KR100711955B1 - 아민 백금 착물의 제조방법 - Google Patents

아민 백금 착물의 제조방법 Download PDF

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Publication number
KR100711955B1
KR100711955B1 KR1020017013049A KR20017013049A KR100711955B1 KR 100711955 B1 KR100711955 B1 KR 100711955B1 KR 1020017013049 A KR1020017013049 A KR 1020017013049A KR 20017013049 A KR20017013049 A KR 20017013049A KR 100711955 B1 KR100711955 B1 KR 100711955B1
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formula
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KR20020018189A (ko
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웡어네스트에스.와이.
잔도메니코크리스텐엠.
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아노르메드 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020017013049A 1999-04-13 2000-04-11 아민 백금 착물의 제조방법 Expired - Fee Related KR100711955B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12893999P 1999-04-13 1999-04-13
US60/128,939 1999-04-13

Publications (2)

Publication Number Publication Date
KR20020018189A KR20020018189A (ko) 2002-03-07
KR100711955B1 true KR100711955B1 (ko) 2007-05-02

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Country Link
US (1) US6518428B1 (https=)
EP (1) EP1165576B1 (https=)
JP (1) JP4756669B2 (https=)
KR (1) KR100711955B1 (https=)
CN (3) CN1916009B (https=)
AR (1) AR043084A1 (https=)
AT (1) ATE309257T1 (https=)
AU (1) AU770006B2 (https=)
BG (1) BG65429B1 (https=)
BR (1) BR0009780B1 (https=)
CA (1) CA2368849C (https=)
CY (1) CY1104965T1 (https=)
CZ (1) CZ303156B6 (https=)
DE (1) DE60023859T2 (https=)
DK (1) DK1165576T3 (https=)
EE (1) EE04747B1 (https=)
ES (1) ES2253214T3 (https=)
HK (1) HK1039336B (https=)
HU (1) HUP0200748A3 (https=)
IL (1) IL145671A0 (https=)
IS (1) IS2711B3 (https=)
MX (1) MXPA01010430A (https=)
MY (1) MY122706A (https=)
NO (1) NO330429B1 (https=)
NZ (1) NZ514736A (https=)
PL (1) PL202731B1 (https=)
RU (1) RU2245340C2 (https=)
SK (1) SK286374B6 (https=)
TW (1) TWI289565B (https=)
UA (1) UA71614C2 (https=)
WO (1) WO2000061590A1 (https=)
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Families Citing this family (30)

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GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
DK1165576T3 (da) 1999-04-13 2006-03-27 Anormed Inc Fremgangsmåde til fremstilling af amin-platin-komplekser
US6413953B1 (en) * 1999-04-13 2002-07-02 Anormed Inc. Pt(IV) antitumor agent
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
US6806289B1 (en) * 2000-07-14 2004-10-19 Stephen J. Lippard Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same
US6894049B1 (en) * 2000-10-04 2005-05-17 Anormed, Inc. Platinum complexes as antitumor agents
WO2005077385A2 (en) 2004-02-18 2005-08-25 Gpc Biotech Ag Methods for treating resistant or refractory tumors
CZ2004964A3 (cs) * 2004-09-14 2006-03-15 Pliva-Lachema A. S. Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo
ES2257178B1 (es) * 2004-09-30 2007-08-16 Universidad Autonoma De Madrid Compuestos de platino de formula trans-(ptc12(isopropilamina)(4-(hidroximetil)-piridina)) y trans-(ptc12(isopropilamina)(3-hidroximetil)-piridina y su aplicacion como farmaco antitumoral.
RU2298556C1 (ru) * 2005-11-17 2007-05-10 Общество с ограниченной ответственностью "ЦитоСтарт" Триметилоламинометановая соль цис-бис [4-нитраминопиридин-n] тетрахлороплатины (iv) и способ ее получения
RU2309158C1 (ru) * 2006-03-27 2007-10-27 Институт химии и химической технологии СО РАН (ИХХТ СО РАН) Способ получения цис-дихлороамминизопропиламинплатины (ii)
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
EP2178893A4 (en) * 2007-07-16 2012-09-19 Poniard Pharmaceuticals Inc ORAL FORMULATIONS FOR PICOPLATIN
WO2009099649A1 (en) * 2008-02-08 2009-08-13 Poniard Pharmaceuticals, Inc. Use of picoplatin and bevacizumab to treat colorectal cancer
US20120123121A1 (en) * 2009-06-12 2012-05-17 Poniard Pharmaceuticals, Inc. Synthesis of picoplatin
RU2451010C1 (ru) * 2011-01-11 2012-05-20 Закрытое Акционерное Общество "Ива Фарм" Палладиево-медные катализаторы гомогенного селективного окисления тиольных групп, комбинация и композиция на их основе и способ терапевтического воздействия
CN105254679B (zh) * 2013-11-19 2018-05-15 辽宁大学 单6-(氮杂环取代)蒽醌二氯化铂配合物及其制备方法和应用
CN103860539B (zh) * 2014-04-14 2016-02-10 于迎涛 一种具有混合轴向配体的Pt（IV）类抗癌药物及制备方法
CN104231000A (zh) * 2014-08-20 2014-12-24 山东铂源药业有限公司 一种抗肿瘤药物甲啶铂的合成方法
US10987353B2 (en) 2016-05-04 2021-04-27 The Wistar Institute Of Anatomy And Biology Methods of treating cancers overexpressing CARM1 with EZH2 inhibitors and platinum-based antineoplastic drugs
KR102137669B1 (ko) * 2019-08-05 2020-07-27 한국과학기술연구원 메탄올 또는 그 전구체 합성용 촉매, 이의 제조방법 및 이를 이용한 메탄올 또는 그 전구체의 제조방법
CN115955962B (zh) 2020-07-08 2024-07-12 代顿治疗股份公司 用于治疗淋巴肿瘤的沙铂
CN113402565B (zh) * 2021-06-16 2023-07-28 中国人民解放军空军军医大学 一类含有泊沙康唑的四价铂配合物、制备方法及其应用
AU2022430214A1 (en) 2022-01-07 2024-08-15 Pharma& Schweiz Gmbh Treating haematological malignancies by means of satraplatin

