KR101296099B1 - 항균성 아미노글리코사이드 동족체 - Google Patents
항균성 아미노글리코사이드 동족체 Download PDFInfo
- Publication number
- KR101296099B1 KR101296099B1 KR1020107012835A KR20107012835A KR101296099B1 KR 101296099 B1 KR101296099 B1 KR 101296099B1 KR 1020107012835 A KR1020107012835 A KR 1020107012835A KR 20107012835 A KR20107012835 A KR 20107012835A KR 101296099 B1 KR101296099 B1 KR 101296099B1
- Authority
- KR
- South Korea
- Prior art keywords
- hydroxy
- amino
- sisomicin
- boc
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CCC1*CC*1 Chemical compound CCC1*CC*1 0.000 description 33
- ULVYVTAMAVPQAS-VMPITWQZSA-N CC(C)(C)OC(/N=C/C)=O Chemical compound CC(C)(C)OC(/N=C/C)=O ULVYVTAMAVPQAS-VMPITWQZSA-N 0.000 description 1
- OZJQRCWOFSKXJR-DNDYEEKYSA-N CC(C)(C)OC(C(C[C@H](C1)O[Si](C)(C)C(C)(C)C)[C@H]1C=O)O Chemical compound CC(C)(C)OC(C(C[C@H](C1)O[Si](C)(C)C(C)(C)C)[C@H]1C=O)O OZJQRCWOFSKXJR-DNDYEEKYSA-N 0.000 description 1
- QJOWOPNNAAWVNV-HDWCROGZSA-N CC(C)(C)OC(N(C)[C@](C1)([C@H]([C@@H](O[C@@H]([C@@H](C[C@@H]([C@H]2C3OC(CNCC4CC4)=CC[C@H]3NC(OCc(cc3)ccc3[N+]([O-])=O)=O)NC(OCc(cc3)ccc3N=O)=O)NC([C@H](CCNC(OCc(cc3)ccc3[N+]([O-])=O)=O)O)=O)[C@H]2O)OC2)O)[C@]12O)=O Chemical compound CC(C)(C)OC(N(C)[C@](C1)([C@H]([C@@H](O[C@@H]([C@@H](C[C@@H]([C@H]2C3OC(CNCC4CC4)=CC[C@H]3NC(OCc(cc3)ccc3[N+]([O-])=O)=O)NC(OCc(cc3)ccc3N=O)=O)NC([C@H](CCNC(OCc(cc3)ccc3[N+]([O-])=O)=O)O)=O)[C@H]2O)OC2)O)[C@]12O)=O QJOWOPNNAAWVNV-HDWCROGZSA-N 0.000 description 1
- HJBSMBIHQHWLKZ-DHDGZNCRSA-N CC(C)(C)OC(NC(C1)CC1(C(N[C@H](C[C@@H](C([C@@H]1O)[C@H]2OC(CNCCO[Si](C)(C)C(C)(C)C)=CC[C@H]2NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)[C@@H]1O[C@H]([C@@H]([C@H]1N(C)C(OC(C)(C)C)=O)O)OC[C@]1(C)O)=O)O)=O Chemical compound CC(C)(C)OC(NC(C1)CC1(C(N[C@H](C[C@@H](C([C@@H]1O)[C@H]2OC(CNCCO[Si](C)(C)C(C)(C)C)=CC[C@H]2NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)[C@@H]1O[C@H]([C@@H]([C@H]1N(C)C(OC(C)(C)C)=O)O)OC[C@]1(C)O)=O)O)=O HJBSMBIHQHWLKZ-DHDGZNCRSA-N 0.000 description 1
- OSKYOZFCZDCIJI-UHFFFAOYSA-N CC(C)(C)OC(NCC(C1)CC1=C)=O Chemical compound CC(C)(C)OC(NCC(C1)CC1=C)=O OSKYOZFCZDCIJI-UHFFFAOYSA-N 0.000 description 1
- YUVPCNHLBSZBAU-GIKRDXRQSA-N CC(C)(C)OC(NCCC(CNCC(O[C@@H]1O[C@H]([C@H](C[C@H]([C@@H]2O[C@H]([C@@H]([C@H]3N(C)C(OC(C)(C)C)=O)O)OC[C@]3(C)O)NC(C(CC3)(CN3C(OC(C)(C)C)=O)O)=O)NC(OC(C)(C)C)=O)[C@@H]2O)=CC[C@H]1NC(OC(C)(C)C)=O)O)=O Chemical compound CC(C)(C)OC(NCCC(CNCC(O[C@@H]1O[C@H]([C@H](C[C@H]([C@@H]2O[C@H]([C@@H]([C@H]3N(C)C(OC(C)(C)C)=O)O)OC[C@]3(C)O)NC(C(CC3)(CN3C(OC(C)(C)C)=O)O)=O)NC(OC(C)(C)C)=O)[C@@H]2O)=CC[C@H]1NC(OC(C)(C)C)=O)O)=O YUVPCNHLBSZBAU-GIKRDXRQSA-N 0.000 description 1
