KR100245284B1 - 이중 d-루프 형성의 진단학적 응용 - Google Patents

이중 d-루프 형성의 진단학적 응용 Download PDF

Info

Publication number
KR100245284B1
KR100245284B1 KR1019940700724A KR19940700724A KR100245284B1 KR 100245284 B1 KR100245284 B1 KR 100245284B1 KR 1019940700724 A KR1019940700724 A KR 1019940700724A KR 19940700724 A KR19940700724 A KR 19940700724A KR 100245284 B1 KR100245284 B1 KR 100245284B1
Authority
KR
South Korea
Prior art keywords
dna
probe
target
chain
double
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019940700724A
Other languages
English (en)
Korean (ko)
Inventor
세나 엘리사피
칼호운 코넬리아제이
자링 데이비드에이
Original Assignee
이노우에 노리유끼
다이낑 고오교 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/520,321 external-priority patent/US5223414A/en
Priority claimed from US07/755,462 external-priority patent/US5273881A/en
Application filed by 이노우에 노리유끼, 다이낑 고오교 가부시키가이샤 filed Critical 이노우에 노리유끼
Application granted granted Critical
Publication of KR100245284B1 publication Critical patent/KR100245284B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Stabilization Of Oscillater, Synchronisation, Frequency Synthesizers (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
KR1019940700724A 1990-05-07 1992-09-04 이중 d-루프 형성의 진단학적 응용 Expired - Fee Related KR100245284B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US07/520,321 US5223414A (en) 1990-05-07 1990-05-07 Process for nucleic acid hybridization and amplification
US7/755,462 1991-09-04
US07/755,462 US5273881A (en) 1990-05-07 1991-09-04 Diagnostic applications of double D-loop formation
US91079192A 1992-07-09 1992-07-09
US7/910,791 1992-07-09
PCT/JP1992/001135 WO1993005178A1 (en) 1990-05-07 1992-09-04 Diagnostic applications of double d-loop formation

Publications (1)

Publication Number Publication Date
KR100245284B1 true KR100245284B1 (ko) 2000-03-02

Family

ID=27414753

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940700724A Expired - Fee Related KR100245284B1 (ko) 1990-05-07 1992-09-04 이중 d-루프 형성의 진단학적 응용

Country Status (13)

