JPWO2009113426A1 - しわ抑制用組成物と皮膚外用組成物 - Google Patents
しわ抑制用組成物と皮膚外用組成物 Download PDFInfo
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- JPWO2009113426A1 JPWO2009113426A1 JP2010502776A JP2010502776A JPWO2009113426A1 JP WO2009113426 A1 JPWO2009113426 A1 JP WO2009113426A1 JP 2010502776 A JP2010502776 A JP 2010502776A JP 2010502776 A JP2010502776 A JP 2010502776A JP WO2009113426 A1 JPWO2009113426 A1 JP WO2009113426A1
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- skin
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- human skin
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
Description
(1)皮膚表面に凹凸起伏の形成を生じる。(シリコンゴム複製法を用いたレプリカ解析を示している図1(a)から図1(b)への変化)
(2)皮膚表面に多数の角質の鱗片剥離を生じる(走査型電子顕微鏡写真を示している図2(a)から図2(b)への変化)
(3)皮膚断面に真皮の多層分離と垂直萎縮が生じる(DMSO凍結割断法を用いた電子顕微鏡写真を示している図3(a)から図3(b)への変化)
ところが驚くべきことに、これら3種(1)(2)(3)のしわ関連症状のいずれも、スクワランにフラーレンを溶解させた油溶状フラーレンの皮膚表面への塗布によって防御されることが確認された。一方、スクワラン単独では無効であることも確認された。
皮膚外用組成物におけるフラーレン類の濃度は、たとえば0.00001〜30質量%であり、使用感的側面などを考慮すると5質量%以下が好ましい。皮膚に適用する場合、外用組成物の量は、たとえば皮膚面積1平方メートル当たり液体0.001〜20ml、好ましくは0.01〜5.0mlであり、外用塗布、湿布または噴霧などにより適用することが望ましい。
皮膚外用組成物の形態の例としては、特に限定されず、たとえば、水溶剤、軟膏、乳液、クリーム、ジェル剤、パック、浴剤、洗浄剤、パップ剤、分散液などのあらゆる外用剤の形態を取ることができ、その剤型についても特に制限はなく、ペースト状、ムース状、ジェル状、粉末状、溶液系、可溶化系、乳化系とすることができる。特に水溶液、乳剤、軟膏剤、ジェル剤、水溶性剤、美容液、パック剤については、これらの剤を外用した後に加湿導入器、振動導入器、イオン導入器、音波導入器、電磁波導入器を用いることによりフラーレン類の皮膚への浸透を促進することができより大きな効果を発揮できる。
<実施例1>
3次元皮膚組織モデル(Test skin LSE-high、東洋紡績)を用いて、下記表1の手順に従って試験サンプルを作製し、リポフラーレンによるシワ抑制試験を行った。
<実施例2>
スクワランに溶解したフラーレン、すなわちリポフラーレンを用いて、NDAによるヒト皮膚角化細胞(HaCaT)の細胞死(アポトーシス)抑制の効果をTUNEL染色により検証した。
<実施例3>
C60フラーレンの割合が概ね95%のC60標品を、植物性スクワランに溶解し、次いでPotter型ホモジナイザーによって減気泡条件下(アスピレータで減圧化して気泡を減少させるに水分散させ、O/Wエマルジョンを形成した。
<実施例4>
真皮、基底膜、表皮、および角質層を有する直径24mmのヒト皮膚通常組織モデルを次の手順にて作製した。
<実施例5>
実施例4と同様の試料を用い、リポフラーレンによるNDA防御効果(細胞核保持効果)を、Hoechst33342核染色を用いた蛍光顕微鏡測定により調べた。スクワランまたはリポフラーレン(C60として2, 50, 200ppm) 150μL/wellをヒト皮膚通常組織モデル(φ 24mm)に投与してインキュベート(5hr, 37℃)した。次いで450μM NDA/wellを含む培地に交換し、インキュベート(42hr, 37℃, 5% CO2)した。PBS(-) 200μLで3回リンスし、凍結後、皮膚切片(厚さ5mm)についてHoechst33342核染色を行い、蛍光顕微鏡で観察した。
<実施例6>
リポフラーレン配合化粧品について、無作為化二重盲検マッチドペア比較試験を行った。被験者23名を対象として、下記表4に示す処方の化粧品(クリーム、左:被験品、フラーレン 1.8μg/日、右:プラセボ、フラーレン 0.0μg/日)を塗布した。I群(11名)には被験品を右半顔に塗布、プラセボを左半顔に塗布し、II群(12名)にはプラセボを右半顔に塗布、被験品を左半顔に塗布した。
<実施例7>
実施例4と同様にして真皮、基底膜、表皮、および角質層を有するヒト皮膚通常組織モデルを作製した。
Claims (4)
- フラーレン類をスクワラン類に溶解した油溶状フラーレンを含有することを特徴とするしわ抑制用組成物。
- フラーレン類として、C60、C70、およびこれらの塩または誘導体から選ばれる少なくとも1種を含有することを特徴とする請求項1に記載のしわ抑制用組成物。
- ヒト皮膚角化細胞および/またはヒト皮膚繊維芽細胞および/またはこれらを含む皮膚組織での過酸化脂質および/または活性酸素を含む酸化ストレスによるDNA2本鎖/1本鎖切断および/またはDNA塩基損傷を含むDNA傷害を防御することを特徴とする請求項1または2に記載のしわ抑制用組成物。
- 請求項1から3のいずれかに記載の組成物からなることを特徴とする皮膚外用組成物。
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