IL166596A0 - Salt of morphine-6-glucoronide - Google Patents
Salt of morphine-6-glucoronideInfo
- Publication number
- IL166596A0 IL166596A0 IL16659605A IL16659605A IL166596A0 IL 166596 A0 IL166596 A0 IL 166596A0 IL 16659605 A IL16659605 A IL 16659605A IL 16659605 A IL16659605 A IL 16659605A IL 166596 A0 IL166596 A0 IL 166596A0
- Authority
- IL
- Israel
- Prior art keywords
- hbr
- morphine
- salt
- glucoronide
- medicament
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 7
- 239000003814 drug Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- GNJCUHZOSOYIEC-GAROZEBRSA-N Morphine-6-glucuronide Chemical compound O([C@H]1C=C[C@H]2[C@H]3CC=4C5=C(C(=CC=4)O)O[C@@H]1[C@]52CCN3C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O GNJCUHZOSOYIEC-GAROZEBRSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0218811.8A GB0218811D0 (en) | 2002-08-14 | 2002-08-14 | Salts of morphine-6-glucuronide |
| PCT/GB2003/003562 WO2004016633A1 (en) | 2002-08-14 | 2003-08-14 | Salt of morphine-6-glucuronide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL166596A0 true IL166596A0 (en) | 2006-01-15 |
Family
ID=9942230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16659605A IL166596A0 (en) | 2002-08-14 | 2005-01-31 | Salt of morphine-6-glucoronide |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20060166900A1 (enExample) |
| EP (1) | EP1537132B1 (enExample) |
| JP (1) | JP4727990B2 (enExample) |
| KR (1) | KR101077501B1 (enExample) |
| AT (1) | ATE315041T1 (enExample) |
| AU (1) | AU2003255790B2 (enExample) |
| CA (1) | CA2494812C (enExample) |
| DE (1) | DE60303149T2 (enExample) |
| DK (1) | DK1537132T3 (enExample) |
| EA (1) | EA008212B1 (enExample) |
| ES (1) | ES2256790T3 (enExample) |
| GB (1) | GB0218811D0 (enExample) |
| IL (1) | IL166596A0 (enExample) |
| NO (1) | NO20051261L (enExample) |
| PL (1) | PL211031B1 (enExample) |
| WO (1) | WO2004016633A1 (enExample) |
| ZA (1) | ZA200501053B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7241805B2 (en) | 2005-06-27 | 2007-07-10 | Biovail Laboratories, Inc. | Modified release formulations of a bupropion salt |
| FR2939437B1 (fr) * | 2008-12-10 | 2010-12-17 | Sanofi Aventis | Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
| FR2939796B1 (fr) * | 2008-12-11 | 2010-12-17 | Sanofi Aventis | Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
| CN107028968B (zh) * | 2016-02-03 | 2020-12-04 | 江苏恒瑞医药股份有限公司 | 一种含有葡萄糖醛酸吗啡或其可药用盐的药物组合物 |
| EP3528797A1 (en) | 2016-10-21 | 2019-08-28 | Somniferum Labs LLC | Compositions, methods and kits for the safe inhaled delivery of targeted opioids for the treatment of pain and addiction |
| CN110054656B (zh) * | 2019-05-28 | 2021-02-02 | 宜昌人福药业有限责任公司 | 一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法 |
| CN113831373B (zh) * | 2020-06-23 | 2023-05-16 | 宜昌人福药业有限责任公司 | 一种吗啡-6-葡萄糖苷酸脱水物杂质的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4908389A (en) * | 1986-08-27 | 1990-03-13 | Warner-Lambert Company | Penetration enhancement system |
| FR2680786B1 (fr) * | 1991-09-04 | 1995-03-10 | Irepa | Procede de synthese de glucuronides d'epoxy-4,5 morphinanes. |
| DE4403709A1 (de) * | 1994-02-07 | 1995-08-10 | Lohmann Therapie Syst Lts | Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid |
| US5460826A (en) * | 1994-06-27 | 1995-10-24 | Alza Corporation | Morphine therapy |
| EP0816375A1 (en) * | 1995-11-29 | 1998-01-07 | Rolabo Sl | Glycoconjugates of opiated substances |
| PT1017696E (pt) * | 1997-09-25 | 2002-09-30 | Lohmann Therapie Syst Lts | Sais de adicao de acido de alcaloides de morfina e sua utilizacao |
| US6740641B2 (en) * | 2001-07-27 | 2004-05-25 | Euro-Celtique, S.A. | Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain |
-
2002
- 2002-08-14 GB GBGB0218811.8A patent/GB0218811D0/en not_active Ceased
-
2003
- 2003-08-14 DE DE60303149T patent/DE60303149T2/de not_active Expired - Lifetime
- 2003-08-14 AT AT03787894T patent/ATE315041T1/de active
- 2003-08-14 ES ES03787894T patent/ES2256790T3/es not_active Expired - Lifetime
- 2003-08-14 JP JP2004528672A patent/JP4727990B2/ja not_active Expired - Fee Related
- 2003-08-14 EA EA200500175A patent/EA008212B1/ru not_active IP Right Cessation
- 2003-08-14 AU AU2003255790A patent/AU2003255790B2/en not_active Ceased
- 2003-08-14 WO PCT/GB2003/003562 patent/WO2004016633A1/en not_active Ceased
- 2003-08-14 EP EP03787894A patent/EP1537132B1/en not_active Expired - Lifetime
- 2003-08-14 DK DK03787894T patent/DK1537132T3/da active
- 2003-08-14 PL PL373553A patent/PL211031B1/pl unknown
- 2003-08-14 US US10/524,149 patent/US20060166900A1/en not_active Abandoned
- 2003-08-14 KR KR1020057002442A patent/KR101077501B1/ko not_active Expired - Fee Related
- 2003-08-14 CA CA2494812A patent/CA2494812C/en not_active Expired - Fee Related
-
2005
- 2005-01-31 IL IL16659605A patent/IL166596A0/xx not_active IP Right Cessation
- 2005-02-04 ZA ZA2005/01053A patent/ZA200501053B/en unknown
- 2005-03-11 NO NO20051261A patent/NO20051261L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004016633A1 (en) | 2004-02-26 |
| KR101077501B1 (ko) | 2011-10-28 |
| KR20050055710A (ko) | 2005-06-13 |
| US20060166900A1 (en) | 2006-07-27 |
| JP4727990B2 (ja) | 2011-07-20 |
| DE60303149D1 (de) | 2006-03-30 |
| CA2494812A1 (en) | 2004-02-26 |
| AU2003255790A1 (en) | 2004-03-03 |
| PL211031B1 (pl) | 2012-04-30 |
| GB0218811D0 (en) | 2002-09-18 |
| EA008212B1 (ru) | 2007-04-27 |
| ZA200501053B (en) | 2005-10-26 |
| CA2494812C (en) | 2011-03-08 |
| ES2256790T3 (es) | 2006-07-16 |
| JP2006500360A (ja) | 2006-01-05 |
| DK1537132T3 (da) | 2006-05-08 |
| EP1537132A1 (en) | 2005-06-08 |
| ATE315041T1 (de) | 2006-02-15 |
| PL373553A1 (en) | 2005-09-05 |
| AU2003255790B2 (en) | 2010-05-27 |
| NO20051261L (no) | 2005-03-11 |
| EA200500175A1 (ru) | 2005-08-25 |
| EP1537132B1 (en) | 2006-01-04 |
| DE60303149T2 (de) | 2006-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |