KR100476796B1 - 오르토치환된벤조일구아니딘,이의제조방법및이를함유하는약제 - Google Patents

오르토치환된벤조일구아니딘,이의제조방법및이를함유하는약제 Download PDF

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Publication number
KR100476796B1
KR100476796B1 KR1019970005214A KR19970005214A KR100476796B1 KR 100476796 B1 KR100476796 B1 KR 100476796B1 KR 1019970005214 A KR1019970005214 A KR 1019970005214A KR 19970005214 A KR19970005214 A KR 19970005214A KR 100476796 B1 KR100476796 B1 KR 100476796B1
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KR
South Korea
Prior art keywords
chloro
formula
compound
hydrochloride
trifluoromethylbenzoylguanidine hydrochloride
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Expired - Fee Related
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KR1019970005214A
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English (en)
Korean (ko)
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KR970061861A (ko
Inventor
우도 알부스
요아힘 브렌델
하인쯔-베르너 클레만
한스 요헨 랑
볼프강 숄쯔
얀-로베르트 쉬바르크
안드레아스 바이헤르트
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훽스트 악티엔게젤샤프트
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Publication of KR970061861A publication Critical patent/KR970061861A/ko
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Publication of KR100476796B1 publication Critical patent/KR100476796B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1019970005214A 1996-02-22 1997-02-21 오르토치환된벤조일구아니딘,이의제조방법및이를함유하는약제 Expired - Fee Related KR100476796B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19606509A DE19606509A1 (de) 1996-02-22 1996-02-22 Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19606509.7 1996-02-22

Publications (2)

Publication Number Publication Date
KR970061861A KR970061861A (ko) 1997-09-12
KR100476796B1 true KR100476796B1 (ko) 2005-07-21

Family

ID=7786043

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970005214A Expired - Fee Related KR100476796B1 (ko) 1996-02-22 1997-02-21 오르토치환된벤조일구아니딘,이의제조방법및이를함유하는약제

Country Status (30)

Country Link
US (1) US5856574A (https=)
EP (1) EP0791577B1 (https=)
JP (1) JP3974677B2 (https=)
KR (1) KR100476796B1 (https=)
CN (1) CN1060764C (https=)
AR (1) AR005933A1 (https=)
AT (1) ATE186296T1 (https=)
AU (1) AU723096B2 (https=)
BR (1) BR9701046A (https=)
CA (1) CA2198176A1 (https=)
CZ (1) CZ287843B6 (https=)
DE (2) DE19606509A1 (https=)
DK (1) DK0791577T3 (https=)
ES (1) ES2140922T3 (https=)
GR (1) GR3032293T3 (https=)
HR (1) HRP970101B1 (https=)
HU (1) HUP9700502A3 (https=)
ID (1) ID16042A (https=)
IL (1) IL120259A (https=)
MX (1) MX9701323A (https=)
MY (1) MY117642A (https=)
NO (1) NO307046B1 (https=)
NZ (1) NZ314268A (https=)
PL (1) PL185752B1 (https=)
RU (1) RU2218329C2 (https=)
SI (1) SI0791577T1 (https=)
SK (1) SK281753B6 (https=)
TR (1) TR199700144A2 (https=)
TW (1) TW404937B (https=)
ZA (1) ZA971514B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19713427A1 (de) * 1997-04-01 1998-10-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CN111099959B (zh) * 2019-12-30 2022-09-02 西安瑞联新材料股份有限公司 一种1,4-二溴-2,5-二碘苯的工业化生产方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DK0612723T3 (da) * 1993-02-20 1998-03-30 Hoechst Ag Substituerede benzoylguanidiner, fremgangsmåde til fremstilling, deres anvendelse som lægemiddel, som inhibitor af den cellulære Na+/H+-udbytning eller som diagnostikum samt lægemiddel med indhold deraf
DE4328869A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4422685A1 (de) * 1994-06-29 1996-01-04 Hoechst Ag Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19517848A1 (de) * 1995-05-16 1996-11-21 Merck Patent Gmbh Fluorhaltige Benzoylguanidine
US5596407A (en) * 1995-06-07 1997-01-21 Varian Associates, Inc Optical detector for echelle spectrometer

Also Published As

Publication number Publication date
AU1477397A (en) 1997-08-28
MY117642A (en) 2004-07-31
NO307046B1 (no) 2000-01-31
HU9700502D0 (en) 1997-04-28
AU723096B2 (en) 2000-08-17
DK0791577T3 (da) 2000-04-25
NO970798D0 (no) 1997-02-21
ZA971514B (en) 1997-08-22
PL318417A1 (en) 1997-09-01
IL120259A (en) 2001-05-20
DE19606509A1 (de) 1997-08-28
SK281753B6 (sk) 2001-07-10
HRP970101A2 (en) 1998-04-30
EP0791577A1 (de) 1997-08-27
DE59700640D1 (de) 1999-12-09
PL185752B1 (pl) 2003-07-31
HUP9700502A2 (en) 1997-12-29
US5856574A (en) 1999-01-05
TW404937B (en) 2000-09-11
IL120259A0 (en) 1997-06-10
JP3974677B2 (ja) 2007-09-12
MX9701323A (es) 1997-08-30
ATE186296T1 (de) 1999-11-15
AR005933A1 (es) 1999-07-21
NZ314268A (en) 1997-11-24
ID16042A (id) 1997-08-28
CZ287843B6 (en) 2001-02-14
SI0791577T1 (en) 2000-02-29
SK23797A3 (en) 1997-11-05
CN1161960A (zh) 1997-10-15
ES2140922T3 (es) 2000-03-01
RU2218329C2 (ru) 2003-12-10
HUP9700502A3 (en) 1998-01-28
BR9701046A (pt) 1998-12-15
GR3032293T3 (en) 2000-04-27
CA2198176A1 (en) 1997-08-22
JPH09227496A (ja) 1997-09-02
CZ52897A3 (cs) 1998-06-17
KR970061861A (ko) 1997-09-12
TR199700144A2 (tr) 1997-09-21
HRP970101B1 (en) 2001-02-28
CN1060764C (zh) 2001-01-17
NO970798L (no) 1997-08-25
EP0791577B1 (de) 1999-11-03

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