Country Link
US (1) US5670316A (cg-RX-API-DMAC7.html)
EP (1) EP0612352B1 (cg-RX-API-DMAC7.html)
JP (1) JP2745816B2 (cg-RX-API-DMAC7.html)
KR (1) KR100245284B1 (cg-RX-API-DMAC7.html)
AT (1) ATE153707T1 (cg-RX-API-DMAC7.html)
AU (1) AU661505B2 (cg-RX-API-DMAC7.html)
CA (1) CA2116215C (cg-RX-API-DMAC7.html)
DE (1) DE69220084T2 (cg-RX-API-DMAC7.html)
DK (1) DK0612352T3 (cg-RX-API-DMAC7.html)
ES (1) ES2101867T3 (cg-RX-API-DMAC7.html)
FI (1) FI941016A7 (cg-RX-API-DMAC7.html)
NO (1) NO313557B1 (cg-RX-API-DMAC7.html)
WO (1) WO1993005178A1 (cg-RX-API-DMAC7.html)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506098A (en) * 1991-09-04 1996-04-09 Daikin Industries, Ltd. In situ hybridization method
AU4115693A (en) * 1992-04-24 1993-11-29 Sri International In vivo homologous sequence targeting in eukaryotic cells
US5929043A (en) * 1995-01-31 1999-07-27 Pangene Corporation Recombinase mediated DNA therapies
FR2737502B1 (fr) * 1995-07-31 1997-10-24 Genset Sa Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
DE69730145T2 (de) 1996-08-29 2005-07-14 Tapestry Pharmaceuticals, Inc., Boulder VERFAHREN ZUM AUFFINDEN, NACHWEISEN, ANREICHERN UND/ODER ISOLIEREN VON ZIEL-NUcLEINSÄURESEQUENZEN UNTER VERWENDUNG VON VON RECA ÄHNLICHER REKOMBINASE
JP3891620B2 (ja) * 1996-11-14 2007-03-14 株式会社アイシン・コスモス研究所 ヘアピン型構造の核酸プローブ分子、及び該核酸プローブ分子を利用した核酸検出方法
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
US6342350B1 (en) * 1997-09-05 2002-01-29 The General Hospital Corporation Alpha-2-macroglobulin diagnostic test
WO1999037755A2 (en) * 1997-12-11 1999-07-29 Pangene Corporation The use of consensus sequences for targeted homologous gene isolation and recombination in gene families
WO1999050446A1 (de) * 1998-04-01 1999-10-07 Wolfrum Juergen Verfahren und vorrichtung zur quantifizierung von dna und rna
US6287772B1 (en) * 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
US6541227B1 (en) * 1998-10-12 2003-04-01 Aisin Seiki Kabushiki Kaisha Preparation of labeled DNA
JP4265028B2 (ja) * 1999-04-14 2009-05-20 アイシン精機株式会社 二本鎖dnaの特異的切断方法およびそのためのキット
WO2000063365A1 (en) * 1999-04-21 2000-10-26 Pangene Corporation Locked nucleic acid hybrids and methods of use
AU2586001A (en) * 1999-12-21 2001-07-03 Ortho-Clinical Diagnostics, Inc. Detection of nucleic acids
CA2397357A1 (en) * 1999-12-28 2001-07-05 David A. Zarling Recombinase mediated gene chip detection
EP1368501A4 (en) * 2001-02-21 2005-01-19 Gene Check Inc MUTATION PROTECTION WITH MUTS AND RECA
AU2002303176A1 (en) * 2001-03-27 2002-10-15 University Of Delaware Genomics applications for modified oligonucleotides
WO2002086167A1 (en) 2001-04-20 2002-10-31 The Penn State Research Foundation Methods for nucleic acid manipulation
US7468244B2 (en) * 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
WO2003027640A2 (en) * 2001-09-28 2003-04-03 University Of Delaware Polymorphism detection and separation
US7244562B2 (en) * 2001-11-01 2007-07-17 Gene Check, Inc. RecA assisted detection of mutations, single nucleotide polymorphisms and specific sequences
PT1499738E (pt) * 2002-02-21 2008-10-20 Asm Scient Inc Amplificação de polimerase recombinase
US7399590B2 (en) * 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
CN1330775C (zh) * 2002-05-08 2007-08-08 爱科来株式会社 靶核酸的检测方法
WO2004007692A2 (en) * 2002-07-17 2004-01-22 U.S.Genomics, Inc. Methods and compositions for analyzing polymers using chimeric tags
US20040224336A1 (en) * 2003-03-11 2004-11-11 Gene Check, Inc. RecA-assisted specific oligonucleotide extension method for detecting mutations, SNPs and specific sequences
EP1651778A1 (en) * 2003-08-01 2006-05-03 U.S. Genomics, Inc. Methods and compositions related to the use of sequence-specific endonucleases for analyzing nucleic acids under non-cleaving conditions
WO2005017205A2 (en) * 2003-08-04 2005-02-24 U. S. Genomics, Inc. Nucleic acid mapping using linear analysis
EP3985125A1 (en) * 2004-06-01 2022-04-20 Abbott Diagnostics Scarborough, Inc. Recombinase polymerase amplification
JP2006055065A (ja) * 2004-08-19 2006-03-02 Toyo Kohan Co Ltd 非対称pcrを用いた核酸の検出方法、ポリヌクレオチドプローブ、それを固定するプローブ固定化担体およびキット
WO2006051988A1 (ja) * 2004-11-15 2006-05-18 Riken 核酸の増幅方法
EP2829615B1 (en) 2005-07-25 2018-05-09 Alere San Diego, Inc. Kit for multiplexing recombinase polymerase amplification
US20090064377A1 (en) * 2005-09-29 2009-03-05 Daphne Yvette Rainey-Wittich Method and means for targeted nucleotide exchange
US20070202522A1 (en) * 2006-02-27 2007-08-30 Salinas Frank G Isothermal screening of tumor cell related nucleic acids
US20080003600A1 (en) * 2006-02-27 2008-01-03 Salinas Frank G Isothermal screening of breast cancer related nucleic acid
US20090061413A1 (en) * 2006-02-27 2009-03-05 Salinas Frank G Isothermal screening of hiv-1 related nucleic acids
