JPS63165397A - 抗ウイルス性化合物 - Google Patents

抗ウイルス性化合物

Info

Publication number
JPS63165397A
JPS63165397A JP62315960A JP31596087A JPS63165397A JP S63165397 A JPS63165397 A JP S63165397A JP 62315960 A JP62315960 A JP 62315960A JP 31596087 A JP31596087 A JP 31596087A JP S63165397 A JPS63165397 A JP S63165397A
Authority
JP
Japan
Prior art keywords
group
formula
hydrogen
compound
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62315960A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0378370B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
サード　ジョージ　ラヒム
ドロシィ　ジェーン　マーチン　プリフォイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of JPS63165397A publication Critical patent/JPS63165397A/ja
Publication of JPH0378370B2 publication Critical patent/JPH0378370B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Silicon Polymers (AREA)
JP62315960A 1986-12-15 1987-12-14 抗ウイルス性化合物 Granted JPS63165397A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868629892A GB8629892D0 (en) 1986-12-15 1986-12-15 Antiviral compounds
GB8629892 1986-12-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2270325A Division JPH03141292A (ja) 1986-12-15 1990-10-08 抗ウィルス性化合物

Publications (2)

Publication Number Publication Date
JPS63165397A true JPS63165397A (ja) 1988-07-08
JPH0378370B2 JPH0378370B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-12-13

Family

ID=10609013

Family Applications (2)

Application Number Title Priority Date Filing Date
JP62315960A Granted JPS63165397A (ja) 1986-12-15 1987-12-14 抗ウイルス性化合物
JP2270325A Pending JPH03141292A (ja) 1986-12-15 1990-10-08 抗ウィルス性化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2270325A Pending JPH03141292A (ja) 1986-12-15 1990-10-08 抗ウィルス性化合物

Country Status (30)

