KR100729292B1 - 결정질의 순수한 모다피닐 및 이의 제조 방법 - Google Patents

결정질의 순수한 모다피닐 및 이의 제조 방법 Download PDF

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KR100729292B1
KR100729292B1 KR1020037001061A KR20037001061A KR100729292B1 KR 100729292 B1 KR100729292 B1 KR 100729292B1 KR 1020037001061 A KR1020037001061 A KR 1020037001061A KR 20037001061 A KR20037001061 A KR 20037001061A KR 100729292 B1 KR100729292 B1 KR 100729292B1
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modafinil
mixture
purity
type
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Expired - Fee Related
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KR20030029636A (ko
Inventor
싱어클라우드
게르숀네오미
시우스아리나
리베르만아니타
아론히메쥬디쓰
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테바 파마슈티컬 인더스트리즈 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Laminated Bodies (AREA)
  • Glass Compositions (AREA)
KR1020037001061A 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법 Expired - Fee Related KR100729292B1 (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US22111000P 2000-07-27 2000-07-27
US60/221,110 2000-07-27
US22649100P 2000-08-18 2000-08-18
US60/226,491 2000-08-18
US22916000P 2000-08-30 2000-08-30
US60/229,160 2000-08-30
US23008800P 2000-09-05 2000-09-05
US60/230,088 2000-09-05
US25933201P 2001-01-02 2001-01-02
US60/259,332 2001-01-02
PCT/US2001/023689 WO2002010125A1 (en) 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same

Related Child Applications (3)

Application Number Title Priority Date Filing Date
KR1020067003797A Division KR20060024028A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067017034A Division KR20060097771A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067026810A Division KR100729298B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법

Publications (2)

Publication Number Publication Date
KR20030029636A KR20030029636A (ko) 2003-04-14
KR100729292B1 true KR100729292B1 (ko) 2007-06-18

Family

ID=27539819

Family Applications (8)

Application Number Title Priority Date Filing Date
KR1020037001061A Expired - Fee Related KR100729292B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020097019167A Ceased KR20090106661A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067003797A Ceased KR20060024028A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020107017690A Expired - Fee Related KR101081212B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020097018672A Expired - Fee Related KR101019448B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020077020660A Expired - Fee Related KR101098749B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067017034A Ceased KR20060097771A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067026810A Expired - Fee Related KR100729298B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법

Family Applications After (7)

Application Number Title Priority Date Filing Date
KR1020097019167A Ceased KR20090106661A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067003797A Ceased KR20060024028A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020107017690A Expired - Fee Related KR101081212B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020097018672A Expired - Fee Related KR101019448B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020077020660A Expired - Fee Related KR101098749B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067017034A Ceased KR20060097771A (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법
KR1020067026810A Expired - Fee Related KR100729298B1 (ko) 2000-07-27 2001-07-27 결정질의 순수한 모다피닐 및 이의 제조 방법

Country Status (24)

Country Link
US (3) US6849120B2 (enExample)
EP (3) EP1309547B1 (enExample)
JP (2) JP4302977B2 (enExample)
KR (8) KR100729292B1 (enExample)
CN (2) CN101186590A (enExample)
AT (1) ATE453618T1 (enExample)
AU (1) AU2001283008A1 (enExample)
CA (3) CA2634702C (enExample)
CY (1) CY1110234T1 (enExample)
CZ (1) CZ2003529A3 (enExample)
DE (3) DE20122504U1 (enExample)
DK (2) DK1309547T3 (enExample)
ES (2) ES2337838T3 (enExample)
HR (2) HRP20030131B1 (enExample)
HU (1) HUP0400927A3 (enExample)
IL (2) IL154122A0 (enExample)
IS (1) IS6699A (enExample)
MX (1) MXPA03000747A (enExample)
NZ (1) NZ524359A (enExample)
PL (1) PL206371B1 (enExample)
PT (2) PT1309547E (enExample)
SK (1) SK2242003A3 (enExample)
WO (1) WO2002010125A1 (enExample)
ZA (1) ZA200300672B (enExample)

Families Citing this family (50)

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JP4593074B2 (ja) * 2000-10-11 2010-12-08 セフアロン・インコーポレーテツド モダフィニル化合物含有組成物
US7749540B2 (en) 2000-10-11 2010-07-06 Cephalon, Inc. Compositions comprising modafinil compounds
CA2477923C (en) 2002-03-01 2021-02-23 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
ITMI20020991A1 (it) 2002-05-10 2003-11-10 Dinamite Dipharma S P A In For Procedimento per la sintesi del modafinil
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US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
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CN102746202B (zh) * 2012-07-04 2013-12-18 广州市博兴化工科技有限公司 一种含有甲基亚砜结构的丙烯酸酯化合物及其制备方法和应用
TW201946625A (zh) 2013-11-15 2019-12-16 美商阿克比治療有限公司 {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式，其組合物及用途
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