KR101066707B1 - 분석 장치의 동적 검출 범위의 확장 방법 - Google Patents
분석 장치의 동적 검출 범위의 확장 방법 Download PDFInfo
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- KR101066707B1 KR101066707B1 KR1020067008703A KR20067008703A KR101066707B1 KR 101066707 B1 KR101066707 B1 KR 101066707B1 KR 1020067008703 A KR1020067008703 A KR 1020067008703A KR 20067008703 A KR20067008703 A KR 20067008703A KR 101066707 B1 KR101066707 B1 KR 101066707B1
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- G08B13/189—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems
- G08B13/194—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems
- G08B13/196—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems using television cameras
- G08B13/19639—Details of the system layout
- G08B13/19641—Multiple cameras having overlapping views on a single scene
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- G—PHYSICS
- G08—SIGNALLING
- G08B—SIGNALLING OR CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
- G08B13/00—Burglar, theft or intruder alarms
- G08B13/18—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength
- G08B13/189—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems
- G08B13/194—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems
- G08B13/196—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems using television cameras
- G08B13/19639—Details of the system layout
- G08B13/19647—Systems specially adapted for intrusion detection in or around a vehicle
- G08B13/1965—Systems specially adapted for intrusion detection in or around a vehicle the vehicle being an aircraft
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- G—PHYSICS
- G08—SIGNALLING
- G08B—SIGNALLING OR CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
- G08B13/00—Burglar, theft or intruder alarms
- G08B13/18—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength
- G08B13/189—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems
- G08B13/194—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems
- G08B13/196—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems using television cameras
- G08B13/19654—Details concerning communication with a camera
- G08B13/19656—Network used to communicate with a camera, e.g. WAN, LAN, Internet
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- G—PHYSICS
- G08—SIGNALLING
- G08B—SIGNALLING OR CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
- G08B13/00—Burglar, theft or intruder alarms
- G08B13/18—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength
- G08B13/189—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems
- G08B13/194—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems
- G08B13/196—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems using television cameras
- G08B13/19663—Surveillance related processing done local to the camera
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- G—PHYSICS
- G08—SIGNALLING
- G08B—SIGNALLING OR CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
- G08B13/00—Burglar, theft or intruder alarms
- G08B13/18—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength
- G08B13/189—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems
- G08B13/194—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems
- G08B13/196—Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems using television cameras
- G08B13/19665—Details related to the storage of video surveillance data
- G08B13/19669—Event triggers storage or change of storage policy
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Abstract
Description
Claims (17)
- i) 다공성 막이 검출 프로브 및 검량 프로브와 소통하고 있고, 검출 프로브는 분석물질에 대해 특이적인 결합 구성원과 접합되어 있으며, 다공성 막이 제1 포획제가 그 안에 고정화되어 있는 검출 대역, 제2 포획제가 그 안에 고정화되어 있는 보상 대역, 및 제3 포획제가 그 안에 고정화되어 있는 검량 대역을 형성하고, 보상 대역이 검출 대역의 하류에 위치하고 있는, 다공성 막을 포함하는 관통흐름 분석 장치를 제공하는 단계;ii) 분석물질을 함유하는 시험 샘플을 접합된 검출 프로브 및 검량 프로브와 접촉시키는 단계;iii) 검출 대역에서 생성된 검출 신호 세기, 보상 대역에서 생성된 보상 신호 세기, 및 검량 대역에서 생성된 검량 신호 세기를 측정하는 단계;iv) 보상 신호의 세기가 검출 신호의 세기에 반비례하는, 보상 신호와 검출 신호의 세기를 비교하는 단계; 및v) 검량 신호의 세기가 검출 신호 및 검량 신호의 세기들에 비하여 일정한, 검량 신호의 세기로 검출 신호 및 보상 신호의 비교된 세기들을 검량하는 단계를 포함하는, 시험 샘플에 있는 분석물질의 존재 또는 양의 검출 방법.
- i) 다공성 막이 광학 검출 프로브 및 광학 검량 프로브와 소통하고 있고, 광학 검출 프로브는 분석물질에 대해 특이적인 결합 구성원과 접합되어 있으며, 다공성 막이 제1 포획제가 그 안에 고정화되어 있는 검출 대역, 제2 포획제가 그 안에 고정화되어 있는 보상 대역, 및 제3 포획제가 그 안에 고정화되어 있는 검량 대역을 형성하고, 보상 대역이 검출 대역의 하류에 위치하고 있는, 다공성 막을 포함하는 관통흐름 분석 장치를 제공하는 단계;ii) 분석물질을 함유하는 시험 샘플을 접합된 광학 검출 프로브 및 광학 검량 프로브와 접촉시키는 단계;iii) 검출 대역에서 생성된 검출 신호 세기, 보상 대역에서 생성된 보상 신호 세기, 및 검량 대역에서 생성된 검량 신호 세기를 광학적으로 측정하는 단계;iv) 보상 신호의 세기가 검출 신호의 세기에 반비례하는, 보상 신호와 검출 신호의 세기를 비교하는 단계; 및v) 검량 신호의 세기가 검출 신호 및 검량 신호의 세기들에 비하여 일정한, 검량 신호의 세기로 검출 신호 및 보상 신호의 비교된 세기들을 검량하는 단계를 포함하는, 시험 샘플에 있는 분석물질의 존재 또는 양의 검출 방법.
