KR100870184B1 - 광범위 2-(치환된-아미노)-벤조티아졸 설폰아미드 ｈｉｖ프로티아제 억제제 - Google Patents

광범위 2-(치환된-아미노)-벤조티아졸 설폰아미드 ｈｉｖ프로티아제 억제제 Download PDF

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KR100870184B1
KR100870184B1 KR1020037010506A KR20037010506A KR100870184B1 KR 100870184 B1 KR100870184 B1 KR 100870184B1 KR 1020037010506 A KR1020037010506 A KR 1020037010506A KR 20037010506 A KR20037010506 A KR 20037010506A KR 100870184 B1 KR100870184 B1 KR 100870184B1
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alkyl
het
aryl
alkanediyl
compound
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KR20030077017A (ko
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도미니크 루이스 네스터 기스레인 서레러스
피에트 톰 베르트 파울 위게린크
게트만다니엘
빔가스톤 버쉐렌
산드린 벤데빌
데베툰마리-피에르
잔 옥타프 안톤 데커펠
사무엘 레오 크리스티안 모르스
허만 오거스티너스 데코크
마리케 크리스티안 조한나 보에츠
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티보텍 파마슈티칼즈 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020037010506A 2001-02-14 2002-02-14 광범위 2-(치환된-아미노)-벤조티아졸 설폰아미드 ｈｉｖ프로티아제 억제제 Expired - Fee Related KR100870184B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP01200529 2001-02-14
EP01200529.4 2001-02-14
US28775801P 2001-05-02 2001-05-02
US60/287,758 2001-05-02
PCT/EP2002/001788 WO2002083657A2 (en) 2001-02-14 2002-02-14 Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors

Publications (2)

Publication Number Publication Date
KR20030077017A KR20030077017A (ko) 2003-09-29
KR100870184B1 true KR100870184B1 (ko) 2008-11-24

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KR1020037010506A Expired - Fee Related KR100870184B1 (ko) 2001-02-14 2002-02-14 광범위 2-(치환된-아미노)-벤조티아졸 설폰아미드 ｈｉｖ프로티아제 억제제

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US (1) US7659404B2 (enExample)
EP (1) EP1370543B1 (enExample)
JP (1) JP4530612B2 (enExample)
KR (1) KR100870184B1 (enExample)
CN (2) CN101230067B (enExample)
AP (1) AP1504A (enExample)
AT (1) ATE343567T1 (enExample)
AU (1) AU2002302363B2 (enExample)
BG (1) BG66301B1 (enExample)
BR (1) BR0207862A (enExample)
CA (1) CA2438304C (enExample)
CY (1) CY1108073T1 (enExample)
CZ (1) CZ304273B6 (enExample)
DE (1) DE60215623T2 (enExample)
DK (1) DK1370543T3 (enExample)
EA (1) EA006096B1 (enExample)
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ES (1) ES2275866T3 (enExample)
HR (1) HRP20030735B1 (enExample)
HU (1) HU229224B1 (enExample)
IL (2) IL157171A0 (enExample)
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NO (1) NO326174B1 (enExample)
NZ (1) NZ527391A (enExample)
PL (1) PL213327B1 (enExample)
PT (1) PT1370543E (enExample)
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SK (1) SK287582B6 (enExample)
WO (1) WO2002083657A2 (enExample)
ZA (1) ZA200306086B (enExample)

