonists of the muscarinic acetylcholine receptor m4
AU2018360581A1 (en) 2017-10-31 2020-06-11 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
IL275333B2 (en) 2017-12-15 2023-09-01 Praxis Biotech LLC Inhibitors of fibroblast activation protein
US11414406B2 (en) 2018-02-02 2022-08-16 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
CN113811529A (zh) 2018-12-21 2021-12-17 普拉西斯生物技术有限责任公司 成纤维细胞激活蛋白抑制剂
CN111620816B (zh) * 2020-05-27 2023-06-02 上海赛默罗生物科技有限公司 螺桨烷类衍生物、其制备方法、药物组合物和用途

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US5736550A (en) * 1994-05-18 1998-04-07 Nisshin Flour Milling Co., Ltd. Pyrimidine derivatives
WO2004087142A1 (en) * 2003-04-04 2004-10-14 Novartis Ag Quinoline-2-one-derivatives for the treatment of airways diseases
US20050227960A1 (en) * 2004-02-19 2005-10-13 Batt Douglas G Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
WO2006028961A2 (en) * 2004-09-03 2006-03-16 Athersys, Inc. Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators

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US6110949A (en) 1999-06-24 2000-08-29 Novartis Ag N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
US6395767B2 (en) * 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
HUP0200849A2 (hu) * 2002-03-06 2004-08-30 Sanofi-Synthelabo N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
TW200401635A (en) * 2002-07-23 2004-02-01 Yamanouchi Pharma Co Ltd 2-Cyano-4-fluoropyrrolidine derivative or salt thereof
WO2004080966A1 (ja) * 2003-03-14 2004-09-23 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
GB0307856D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Organic compounds
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Patent Citations (5)

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US5736550A (en) * 1994-05-18 1998-04-07 Nisshin Flour Milling Co., Ltd. Pyrimidine derivatives
EP0760368B1 (en) * 1994-05-18 1999-07-28 Nisshin Flour Milling Co., Ltd. Pyrimidine derivatives
WO2004087142A1 (en) * 2003-04-04 2004-10-14 Novartis Ag Quinoline-2-one-derivatives for the treatment of airways diseases
US20050227960A1 (en) * 2004-02-19 2005-10-13 Batt Douglas G Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
WO2006028961A2 (en) * 2004-09-03 2006-03-16 Athersys, Inc. Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators

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Also Published As

Publication number Publication date
AU2007345133A1 (en) 2008-07-31
AU2007345133B2 (en) 2013-02-21
EP2133077A1 (en) 2009-12-16
HK1117164A1 (en) 2009-01-09
EP2133077A4 (en) 2010-12-22
CN101230058A (zh) 2008-07-30
RU2447063C2 (ru) 2012-04-10
KR20090108093A (ko) 2009-10-14
US8178575B2 (en) 2012-05-15
BRPI0719650A2 (pt) 2013-12-10
US20100016314A1 (en) 2010-01-21
WO2008089636A1 (en) 2008-07-31
JP2010516635A (ja) 2010-05-20
CN101914092B (zh) 2012-12-26
CA2673164A1 (en) 2008-07-31
CN101914092A (zh) 2010-12-15
KR101482159B1 (ko) 2015-01-13
CA2673164C (en) 2016-05-10
EP2133077B1 (en) 2014-08-13
RU2009124304A (ru) 2011-02-27
MX2009007765A (es) 2009-07-30
JP5424256B2 (ja) 2014-02-26

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Legal Events

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PC1 Assignment before grant (sect. 113)

Owner name: JIANGSU HANSOH PHARMACEUTICAL CO., LTD.; SHANGHAI

Free format text: FORMER APPLICANT(S): SHANGHAI HENGRUI PHARMACEUTICAL CO.LTD.

TH Corrigenda

Free format text: IN VOL 27 , NO 7 , PAGE(S) 1007 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME JIANGSU HANSOH PHARMACEUTICAL CO., LTD., APPLICATION NO. 2007345133, UNDER INID (71) CORRECT THE CO-APPLICANT TO READ SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired