KR101235103B1 - 야누스 키나제의 억제제로서 유용한 아자인돌 - Google Patents

야누스 키나제의 억제제로서 유용한 아자인돌 Download PDF

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KR101235103B1
KR101235103B1 KR1020127014597A KR20127014597A KR101235103B1 KR 101235103 B1 KR101235103 B1 KR 101235103B1 KR 1020127014597 A KR1020127014597 A KR 1020127014597A KR 20127014597 A KR20127014597 A KR 20127014597A KR 101235103 B1 KR101235103 B1 KR 101235103B1
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South Korea
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compound
ring
aliphatic
unsubstituted
formula
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KR20120091305A (ko
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룩 파머
가브리엘 마르티네-보텔라
알버트 피어스
프란세스코 살리투로
지안 왕
마리온 위너메이커
톈성 왕
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버텍스 파마슈티칼스 인코포레이티드
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase

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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
KR1020127014597A 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌 Expired - Fee Related KR101235103B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75936706P 2006-01-17 2006-01-17
US60/759,367 2006-01-17
US84247106P 2006-09-06 2006-09-06
US60/842,471 2006-09-06
PCT/US2007/001225 WO2007084557A2 (en) 2006-01-17 2007-01-17 Azaindoles useful as inhibitors of janus kinases

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020087017472A Division KR101409727B1 (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌

Publications (2)

Publication Number Publication Date
KR20120091305A KR20120091305A (ko) 2012-08-17
KR101235103B1 true KR101235103B1 (ko) 2013-02-21

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ID=38197739

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020127014597A Expired - Fee Related KR101235103B1 (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌
KR1020137005929A Withdrawn KR20130041313A (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌
KR1020087017472A Expired - Fee Related KR101409727B1 (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020137005929A Withdrawn KR20130041313A (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌
KR1020087017472A Expired - Fee Related KR101409727B1 (ko) 2006-01-17 2007-01-17 야누스 키나제의 억제제로서 유용한 아자인돌

Country Status (19)

Country Link
US (6) US7767816B2 (enExample)
EP (3) EP2537849A3 (enExample)
JP (4) JP5591471B2 (enExample)
KR (3) KR101235103B1 (enExample)
CN (3) CN102532133A (enExample)
AR (1) AR060316A1 (enExample)
AU (1) AU2007207533B8 (enExample)
BR (2) BRPI0706537A2 (enExample)
CA (1) CA2636189A1 (enExample)
CL (1) CL2008002140A1 (enExample)
HK (1) HK1210780A1 (enExample)
IL (1) IL191902A0 (enExample)
NO (1) NO20083501L (enExample)
NZ (3) NZ592968A (enExample)
RU (2) RU2453548C2 (enExample)
TW (4) TWI423976B (enExample)
UA (1) UA95940C2 (enExample)
WO (1) WO2007084557A2 (enExample)
ZA (2) ZA200805053B (enExample)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2560454C (en) 2004-03-30 2013-05-21 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of jak and other protein kinases
ES2380795T3 (es) * 2005-05-20 2012-05-18 Vertex Pharmaceuticals, Inc. Pirrolopiridinas útiles como inhibidores de proteínas quinasas
EP2270014A1 (en) 2005-09-22 2011-01-05 Incyte Corporation Azepine inhibitors of janus kinases
DK3184526T3 (en) 2005-12-13 2019-01-14 Incyte Holdings Corp PYRROLO [2,3-D] PYRIMIDINE DERIVATIVES AS A JANUS-KINASE INHIBITOR
EP2537849A3 (en) * 2006-01-17 2013-04-03 Vertex Pharmaceuticals, Inc. Azaindoles useful as inhibitors of janus kinases
RU2008143361A (ru) * 2006-04-05 2010-05-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Деазапурины в качестве ингибиторов янус-киназ
US7754838B2 (en) * 2006-08-08 2010-07-13 E.I. Du Pont De Nemours And Company Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide
NZ577798A (en) * 2006-12-21 2012-04-27 Vertex Pharma 5-cyano-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
US8513270B2 (en) 2006-12-22 2013-08-20 Incyte Corporation Substituted heterocycles as Janus kinase inhibitors
AU2008228768A1 (en) * 2007-03-22 2008-09-25 Vertex Pharmaceuticals Incorporated N-heterocyclic compounds useful as inhibitors of Janus Kinases
EP2740731B1 (en) 2007-06-13 2016-03-23 Incyte Holdings Corporation Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
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KR20120091305A (ko) 2012-08-17
TW201302746A (zh) 2013-01-16
EP1973911B1 (en) 2016-01-13
JP5728454B2 (ja) 2015-06-03
US8163917B2 (en) 2012-04-24
US20160008359A1 (en) 2016-01-14
KR20080085174A (ko) 2008-09-23
JP2013010793A (ja) 2013-01-17
US20130237516A1 (en) 2013-09-12
RU2011151085A (ru) 2013-06-20
RU2008133613A (ru) 2010-02-27
EP2559694A2 (en) 2013-02-20
BRPI0706537A2 (pt) 2011-03-29
US8822681B2 (en) 2014-09-02
WO2007084557A2 (en) 2007-07-26
US9120790B2 (en) 2015-09-01
AU2007207533B8 (en) 2012-06-28
TW200806664A (en) 2008-02-01
EP2537849A2 (en) 2012-12-26
NZ592968A (en) 2012-08-31
CL2008002140A1 (es) 2009-03-06

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