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US5665771A (en) * 1995-02-14 1997-09-09 Johnson Matthey Public Limited Company Platinum complexes

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US4533502A (en) * 1983-02-22 1985-08-06 Rochon Fernande D Platinum (II) compounds and their preparation
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DK1165576T3 (da) 1999-04-13 2006-03-27 Anormed Inc Fremgangsmåde til fremstilling af amin-platin-komplekser

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Publication number Priority date Publication date Assignee Title
US5665771A (en) * 1995-02-14 1997-09-09 Johnson Matthey Public Limited Company Platinum complexes

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Publication number Publication date
AU3951000A (en) 2000-11-14
EE04747B1 (et) 2006-12-15
EE200100536A (et) 2003-02-17
JP4756669B2 (ja) 2011-08-24
DK1165576T3 (da) 2006-03-27
IS6092A (is) 2001-09-28
IS2709B (is) 2011-01-15
IS2711B3 (is) 2011-01-15
HK1039336B (en) 2006-01-27
CZ20013648A3 (cs) 2002-02-13
ES2253214T3 (es) 2006-06-01
CN1916009A (zh) 2007-02-21
IL145671A0 (en) 2002-06-30
MXPA01010430A (es) 2002-03-27
BR0009780B1 (pt) 2013-09-24
HK1039336A1 (en) 2002-04-19
HUP0200748A2 (hu) 2002-07-29
BG65429B1 (bg) 2008-07-31
AR043084A1 (es) 2005-07-20
CY1104965T1 (el) 2010-03-03
JP2002541263A (ja) 2002-12-03
NO20014957D0 (no) 2001-10-12
CN1350540A (zh) 2002-05-22
MY122706A (en) 2006-04-29
CA2368849A1 (en) 2000-10-19
UA71614C2 (en) 2004-12-15
RU2245340C2 (ru) 2005-01-27
HK1100562A1 (en) 2007-09-21
EP1165576A1 (en) 2002-01-02
NZ514736A (en) 2004-01-30
ATE309257T1 (de) 2005-11-15
CA2368849C (en) 2011-01-25
EP1165576B1 (en) 2005-11-09
CN1847253A (zh) 2006-10-18
NO330429B1 (no) 2011-04-11
ZA200107965B (en) 2003-01-02
DE60023859D1 (de) 2005-12-15
US6518428B1 (en) 2003-02-11
CN1916009B (zh) 2010-12-15
CZ303156B6 (cs) 2012-05-09
TWI289565B (en) 2007-11-11
PL351612A1 (en) 2003-05-05
BR0009780A (pt) 2002-01-02
DE60023859T2 (de) 2006-08-03
SK14682001A3 (sk) 2002-01-07
AU770006B2 (en) 2004-02-12
WO2000061590A1 (en) 2000-10-19
SK286374B6 (sk) 2008-08-05
NO20014957L (no) 2001-12-03
PL202731B1 (pl) 2009-07-31
CN100460412C (zh) 2009-02-11
CN1250559C (zh) 2006-04-12
KR20020018189A (ko) 2002-03-07
HUP0200748A3 (en) 2010-01-28
BG106090A (en) 2002-06-28

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