Country Link
US (1) US5079235A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (3) EP0417560A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPS63165397A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR880007521A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN87108265A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE88713T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU601529B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1319143C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (3) CS275398B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (2) DD264924A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3785651T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (2) DK654287A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2054693T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (2) FI941523L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB8629892D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (4) HU202112B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (2) IE930471L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (3) IL95141A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LT (1) LT2064B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LV (1) LV5273A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MC (1) MC1882A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX9203216A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO167576C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ222898A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (2) PH24104A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (3) PL158050B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT86356B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2036199C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU1731064A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA879382B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2828642B2 (ja) * 1987-06-24 1998-11-25 ハワード フローレイ インスティテュト オブ イクスペリメンタル フィジオロジー アンド メディシン ヌクレオシド誘導体
US4954485A (en) * 1987-10-20 1990-09-04 Sanyo-Kokusaku Pulp Co., Ltd. 2',3'-dideoxy-4-thio-uridine derivatives, process for their preparation and antivirus agents using them
EP0346108A3 (en) * 1988-06-09 1991-04-24 The Wellcome Foundation Limited Anti-infective nucleosides
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
GB8827339D0 (en) * 1988-11-23 1988-12-29 Wellcome Found Antiviral compounds
US5006646A (en) * 1989-02-22 1991-04-09 Yuki Gosei Kogyo Co., Ltd. Process for preparing 2'-deoxy-5-trifluoromethyl-beta-uridine
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
US6337209B1 (en) 1992-02-26 2002-01-08 Glaxo Wellcome Inc. Molecular constructs containing a carcinoembryonic antigen regulatory sequence
GB8919607D0 (en) * 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
GB9008696D0 (en) * 1990-04-18 1990-06-13 Wellcome Found Anti-viral compounds
GB9012899D0 (en) * 1990-06-09 1990-08-01 Wellcome Found Anti-hbv pyrimidine nucleoside
GB9014618D0 (en) * 1990-06-30 1990-08-22 Wellcome Found Process for the preparation of pyrimidine nucleosides
US5643913A (en) * 1990-07-19 1997-07-01 Glaxo Wellcome Inc. Pharmaceutical compositions of 5-substituted uracil compounds
DE69128626T2 (de) 1990-07-19 1998-05-20 The Wellcome Foundation Ltd., Greenford Enzyminaktivatoren
GB9020930D0 (en) 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
GB9104165D0 (en) * 1991-02-27 1991-04-17 Wellcome Found Novel entities for hiv therapy
GB9111580D0 (en) * 1991-05-30 1991-07-24 Wellcome Found Nucleoside derivative
US5646123A (en) * 1991-06-10 1997-07-08 Alberta Research Council Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen
US5580858A (en) * 1991-06-10 1996-12-03 Alberta Research Council Immunosuppressive and tolerogenic modified Lewisx compounds
HU207524B (en) * 1991-11-22 1993-04-28 Mta Koezponti Kemiai Kutato In Industrial process for producing 5-alkyl-2'-deoxy-beta-uridines with stereoselective synthesis
US5484908A (en) * 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
EP1256589A3 (en) * 1991-11-26 2003-09-17 Isis Pharmaceuticals, Inc. Oligomers containing modified pyrimidines
JP2823358B2 (ja) * 1992-05-26 1998-11-11 アルバータ リサーチ カウンスル 免疫抑制性および寛容原性修飾ルイス▲上ｃ▼およびＬａｃＮＡｃ化合物
CA2119315A1 (en) * 1993-03-18 1994-09-19 Tsujiaki Hata Nucleoside derivatives and anti-herpes composition
US6432924B1 (en) 1993-12-26 2002-08-13 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
WO1996018636A1 (fr) * 1994-12-13 1996-06-20 Taiho Pharmaceutical Co., Ltd. Derives de nucleoside substitues en 3'
WO1997023230A1 (en) * 1995-12-22 1997-07-03 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
WO1997027849A1 (fr) * 1996-02-02 1997-08-07 Showa Shell Sekiyu K.K. Medicaments pour traiter les infections provoquees par le virus de l'herpes et compositions preventives pour empecher un retour de l'infection, contenant tous les deux des derives triterpeniques comme principe actif
CN1911237B (zh) * 1998-08-10 2010-09-15 艾丹尼克斯(开曼)有限公司 用于治疗乙型肝炎的β-L-2＇-脱氧-核苷
US6653318B1 (en) 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
AU2002360697B2 (en) 2001-12-20 2009-04-23 Beth Israel Deaconess Medical Center Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
JP2008521930A (ja) 2004-12-03 2008-06-26 アドヘレックス テクノロジーズ， インコーポレイテッド ５−ｆｕおよび５−ｆｕプロドラッグと併用してｄｐｄ阻害物質を投与するための方法
US8466266B2 (en) 2008-04-01 2013-06-18 Biosearch Technologies, Inc. Stabilized nucleic acid dark quencher-fluorophore probes
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
CA2777546C (en) 2009-10-14 2019-11-05 Adherex Technologies, Inc. Treating neurotoxicity associated with combinations of 5-fu or its prodrugs and dpd inhibitors
DK3126517T3 (da) * 2014-03-30 2020-01-20 Cepheid Modificerede cytosin-polynukleotid-oligomere og fremgangsmåder

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4274544A (en) * 1980-03-11 1981-06-23 The Continental Group, Inc. Single-piece plastic closure having integral seal forming means
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
EP0082667A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc Pharmaceutical compositions
EP0095294A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0097039A1 (en) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections
GB8517402D0 (en) * 1985-07-10 1985-08-14 Wellcome Found Treatment of viral infections
DK167377B1 (da) * 1985-09-17 1993-10-25 Wellcome Found 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds

