CS275398B2 - Method of pyrimidine nucleosides preparation - Google Patents

Method of pyrimidine nucleosides preparation

Info

Publication number
CS275398B2
CS275398B2 CS879161A CS916187A CS275398B2 CS 275398 B2 CS275398 B2 CS 275398B2 CS 879161 A CS879161 A CS 879161A CS 916187 A CS916187 A CS 916187A CS 275398 B2 CS275398 B2 CS 275398B2
Authority
CS
Czechoslovakia
Prior art keywords
pyrimidine nucleosides
preparation
nucleosides preparation
cytomegalovirus
prophylaxis
Prior art date
Application number
CS879161A
Other languages
Czech (cs)
English (en)
Other versions
CS916187A2 (en
Inventor
Saad George Rahim
Dorothy Jane Martin Purifoy
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Priority to CS877675A priority Critical patent/CS275402B6/cs
Publication of CS916187A2 publication Critical patent/CS916187A2/cs
Publication of CS275398B2 publication Critical patent/CS275398B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Silicon Polymers (AREA)
CS879161A 1986-12-15 1987-12-14 Method of pyrimidine nucleosides preparation CS275398B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS877675A CS275402B6 (en) 1986-12-15 1987-12-14 Method of pyrimidine nucleosides preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868629892A GB8629892D0 (en) 1986-12-15 1986-12-15 Antiviral compounds

Publications (2)

Publication Number Publication Date
CS916187A2 CS916187A2 (en) 1991-02-12
CS275398B2 true CS275398B2 (en) 1992-02-19

Family

ID=10609013

Family Applications (3)

Application Number Title Priority Date Filing Date
CS879161A CS275398B2 (en) 1986-12-15 1987-12-14 Method of pyrimidine nucleosides preparation
CS877675A CS275402B6 (en) 1986-12-15 1987-12-14 Method of pyrimidine nucleosides preparation
CS913425A CS342591A3 (en) 1986-12-15 1987-12-14 Pharmaceuticals comprising 1-(beta-d-arabinofuranosyl)-5-propinyluracil

Family Applications After (2)

Application Number Title Priority Date Filing Date
CS877675A CS275402B6 (en) 1986-12-15 1987-12-14 Method of pyrimidine nucleosides preparation
CS913425A CS342591A3 (en) 1986-12-15 1987-12-14 Pharmaceuticals comprising 1-(beta-d-arabinofuranosyl)-5-propinyluracil

Country Status (30)

Country Link
US (1) US5079235A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (3) EP0272065B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPS63165397A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR880007521A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN87108265A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE88713T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU601529B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1319143C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (3) CS275398B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (2) DD264924A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3785651T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (2) DK654287A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2054693T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (2) FI941523A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB8629892D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (4) HU199867B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (2) IE930471L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (3) IL95141A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LT (1) LT2064B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LV (1) LV5273A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MC (1) MC1882A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX9203216A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO167576C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ222898A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (2) PH24104A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (3) PL158050B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT86356B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2036199C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU1731064A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA879382B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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EP0346108A3 (en) * 1988-06-09 1991-04-24 The Wellcome Foundation Limited Anti-infective nucleosides
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
GB8827339D0 (en) * 1988-11-23 1988-12-29 Wellcome Found Antiviral compounds
US5006646A (en) * 1989-02-22 1991-04-09 Yuki Gosei Kogyo Co., Ltd. Process for preparing 2'-deoxy-5-trifluoromethyl-beta-uridine
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
US6337209B1 (en) 1992-02-26 2002-01-08 Glaxo Wellcome Inc. Molecular constructs containing a carcinoembryonic antigen regulatory sequence
GB8919607D0 (en) * 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
GB9008696D0 (en) * 1990-04-18 1990-06-13 Wellcome Found Anti-viral compounds
GB9012899D0 (en) * 1990-06-09 1990-08-01 Wellcome Found Anti-hbv pyrimidine nucleoside
GB9014618D0 (en) * 1990-06-30 1990-08-22 Wellcome Found Process for the preparation of pyrimidine nucleosides
WO1992001452A1 (en) 1990-07-19 1992-02-06 The Wellcome Foundation Limited Enzyme inactivators
US5643913A (en) * 1990-07-19 1997-07-01 Glaxo Wellcome Inc. Pharmaceutical compositions of 5-substituted uracil compounds
GB9020930D0 (en) 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
GB9104165D0 (en) * 1991-02-27 1991-04-17 Wellcome Found Novel entities for hiv therapy
GB9111580D0 (en) * 1991-05-30 1991-07-24 Wellcome Found Nucleoside derivative
US5646123A (en) * 1991-06-10 1997-07-08 Alberta Research Council Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen
US5580858A (en) * 1991-06-10 1996-12-03 Alberta Research Council Immunosuppressive and tolerogenic modified Lewisx compounds
HU207524B (en) * 1991-11-22 1993-04-28 Mta Koezponti Kemiai Kutato In Industrial process for producing 5-alkyl-2'-deoxy-beta-uridines with stereoselective synthesis
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
EP1256589A3 (en) * 1991-11-26 2003-09-17 Isis Pharmaceuticals, Inc. Oligomers containing modified pyrimidines
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5484908A (en) * 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
EP0643718A4 (en) * 1992-05-26 1998-08-05 Alberta Res Council MODIFIED LEWIS ™ C AND LacNAc COMPOUNDS WITH TOLERANCE AND IMMUNOSUPPRESSANT EFFECT.
CA2119315A1 (en) * 1993-03-18 1994-09-19 Tsujiaki Hata Nucleoside derivatives and anti-herpes composition
US6432924B1 (en) 1993-12-26 2002-08-13 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
KR0177372B1 (ko) * 1994-12-13 1999-04-01 아키라 마츠다 3'-치환 뉴클레오시드 유도체
US6136791A (en) * 1995-12-22 2000-10-24 East Carolina University Agent and method for treating disorders associated with cytidine deaminase or deoxycytidine deaminase overexpression
WO1997027849A1 (fr) * 1996-02-02 1997-08-07 Showa Shell Sekiyu K.K. Medicaments pour traiter les infections provoquees par le virus de l'herpes et compositions preventives pour empecher un retour de l'infection, contenant tous les deux des derives triterpeniques comme principe actif
CN1911237B (zh) * 1998-08-10 2010-09-15 艾丹尼克斯(开曼)有限公司 用于治疗乙型肝炎的β-L-2＇-脱氧-核苷
US6653318B1 (en) * 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US7211570B2 (en) * 2001-12-20 2007-05-01 Pharmasset, Inc. Treatment of EBV and KHSV infection
MX2007006646A (es) 2004-12-03 2007-11-16 Adherex Technologies Inc Metodos para administrar inhibidores de dihidropirimidina deshidrogenasa en combinacion con 5-fluorouracilo y profarmacos de 5-fluorouracilo.
ES2633786T3 (es) 2008-04-01 2017-09-25 Biosearch Technologies, Inc. Sondas de fluoróforo atenuadoras oscuras de ácido nucleico estabilizado
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
MX2012004383A (es) 2009-10-14 2012-08-23 Adherex Technologies Inc Tratamiento de neurotoxicidad asociada con las combinaciones de 5-florouracilo (5-fu) o sus profarmacos e inhibidores de dihidropiridimina (dpd).
CN106460058B (zh) * 2014-03-30 2019-07-09 赛沛 经修饰的胞嘧啶多核苷酸寡聚物和方法