- MLDSDVASYUUDLT-UHFFFAOYSA-N CC(C)(C)OC(NCCC=O)=O Chemical compound CC(C)(C)OC(NCCC=O)=O MLDSDVASYUUDLT-UHFFFAOYSA-N 0.000 description 1
- JXRGVHGMMFLFHN-CSZAIRSQSA-N CC(C)(C)OC(NCCS(N[C@H](C[C@@H]([C@H]([C@@H]1O)O[C@H]2OC(CNCC(CO)O)=CC[C@H]2NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)[C@@H]1O[C@H]([C@@H]([C@H]1N(C)C(OC(C)(C)C)=O)O)OC[C@]1(C)O)(=O)=O)=O Chemical compound CC(C)(C)OC(NCCS(N[C@H](C[C@@H]([C@H]([C@@H]1O)O[C@H]2OC(CNCC(CO)O)=CC[C@H]2NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)[C@@H]1O[C@H]([C@@H]([C@H]1N(C)C(OC(C)(C)C)=O)O)OC[C@]1(C)O)(=O)=O)=O JXRGVHGMMFLFHN-CSZAIRSQSA-N 0.000 description 1
- JIDZTCUVWGXVSQ-OINIXVGBSA-N CC(C)(C)OC(NC[C@@H](C(N[C@H](C[C@@H](C([C@@H]1O)C#[O]#CC2OC(CNCC(C3)CN3C(OC(C)(C)C)=O)=CC[C@H]2NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)[C@@H]1O[C@H]([C@@H]([C@H]1N(C)C(OC(C)(C)C)=O)O)OC[C@]1(C)O)=O)[O]#C)=O Chemical compound CC(C)(C)OC(NC[C@@H](C(N[C@H](C[C@@H](C([C@@H]1O)C#[O]#CC2OC(CNCC(C3)CN3C(OC(C)(C)C)=O)=CC[C@H]2NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)[C@@H]1O[C@H]([C@@H]([C@H]1N(C)C(OC(C)(C)C)=O)O)OC[C@]1(C)O)=O)[O]#C)=O JIDZTCUVWGXVSQ-OINIXVGBSA-N 0.000 description 1
- LWNFEKQEBJEOPS-UWCLRFLISA-N CC(C)(C)OC(NC[C@@H](C(N[C@H](C[C@@H](C([C@@H]1O)[C@H]2OC(CNCC3(CC3)NC(OC(C)(C)C)=O)=CC[C@H]2NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)[C@@H]1O[C@H]([C@@H]([C@H]1N(C)C(OC(C)(C)C)=O)O)OC[C@]1(C)O)=O)O)=O Chemical compound CC(C)(C)OC(NC[C@@H](C(N[C@H](C[C@@H](C([C@@H]1O)[C@H]2OC(CNCC3(CC3)NC(OC(C)(C)C)=O)=CC[C@H]2NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)[C@@H]1O[C@H]([C@@H]([C@H]1N(C)C(OC(C)(C)C)=O)O)OC[C@]1(C)O)=O)O)=O LWNFEKQEBJEOPS-UWCLRFLISA-N 0.000 description 1
- POFRKIKNYDLTJR-JFHMYQNESA-N CC(C)(C)OC(NC[C@H](C(N[C@H](C[C@@H]([C@H]([C@@H]1O)[O]([C@H]2OC(CNCC(CO)O)=CC[C@H]2NC(OCc(cc2)ccc2[N+]([O-])=O)=O)(=C)#C)NC(OCc(cc2)ccc2N)=O)[C@@H]1[O]([C@H]([C@@H]([C@H]1[N](C)(C(OC(C)(C)C)=O)#C)O)OC[C@]1(C)O)#C)=O)O)=O Chemical compound CC(C)(C)OC(NC[C@H](C(N[C@H](C[C@@H]([C@H]([C@@H]1O)[O]([C@H]2OC(CNCC(CO)O)=CC[C@H]2NC(OCc(cc2)ccc2[N+]([O-])=O)=O)(=C)#C)NC(OCc(cc2)ccc2N)=O)[C@@H]1[O]([C@H]([C@@H]([C@H]1[N](C)(C(OC(C)(C)C)=O)#C)O)OC[C@]1(C)O)#C)=O)O)=O POFRKIKNYDLTJR-JFHMYQNESA-N 0.000 description 1
- ZAGJIVMZNSIQHQ-LFBCAGARSA-N CC(C)(C)OC(N[C@@H](C[C@H]([C@@H]1O[C@H]([C@@H]([C@H]2N(C)C(OC(C)(C)C)=O)O)OC[C@]2(C)O)NC(OC(C)(C)C)=O)C[C@@H]1O)=O Chemical compound CC(C)(C)OC(N[C@@H](C[C@H]([C@@H]1O[C@H]([C@@H]([C@H]2N(C)C(OC(C)(C)C)=O)O)OC[C@]2(C)O)NC(OC(C)(C)C)=O)C[C@@H]1O)=O ZAGJIVMZNSIQHQ-LFBCAGARSA-N 0.000 description 1
