KR101067254B1 - 단백질 키나제 억제제로서의 피리미딘 유도체 및 이를 포함하는 조성물 - Google Patents

단백질 키나제 억제제로서의 피리미딘 유도체 및 이를 포함하는 조성물 Download PDF

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KR101067254B1
KR101067254B1 KR1020047020794A KR20047020794A KR101067254B1 KR 101067254 B1 KR101067254 B1 KR 101067254B1 KR 1020047020794 A KR1020047020794 A KR 1020047020794A KR 20047020794 A KR20047020794 A KR 20047020794A KR 101067254 B1 KR101067254 B1 KR 101067254B1
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KR20050009756A (ko
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샤리에쟝-다미엥
마체이프란체스카
케이데이비드
밀러앤드류
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버텍스 파마슈티칼스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P11/06—Antiasthmatics
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
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  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020047020794A 2002-06-20 2003-06-19 단백질 키나제 억제제로서의 피리미딘 유도체 및 이를 포함하는 조성물 Expired - Fee Related KR101067254B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39065802P 2002-06-20 2002-06-20
US60/390,658 2002-06-20
US41160902P 2002-09-18 2002-09-18
US60/411,609 2002-09-18
PCT/US2003/019266 WO2004000833A1 (en) 2002-06-20 2003-06-19 Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase

Related Child Applications (1)

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KR1020107028539A Division KR101141959B1 (ko) 2002-06-20 2003-06-19 단백질 키나제 억제제로서의 피리미딘 유도체 및 이를 포함하는 조성물

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KR20050009756A KR20050009756A (ko) 2005-01-25
KR101067254B1 true KR101067254B1 (ko) 2011-09-27

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KR1020107028539A Expired - Fee Related KR101141959B1 (ko) 2002-06-20 2003-06-19 단백질 키나제 억제제로서의 피리미딘 유도체 및 이를 포함하는 조성물
KR1020047020794A Expired - Fee Related KR101067254B1 (ko) 2002-06-20 2003-06-19 단백질 키나제 억제제로서의 피리미딘 유도체 및 이를 포함하는 조성물

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US (4) US20040049032A1 (enExample)
EP (4) EP1746093B1 (enExample)
JP (5) JP4237701B2 (enExample)
KR (2) KR101141959B1 (enExample)
CN (1) CN100484934C (enExample)
AR (1) AR040286A1 (enExample)
AT (2) ATE556068T1 (enExample)
AU (1) AU2003245568B2 (enExample)
BR (1) BR0312443A (enExample)
CA (1) CA2489824C (enExample)
CO (1) CO5680433A2 (enExample)
DE (1) DE60336092D1 (enExample)
EA (2) EA015990B1 (enExample)
EC (1) ECSP055561A (enExample)
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HR (1) HRP20050064A2 (enExample)
IL (1) IL165849A0 (enExample)
IS (2) IS7606A (enExample)
MX (1) MXPA05000068A (enExample)
MY (1) MY141867A (enExample)
NO (2) NO331925B1 (enExample)
NZ (4) NZ537720A (enExample)
PL (1) PL374953A1 (enExample)
SG (1) SG170614A1 (enExample)
TW (2) TWI297684B (enExample)
WO (1) WO2004000833A1 (enExample)

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