KR100674672B1 - 키토산 함유 다당, 그 제조방법 및 용도 - Google Patents
키토산 함유 다당, 그 제조방법 및 용도 Download PDFInfo
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- KR100674672B1 KR100674672B1 KR1020057005950A KR20057005950A KR100674672B1 KR 100674672 B1 KR100674672 B1 KR 100674672B1 KR 1020057005950 A KR1020057005950 A KR 1020057005950A KR 20057005950 A KR20057005950 A KR 20057005950A KR 100674672 B1 KR100674672 B1 KR 100674672B1
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- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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Abstract
Description
키토산 함유 다당시료 | 원재료질량 | 키토산 함유 다당의 건조질량 | 글루코사민함량(%) 주1 | 비고 |
제조예2 | 440g | 1050mg | 55.5 | 믹서로 분쇄처리 |
제조예3 | 546g | 2702mg | 19.6 | 슬라이스한 버섯사용 |
제조예4 | 200g | 643mg | 71.3 | 오토크레이브처리 |
제조예5 | 200g | 713mg | 37.6 | 오토크레이브처리 |
제조예6 | 3.2kg | 10.8g | 64.1 | 셀룰라아제사용 |
왕게큐티쿨라(cuticula) | 8g* | 801mg | 82 | *키틴1g에 상당 |
중하큐티쿨라 | 16g* | 781mg | 85 | *키틴1g에 상당 |
원재료 | 키토산 함유 다당 함유량(mg) (주2) | 글루코사민 함유량(%) | 키토산 함유 다당 분자량(만) |
민가닥버섯 | 86 | 24 | 15.8 |
표고버섯 | 217 | 26 | 12.3 |
팽이버섯 | 496 | 15 | 12.9 |
아가리쿠스 비스포라스 | 239 | 51 | 39.8 |
마이다케 | 19 | 26 | 19.5 |
나메코 | 5.2 | - | 1.70 |
왕게 | 약10그램 | 76 |
측정법 | 분자량 | ||
제조예3 | 제조예6 | 게키토산 | |
겔여과크로마토그래피법 | - | 약15만 | 40만 |
오스트왈드형 점도계 | 6~13만 | 14~28만 | 40~58만 |
검사항목 | 투여전 | 투여후 | 표준치(참고) |
체중 | 58.6kg | 59.0kg | |
혈압 | 최고 120 최저80 | 최고 98 최저64 | 90-139 50-89 |
당뇨 뇨단백 | 3(+) 1(-) | 1(-) 1(-) | 1(-) 1(-) |
총콜레스테롤 | 160 | 141 | 120-219 |
중성지방 | 71 | 60 | 30-149 |
뇨산 클레아티닌 요소질소 | 7.7 0.7 12.9 | 6.5 0.8 11.8 | 4.0-7.5 0.7-1.2 8-21.9 |
수시혈당(식후2시간) | 145 | 112 | 70~110 |
Claims (13)
- 하기의 특성을 갖는 키토산 함유 다당 :(1) 구성당: 글루코사민과 글루코오스로 구성되며, 구성몰비가 1~5 : 5~1이다.(2) 분자량: 오스트왈드형 점도계로 측정한 분자량은 5만~40만이다. 또한, 겔 여과 크로마토그래피에 의해 측정한 분자량은 4만~20만이다.(3) 구성단위: 키토산 부분과 글루칸 부분으로 구성되어 있다.(4) 결합의 종류: β(1→4) 결합 및 β(1→6) 결합을 함유하나, β(1→3)결합을 함유하지 않는다.(5) 효소에 의한 분해성: 키토사나아제에 의해 올리고당으로 분해되나, 셀룰라아제에 의해 분해되지 않는다.(6) 단백질 및 환원성 다당: 단백질 및 환원성 다당을 포함하지 않는다.(7) 정색반응: 요소-전분반응에 음성이다.(8) 물질의 색; 무색(백색)이다.(9) 용해성: 5-10 질량%의 초산, 사과산 또는 아스코르빈산 수용액에 용해하나, 물, 에탄올, pH 10 이상의 알칼리성 수용액에는 용해하지 않는다.