- PWEPDHBLANVHMB-GSJWXZFOSA-N CC(C)(C)OC(N[C@@H](C[C@H]([C@@H]1O[C@H]([C@@H]([C@H]2N(C)C(OC(C)(C)C)=O)O)OC[C@]2(C)O)NC([C@H](CC/C=N/C(OC(C)(C)C)=O)O)=O)C[C@@H]1O)=O Chemical compound CC(C)(C)OC(N[C@@H](C[C@H]([C@@H]1O[C@H]([C@@H]([C@H]2N(C)C(OC(C)(C)C)=O)O)OC[C@]2(C)O)NC([C@H](CC/C=N/C(OC(C)(C)C)=O)O)=O)C[C@@H]1O)=O PWEPDHBLANVHMB-GSJWXZFOSA-N 0.000 description 1
- YGSRSDDBDZCCDA-QWRGUYRKSA-N CC(C)(C)OC(N[C@@H](C[C@H]1C=O)CN1C(OC(C)(C)C)=O)=O Chemical compound CC(C)(C)OC(N[C@@H](C[C@H]1C=O)CN1C(OC(C)(C)C)=O)=O YGSRSDDBDZCCDA-QWRGUYRKSA-N 0.000 description 1
- YQIKEFILSXVYBP-MJBXVCDLSA-N CC(C)(C)OC(N[C@H](C[C@@H](C1)C=O)[C@H]1O[Si](C)(C)C(C)(C)C)=O Chemical compound CC(C)(C)OC(N[C@H](C[C@@H](C1)C=O)[C@H]1O[Si](C)(C)C(C)(C)C)=O YQIKEFILSXVYBP-MJBXVCDLSA-N 0.000 description 1
- OGHWHCAKEZVGAY-VSMLPLABSA-N CC(CN[C@H]1[C@@H](C([C@H](C[C@H]([C@@H]2O[C@H]([C@@H]([C@H]3N(C)C(OC(C)(C)C)=O)O)OC[C@]3(C)O)NC([C@H](CCNC(OC(C)(C)C)=O)O)=O)NC(OC(C)(C)C)=O)[C@@H]2O)OC(CN)=CC1)CO Chemical compound CC(CN[C@H]1[C@@H](C([C@H](C[C@H]([C@@H]2O[C@H]([C@@H]([C@H]3N(C)C(OC(C)(C)C)=O)O)OC[C@]3(C)O)NC([C@H](CCNC(OC(C)(C)C)=O)O)=O)NC(OC(C)(C)C)=O)[C@@H]2O)OC(CN)=CC1)CO OGHWHCAKEZVGAY-VSMLPLABSA-N 0.000 description 1
- KVTKURQAIMSVJE-UHFFFAOYSA-N CCC1=CCCCO1 Chemical compound CCC1=CCCCO1 KVTKURQAIMSVJE-UHFFFAOYSA-N 0.000 description 1
- DVOBWGYOTJOCAJ-UHFFFAOYSA-N NCC1=CCCCO1 Chemical compound NCC1=CCCCO1 DVOBWGYOTJOCAJ-UHFFFAOYSA-N 0.000 description 1
- AVUYDXAPBJERDH-JTQLQIEISA-N [O-][N+](c1ccc(COC(NCC[C@@H](C(O)=O)O)=O)cc1)=O Chemical compound [O-][N+](c1ccc(COC(NCC[C@@H](C(O)=O)O)=O)cc1)=O AVUYDXAPBJERDH-JTQLQIEISA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98964507P | 2007-11-21 | 2007-11-21 | |
| US60/989,645 | 2007-11-21 | ||
| PCT/US2008/084399 WO2009067692A1 (en) | 2007-11-21 | 2008-11-21 | Antibacterial aminoglycoside analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20100110297A KR20100110297A (ko) | 2010-10-12 |
| KR101296099B1 true KR101296099B1 (ko) | 2014-02-26 |
Family
ID=40512286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107012835A Active KR101296099B1 (ko) | 2007-11-21 | 2008-11-21 | 항균성 아미노글리코사이드 동족체 |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US8383596B2 (enExample) |
| EP (2) | EP3150617B1 (enExample) |
| JP (2) | JP4986310B2 (enExample) |
| KR (1) | KR101296099B1 (enExample) |
| CN (2) | CN103360440B (enExample) |
| AU (1) | AU2008326297B2 (enExample) |
| BR (1) | BRPI0819319B8 (enExample) |
| CA (1) | CA2706369C (enExample) |