- 제1 또는 2항에 있어서, 상기 검출 대역 및 상기 보상 대역에서 상기 접합된 검출 프로브를 여기시키는 단계를 추가로 포함하고, 이때 이러한 여기가 상기 접합된 검출 프로브가 상기 검출 신호 및 상기 보상 신호를 방출하게 하는 방법.
- 제1 또는 2항에 있어서, 다수개의 소정의 분석물질 농도에 대하여 검량 신호의 세기에 의해 검량된 보상 신호에 대한 검출 신호의 비를 플롯팅하여 검량 곡선을 생성시키는 단계를 추가로 포함하는 방법.
- 검출 프로브 및 검량 프로브와 소통하고 있는 다공성 막을 포함하고, 이 때 검출 프로브는 분석물질에 대한 특이적 결합 구성원과 접합되어 있고, 다공성 막은접합된 검출 프로브 또는 그의 착물의 적어도 일부분에 결합하여 일정 세기를 갖는 검출 신호를 생성시키도록 구성된 제1 포획제가 그 안에 고정화되어 있는 검출 대역;검출 대역을 통과하는 접합된 검출 프로브 또는 그의 착물에 결합하여 일정 세기를 갖는 보상 신호를 생성시키도록 구성된 제2 포획제가 그 안에 고정화되어 있으며 이 때 보상 신호의 세기는 검출 신호의 세기에 반비례하는, 상기 검출 대역으로부터 하류에 위치하는 보상 대역; 및검량 프로브에 결합하여 검출 및 보상 신호들의 세기들에 비하여 세기가 일정한 검량 신호를 생성시키도록 구성된 제3 포획제가 그 안에 고정화되어 있는 검량 대역을 형성하고, 이 때 시험 샘플 내의 분석물질의 양은 상기 검량 신호 세기에 의해 검량되었을 때 상기 보상 신호 세기에 대한 상기 검출 신호 세기의 비에 비례하는, 시험 샘플에 있는 분석물질의 존재 또는 양 검출용 관통흐름 분석 장치.
- 제5항에 있어서, 상기 접합된 검출 프로브가 발색체, 촉매, 발광 화합물, 방사성 화합물, 시각적 표지, 리포좀, 및 이들의 조합물로 이루어진 군으로부터 선택된 물질을 포함하는 관통흐름 분석 장치.
- 제5 또는 6항에 있어서, 상기 접합된 검출 프로브가 발광 화합물을 포함하는 관통흐름 분석 장치.
- 제5 또는 6항에 있어서, 상기 접합된 검출 프로브가 시각적 표지를 포함하는 관통흐름 분석 장치.
- 제5 또는 6항에 있어서, 상기 특이적 결합 구성원이 항원, 합텐, 압타머, 1차 또는 2차 항체, 비오틴, 및 이들의 조합물로 이루어진 군으로부터 선택되는 관통흐름 분석 장치.
- 제5 또는 6항에 있어서, 상기 제1 포획제가 항원, 합텐, 단백질 A 또는 G, 뉴트라비딘, 아비딘, 스트렙타비딘, 캅타비딘, 1차 또는 2차 항체 및 이들의 착물로 이루어진 군으로부터 선택되는 관통흐름 분석 장치.
- 제5 또는 6항에 있어서, 상기 제2 포획제가 항원, 합텐, 단백질 A 또는 G, 뉴트라비딘, 아비딘, 스트렙타비딘, 캅타비딘, 1차 또는 2차 항체 및 이들의 착물로 이루어진 군으로부터 선택되는 관통흐름 분석 장치.
- 제5 또는 6항에 있어서, 상기 제2 포획제가 고분자전해질(polyelectrolyte)을 포함하는 관통흐름 분석 장치.
- 제12항에 있어서, 상기 고분자전해질이 알짜 양 전하를 갖는 관통흐름 분석 장치.
- 제13항에 있어서, 상기 고분자전해질이 폴리리신, 폴리에틸렌이민, 에피클로로히드린-관능화 폴리아민 또는 폴리아미도아민, 폴리디알릴디메틸-암모늄 클로라이드, 양이온성 셀룰로스 유도체 및 이들의 조합물로 이루어진 군으로부터 선택된 관통흐름 분석 장치.
- 제12항에 있어서, 상기 고분자전해질이 알짜 음 전하를 갖는 관통흐름 분석 장치.
- 제5 또는 6항에 있어서, 상기 제3 포획제가 항원, 합텐, 단백질 A 또는 G, 뉴트라비딘, 아비딘, 스트렙타비딘, 캅타비딘, 1차 또는 2차 항체 또는 이들의 착물을 포함하는 관통흐름 분석 장치.
- 제5 또는 6항에 있어서, 상기 분석 장치가 샌드위치-타입 분석 장치인 관통흐름 분석 장치.
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US10/719,976 US7781172B2 (en) | 2003-11-21 | 2003-11-21 | Method for extending the dynamic detection range of assay devices |
US10/719,976 | 2003-11-21 |
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US7781172B2 (en) | 2010-08-24 |
WO2005057214A1 (en) | 2005-06-23 |
EP1685403A1 (en) | 2006-08-02 |
CN1879019A (zh) | 2006-12-13 |
CN1879019B (zh) | 2011-08-17 |
US7640083B2 (en) | 2009-12-29 |
KR20060126964A (ko) | 2006-12-11 |
US20050112780A1 (en) | 2005-05-26 |
US20040230352A1 (en) | 2004-11-18 |
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