- 제 1 항에 있어서, 글루코오스와 글루코사민의 구성몰비가 1:1인 것을 특징으로 하는 키토산 함유 다당.
- 제 1 항에 있어서, 키토산 함유량이 18~72%인 것을 특징으로 하는 키토산 함유 다당.
- 제 1 항에 있어서, 키토산 부분이 글루코사민의 호모폴리머인 것을 특징으로 하는 키토산 함유 다당.
- 제 1 항에 있어서, 글루칸 부분이 글루코오스의 호모폴리머인 것을 특징으로 하는 키토산 함유 다당.
- 버섯을 25~50 질량%의 가성 알칼리 수용액 중에서 가열 처리한 후, 고액분리하고, 얻어진 고형분을 유기산 수용액에 용해하고, 여기에 알코올을 첨가하거나 또는 pH 10 이상이 되도록 가성 알칼리를 첨가하여 침전을 생기게 하고, 이 침전을 세정, 건조하는 것을 특징으로 하는 상기 청구항 1 내지 5 중 어느 한 항에서 정의된 키토산 함유 다당의 제조방법.
- 제 6 항에 있어서, 가성 알칼리 수용액 중에서 가열처리 전에, 버섯을 셀룰라아제 또는 글루카나아제에 의해 예비 처리하는 것을 특징으로 하는 제조방법.
- 제 6 항에 있어서, 상기 버섯이 아가리쿠스 비스포라스인 것을 특징으로 하는 제조방법.
- 버섯을 25~50 질량%의 가성 알칼리 수용액 중에서 가열 처리한 후, 점도를 3~20 mPa·s로 조정한 후, 고액분리하고, 얻어진 고형분을 세정, 건조하는 것을 특징으로 하는 상기 청구항 1 내지 5 중 어느 한 항에서 정의된 키토산 함유 다당의 제조방법.
- 제 9 항에 있어서, 가성 알칼리 수용액 중에서 가열 처리한 후, 물 또는 산을 첨가하여 점도를 3~20 mPa·s로 조정하는 것을 특징으로 하는 제조방법.
- 상기 청구항 1 내지 5 중 어느 한 항에서 정의된 키토산 함유 다당을 유효성분으로 함유하는 것을 특징으로 하는 총콜레스테롤(overall cholesterol) 강하제.
- 상기 청구항 1 내지 5 중 어느 한 항에서 정의된 키토산 함유 다당을 유효성분으로 함유하는 것을 특징으로 하는 고혈압 및 당뇨병의 치료 예방용 의약조성물.
- 상기 청구항 1 내지 5 중 어느 한 항에서 정의된 키토산 함유 다당을 유효성분으로 함유하는 식품.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2002295379 | 2002-10-08 | ||
JPJP-P-2002-00295379 | 2002-10-08 |
Publications (2)
Publication Number | Publication Date |
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KR20050061517A KR20050061517A (ko) | 2005-06-22 |
KR100674672B1 true KR100674672B1 (ko) | 2007-01-29 |
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Country | Link |
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US (1) | US7195675B2 (ko) |
EP (1) | EP1550674B1 (ko) |
JP (1) | JP5102435B2 (ko) |
KR (1) | KR100674672B1 (ko) |
CN (1) | CN1330671C (ko) |
AU (1) | AU2003271132A1 (ko) |
CA (1) | CA2501820C (ko) |
HK (1) | HK1085489A1 (ko) |
TW (1) | TWI247752B (ko) |
WO (1) | WO2004033502A1 (ko) |
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CN112522344B (zh) * | 2020-12-23 | 2022-09-13 | 上海市农业科学院 | 一种猴头菇子实体粉固态酶解的方法 |
CN112992276B (zh) * | 2021-02-05 | 2022-10-18 | 滨州学院 | 不同水浴温度下鼠妇虫制备壳聚糖产率预测方法 |
CN113322294A (zh) * | 2021-06-30 | 2021-08-31 | 安徽本森堂生物科技有限公司 | 一种利用灵芝废渣发酵生产壳聚糖的方法 |
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JPS5344664A (en) * | 1976-10-04 | 1978-04-21 | Eisai Co Ltd | Seasoning and food and drink with same |
IT1104351B (it) * | 1978-06-14 | 1985-10-21 | Muzzarelli Riccardo | Il complesso glucano chitosano il metodo della sua produzione a partire da muffe funghi e lieviti e i suoi usi |