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WO2000073511A1 (en) 1999-05-28 2000-12-07 Virco Nv New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance
EP1356082A2 (en) 2000-10-20 2003-10-29 Virco Bvba Mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance
ATE343567T1 (de) 2001-02-14 2006-11-15 Tibotec Pharm Ltd Breitspektrum 2-(substituierte-amino)- benzothiazol-sulfonamide hiv protease inhibitoren
US7109230B2 (en) 2002-01-07 2006-09-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
EP1520247B1 (en) 2002-07-01 2009-05-27 Tibotec Pharmaceuticals Ltd. Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance
WO2004003223A2 (en) 2002-07-01 2004-01-08 Tibotec Pharmaceuticals Ltd. New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance
JP4879484B2 (ja) * 2002-08-02 2012-02-22 テイボテク・フアーマシユーチカルズ・リミテツド 広スペクトルの２−アミノ−ベンゾチアゾールスルホンアミドｈｉｖプロテアーゼ阻害剤
PL374948A1 (en) * 2002-08-02 2005-11-14 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors
PL1670773T3 (pl) * 2003-09-30 2007-06-29 Tibotec Pharm Ltd Sposób wytwarzania sulfonamidów benzoksazolu i ich związków pośrednich
DE10360835A1 (de) * 2003-12-23 2005-07-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bicyclische Imidazolverbindungen, deren Herstellung und deren Verwendung als Arzneimittel
AU2005244121B2 (en) * 2004-05-07 2012-01-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
ES2331257T3 (es) 2005-02-25 2009-12-28 Tibotec Pharmaceuticals Sintesis de precursores de inhibidores de proteasas.
AR053845A1 (es) 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
JO2841B1 (en) * 2006-06-23 2014-09-15 تيبوتيك فارماسيوتيكالز ليمتد 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV)
WO2011061590A1 (en) 2009-11-17 2011-05-26 Hetero Research Foundation Novel carboxamide derivatives as hiv inhibitors
JO3090B1 (ar) * 2009-12-11 2017-03-15 Janssen Sciences Ireland Uc 5- امينو-4- هيدروكسي-بنتويل اميدات
US9024038B2 (en) 2010-12-27 2015-05-05 Purdue Research Foundation Compunds and methods for treating HIV
US8987250B2 (en) 2012-04-20 2015-03-24 Gilead Sciences, Inc. Therapeutic compounds
CN104000824B (zh) * 2014-05-28 2016-07-06 中山大学 苯并五元杂环类化合物在制备抗hiv-1病毒药物中的应用
US11439608B2 (en) 2017-09-25 2022-09-13 Qun Lu Roles of modulators of intersectin-CDC42 signaling in Alzheimer's disease
CN116354903B (zh) * 2021-12-28 2025-09-09 南京药石科技股份有限公司 一种6-苯并噻唑磺酰氯的制备方法
WO2024206093A1 (en) * 2023-03-24 2024-10-03 Purdue Research Foundation Hiv-1p rotease inhibitors and uses thereof

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WO1995006030A1 (en) 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1996028463A1 (en) 1995-03-10 1996-09-19 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1999065870A2 (en) 1998-06-19 1999-12-23 Vertex Pharmaceuticals Incorporated Sulfonamide inhibitors of aspartyl protease

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WO1999067254A2 (en) 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
ATE343567T1 (de) 2001-02-14 2006-11-15 Tibotec Pharm Ltd Breitspektrum 2-(substituierte-amino)- benzothiazol-sulfonamide hiv protease inhibitoren

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WO1995006030A1 (en) 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1996028463A1 (en) 1995-03-10 1996-09-19 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1999065870A2 (en) 1998-06-19 1999-12-23 Vertex Pharmaceuticals Incorporated Sulfonamide inhibitors of aspartyl protease

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EE200300381A (et) 2003-12-15
AU2002302363B2 (en) 2008-05-01
US20040116485A1 (en) 2004-06-17
KR20030077017A (ko) 2003-09-29
BR0207862A (pt) 2004-06-22
HUP0303257A2 (hu) 2004-01-28
CY1108073T1 (el) 2014-02-12
MXPA03007236A (es) 2003-12-04
HRP20030735B1 (en) 2012-02-29
SK11022003A3 (sk) 2004-07-07
BG108143A (en) 2004-07-30
WO2002083657A3 (en) 2003-02-13
CA2438304C (en) 2011-04-12
CN100369904C (zh) 2008-02-20
SK287582B6 (sk) 2011-03-04
HU229224B1 (en) 2013-09-30
EA200300891A1 (ru) 2004-02-26
EA006096B1 (ru) 2005-08-25
PT1370543E (pt) 2007-02-28
US7659404B2 (en) 2010-02-09
NO326174B1 (no) 2008-10-13
DE60215623T2 (de) 2007-08-30
DE60215623D1 (de) 2006-12-07
DK1370543T3 (da) 2007-02-19
CN1525962A (zh) 2004-09-01
EP1370543B1 (en) 2006-10-25
AP1504A (en) 2005-12-10
NO20033584D0 (no) 2003-08-13
ZA200306086B (en) 2005-01-26
BG66301B1 (bg) 2013-03-29
ES2275866T3 (es) 2007-06-16
CN101230067A (zh) 2008-07-30
NO20033584L (no) 2003-10-14
CZ304273B6 (cs) 2014-02-12
WO2002083657A2 (en) 2002-10-24
IL157171A0 (en) 2004-02-08
PL363778A1 (en) 2004-11-29
CZ20032415A3 (cs) 2004-04-14
IL157171A (en) 2012-10-31
JP4530612B2 (ja) 2010-08-25
HRP20030735A2 (en) 2005-08-31
NZ527391A (en) 2005-04-29
SI1370543T1 (sl) 2007-04-30
HK1061233A1 (en) 2004-09-10
CN101230067B (zh) 2011-06-15
AP2003002856A0 (en) 2003-09-30
EE05385B1 (et) 2011-02-15
PL213327B1 (pl) 2013-02-28
EP1370543A2 (en) 2003-12-17
CA2438304A1 (en) 2002-10-24
ATE343567T1 (de) 2006-11-15
JP2004518767A (ja) 2004-06-24

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