KR101077501B1 - 모르핀-6-글루쿠로나이드의 염 - Google Patents

모르핀-6-글루쿠로나이드의 염 Download PDF

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Publication number
KR101077501B1
KR101077501B1 KR1020057002442A KR20057002442A KR101077501B1 KR 101077501 B1 KR101077501 B1 KR 101077501B1 KR 1020057002442 A KR1020057002442 A KR 1020057002442A KR 20057002442 A KR20057002442 A KR 20057002442A KR 101077501 B1 KR101077501 B1 KR 101077501B1
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KR
South Korea
Prior art keywords
hbr
salts
solution
morphine
glucuronide
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020057002442A
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English (en)
Korean (ko)
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KR20050055710A (ko
Inventor
존 에이트켄 그레이엄
헤르비히 슈나이더
루돌프 프란쯔마이어
안드레아스 코흐
Original Assignee
파이온 유케이 리미티드
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Application granted granted Critical
Publication of KR101077501B1 publication Critical patent/KR101077501B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020057002442A 2002-08-14 2003-08-14 모르핀-6-글루쿠로나이드의 염 Expired - Fee Related KR101077501B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0218811.8A GB0218811D0 (en) 2002-08-14 2002-08-14 Salts of morphine-6-glucuronide
GB0218811.8 2002-08-14

Publications (2)

Publication Number Publication Date
KR20050055710A KR20050055710A (ko) 2005-06-13
KR101077501B1 true KR101077501B1 (ko) 2011-10-28

Family

ID=9942230

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057002442A Expired - Fee Related KR101077501B1 (ko) 2002-08-14 2003-08-14 모르핀-6-글루쿠로나이드의 염

Country Status (17)

Country Link
US (1) US20060166900A1 (enExample)
EP (1) EP1537132B1 (enExample)
JP (1) JP4727990B2 (enExample)
KR (1) KR101077501B1 (enExample)
AT (1) ATE315041T1 (enExample)
AU (1) AU2003255790B2 (enExample)
CA (1) CA2494812C (enExample)
DE (1) DE60303149T2 (enExample)
DK (1) DK1537132T3 (enExample)
EA (1) EA008212B1 (enExample)
ES (1) ES2256790T3 (enExample)
GB (1) GB0218811D0 (enExample)
IL (1) IL166596A0 (enExample)
NO (1) NO20051261L (enExample)
PL (1) PL211031B1 (enExample)
WO (1) WO2004016633A1 (enExample)
ZA (1) ZA200501053B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ561375A (en) 2005-06-27 2011-06-30 Biovail Lab Int Srl Bupropion hydrobromide, and crystalline forms, compositions, and uses of this compound
FR2939437B1 (fr) * 2008-12-10 2010-12-17 Sanofi Aventis Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique
FR2939796B1 (fr) * 2008-12-11 2010-12-17 Sanofi Aventis Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique
CN107028968B (zh) * 2016-02-03 2020-12-04 江苏恒瑞医药股份有限公司 一种含有葡萄糖醛酸吗啡或其可药用盐的药物组合物
US20180110725A1 (en) 2016-10-21 2018-04-26 Somniferum Labs LLC Compositions, methods and kits for the safe inhaled delivery of targeted opioids for the treatment of pain and addiction
CN110054656B (zh) * 2019-05-28 2021-02-02 宜昌人福药业有限责任公司 一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
CN113831373B (zh) * 2020-06-23 2023-05-16 宜昌人福药业有限责任公司 一种吗啡-6-葡萄糖苷酸脱水物杂质的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
FR2680786B1 (fr) * 1991-09-04 1995-03-10 Irepa Procede de synthese de glucuronides d'epoxy-4,5 morphinanes.
DE4403709A1 (de) * 1994-02-07 1995-08-10 Lohmann Therapie Syst Lts Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
US5460826A (en) * 1994-06-27 1995-10-24 Alza Corporation Morphine therapy
JPH10513485A (ja) * 1995-11-29 1998-12-22 ロラボ エセ エレ オピエート性物質の糖結合体
JP2001517669A (ja) * 1997-09-25 2001-10-09 エルティエス ローマン テラピー−ズュステーメ アーゲー モルヒネアルカロイド類の酸添加塩類およびその応用
US6740641B2 (en) * 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain

Also Published As

Publication number Publication date
JP4727990B2 (ja) 2011-07-20
EA200500175A1 (ru) 2005-08-25
CA2494812C (en) 2011-03-08
ZA200501053B (en) 2005-10-26
CA2494812A1 (en) 2004-02-26
WO2004016633A1 (en) 2004-02-26
US20060166900A1 (en) 2006-07-27
NO20051261L (no) 2005-03-11
DK1537132T3 (da) 2006-05-08
AU2003255790A1 (en) 2004-03-03
EP1537132A1 (en) 2005-06-08
GB0218811D0 (en) 2002-09-18
DE60303149T2 (de) 2006-09-28
DE60303149D1 (de) 2006-03-30
PL211031B1 (pl) 2012-04-30
AU2003255790B2 (en) 2010-05-27
KR20050055710A (ko) 2005-06-13
EP1537132B1 (en) 2006-01-04
PL373553A1 (en) 2005-09-05
EA008212B1 (ru) 2007-04-27
IL166596A0 (en) 2006-01-15
ES2256790T3 (es) 2006-07-16
ATE315041T1 (de) 2006-02-15
JP2006500360A (ja) 2006-01-05

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