KR100573333B1 - 지질 수준 저하를 위한 시부트라민 동족체의 용도 - Google Patents

지질 수준 저하를 위한 시부트라민 동족체의 용도 Download PDF

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Publication number
KR100573333B1
KR100573333B1 KR1019997002490A KR19997002490A KR100573333B1 KR 100573333 B1 KR100573333 B1 KR 100573333B1 KR 1019997002490 A KR1019997002490 A KR 1019997002490A KR 19997002490 A KR19997002490 A KR 19997002490A KR 100573333 B1 KR100573333 B1 KR 100573333B1
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KR
South Korea
Prior art keywords
formula
delete delete
pharmaceutically acceptable
compound
pharmaceutical composition
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Expired - Fee Related
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KR1019997002490A
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English (en)
Korean (ko)
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KR20000048567A (ko
Inventor
피터 피니안 켈리
스티븐 폴 존스
Original Assignee
애보트 게엠베하 운트 콤파니 카게
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Publication of KR20000048567A publication Critical patent/KR20000048567A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Fats And Perfumes (AREA)
  • Analogue/Digital Conversion (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1019997002490A 1996-09-25 1997-09-15 지질 수준 저하를 위한 시부트라민 동족체의 용도 Expired - Fee Related KR100573333B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9619961.7 1996-09-25
GBGB9619961.7A GB9619961D0 (en) 1996-09-25 1996-09-25 Medical treatment

Publications (2)

Publication Number Publication Date
KR20000048567A KR20000048567A (ko) 2000-07-25
KR100573333B1 true KR100573333B1 (ko) 2006-04-24

Family

ID=10800447

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997002490A Expired - Fee Related KR100573333B1 (ko) 1996-09-25 1997-09-15 지질 수준 저하를 위한 시부트라민 동족체의 용도

Country Status (26)

Country Link
US (1) US6187820B1 (enExample)
EP (1) EP0973511B1 (enExample)
JP (1) JP4143126B2 (enExample)
KR (1) KR100573333B1 (enExample)
CN (1) CN1173696C (enExample)
AT (1) ATE239459T1 (enExample)
AU (1) AU724645B2 (enExample)
BG (1) BG64472B1 (enExample)
BR (1) BR9711411A (enExample)
CA (1) CA2266378C (enExample)
CZ (1) CZ291879B6 (enExample)
DE (1) DE69721833T2 (enExample)
DK (1) DK0973511T3 (enExample)
ES (1) ES2199354T3 (enExample)
GB (1) GB9619961D0 (enExample)
HU (1) HU224711B1 (enExample)
IL (1) IL128820A (enExample)
NO (1) NO991424L (enExample)
NZ (1) NZ334550A (enExample)
PL (1) PL190017B1 (enExample)
PT (1) PT973511E (enExample)
RU (1) RU2197959C2 (enExample)
SK (1) SK284282B6 (enExample)
TR (1) TR199900648T2 (enExample)
UA (1) UA63916C2 (enExample)
WO (1) WO1998013034A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974838B2 (en) 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
US6331571B1 (en) * 1998-08-24 2001-12-18 Sepracor, Inc. Methods of treating and preventing attention deficit disorders
AU2007200334B8 (en) * 1998-08-24 2010-10-21 Sepracor, Inc. Methods of using and compositions comprising dopamine reuptake inhibitors
US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
US6476078B2 (en) 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6046242A (en) * 1998-11-27 2000-04-04 Basf Aktiengesellschaft Use of aryl-substituted cyclobutylalkylamines for treating urinary incontinence
US6323242B1 (en) 1998-12-02 2001-11-27 Peter Sterling Mueller Treatment of disorders secondary to organic impairments
US6696495B2 (en) 1998-12-02 2004-02-24 Snowden Pharmaceuticals, Llc Treatment of disorders secondary to organic impairments
US6552087B1 (en) 1999-03-19 2003-04-22 Abbott Gmbh & Co. Kg Therapeutic agent comprising (+)-sibutramine
AU3894500A (en) * 1999-03-19 2000-10-09 Knoll Pharmaceutical Company Prevention of cardiovascular disease
US6399826B1 (en) 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
FR2814678B1 (fr) * 2000-10-04 2002-12-20 Aventis Pharma Sa Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite
US6610887B2 (en) 2001-04-13 2003-08-26 Sepracor Inc. Methods of preparing didesmethylsibutramine and other sibutramine derivatives
HRP20050307A2 (en) * 2002-10-05 2006-12-31 Hanmi Pharm. Co. Ltd. Pharmaceutical composition comprising crystalline sibutramine methanesulfonate hemihydrate
EP1622600A1 (en) * 2003-04-28 2006-02-08 Cipla Ltd. Pharmaceutical formulation comprising anti-obesity agent and acidulant
US20050032908A1 (en) * 2003-08-04 2005-02-10 Beckman Kristen M. Methods for treating metabolic syndrome
US20050131074A1 (en) * 2003-08-04 2005-06-16 Beckman Kristen M. Methods for treating metabolic syndrome
KR100618176B1 (ko) 2004-12-02 2006-09-01 휴먼팜 주식회사 시부트라민 주석산염, 이의 제조 방법 및 이를 포함하는약학적 조성물
JP2008526836A (ja) * 2005-01-06 2008-07-24 シージェー チェイルジェダン コーポレーション シブトラミンの無機酸塩
KR20060080818A (ko) 2005-01-06 2006-07-11 씨제이 주식회사 시부트라민의 술폰산염
KR20060080817A (ko) 2005-01-06 2006-07-11 씨제이 주식회사 시부트라민의 디카복실산염
KR20060093564A (ko) * 2005-02-22 2006-08-25 종근당바이오 주식회사 무수 시부트라민 말산염 및 이의 제조 방법
KR100627687B1 (ko) * 2005-04-20 2006-09-25 주식회사 씨티씨바이오 시부트라민 유리염기 함유 조성물 및 이의 제조방법
KR100814384B1 (ko) * 2006-02-10 2008-03-18 대화제약 주식회사 시부트라민 염을 함유하는 약학 조성물 및 이의 제조방법
WO2008034142A2 (en) 2006-09-15 2008-03-20 Reviva Pharmaceuticals, Inc. Synthesis, methods of using, and compositions of cycloalkylmethylamines
BRPI0716002A2 (pt) * 2006-11-22 2013-07-30 Sk Chemicals Co Ltd complexo de inclusço, processo de preparaÇço de um complexo de inclusço e composiÇço de tratamento e prevenÇço de hipocondria e obesidade
WO2010082216A2 (en) * 2008-12-08 2010-07-22 Matrix Laboratories Ltd Novel salts of sibutramine and their crystal forms
WO2012003501A2 (en) 2010-07-02 2012-01-05 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
US9238625B2 (en) 2011-12-30 2016-01-19 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0397831A1 (en) * 1988-11-29 1990-11-22 Boots Co Plc TREATMENT OF OBESITAS.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52768B1 (en) 1981-04-06 1988-02-17 Boots Co Ltd 1-arylcyclobutylalkylamine compounds useful as therapeutic agents
GB8531071D0 (en) * 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound
GB8704777D0 (en) * 1987-02-28 1987-04-01 Boots Co Plc Medical treatment
JP2675573B2 (ja) * 1988-03-31 1997-11-12 科研製薬株式会社 脳機能改善剤
US5459164A (en) * 1994-02-03 1995-10-17 Boots Pharmaceuticals, Inc. Medical treatment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0397831A1 (en) * 1988-11-29 1990-11-22 Boots Co Plc TREATMENT OF OBESITAS.