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GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
US4274544A (en) * 1980-03-11 1981-06-23 The Continental Group, Inc. Single-piece plastic closure having integral seal forming means
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EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
EP0095294A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0097039A1 (en) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections
GB8517402D0 (en) * 1985-07-10 1985-08-14 Wellcome Found Treatment of viral infections
DE3650741T2 (de) * 1985-09-17 2000-10-12 The Wellcome Foundation Ltd., Greenford Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten.
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds

Also Published As

Publication number Publication date
SU1731064A3 (ru) 1992-04-30
PL277927A1 (en) 1989-08-21
EP0272065A2 (en) 1988-06-22
US5079235A (en) 1992-01-07
AU8252187A (en) 1988-06-16
NO875209D0 (no) 1987-12-14
CS767588A3 (en) 1991-02-12
JPH03141292A (ja) 1991-06-17
PH24870A (en) 1990-12-26
AU626041B2 (en) 1992-07-23
FI875487A0 (fi) 1987-12-14
HU199867B (en) 1990-03-28
HU200932B (en) 1990-09-28
CS916187A2 (en) 1991-02-12
LV5273A3 (lv) 1993-10-10
IL84810A0 (en) 1988-06-30
AU601529B2 (en) 1990-09-13
EP0486477A3 (en) 1992-06-17
FI941523L (fi) 1994-03-31
DK654287A (da) 1988-06-16
CS275402B6 (en) 1992-02-19
RU2036199C1 (ru) 1995-05-27
DE3785651D1 (de) 1993-06-03
PT86356B (pt) 1990-11-07
DD274766A5 (de) 1990-01-03
DE3785651T2 (de) 1993-11-11
HU207735B (en) 1993-05-28
ES2054693T3 (es) 1994-08-16
HU903829D0 (en) 1990-11-28
EP0486477A2 (en) 1992-05-20
DK169991A (da) 1991-10-04
ATE88713T1 (de) 1993-05-15
NZ222898A (en) 1990-12-21
LT2064B (lt) 1993-06-15
GB8629892D0 (en) 1987-01-28
JPH0378370B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-12-13
NO167576B (no) 1991-08-12
IL95141A0 (en) 1991-06-10
EP0272065B1 (en) 1993-04-28
PL160322B1 (pl) 1993-02-26
FI875487A7 (fi) 1988-06-16
PL269462A1 (en) 1989-06-26
JPS63165397A (ja) 1988-07-08
PL160321B1 (pl) 1993-02-26
MX9203216A (es) 1992-07-01
IL84810A (en) 1992-05-25
HU202112B (en) 1991-02-28
DK654287D0 (da) 1987-12-14
PH24104A (en) 1990-03-05
HUT46336A (en) 1988-10-28
EP0272065A3 (en) 1988-11-17
MC1882A1 (fr) 1989-01-24
FI941523A7 (fi) 1994-03-31
KR880007521A (ko) 1988-08-27
IE930470L (en) 1988-06-15
CS342591A3 (en) 1992-04-15
DK169991D0 (da) 1991-10-04
ZA879382B (en) 1989-08-30
CN87108265A (zh) 1988-07-13
PL158050B1 (pl) 1992-07-31
CN1080292A (zh) 1994-01-05
PT86356A (en) 1988-01-01
EP0417560A1 (en) 1991-03-20
NO167576C (no) 1991-11-20
IL95141A (en) 1992-05-25
DK168323B1 (da) 1994-03-14
FI941523A0 (fi) 1994-03-31
NO875209L (no) 1988-06-16
DD264924A5 (de) 1989-02-15
IE930471L (en) 1988-06-15
AU5989090A (en) 1990-11-08
CA1319143C (en) 1993-06-15
PL277926A1 (en) 1989-08-21

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