Also Published As

Publication number Publication date
NO167576C (no) 1991-11-20
JPH0378370B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-12-13
HUT46336A (en) 1988-10-28
CS916187A2 (en) 1991-02-12
CN87108265A (zh) 1988-07-13
FI875487A0 (fi) 1987-12-14
CS275402B6 (en) 1992-02-19
FI941523A7 (fi) 1994-03-31
GB8629892D0 (en) 1987-01-28
AU8252187A (en) 1988-06-16
AU626041B2 (en) 1992-07-23
PH24104A (en) 1990-03-05
PL160321B1 (pl) 1993-02-26
HU199867B (en) 1990-03-28
PL160322B1 (pl) 1993-02-26
SU1731064A3 (ru) 1992-04-30
KR880007521A (ko) 1988-08-27
AU5989090A (en) 1990-11-08
MX9203216A (es) 1992-07-01
HU207735B (en) 1993-05-28
HU903829D0 (en) 1990-11-28
PL269462A1 (en) 1989-06-26
LV5273A3 (lv) 1993-10-10
HU202112B (en) 1991-02-28
NZ222898A (en) 1990-12-21
IL95141A0 (en) 1991-06-10
EP0417560A1 (en) 1991-03-20
IL84810A0 (en) 1988-06-30
PL158050B1 (pl) 1992-07-31
CS767588A3 (en) 1991-02-12
ZA879382B (en) 1989-08-30
JPH03141292A (ja) 1991-06-17
IE930471L (en) 1988-06-15
ATE88713T1 (de) 1993-05-15
IE930470L (en) 1988-06-15
FI941523A0 (fi) 1994-03-31
RU2036199C1 (ru) 1995-05-27
NO875209L (no) 1988-06-16
DE3785651D1 (de) 1993-06-03
MC1882A1 (fr) 1989-01-24
EP0272065B1 (en) 1993-04-28
ES2054693T3 (es) 1994-08-16
US5079235A (en) 1992-01-07
PT86356A (en) 1988-01-01
CS342591A3 (en) 1992-04-15
PT86356B (pt) 1990-11-07
EP0272065A2 (en) 1988-06-22
DK654287A (da) 1988-06-16
DD274766A5 (de) 1990-01-03
DK169991D0 (da) 1991-10-04
PL277927A1 (en) 1989-08-21
CN1080292A (zh) 1994-01-05
CS275398B2 (en) 1992-02-19
DK169991A (da) 1991-10-04
HU200932B (en) 1990-09-28
CA1319143C (en) 1993-06-15
NO875209D0 (no) 1987-12-14
PL277926A1 (en) 1989-08-21
IL95141A (en) 1992-05-25
FI941523L (fi) 1994-03-31
EP0272065A3 (en) 1988-11-17
DK654287D0 (da) 1987-12-14
DK168323B1 (da) 1994-03-14
DD264924A5 (de) 1989-02-15
PH24870A (en) 1990-12-26
DE3785651T2 (de) 1993-11-11
EP0486477A2 (en) 1992-05-20
FI875487A7 (fi) 1988-06-16
IL84810A (en) 1992-05-25
LT2064B (lt) 1993-06-15
NO167576B (no) 1991-08-12
AU601529B2 (en) 1990-09-13
EP0486477A3 (en) 1992-06-17

Similar Documents

Publication Publication Date Title
JPS63165397A (ja) 抗ウイルス性化合物
EP0294114B1 (en) Antiviral compounds
EP0199451B1 (en) Therapeutic nucleosides
US5646125A (en) Polysubstituted benzimidazoles as antiviral agents
KR100225986B1 (ko) 항바이러스성 누클레오시드 배합제
JPH04506661A (ja) 抗ビールスピリミジンヌクレオシド
JPS61280500A (ja) ヌクレオシド化合物
JPH08501071A (ja) １，５−アンヒドロヘキシトールヌクレオシド類似体および該類似体の医薬としての使用
EP0305117B1 (en) 2',3'-dideoxy-3'-fluorothymidine and related compounds for the treatment of adenovirus infections
JPS63239294A (ja) 新規アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
IE903502A1 (en) Further antiviral pyrimidine nucleosides
US4863906A (en) 2'-deoxy-5-ethynyluridine-3',5'-diestens for treatment of VZV and CMV infections
JP2523527B2 (ja) ３′−アジド−ヌクレオシド類、それらの製造法、およびそれらからなる抗ビ−ルス剤
US5028596A (en) 1-(β-D-arabinofuranosyl)-5-propynyluracil for treatment of VZV infections
EP0461815A1 (en) Anti-HBV pyrimidine nucleoside
JPH0625061B2 (ja) 抗ウイルス性化合物
EP0375164B1 (en) Antiviral compounds
JPH06172365A (ja) １０−チアイソアロキサジン誘導体およびその用途
JPH013185A (ja) 活性化合物、その製法及びそれを含む医薬組成物