Also Published As

Publication number Publication date
IL128820A0 (en) 2000-01-31
EP0973511B1 (en) 2003-05-07
JP4143126B2 (ja) 2008-09-03
HUP9903823A3 (en) 2000-07-28
NO991424D0 (no) 1999-03-24
BR9711411A (pt) 1999-08-17
IL128820A (en) 2001-10-31
NO991424L (no) 1999-03-24
TR199900648T2 (xx) 1999-06-21
UA63916C2 (uk) 2004-02-16
AU4774197A (en) 1998-04-17
PL332367A1 (en) 1999-09-13
CA2266378A1 (en) 1998-04-02
RU2197959C2 (ru) 2003-02-10
CA2266378C (en) 2007-02-13
HU224711B1 (en) 2006-01-30
JP2001500883A (ja) 2001-01-23
NZ334550A (en) 2000-09-29
DE69721833T2 (de) 2003-12-24
ES2199354T3 (es) 2004-02-16
AU724645B2 (en) 2000-09-28
PT973511E (pt) 2003-08-29
BG103249A (bg) 1999-09-30
CN1173696C (zh) 2004-11-03
PL190017B1 (pl) 2005-10-31
GB9619961D0 (en) 1996-11-13
HUP9903823A2 (hu) 2000-06-28
SK284282B6 (sk) 2004-12-01
DE69721833D1 (de) 2003-06-12
EP0973511A1 (en) 2000-01-26
KR20000048567A (ko) 2000-07-25
CZ291879B6 (cs) 2003-06-18
US6187820B1 (en) 2001-02-13
BG64472B1 (bg) 2005-04-30
WO1998013034A1 (en) 1998-04-02
ATE239459T1 (de) 2003-05-15
CN1231605A (zh) 1999-10-13
DK0973511T3 (da) 2003-08-25
SK32099A3 (en) 1999-12-10
CZ93299A3 (cs) 2000-07-12

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