| CY (1) | CY1118915T1 (enExample) |
| DK (1) | DK2217610T3 (enExample) |
| EA (1) | EA017824B1 (enExample) |
| ES (1) | ES2613936T3 (enExample) |
| HR (1) | HRP20170154T1 (enExample) |
| HU (1) | HUE030523T2 (enExample) |
| IL (1) | IL205880A (enExample) |
| LT (1) | LT2217610T (enExample) |
| MX (1) | MX2010005632A (enExample) |
| PL (1) | PL2217610T3 (enExample) |
| PT (1) | PT2217610T (enExample) |
| SI (1) | SI2217610T1 (enExample) |
| TW (1) | TWI425947B (enExample) |
| WO (1) | WO2009067692A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1957507B1 (en) | 2005-12-02 | 2018-10-24 | Ionis Pharmaceuticals, Inc. | Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents |
| US20080300199A1 (en) * | 2007-04-10 | 2008-12-04 | Achaogen Inc. | Antibacterial 1,4,5-substituted aminoglycoside analogs |
| MX2010005632A (es) | 2007-11-21 | 2010-09-10 | Achaogen Inc | Analogos de aminoglucosidos antibacterianos. |
| WO2010030690A1 (en) | 2008-09-10 | 2010-03-18 | Isis Pharmaceuticals, Inc. | Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs |
| WO2010030704A2 (en) | 2008-09-10 | 2010-03-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010042851A1 (en) | 2008-10-09 | 2010-04-15 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010042850A1 (en) | 2008-10-09 | 2010-04-15 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| CA2761756A1 (en) * | 2009-05-14 | 2010-11-18 | Achaogen, Inc. | Treatment of urinary tract infections with antibacterial aminoglycoside compounds |
| CN102481307B (zh) * | 2009-05-14 | 2016-08-24 | 尔察祯有限公司 | 使用抗菌氨基糖苷化合物治疗肺炎克雷伯杆菌感染 |
| WO2010132839A2 (en) * | 2009-05-14 | 2010-11-18 | Achaogen, Inc. | Aminoglycoside dosing regimens |
| WO2010132759A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of dibekacin |
| WO2010132765A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010132760A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of tobramycin |
| WO2010132757A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010132768A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of sisomicin |
| WO2010147836A1 (en) | 2009-06-17 | 2010-12-23 | Achaogen, Inc. | Combination therapies using antibacterial aminoglycoside compounds |
| CN102596981A (zh) | 2009-10-09 | 2012-07-18 | 尔察祯有限公司 | 抗菌氨基糖苷类类似物 |
| TW201304784A (zh) | 2010-11-17 | 2013-02-01 | Achaogen Inc | 抗菌性胺基糖苷類似物 |
| US9238670B2 (en) | 2013-03-15 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Aminoglycoside antibiotics with reduced ototoxicity |
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