SE451849B (sv) * | 1985-12-11 | 1987-11-02 | Svenska Sockerfabriks Ab | Sett att syntetisera glykosidiska bindningar samt anvendning av pa detta sett erhallna produkter |
US5000000A (en) * | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
CA2008344C (en) * | 1989-01-25 | 2001-02-20 | Sadami Ishibashi | Deodorizer |
GB2259709A (en) * | 1991-09-19 | 1993-03-24 | British Textile Tech | Production of chitin/chitosan |
CN1032428C (zh) * | 1992-08-15 | 1996-07-31 | 樊菊芬 | 香菇多糖或香菇菌多糖提取新工艺 |
CN1093714A (zh) * | 1993-03-11 | 1994-10-19 | 福州梅峰制药厂 | 香菇多糖 |
EP0976400A4 (en) * | 1997-04-04 | 2002-05-08 | Mdf Co Ltd | PREVENTIVE MEASURES AND REMEDY FOR KIDNEY DISEASE |
CN1157222C (zh) * | 1997-04-04 | 2004-07-14 | Mdf株式会社 | 蘑菇亲水溶剂提取物在制造肾病的预防或者治疗药或者食品中的应用 |
US5905035A (en) * | 1997-04-15 | 1999-05-18 | Asahi Kasei Kogyo Kabushiki Kaisha | Fungus useful for chitin production |
JP2000290187A (ja) * | 1999-04-05 | 2000-10-17 | Toshio Sato | キトサン入りソフトカプセル及びその製造方法 |
US6485946B1 (en) * | 1999-07-08 | 2002-11-26 | Food Industry Research And Development Institute | Production of chitosan and chitin |
US6255085B1 (en) * | 1999-07-08 | 2001-07-03 | Food Industry Research & Development Institute | Production of chitosan and chitin |
FR2805465B1 (fr) * | 2000-02-28 | 2003-02-21 | Medecine Information Formation | Nouvelles compositions pharmaceutique ou dietetiques a base de champignons |
CA2313836C (en) * | 2000-03-15 | 2009-06-09 | Cargill, Incorporated | Chitosan and method of preparing chitosan |
US20020115639A1 (en) * | 2001-02-16 | 2002-08-22 | Weiyu Fan | Glucosamine and method of making glucosamine from microbial blomass |
BE1014638A6 (fr) * | 2002-02-12 | 2004-02-03 | Univ Liege | Methode de preparation de derives de la paroi cellulaire a partir de biomasse. |
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US20050236328A1 (en) | 2005-10-27 |
CN1720265A (zh) | 2006-01-11 |
JP5102435B2 (ja) | 2012-12-19 |
EP1550674B1 (en) | 2016-12-07 |
CA2501820C (en) | 2009-12-15 |
WO2004033502A1 (ja) | 2004-04-22 |
JPWO2004033502A1 (ja) | 2006-02-09 |
AU2003271132A1 (en) | 2004-05-04 |
EP1550674A1 (en) | 2005-07-06 |
CA2501820A1 (en) | 2004-04-22 |
EP1550674A4 (en) | 2011-06-15 |
TW200528475A (en) | 2005-09-01 |
US7195675B2 (en) | 2007-03-27 |
CN1330671C (zh) | 2007-08-08 |
KR20050061517A (ko) | 2005-06-22 |
HK1085489A1 (en) | 2006-08-25 |
TWI247752B (en) | 2006-01-21 |
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