US20080220421A1 (en) * 2006-02-27 2008-09-11 Salinas Frank G Isothermal screening for nucleic acids associated with diseases and conditions of the gi tract
US8071308B2 (en) 2006-05-04 2011-12-06 Alere San Diego, Inc. Recombinase polymerase amplification
EP2432795B1 (en) 2009-05-20 2015-03-04 Alere San Diego, Inc. Dna glycosylase/lyase and ap endonuclease substrates
EP2438196B1 (en) 2009-06-05 2016-12-21 Alere San Diego, Inc. Recombinase polymerase amplification reagents and kits
CA2792433C (en) 2010-03-08 2016-10-11 Gerassimos Makrigiorgos Full cold-pcr enrichment with reference blocking sequence
EP2691541B1 (en) 2011-03-31 2017-10-18 Dana-Farber Cancer Institute, Inc. Method for enriching in single-stranded mutant sequences from mixture of wild-type and mutant sequences
JP5961247B2 (ja) 2011-04-07 2016-08-02 アリーア サン ディエゴ, インコーポレイテッド リコンビナーゼポリメラーゼ増幅混合物のモニタリング
EP2839026B1 (en) 2012-04-19 2016-08-10 Life Technologies Corporation Nucleic acid amplification
WO2013158313A1 (en) 2012-04-19 2013-10-24 Life Technologies Corporation Nucleic acid amplification
WO2014020137A1 (en) * 2012-08-02 2014-02-06 Qiagen Gmbh Recombinase mediated targeted dna enrichment for next generation sequencing
EP3257952B1 (en) 2012-09-11 2020-02-12 Life Technologies Corporation Nucleic acid amplification
WO2014043143A1 (en) 2012-09-11 2014-03-20 Life Technologies Corporation Nucleic acid amplification
US20170009288A1 (en) 2014-02-03 2017-01-12 Thermo Fisher Scientific Baltics Uab Method for controlled dna fragmentation
WO2015191815A1 (en) 2014-06-13 2015-12-17 Life Technologies Corporation Multiplex nucleic acid amplification
WO2016201142A1 (en) 2015-06-09 2016-12-15 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
JP6941568B2 (ja) * 2015-06-24 2021-09-29 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド ヌクレアーゼを使用する野生型dnaの選択的分解および突然変異体対立遺伝子の濃縮
HK1258716A1 (zh) 2015-12-09 2019-11-15 Life Technologies Corporation 与表面结合的核酸分子的检测和量化
LT3402880T (lt) 2016-01-15 2024-03-12 Thermo Fisher Scientific Baltics Uab Termofiliniai dnr polimerazės mutantai
WO2017214561A1 (en) 2016-06-10 2017-12-14 Life Technologies Corporation Methods and compositions for nucleic acid amplification
WO2018071522A1 (en) 2016-10-11 2018-04-19 Life Technologies Corporation Rapid amplification of nucleic acids
CA3046953A1 (en) 2016-12-12 2018-06-21 Dana Farber Cancer Institute, Inc. Compositions and methods for molecular barcoding of dna molecules prior to mutation enrichment and/or mutation detection
US11542540B2 (en) 2017-06-16 2023-01-03 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
EP3645710A1 (en) 2017-06-26 2020-05-06 Thermo Fisher Scientific Baltics Uab Thermophilic dna polymerase mutants
DE102017114537A1 (de) * 2017-06-29 2019-01-03 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und optischer Sensor
WO2019094524A1 (en) 2017-11-07 2019-05-16 Life Technologies Corporation Methods and compositions for manipulating nucleic acids
US12226745B2 (en) 2017-11-07 2025-02-18 Life Technologies Corporation Methods and compositions for manipulating nucleic acids
EP3963103B1 (en) 2019-05-03 2024-02-28 Life Technologies Corporation Methods and compositions for manipulating nucleic acids
CN114514328A (zh) 2019-08-21 2022-05-17 生命技术公司 用于测序的系统和方法
WO2022104272A1 (en) 2020-11-16 2022-05-19 Life Technologies Corporation System and method for sequencing
NL2033124B1 (en) 2022-09-23 2024-03-29 Rapidemic B V Methods and device for multiple-label nucleic acid amplification and detection
WO2025144744A1 (en) 2023-12-29 2025-07-03 Life Technologies Corporation Enrichment of clonal substrates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
CA1254114A (en) * 1984-05-07 1989-05-16 Allied Corporation Displacement polynucleotide assay employing recombination protein and diagnostic kit
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
WO1985005685A1 (en) * 1984-06-01 1985-12-19 National Biomedical Research Foundation Catalyzed nucleic acid hybridization using enzymatic reagent
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
EP0236491A1 (en) * 1985-09-18 1987-09-16 Yale University RecA NUCLEOPROTEIN FILAMENT AND METHODS
US4888274A (en) * 1985-09-18 1989-12-19 Yale University RecA nucleoprotein filament and methods
DE3888653T2 (de) * 1987-12-21 1994-07-07 Applied Biosystems Verfahren und Testsatz zum Nachweis einer Nukleinsäure-Sequenz.
AU2735988A (en) * 1987-12-21 1989-07-13 Amoco Corporation Target and background capture methods with amplification for affinity assays
US5273881A (en) * 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
US5223414A (en) * 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
US5506098A (en) * 1991-09-04 1996-04-09 Daikin Industries, Ltd. In situ hybridization method

