KR100266499B1 - 나프티리딘 카복실산 유도체의 염 및 그의 수화물 - Google Patents

나프티리딘 카복실산 유도체의 염 및 그의 수화물 Download PDF

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Publication number
KR100266499B1
KR100266499B1 KR1019980009717A KR19980009717A KR100266499B1 KR 100266499 B1 KR100266499 B1 KR 100266499B1 KR 1019980009717 A KR1019980009717 A KR 1019980009717A KR 19980009717 A KR19980009717 A KR 19980009717A KR 100266499 B1 KR100266499 B1 KR 100266499B1
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KR
South Korea
Prior art keywords
hydrate
hydrates
compound
relative humidity
methanesulfonic acid
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Application number
KR1019980009717A
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English (en)
Korean (ko)
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KR19980080504A (ko
Inventor
최훈
남두현
장재혁
이태희
최종류
박기숙
이진화
김애리
Original Assignee
성재갑
주식회사엘지화학
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 성재갑, 주식회사엘지화학 filed Critical 성재갑
Publication of KR19980080504A publication Critical patent/KR19980080504A/ko
Application granted granted Critical
Publication of KR100266499B1 publication Critical patent/KR100266499B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019980009717A 1997-03-21 1998-03-20 나프티리딘 카복실산 유도체의 염 및 그의 수화물 KR100266499B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19970009840 1997-03-21
KR1019970009840 1997-03-21
KR97-9840 1997-03-21

Publications (2)

Publication Number Publication Date
KR19980080504A KR19980080504A (ko) 1998-11-25
KR100266499B1 true KR100266499B1 (ko) 2000-12-01

Family

ID=19500439

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980009717A KR100266499B1 (ko) 1997-03-21 1998-03-20 나프티리딘 카복실산 유도체의 염 및 그의 수화물

Country Status (39)

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US (9) US7700617B2 ( )
EP (2) EP1179533B1 ( )
JP (3) JP3759962B2 ( )
KR (1) KR100266499B1 ( )
CN (1) CN1131229C ( )
AP (1) AP1331A ( )
AR (1) AR012125A1 ( )
AT (2) ATE257836T1 ( )
AU (1) AU726634B2 ( )
BG (1) BG63972B1 ( )
BR (1) BR9808290A ( )
CA (1) CA2283671C ( )
CZ (2) CZ288673B6 ( )
DE (2) DE69821147T2 ( )
DK (2) DK0981527T3 ( )
DZ (1) DZ2448A1 ( )
EA (1) EA001674B1 ( )
ES (2) ES2198697T3 ( )
HK (1) HK1026698A1 ( )
HU (2) HU227536B1 ( )
ID (1) ID22681A ( )
IL (2) IL131812A0 ( )
IN (1) IN188178B ( )
IS (2) IS2093B ( )
MA (1) MA24500A1 ( )
MY (1) MY137653A ( )
NO (1) NO312515B1 ( )
NZ (1) NZ337748A ( )
OA (1) OA11161A ( )
PE (1) PE67999A1 ( )
PL (1) PL191815B1 ( )
PT (2) PT981527E ( )
SA (1) SA98181055B1 ( )
SI (2) SI1179533T1 ( )
SK (1) SK284107B6 ( )
TR (1) TR199902313T2 ( )
UA (1) UA56218C2 ( )
WO (1) WO1998042705A1 ( )
ZA (1) ZA982335B ( )

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US6331550B1 (en) 1999-06-29 2001-12-18 Smithkline Beecham Corporation Methods of use of quinolone compounds against anaerobic pathogenic bacteria
US6262071B1 (en) 1999-06-29 2001-07-17 Smithkline Beecham Corporation Methods of use of antimicrobial compounds against pathogenic amycoplasma bacteria
US6803376B1 (en) 1999-06-29 2004-10-12 Smithkline Beecham Corporation Method of use of quinolone compounds against pneumococcal and haemophilus bacteria
CA2282066C (en) 1999-06-29 2010-09-07 Smithkline Beecham Corporation Methods of use of quinolone compounds against atypical upper respiratory pathogenic bacteria
GB9920917D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
JP2001097863A (ja) * 1999-09-24 2001-04-10 Smithkline Beecham Corp 嫌気性病原菌に対するフルオロキノロン化合物の使用法
JP2001097864A (ja) * 1999-09-24 2001-04-10 Smithkline Beecham Corp 呼吸管および尿路病原性細菌に対するフルオロキノリン化合物の使用方法
GR1003520B (el) * 1999-09-22 2001-01-22 Smithkline Beecham Plc Μεθοδος χρησης ενωσεων φλουοροκινολονης εναντια σε νοσοκομειακα αρνητικα κατα gramμ παθογενων βακτηριδιων
JP2001097891A (ja) * 1999-09-24 2001-04-10 Smithkline Beecham Corp 呼吸器系病原菌に対するフルオロキノロン化合物の使用法
WO2001021176A1 (en) * 1999-09-22 2001-03-29 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against bacteria
GR1003521B (el) * 1999-09-23 2001-01-22 Smithkline Beecham Plc Μεθοδοι χρησεως ενωσεων φλουοροκινολονης εναντια κατα gram θετικων παθογονων βακτηριδιων
KR20010091379A (ko) * 2000-03-15 2001-10-23 성재갑 7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법
ATE410225T1 (de) 2001-08-02 2008-10-15 Lg Life Sciences Ltd Verfahren zur herstellung von amino-geschützten 4-aminomethylene-pyrrolidin-3-on-derivaten, gemifloxacin und deren salze
PT1458391E (pt) * 2001-11-30 2007-12-10 Lg Life Sciences Ltd Um processo para tratamento de infecções bacterianas através do uso de gemifloxacina ou um seu sal e um antibiótico b-lactâmico
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WO2010001408A2 (en) * 2008-06-06 2010-01-07 Matrix Laboratories Ltd. Novel polymorphic forms of gemifloxacin mesylate
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EP2491921A1 (en) * 2011-02-25 2012-08-29 Deva Holding Anonim Sirketi Conservation of anhydrous form of gemifloxacin
KR102220969B1 (ko) * 2012-02-27 2021-02-25 브리스톨-마이어스 스큅 컴퍼니 N-(5S,6S,9R)-5-아미노-6-(2,3-디플루오로페닐)-6,7,8,9-테트라히드로-5H-시클로헵타[b]피리딘-9-일-4-(2-옥소-2,3-디히드로-1H-이미다조[4,5-b]피리딘-1-일)피페리딘-1-카르복실레이트, 헤미술페이트 염
CZ2016104A3 (cs) * 2016-02-24 2017-09-06 Zentiva, K.S. Krystalické modifikace solí methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}fenyl)amino](fenyl)methyliden}-2-oxo-2,3-dihydro-1H-indol-6-karboxylátu a způsoby jejich přípravy