Also Published As

Publication number Publication date
AU2540192A (en) 1993-04-05
ES2101867T3 (es) 1997-07-16
EP0612352A1 (en) 1994-08-31
NO313557B1 (no) 2002-10-21
AU661505B2 (en) 1995-07-27
EP0612352B1 (en) 1997-05-28
US5670316A (en) 1997-09-23
WO1993005178A1 (en) 1993-03-18
FI941016L (fi) 1994-05-03
CA2116215C (en) 1998-12-22
FI941016A0 (fi) 1994-03-03
FI941016A7 (fi) 1994-05-03
ATE153707T1 (de) 1997-06-15
NO940744L (cg-RX-API-DMAC7.html) 1994-05-02
CA2116215A1 (en) 1993-03-05
JPH06510201A (ja) 1994-11-17
DE69220084D1 (de) 1997-07-03
NO940744D0 (no) 1994-03-03
JP2745816B2 (ja) 1998-04-28
DE69220084T2 (de) 1997-09-11
DK0612352T3 (da) 1997-06-30

Similar Documents

Publication Publication Date Title
KR100245284B1 (ko) 이중 d-루프 형성의 진단학적 응용
US5273881A (en) Diagnostic applications of double D-loop formation
JP2819830B2 (ja) インサイチューハイブリダイゼーション法
US6027877A (en) Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, purification of amplified DNA samples and allele identification
US5545524A (en) Compositions and methods for chromosome region-specific probes
JP2685143B2 (ja) 標識用組成物
EP0281927B1 (en) Assay for nucleic acid sequences in a sample
EP1206577B1 (en) Binary encoded sequence tags
US20070042365A1 (en) Assay for detecting methylation changes in nucleic acids using an intercalating nucleic acid
US6054266A (en) Nucleic acid detection with separation
JP2002516667A (ja) 修飾バックボーンを有するアンチセンスプローブと核酸の液中ハイブリッド形成
JP2002502614A (ja) ミスマッチ検出技術
EP0322311B1 (en) Method and kit for detecting a nucleic acid sequence
JPH09508268A (ja) 核酸の配列決定
JP2015508995A (ja) 核酸ハイブリダイゼーションプローブ
JP2761159B2 (ja) 相補的核酸配列の検出方法及びそのためのキット
US20240309434A1 (en) Targeted rare allele crispr enrichment
JPH01501339A (ja) 改良された核酸ハイブリダイゼーション方法及びそれに用いるキット
EP0439502A1 (en) A purification process for covalently bound dna/protein complexes
CN1434873B (zh) 选择性分离核酸的方法
US20100021971A1 (en) Method to remove repetitive sequences from human dna
JP5967785B2 (ja) 標的核酸の検出方法
US20080318215A1 (en) Apparatus, methods and products for detecting genetic mutation
JPH03123500A (ja) 核酸の分別方法
JP2001522588A (ja) 特異的ヌクレオチド配列を検出するための方法および組成物

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

FPAY Annual fee payment

Payment date: 20041001

Year of fee payment: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R14-asn-PN2301

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20051130

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20051130

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000