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GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process

Also Published As

Publication number Publication date
HU227536B1 (en) 2011-08-29
US7700617B2 (en) 2010-04-20
US20160264569A1 (en) 2016-09-15
PE67999A1 (es) 1999-09-30
US20170253588A1 (en) 2017-09-07
EP0981527A1 (en) 2000-03-01
DZ2448A1 (fr) 2003-01-11
HK1026698A1 (en) 2000-12-22
AP9901649A0 (en) 1999-09-30
BG63972B1 (bg) 2003-08-29
WO1998042705A1 (en) 1998-10-01
US20080039488A1 (en) 2008-02-14
SK123699A3 (en) 2000-08-14
ATE239724T1 (de) 2003-05-15
MA24500A1 (fr) 1998-10-01
BG103750A (en) 2000-06-30
EP0981527B1 (en) 2003-05-07
US20130065917A1 (en) 2013-03-14
NO312515B1 (no) 2002-05-21
HUP0000728A3 (en) 2002-12-28
AP1331A (en) 2004-11-26
CZ328299A3 (cs) 2000-02-16
ATE257836T1 (de) 2004-01-15
US20100240694A1 (en) 2010-09-23
PT981527E (pt) 2003-09-30
NO994595L (no) 1999-09-21
JP2009051851A (ja) 2009-03-12
IL131812A (en) 2006-04-10
IS2095B (is) 2006-04-12
HUP0000728A2 (hu) 2000-09-28
CN1251101A (zh) 2000-04-19
EA199900855A1 (ru) 2000-04-24
EP1179533A3 (en) 2002-03-20
BR9808290A (pt) 2000-05-16
ES2213669T3 (es) 2004-09-01
PL191815B1 (pl) 2006-07-31
CA2283671A1 (en) 1998-10-01
US20090182006A1 (en) 2009-07-16
AU726634B2 (en) 2000-11-16
UA56218C2 (uk) 2003-05-15
OA11161A (en) 2003-04-25
NO994595D0 (no) 1999-09-21
JP2004002413A (ja) 2004-01-08
CZ288673B6 (cs) 2001-08-15
DE69814378T2 (de) 2004-02-26
US20150291585A1 (en) 2015-10-15
TR199902313T2 (xx) 1999-12-21
KR19980080504A (ko) 1998-11-25
CA2283671C (en) 2003-09-16
IS2093B (is) 2006-04-12
US20110312987A1 (en) 2011-12-22
PL335812A1 (en) 2000-05-22
EP1179533B1 (en) 2004-01-14
SA98181055B1 (ar) 2006-10-11
IL131812A0 (en) 2001-03-19
ID22681A (id) 1999-12-09
IS5181A (is) 1999-09-14
JP3759962B2 (ja) 2006-03-29
DE69821147T2 (de) 2004-11-11
EP1179533A2 (en) 2002-02-13
PT1179533E (pt) 2004-05-31
AU6636698A (en) 1998-10-20
DK1179533T3 (da) 2004-05-03
CN1131229C (zh) 2003-12-17
AR012125A1 (es) 2000-09-27
DK0981527T3 (da) 2003-09-01
SK284107B6 (sk) 2004-09-08
HU225412B1 (en) 2006-11-28
ES2198697T3 (es) 2004-02-01
DE69821147D1 (de) 2004-02-19
ZA982335B (en) 1999-11-23
HUP0600401A3 (en) 2010-05-28
HU0600401D0 (en) 2006-07-28
IS7952A (is) 2005-07-21
US20140187576A1 (en) 2014-07-03
JP2000510484A (ja) 2000-08-15
NZ337748A (en) 2001-03-30
JP4781614B2 (ja) 2011-09-28
SI0981527T1 (en) 2003-10-31
MY137653A (en) 2009-02-27
SI1179533T1 (en) 2004-04-30
IN188178B ( ) 2002-08-31
DE69814378D1 (de) 2003-06-12
CZ288715B6 (cs) 2001-08-15
EA001674B1 (ru) 2001-06-25

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